JP2009527768A - 超偏極方法、システムおよび組成物 - Google Patents

超偏極方法、システムおよび組成物 Download PDF

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JP2009527768A
JP2009527768A JP2008556426A JP2008556426A JP2009527768A JP 2009527768 A JP2009527768 A JP 2009527768A JP 2008556426 A JP2008556426 A JP 2008556426A JP 2008556426 A JP2008556426 A JP 2008556426A JP 2009527768 A JP2009527768 A JP 2009527768A
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hyperpolarized
solvent
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beneficial agent
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ベルザー，アブラム
カレチョフスキー，ニール
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Steroid Compounds (AREA)
JP2008556426A 2006-02-21 2007-02-21 超偏極方法、システムおよび組成物 Pending JP2009527768A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77519606P 2006-02-21 2006-02-21
US80269906P 2006-05-23 2006-05-23
PCT/US2007/004654 WO2007136439A2 (en) 2006-02-21 2007-02-21 Hyperpolarization methods, systems and compositions

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JP2009527768A true JP2009527768A (ja) 2009-07-30
JP2009527768A5 JP2009527768A5 (https=) 2010-03-25

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US (2) US20090016964A1 (https=)
EP (1) EP1986702A4 (https=)
JP (1) JP2009527768A (https=)
KR (2) KR101095943B1 (https=)
CN (1) CN101511264A (https=)
AU (1) AU2007254464B2 (https=)
CA (1) CA2643306C (https=)
WO (1) WO2007136439A2 (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013523298A (ja) * 2010-04-08 2013-06-17 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 過分極基質の製造方法およびｍｒｉのための方法
JP2013542036A (ja) * 2010-11-16 2013-11-21 アスペクト イメージング リミテッド 非侵襲的に過分極した画像を生成するシステム及び方法
JP2016519306A (ja) * 2013-05-03 2016-06-30 クオンタム ヴァリー インベストメント ファンド リミテッド パートナーシップ スピン偏極の移動
JP2016520825A (ja) * 2013-05-03 2016-07-14 クオンタム ヴァリー インベストメント ファンド リミテッド パートナーシップ 空洞を使用するスピン集団の偏極
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
JP2017219519A (ja) * 2016-06-10 2017-12-14 日本電信電話株式会社 熱可塑性ポリエステルの延性低下による寿命の推定方法
JP2020500857A (ja) * 2016-11-23 2020-01-16 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 生物学的製剤の粒子媒介送達
JP2023552496A (ja) * 2020-12-07 2023-12-15 エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング パラ水素を使用する超偏極化合物の生成のためのシステム及び方法
JP2024505215A (ja) * 2021-01-30 2024-02-05 エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 過分極材料の生成のためのシステムおよび方法

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5183068B2 (ja) * 2003-12-22 2013-04-17 フィンレイ，ウォーレン，エイチ 大気噴出凍結乾燥法による粉末形成
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2016089858A1 (en) * 2014-12-02 2016-06-09 Neal Kalechofsky Systems and related methods for rapdily moving materials into and out of a cryogenic environment
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US20170269180A1 (en) * 2006-02-21 2017-09-21 Millikelvin Technologies Llc Systems and related methods for rapidly moving materials into and out of a cryogenic environment
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
WO2008149118A1 (en) * 2007-06-08 2008-12-11 Oxford Instruments Molecular Biotools Limited Sample preparation method for enhancement of nmr sensitivity
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
AU2009251528B2 (en) * 2008-04-04 2014-09-18 Millikelvin Technologies Llc Manufacture, transport and delivery of material containing highly polarized nuclei
WO2010014893A2 (en) * 2008-07-31 2010-02-04 Duke University Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof
US9289518B2 (en) 2008-08-22 2016-03-22 The Brigham And Women's Hospital Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE
EP2374016B1 (en) 2008-12-10 2017-05-10 University of York Pulse sequencing with hyperpolarisable nuclei
DE212010000123U1 (de) * 2009-08-26 2012-09-13 Aspect Magnet Technologies Ltd. Mittel zur Durchführung einer Bildgebung mit hyperpolarisiertem Gas
EP2473198A4 (en) * 2009-08-31 2015-06-24 Millikelvin Technologies Llc SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF
US9222995B2 (en) 2010-02-16 2015-12-29 Koninklijke Philips N.V. Apparatus and method for dispensing a hyperpolarized fluid
WO2011116341A2 (en) * 2010-03-19 2011-09-22 Tang Joel A Longevity of hyperpolarized enhanced signals for nmr spectroscopy
WO2012145733A1 (en) 2011-04-22 2012-10-26 Vanderbilt University Para-hydrogen polarizer
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US20150234105A1 (en) * 2012-06-29 2015-08-20 Eduardo Andres Larrain Sanchez System that can be used to polarise glass, acrylic and similar automatically as required by the user
US9329246B2 (en) * 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) * 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
US9606200B2 (en) 2013-08-27 2017-03-28 Bruker Biospin Corporation Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization
US9874622B2 (en) * 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
GB201412040D0 (en) * 2014-07-07 2014-08-20 Nottingham University Hospitals Nhs Trust Magnetic resonance imaging methods for the study of gastronintestinal transit
EP3174558B1 (en) * 2014-07-29 2019-03-06 Bracco Imaging S.p.A Preparation of amorphous samples for dnp from solid crystalline substrates
US10088536B2 (en) 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
US11926525B2 (en) 2015-09-07 2024-03-12 The University Of Nottingham Production of hyperpolarized gas
GB201703658D0 (en) * 2017-03-07 2017-04-19 Univ York Hyperpolarization in aqueous media via SABRE
CN108627532B (zh) * 2017-03-23 2020-10-16 中国科学院大连化学物理研究所 一种用于原位核磁共振检测甲烷和水吸附状态的装置及方法
WO2019071090A1 (en) * 2017-10-06 2019-04-11 University Of Florida Research Foundation METHODS AND SYSTEMS FOR PRODUCTION, USE, AND ADMINISTRATION OF HYPERPOLARIZED FLUIDS
FR3074302B1 (fr) * 2017-11-28 2019-11-22 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede et appareil d'hyperpolarisation de spins, notamment electroniques
EP3756024B1 (en) * 2018-02-19 2026-04-29 BRUKER FRANCE (Société par Actions Simplifiée) Nuclear spin hyperpolarization in a porous matrix
WO2020104854A2 (en) * 2018-11-21 2020-05-28 Nvision Imaging Technologies Gmbh Systems and method for generation of hyperpolarized materials
WO2020178310A1 (en) 2019-03-04 2020-09-10 Danmarks Tekniske Universitet Cleaning of a fluid path system for hyperpolarization of a pharmaceutical product
CN111537540A (zh) * 2020-05-18 2020-08-14 中国科学院精密测量科学与技术创新研究院 一种用于低磁场下仲氢诱导极化装置及方法
US12409239B2 (en) 2021-06-25 2025-09-09 Beacon Mri Ltd Particles for use in hyperpolarization
CN119086618B (zh) * 2023-09-06 2025-10-03 中国科学院精密测量科学与技术创新研究院 用于超极化129Xe磁共振分子探针流动采样的装置及方法
WO2025111525A1 (en) * 2023-11-22 2025-05-30 University Of Wyoming Apparatus and methods for magnetically assisted alteration or transformation of organic substances
WO2025160283A1 (en) * 2024-01-24 2025-07-31 Vizma Life Sciences, Inc. Contrast agent device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503646A (ja) * 1996-03-29 2001-03-21 ローレンス バークレー ナショナル ラボラトリィ 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強
JP2001513661A (ja) * 1997-01-08 2001-09-04 ナイコムド イメージング エーエス 磁気共鳴画像法
US20030185760A1 (en) * 2002-03-26 2003-10-02 Gregory Lanza Paramagnetic particles that provide improved relaxivity
JP2005021323A (ja) * 2003-07-01 2005-01-27 Ge Medical Systems Global Technology Co Llc 磁気共鳴撮像装置および超偏極希ガス供給システム

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617860A (en) 1995-06-07 1997-04-08 Smithsonian Astrophysical Observatory Method and system for producing polarized 129 Xe gas
US5617859A (en) * 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
US5642625A (en) 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas
US5809801A (en) 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
JP2002508687A (ja) 1997-06-19 2002-03-19 ナイコムド イメージング エーエス 磁気共鳴（ｍｒ）イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像（ｏｒｍｉ）法
WO1999009149A1 (en) * 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Three-dimensional polymer matrices
ES2209167T3 (es) 1997-08-12 2004-06-16 Bracco Research S.A. Composiciones administrables y metodo para produccion de imagenes por resonancia magnetica.
AU1047399A (en) 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
HU222711B1 (hu) 1997-12-12 2003-09-29 Medi-Physics, Inc, Polarizált gáz akkumulátor és fżtżköpeny, eljárás polarizált gáz összegyżjtésére és felengedésére, valamint polarizált gáztermék
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
HUP0104279A3 (en) * 1998-06-17 2002-05-28 Medi Physics Inc Princeton Hyperpolarized gas transport device and associated transport method
JP2002518652A (ja) * 1998-06-17 2002-06-25 メディ‐フィジクス，インコーポレイテッド 過分極化されたガスのための弾性容器
JP2002522750A (ja) * 1998-08-05 2002-07-23 ユニバーシティ・オブ・ピッツバーグ シトクロムｐ４５０媒介反応における有機化合物の反応性のモデル化
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process
US6648130B1 (en) 1999-08-11 2003-11-18 Medi-Physics, Inc. Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets
GB0001727D0 (en) * 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
DK1330659T3 (da) 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
AU1403902A (en) 2000-11-03 2002-05-15 Amersham Health As Methods and devices for polarised nmr samples
NO20025124D0 (no) * 2002-10-25 2002-10-25 Amersham Health As Metode
EP1620154A1 (en) * 2003-04-22 2006-02-01 Medi-Physics, Inc. Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
US20060124510A1 (en) * 2004-10-12 2006-06-15 Neal Kalechofsky Devices, materials and methods for sorting, separating and sizing very small particles
US20050187398A1 (en) * 2003-10-31 2005-08-25 Andrew Bell Single component cationic palladium proinitiators for the latent polymerization of cycloolefins
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
DE102004011874B4 (de) * 2004-03-11 2006-04-20 Universitätsklinikum Freiburg Verfahren zur Messung der Magnetresonanz (NMR) mittels Continuously Refocused Multiecho Spectroscopic Imaging
FR2881226B1 (fr) 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
AU2009251528B2 (en) 2008-04-04 2014-09-18 Millikelvin Technologies Llc Manufacture, transport and delivery of material containing highly polarized nuclei
EP2473198A4 (en) 2009-08-31 2015-06-24 Millikelvin Technologies Llc SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503646A (ja) * 1996-03-29 2001-03-21 ローレンス バークレー ナショナル ラボラトリィ 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強
JP2001513661A (ja) * 1997-01-08 2001-09-04 ナイコムド イメージング エーエス 磁気共鳴画像法
US20030185760A1 (en) * 2002-03-26 2003-10-02 Gregory Lanza Paramagnetic particles that provide improved relaxivity
JP2005021323A (ja) * 2003-07-01 2005-01-27 Ge Medical Systems Global Technology Co Llc 磁気共鳴撮像装置および超偏極希ガス供給システム

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN7013003005; Ｖｅｒｈｕｌｓｔ　Ａ　Ｓ: 'Ｏｐｔｉｃａｌ　ｐｕｍｐｉｎｇ　ｅｘｐｅｒｉｍｅｎｔｓ　ｔｏ　ｉｎｃｒｅａｓｅ　ｔｈｅ　ｐｏｌａｒｉｚａｔｉｏｎ　ｉｎ　ｎｕｃｌｅａｒ-ｓｐｉｎ　ｂａｓｅｄ　ｑｕａｎｔｕｍ　ｃｏｍｐｕｔｅｒｓ' ＰｈＤ　Ｔｈｅｓｉｓ，Ｓｔａｎｆｏｒｄ　Ｕｎｉｖｅｒｓｉｔｙ , 200412, Ｐ．ｉ-ｘｘｉｖ　ａｎｄ　Ｐ．１-２５１ *

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JP2013523298A (ja) * 2010-04-08 2013-06-17 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 過分極基質の製造方法およびｍｒｉのための方法
US9694090B2 (en) 2010-04-08 2017-07-04 Bracco Imaging S.P.A. Process for preparing hyperpolarized substrates and method for MRI
JP2013542036A (ja) * 2010-11-16 2013-11-21 アスペクト イメージング リミテッド 非侵襲的に過分極した画像を生成するシステム及び方法
JP2016052545A (ja) * 2010-11-16 2016-04-14 アスペクト イメージング リミテッド 非侵襲的に過分極した画像を生成するシステム及び方法
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US10197642B2 (en) 2013-05-03 2019-02-05 Quantum Valley Investment Fund LP Using a thermally-isolated cavity to polarize a spin ensemble
US10371767B2 (en) 2013-05-03 2019-08-06 Quantum Valley Investment Fund LP Efficient spin polarization
JP2016520825A (ja) * 2013-05-03 2016-07-14 クオンタム ヴァリー インベストメント ファンド リミテッド パートナーシップ 空洞を使用するスピン集団の偏極
US10184994B2 (en) 2013-05-03 2019-01-22 Quantum Valley Investment Fund LP Polarizing a spin ensemble for magnetic resonance imaging
JP2016519306A (ja) * 2013-05-03 2016-06-30 クオンタム ヴァリー インベストメント ファンド リミテッド パートナーシップ スピン偏極の移動
US10197641B2 (en) 2013-05-03 2019-02-05 Quantum Valley Investment Fund LP Using a cavity to polarize a spin ensemble
US10197643B2 (en) 2013-05-03 2019-02-05 Quantum Valley Investment Fund LP Transferring spin polarization
JP2017219519A (ja) * 2016-06-10 2017-12-14 日本電信電話株式会社 熱可塑性ポリエステルの延性低下による寿命の推定方法
JP2020500857A (ja) * 2016-11-23 2020-01-16 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 生物学的製剤の粒子媒介送達
JP7121005B2 (ja) 2016-11-23 2022-08-17 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 生物学的製剤の粒子媒介送達
US12036232B2 (en) 2016-11-23 2024-07-16 Mayo Foundation For Medical Education And Research Particle-mediated delivery of biologics
JP2023552496A (ja) * 2020-12-07 2023-12-15 エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング パラ水素を使用する超偏極化合物の生成のためのシステム及び方法
JP7846128B2 (ja) 2020-12-07 2026-04-14 エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング パラ水素を使用する超偏極化合物の生成のためのシステム及び方法
JP2024505215A (ja) * 2021-01-30 2024-02-05 エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 過分極材料の生成のためのシステムおよび方法

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AU2007254464B2 (en) 2013-02-21
WO2007136439A3 (en) 2008-10-23
CN101511264A (zh) 2009-08-19
KR101095943B1 (ko) 2011-12-19
US8703201B2 (en) 2014-04-22
KR20080096840A (ko) 2008-11-03
US20090016964A1 (en) 2009-01-15
AU2007254464A1 (en) 2007-11-29
CA2643306C (en) 2016-05-03
WO2007136439A2 (en) 2007-11-29
KR101321862B1 (ko) 2013-10-28
KR20080091402A (ko) 2008-10-10
EP1986702A2 (en) 2008-11-05
CA2643306A1 (en) 2007-11-29
US20120114851A1 (en) 2012-05-10
EP1986702A4 (en) 2012-12-12

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