WO2003045986A3 - Purified polypeptides involved in general metabolism as possible drug targets - Google Patents

Purified polypeptides involved in general metabolism as possible drug targets Download PDF

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Publication number
WO2003045986A3
WO2003045986A3 PCT/CA2002/001785 CA0201785W WO03045986A3 WO 2003045986 A3 WO2003045986 A3 WO 2003045986A3 CA 0201785 W CA0201785 W CA 0201785W WO 03045986 A3 WO03045986 A3 WO 03045986A3
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WO
WIPO (PCT)
Prior art keywords
drug targets
purified polypeptides
polypeptides involved
possible drug
general metabolism
Prior art date
Application number
PCT/CA2002/001785
Other languages
French (fr)
Other versions
WO2003045986A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Veronica Canadien
Megan Domagala
Simon Houston
Qin Li
Kamran Mansoury
Sasha Necakov
Kathleen Nethery
Hui Ouyang
Benjamin Pinder
Bay Sheldrick
Francois Vallee
Olga Wrezel
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Veronica Canadien
Megan Domagala
Simon Houston
Qin Li
Kamran Mansoury
Sasha Necakov
Kathleen Nethery
Hui Ouyang
Benjamin Pinder
Bay Sheldrick
Francois Vallee
Olga Wrezel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Muhammad Zahoor Alam, Donald Awrey, Bryan Beattie, Veronica Canadien, Megan Domagala, Simon Houston, Qin Li, Kamran Mansoury, Sasha Necakov, Kathleen Nethery, Hui Ouyang, Benjamin Pinder, Bay Sheldrick, Francois Vallee, Olga Wrezel filed Critical Affinium Pharm Inc
Priority to AU2002364771A priority Critical patent/AU2002364771A1/en
Publication of WO2003045986A2 publication Critical patent/WO2003045986A2/en
Publication of WO2003045986A3 publication Critical patent/WO2003045986A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01016—Glutamine-fructose-6-phosphate transaminase (isomerizing) (2.6.1.16), i.e. glucosamine-6-phosphate-synthase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02013—Fructose-bisphosphate aldolase (4.1.2.13)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
PCT/CA2002/001785 2001-11-26 2002-11-26 Purified polypeptides involved in general metabolism as possible drug targets WO2003045986A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002364771A AU2002364771A1 (en) 2001-11-26 2002-11-26 Purified polypeptides involved in general metabolism as possible drug targets

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US33334201P 2001-11-26 2001-11-26
US33334001P 2001-11-26 2001-11-26
US33341401P 2001-11-26 2001-11-26
US33341901P 2001-11-26 2001-11-26
US33342301P 2001-11-26 2001-11-26
US60/333,340 2001-11-26
US60/333,342 2001-11-26
US60/333,419 2001-11-26
US60/333,423 2001-11-26
US60/333,414 2001-11-26
US34195101P 2001-12-19 2001-12-19
US60/341,951 2001-12-19
US34255801P 2001-12-20 2001-12-20
US34255701P 2001-12-20 2001-12-20
US60/342,558 2001-12-20
US60/342,557 2001-12-20
US34361301P 2001-12-28 2001-12-28
US34427201P 2001-12-28 2001-12-28
US60/343,613 2001-12-28
US60/344,272 2001-12-28

Publications (2)

Publication Number Publication Date
WO2003045986A2 WO2003045986A2 (en) 2003-06-05
WO2003045986A3 true WO2003045986A3 (en) 2003-12-11

Family

ID=27581240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001785 WO2003045986A2 (en) 2001-11-26 2002-11-26 Purified polypeptides involved in general metabolism as possible drug targets

Country Status (2)

Country Link
AU (1) AU2002364771A1 (en)
WO (1) WO2003045986A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070955A2 (en) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070955A2 (en) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EPOP [online] 8 August 2001 (2001-08-08), "Sequence 472 from patent WO0148209", XP002244322, Database accession no. AX189271 *
DATABASE GENESEQ [online] 14 February 2002 (2002-02-14), "E. coli cellular proliferation protein #392", XP002244321, Database accession no. AAU34811 *
DATABASE PDB [online] 19 August 2001 (2001-08-19), "glucose-inhibited division protein b", XP002244323, Database accession no. 1JSX *
DATABASE SWALL [online] 1 August 1990 (1990-08-01), "Methyltransferase gidB", XP002244320, Database accession no. P17113 *
MUSHEGIAN A R ET AL: "A minimal gene set for cellular life derived by comparison of complete bacterial genomes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, September 1996 (1996-09-01), pages 10268 - 10273, XP002126189, ISSN: 0027-8424 *
ROMANOWSKI ET AL.: "Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold", PROTEINS, vol. 47, 2002, pages 563 - 567, XP002244319 *

Also Published As

Publication number Publication date
WO2003045986A2 (en) 2003-06-05
AU2002364771A8 (en) 2003-06-10
AU2002364771A1 (en) 2003-06-10

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