JP2009527768A5 - - Google Patents
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- JP2009527768A5 JP2009527768A5 JP2008556426A JP2008556426A JP2009527768A5 JP 2009527768 A5 JP2009527768 A5 JP 2009527768A5 JP 2008556426 A JP2008556426 A JP 2008556426A JP 2008556426 A JP2008556426 A JP 2008556426A JP 2009527768 A5 JP2009527768 A5 JP 2009527768A5
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- target substance
- hyperpolarization
- hyperpolarized
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 18
- 239000002904 solvent Substances 0.000 claims 16
- 239000013076 target substance Substances 0.000 claims 9
- 230000002102 hyperpolarization Effects 0.000 claims 8
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 6
- 238000004458 analytical method Methods 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 230000010287 polarization Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- RYHBNJHYFVUHQT-SVYQBANQSA-N (2H8)-1,4-Dioxane Chemical compound [2H]C1([2H])OC([2H])([2H])C([2H])([2H])OC1([2H])[2H] RYHBNJHYFVUHQT-SVYQBANQSA-N 0.000 claims 1
- QPFMBZIOSGYJDE-QDNHWIQGSA-N 1,1,2,2-tetrachlorethane-d2 Chemical compound [2H]C(Cl)(Cl)C([2H])(Cl)Cl QPFMBZIOSGYJDE-QDNHWIQGSA-N 0.000 claims 1
- OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ZMXDDKWLCZADIW-YYWVXINBSA-N N,N-dimethylformamide-d7 Chemical compound [2H]C(=O)N(C([2H])([2H])[2H])C([2H])([2H])[2H] ZMXDDKWLCZADIW-YYWVXINBSA-N 0.000 claims 1
- 238000005481 NMR spectroscopy Methods 0.000 claims 1
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 claims 1
- CSCPPACGZOOCGX-WFGJKAKNSA-N acetone d6 Chemical compound [2H]C([2H])([2H])C(=O)C([2H])([2H])[2H] CSCPPACGZOOCGX-WFGJKAKNSA-N 0.000 claims 1
- WEVYAHXRMPXWCK-FIBGUPNXSA-N acetonitrile-d3 Chemical compound [2H]C([2H])([2H])C#N WEVYAHXRMPXWCK-FIBGUPNXSA-N 0.000 claims 1
- UHOVQNZJYSORNB-MZWXYZOWSA-N benzene-d6 Chemical compound [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H] UHOVQNZJYSORNB-MZWXYZOWSA-N 0.000 claims 1
- 239000000084 colloidal system Substances 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- YMWUJEATGCHHMB-DICFDUPASA-N dichloromethane-d2 Chemical compound [2H]C([2H])(Cl)Cl YMWUJEATGCHHMB-DICFDUPASA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-LIDOUZCJSA-N ethanol-d6 Chemical compound [2H]OC([2H])([2H])C([2H])([2H])[2H] LFQSCWFLJHTTHZ-LIDOUZCJSA-N 0.000 claims 1
- BDAGIHXWWSANSR-PFUFQJKNSA-N formic acid-d2 Chemical compound [2H]OC([2H])=O BDAGIHXWWSANSR-PFUFQJKNSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- LYGJENNIWJXYER-FIBGUPNXSA-N nitromethane-d3 Chemical compound [2H]C([2H])([2H])[N+]([O-])=O LYGJENNIWJXYER-FIBGUPNXSA-N 0.000 claims 1
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 claims 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims 1
- WYURNTSHIVDZCO-SVYQBANQSA-N oxolane-d8 Chemical compound [2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H] WYURNTSHIVDZCO-SVYQBANQSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- JUJWROOIHBZHMG-RALIUCGRSA-N pyridine-d5 Chemical compound [2H]C1=NC([2H])=C([2H])C([2H])=C1[2H] JUJWROOIHBZHMG-RALIUCGRSA-N 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- DTQVDTLACAAQTR-DYCDLGHISA-N trifluoroacetic acid-d1 Chemical compound [2H]OC(=O)C(F)(F)F DTQVDTLACAAQTR-DYCDLGHISA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77519606P | 2006-02-21 | 2006-02-21 | |
| US80269906P | 2006-05-23 | 2006-05-23 | |
| PCT/US2007/004654 WO2007136439A2 (en) | 2006-02-21 | 2007-02-21 | Hyperpolarization methods, systems and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009527768A JP2009527768A (ja) | 2009-07-30 |
| JP2009527768A5 true JP2009527768A5 (https=) | 2010-03-25 |
Family
ID=38723740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556426A Pending JP2009527768A (ja) | 2006-02-21 | 2007-02-21 | 超偏極方法、システムおよび組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20090016964A1 (https=) |
| EP (1) | EP1986702A4 (https=) |
| JP (1) | JP2009527768A (https=) |
| KR (2) | KR101095943B1 (https=) |
| CN (1) | CN101511264A (https=) |
| AU (1) | AU2007254464B2 (https=) |
| CA (1) | CA2643306C (https=) |
| WO (1) | WO2007136439A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5183068B2 (ja) * | 2003-12-22 | 2013-04-17 | フィンレイ，ウォーレン，エイチ | 大気噴出凍結乾燥法による粉末形成 |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| WO2016089858A1 (en) * | 2014-12-02 | 2016-06-09 | Neal Kalechofsky | Systems and related methods for rapdily moving materials into and out of a cryogenic environment |
| WO2007136439A2 (en) | 2006-02-21 | 2007-11-29 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
| US20170269180A1 (en) * | 2006-02-21 | 2017-09-21 | Millikelvin Technologies Llc | Systems and related methods for rapidly moving materials into and out of a cryogenic environment |
| US7631507B2 (en) * | 2006-11-02 | 2009-12-15 | General Electric Company | Methods and devices for polarized samples for use in MRI |
| WO2008149118A1 (en) * | 2007-06-08 | 2008-12-11 | Oxford Instruments Molecular Biotools Limited | Sample preparation method for enhancement of nmr sensitivity |
| JP5570996B2 (ja) | 2007-12-14 | 2014-08-13 | エアロデザインズ インコーポレイテッド | エアロゾル化可能な食料品の送達 |
| AU2009251528B2 (en) * | 2008-04-04 | 2014-09-18 | Millikelvin Technologies Llc | Manufacture, transport and delivery of material containing highly polarized nuclei |
| WO2010014893A2 (en) * | 2008-07-31 | 2010-02-04 | Duke University | Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof |
| US9289518B2 (en) | 2008-08-22 | 2016-03-22 | The Brigham And Women's Hospital | Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE |
| EP2374016B1 (en) | 2008-12-10 | 2017-05-10 | University of York | Pulse sequencing with hyperpolarisable nuclei |
| DE212010000123U1 (de) * | 2009-08-26 | 2012-09-13 | Aspect Magnet Technologies Ltd. | Mittel zur Durchführung einer Bildgebung mit hyperpolarisiertem Gas |
| EP2473198A4 (en) * | 2009-08-31 | 2015-06-24 | Millikelvin Technologies Llc | SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF |
| US9222995B2 (en) | 2010-02-16 | 2015-12-29 | Koninklijke Philips N.V. | Apparatus and method for dispensing a hyperpolarized fluid |
| WO2011116341A2 (en) * | 2010-03-19 | 2011-09-22 | Tang Joel A | Longevity of hyperpolarized enhanced signals for nmr spectroscopy |
| WO2011124672A1 (en) * | 2010-04-08 | 2011-10-13 | Bracco Imaging Spa | Process for preparing hyperpolarized substrates and method for mri |
| US20130237803A1 (en) * | 2010-11-16 | 2013-09-12 | Aspect Imaging Ltd. | System and Method for Generating Invasively Hyperpolarized Images |
| WO2012145733A1 (en) | 2011-04-22 | 2012-10-26 | Vanderbilt University | Para-hydrogen polarizer |
| WO2013053839A1 (en) | 2011-10-12 | 2013-04-18 | Bracco Imaging Spa | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
| WO2013083535A1 (en) | 2011-12-05 | 2013-06-13 | Bracco Imaging Spa | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis |
| GB2498181A (en) * | 2011-12-29 | 2013-07-10 | Bruker Biospin Gmbh | Device and method for rapid dynamic nuclear polarisation |
| US20150234105A1 (en) * | 2012-06-29 | 2015-08-20 | Eduardo Andres Larrain Sanchez | System that can be used to polarise glass, acrylic and similar automatically as required by the user |
| US9329246B2 (en) * | 2012-10-03 | 2016-05-03 | Bruker Biospin Ag | Method for hyperpolarization transfer in the liquid state |
| US9404984B2 (en) * | 2012-11-06 | 2016-08-02 | Bruker Uk Limited | Method of hyperpolarization applying brute force using particulate acceleration agents |
| EP2992344B1 (en) * | 2013-05-03 | 2020-10-07 | Quantum Valley Investment Fund LP | Transferring spin polarization |
| JP6359642B2 (ja) * | 2013-05-03 | 2018-07-18 | クオンタム ヴァリー インベストメント ファンド リミテッド パートナーシップ | 効率的スピン偏極 |
| US9606200B2 (en) | 2013-08-27 | 2017-03-28 | Bruker Biospin Corporation | Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization |
| US9874622B2 (en) * | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
| GB201412040D0 (en) * | 2014-07-07 | 2014-08-20 | Nottingham University Hospitals Nhs Trust | Magnetic resonance imaging methods for the study of gastronintestinal transit |
| EP3174558B1 (en) * | 2014-07-29 | 2019-03-06 | Bracco Imaging S.p.A | Preparation of amorphous samples for dnp from solid crystalline substrates |
| US10088536B2 (en) | 2015-03-27 | 2018-10-02 | Bruker Biospin Corporation | Sample introduction system and method for polarization |
| US11926525B2 (en) | 2015-09-07 | 2024-03-12 | The University Of Nottingham | Production of hyperpolarized gas |
| JP6592405B2 (ja) * | 2016-06-10 | 2019-10-16 | 日本電信電話株式会社 | 熱可塑性ポリエステルの延性低下による寿命の推定方法 |
| EP3544591B1 (en) * | 2016-11-23 | 2022-04-20 | Mayo Foundation for Medical Education and Research | Particle-mediated delivery of biologics |
| GB201703658D0 (en) * | 2017-03-07 | 2017-04-19 | Univ York | Hyperpolarization in aqueous media via SABRE |
| CN108627532B (zh) * | 2017-03-23 | 2020-10-16 | 中国科学院大连化学物理研究所 | 一种用于原位核磁共振检测甲烷和水吸附状态的装置及方法 |
| WO2019071090A1 (en) * | 2017-10-06 | 2019-04-11 | University Of Florida Research Foundation | METHODS AND SYSTEMS FOR PRODUCTION, USE, AND ADMINISTRATION OF HYPERPOLARIZED FLUIDS |
| FR3074302B1 (fr) * | 2017-11-28 | 2019-11-22 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Procede et appareil d'hyperpolarisation de spins, notamment electroniques |
| EP3756024B1 (en) * | 2018-02-19 | 2026-04-29 | BRUKER FRANCE (Société par Actions Simplifiée) | Nuclear spin hyperpolarization in a porous matrix |
| WO2020104854A2 (en) * | 2018-11-21 | 2020-05-28 | Nvision Imaging Technologies Gmbh | Systems and method for generation of hyperpolarized materials |
| WO2020178310A1 (en) | 2019-03-04 | 2020-09-10 | Danmarks Tekniske Universitet | Cleaning of a fluid path system for hyperpolarization of a pharmaceutical product |
| CN111537540A (zh) * | 2020-05-18 | 2020-08-14 | 中国科学院精密测量科学与技术创新研究院 | 一种用于低磁场下仲氢诱导极化装置及方法 |
| EP4256357A1 (en) * | 2020-12-07 | 2023-10-11 | NVision Imaging Technologies GmbH | Systems and methods for generation of hyperpolarized compounds using parahydrogen |
| EP4285131A2 (en) * | 2021-01-30 | 2023-12-06 | NVision Imaging Technologies GmbH | Systems and methods for generation of hyperpolarized materials |
| US12409239B2 (en) | 2021-06-25 | 2025-09-09 | Beacon Mri Ltd | Particles for use in hyperpolarization |
| CN119086618B (zh) * | 2023-09-06 | 2025-10-03 | 中国科学院精密测量科学与技术创新研究院 | 用于超极化129Xe磁共振分子探针流动采样的装置及方法 |
| WO2025111525A1 (en) * | 2023-11-22 | 2025-05-30 | University Of Wyoming | Apparatus and methods for magnetically assisted alteration or transformation of organic substances |
| WO2025160283A1 (en) * | 2024-01-24 | 2025-07-31 | Vizma Life Sciences, Inc. | Contrast agent device |
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| WO1991012024A1 (en) | 1990-02-12 | 1991-08-22 | Hafslund Nycomed Innovation Ab | Triarylmethyl radicals and the use of inert carbon free radicals in mri |
| US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5545396A (en) | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
| US5617860A (en) | 1995-06-07 | 1997-04-08 | Smithsonian Astrophysical Observatory | Method and system for producing polarized 129 Xe gas |
| US5617859A (en) * | 1995-10-02 | 1997-04-08 | General Electric Company | Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures |
| IL126347A (en) | 1996-03-29 | 2003-11-23 | Lawrence Berkeley National Lab | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
| US5642625A (en) | 1996-03-29 | 1997-07-01 | The Trustees Of Princeton University | High volume hyperpolarizer for spin-polarized noble gas |
| US5809801A (en) | 1996-03-29 | 1998-09-22 | The Trustees Of Princeton University | Cryogenic accumulator for spin-polarized xenon-129 |
| GB9614139D0 (en) | 1996-07-05 | 1996-09-04 | Nycomed Imaging As | Method |
| EP0951650B1 (en) * | 1997-01-08 | 2003-12-10 | Amersham Health AS | Method of magnetic resonance imaging |
| JP2002508687A (ja) | 1997-06-19 | 2002-03-19 | ナイコムド イメージング エーエス | 磁気共鳴（ｍｒ）イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像（ｏｒｍｉ）法 |
| WO1999009149A1 (en) * | 1997-08-01 | 1999-02-25 | Massachusetts Institute Of Technology | Three-dimensional polymer matrices |
| ES2209167T3 (es) | 1997-08-12 | 2004-06-16 | Bracco Research S.A. | Composiciones administrables y metodo para produccion de imagenes por resonancia magnetica. |
| AU1047399A (en) | 1997-11-12 | 1999-05-31 | Nycomed Imaging As | Para-hydrogen labelled agents and their use in magnetic resonance imaging |
| HU222711B1 (hu) | 1997-12-12 | 2003-09-29 | Medi-Physics, Inc, | Polarizált gáz akkumulátor és fżtżköpeny, eljárás polarizált gáz összegyżjtésére és felengedésére, valamint polarizált gáztermék |
| US6278893B1 (en) | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| HUP0104279A3 (en) * | 1998-06-17 | 2002-05-28 | Medi Physics Inc Princeton | Hyperpolarized gas transport device and associated transport method |
| JP2002518652A (ja) * | 1998-06-17 | 2002-06-25 | メディ‐フィジクス，インコーポレイテッド | 過分極化されたガスのための弾性容器 |
| JP2002522750A (ja) * | 1998-08-05 | 2002-07-23 | ユニバーシティ・オブ・ピッツバーグ | シトクロムｐ４５０媒介反応における有機化合物の反応性のモデル化 |
| GB9911681D0 (en) * | 1999-05-19 | 1999-07-21 | Nycomed Imaging As | Process |
| US6648130B1 (en) | 1999-08-11 | 2003-11-18 | Medi-Physics, Inc. | Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets |
| GB0001727D0 (en) * | 2000-01-25 | 2000-03-15 | Oxford Instr Uk Ltd | Hyperpolarization of a noble gas |
| DK1330659T3 (da) | 2000-11-03 | 2006-12-18 | Amersham Health As | Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser |
| AU1403902A (en) | 2000-11-03 | 2002-05-15 | Amersham Health As | Methods and devices for polarised nmr samples |
| US6869591B2 (en) * | 2002-03-26 | 2005-03-22 | Barnes-Jewish Hospital | Paramagnetic particles that provide improved relaxivity |
| NO20025124D0 (no) * | 2002-10-25 | 2002-10-25 | Amersham Health As | Metode |
| EP1620154A1 (en) * | 2003-04-22 | 2006-02-01 | Medi-Physics, Inc. | Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery |
| JP4405758B2 (ja) * | 2003-07-01 | 2010-01-27 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 磁気共鳴撮像装置 |
| US20060124510A1 (en) * | 2004-10-12 | 2006-06-15 | Neal Kalechofsky | Devices, materials and methods for sorting, separating and sizing very small particles |
| US20050187398A1 (en) * | 2003-10-31 | 2005-08-25 | Andrew Bell | Single component cationic palladium proinitiators for the latent polymerization of cycloolefins |
| DE102004002639A1 (de) * | 2004-01-19 | 2005-09-15 | Forschungszentrum Jülich GmbH | Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens |
| DE102004011874B4 (de) * | 2004-03-11 | 2006-04-20 | Universitätsklinikum Freiburg | Verfahren zur Messung der Magnetresonanz (NMR) mittels Continuously Refocused Multiecho Spectroscopic Imaging |
| FR2881226B1 (fr) | 2005-01-27 | 2007-04-27 | Commissariat Energie Atomique | Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source |
| GB0514303D0 (en) * | 2005-07-12 | 2005-08-17 | Oxford Instr Molecular Biotool | Magnet assembly |
| WO2007136439A2 (en) | 2006-02-21 | 2007-11-29 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
| AU2009251528B2 (en) | 2008-04-04 | 2014-09-18 | Millikelvin Technologies Llc | Manufacture, transport and delivery of material containing highly polarized nuclei |
| EP2473198A4 (en) | 2009-08-31 | 2015-06-24 | Millikelvin Technologies Llc | SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF |
-
2007
- 2007-02-21 WO PCT/US2007/004654 patent/WO2007136439A2/en not_active Ceased
- 2007-02-21 KR KR1020087023005A patent/KR101095943B1/ko not_active Expired - Fee Related
- 2007-02-21 CA CA2643306A patent/CA2643306C/en not_active Expired - Fee Related
- 2007-02-21 EP EP07808986A patent/EP1986702A4/en not_active Withdrawn
- 2007-02-21 CN CNA2007800114443A patent/CN101511264A/zh active Pending
- 2007-02-21 KR KR1020087023208A patent/KR101321862B1/ko not_active Expired - Fee Related
- 2007-02-21 JP JP2008556426A patent/JP2009527768A/ja active Pending
- 2007-02-21 AU AU2007254464A patent/AU2007254464B2/en not_active Ceased
-
2008
- 2008-08-18 US US12/193,536 patent/US20090016964A1/en not_active Abandoned
-
2011
- 2011-12-22 US US13/335,076 patent/US8703201B2/en not_active Expired - Fee Related
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