AU2007254464B2 - Hyperpolarization methods, systems and compositions - Google Patents

Hyperpolarization methods, systems and compositions Download PDF

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Publication number
AU2007254464B2
AU2007254464B2 AU2007254464A AU2007254464A AU2007254464B2 AU 2007254464 B2 AU2007254464 B2 AU 2007254464B2 AU 2007254464 A AU2007254464 A AU 2007254464A AU 2007254464 A AU2007254464 A AU 2007254464A AU 2007254464 B2 AU2007254464 B2 AU 2007254464B2
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hyperpolarized
beneficial agent
hyperpolarization
solvent
accordance
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AU2007254464A
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AU2007254464A1 (en
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Avrum Belzer
Neal Kalechofsky
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Priority to AU2013205838A priority Critical patent/AU2013205838B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Steroid Compounds (AREA)
AU2007254464A 2006-02-21 2007-02-21 Hyperpolarization methods, systems and compositions Ceased AU2007254464B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013205838A AU2013205838B2 (en) 2006-02-21 2013-05-13 Hyperpolarization Methods, Systems and Compositions

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77519606P 2006-02-21 2006-02-21
US60/775,196 2006-02-21
US80269906P 2006-05-23 2006-05-23
US60/802,699 2006-05-23
PCT/US2007/004654 WO2007136439A2 (en) 2006-02-21 2007-02-21 Hyperpolarization methods, systems and compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013205838A Division AU2013205838B2 (en) 2006-02-21 2013-05-13 Hyperpolarization Methods, Systems and Compositions

Publications (2)

Publication Number Publication Date
AU2007254464A1 AU2007254464A1 (en) 2007-11-29
AU2007254464B2 true AU2007254464B2 (en) 2013-02-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007254464A Ceased AU2007254464B2 (en) 2006-02-21 2007-02-21 Hyperpolarization methods, systems and compositions

Country Status (8)

Country Link
US (2) US20090016964A1 (https=)
EP (1) EP1986702A4 (https=)
JP (1) JP2009527768A (https=)
KR (2) KR101095943B1 (https=)
CN (1) CN101511264A (https=)
AU (1) AU2007254464B2 (https=)
CA (1) CA2643306C (https=)
WO (1) WO2007136439A2 (https=)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5183068B2 (ja) * 2003-12-22 2013-04-17 フィンレイ，ウォーレン，エイチ 大気噴出凍結乾燥法による粉末形成
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2016089858A1 (en) * 2014-12-02 2016-06-09 Neal Kalechofsky Systems and related methods for rapdily moving materials into and out of a cryogenic environment
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US20170269180A1 (en) * 2006-02-21 2017-09-21 Millikelvin Technologies Llc Systems and related methods for rapidly moving materials into and out of a cryogenic environment
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
WO2008149118A1 (en) * 2007-06-08 2008-12-11 Oxford Instruments Molecular Biotools Limited Sample preparation method for enhancement of nmr sensitivity
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
AU2009251528B2 (en) * 2008-04-04 2014-09-18 Millikelvin Technologies Llc Manufacture, transport and delivery of material containing highly polarized nuclei
WO2010014893A2 (en) * 2008-07-31 2010-02-04 Duke University Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof
US9289518B2 (en) 2008-08-22 2016-03-22 The Brigham And Women's Hospital Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE
EP2374016B1 (en) 2008-12-10 2017-05-10 University of York Pulse sequencing with hyperpolarisable nuclei
DE212010000123U1 (de) * 2009-08-26 2012-09-13 Aspect Magnet Technologies Ltd. Mittel zur Durchführung einer Bildgebung mit hyperpolarisiertem Gas
EP2473198A4 (en) * 2009-08-31 2015-06-24 Millikelvin Technologies Llc SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF
US9222995B2 (en) 2010-02-16 2015-12-29 Koninklijke Philips N.V. Apparatus and method for dispensing a hyperpolarized fluid
WO2011116341A2 (en) * 2010-03-19 2011-09-22 Tang Joel A Longevity of hyperpolarized enhanced signals for nmr spectroscopy
WO2011124672A1 (en) * 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
US20130237803A1 (en) * 2010-11-16 2013-09-12 Aspect Imaging Ltd. System and Method for Generating Invasively Hyperpolarized Images
WO2012145733A1 (en) 2011-04-22 2012-10-26 Vanderbilt University Para-hydrogen polarizer
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US20150234105A1 (en) * 2012-06-29 2015-08-20 Eduardo Andres Larrain Sanchez System that can be used to polarise glass, acrylic and similar automatically as required by the user
US9329246B2 (en) * 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) * 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
EP2992344B1 (en) * 2013-05-03 2020-10-07 Quantum Valley Investment Fund LP Transferring spin polarization
JP6359642B2 (ja) * 2013-05-03 2018-07-18 クオンタム ヴァリー インベストメント ファンド リミテッド パートナーシップ 効率的スピン偏極
US9606200B2 (en) 2013-08-27 2017-03-28 Bruker Biospin Corporation Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization
US9874622B2 (en) * 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
GB201412040D0 (en) * 2014-07-07 2014-08-20 Nottingham University Hospitals Nhs Trust Magnetic resonance imaging methods for the study of gastronintestinal transit
EP3174558B1 (en) * 2014-07-29 2019-03-06 Bracco Imaging S.p.A Preparation of amorphous samples for dnp from solid crystalline substrates
US10088536B2 (en) 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
US11926525B2 (en) 2015-09-07 2024-03-12 The University Of Nottingham Production of hyperpolarized gas
JP6592405B2 (ja) * 2016-06-10 2019-10-16 日本電信電話株式会社 熱可塑性ポリエステルの延性低下による寿命の推定方法
EP3544591B1 (en) * 2016-11-23 2022-04-20 Mayo Foundation for Medical Education and Research Particle-mediated delivery of biologics
GB201703658D0 (en) * 2017-03-07 2017-04-19 Univ York Hyperpolarization in aqueous media via SABRE
CN108627532B (zh) * 2017-03-23 2020-10-16 中国科学院大连化学物理研究所 一种用于原位核磁共振检测甲烷和水吸附状态的装置及方法
WO2019071090A1 (en) * 2017-10-06 2019-04-11 University Of Florida Research Foundation METHODS AND SYSTEMS FOR PRODUCTION, USE, AND ADMINISTRATION OF HYPERPOLARIZED FLUIDS
FR3074302B1 (fr) * 2017-11-28 2019-11-22 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede et appareil d'hyperpolarisation de spins, notamment electroniques
EP3756024B1 (en) * 2018-02-19 2026-04-29 BRUKER FRANCE (Société par Actions Simplifiée) Nuclear spin hyperpolarization in a porous matrix
WO2020104854A2 (en) * 2018-11-21 2020-05-28 Nvision Imaging Technologies Gmbh Systems and method for generation of hyperpolarized materials
WO2020178310A1 (en) 2019-03-04 2020-09-10 Danmarks Tekniske Universitet Cleaning of a fluid path system for hyperpolarization of a pharmaceutical product
CN111537540A (zh) * 2020-05-18 2020-08-14 中国科学院精密测量科学与技术创新研究院 一种用于低磁场下仲氢诱导极化装置及方法
EP4256357A1 (en) * 2020-12-07 2023-10-11 NVision Imaging Technologies GmbH Systems and methods for generation of hyperpolarized compounds using parahydrogen
EP4285131A2 (en) * 2021-01-30 2023-12-06 NVision Imaging Technologies GmbH Systems and methods for generation of hyperpolarized materials
US12409239B2 (en) 2021-06-25 2025-09-09 Beacon Mri Ltd Particles for use in hyperpolarization
CN119086618B (zh) * 2023-09-06 2025-10-03 中国科学院精密测量科学与技术创新研究院 用于超极化129Xe磁共振分子探针流动采样的装置及方法
WO2025111525A1 (en) * 2023-11-22 2025-05-30 University Of Wyoming Apparatus and methods for magnetically assisted alteration or transformation of organic substances
WO2025160283A1 (en) * 2024-01-24 2025-07-31 Vizma Life Sciences, Inc. Contrast agent device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017110A1 (en) * 1996-03-29 2003-01-23 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
US20030185760A1 (en) * 2002-03-26 2003-10-02 Gregory Lanza Paramagnetic particles that provide improved relaxivity

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617860A (en) 1995-06-07 1997-04-08 Smithsonian Astrophysical Observatory Method and system for producing polarized 129 Xe gas
US5617859A (en) * 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
US5642625A (en) 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas
US5809801A (en) 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
EP0951650B1 (en) * 1997-01-08 2003-12-10 Amersham Health AS Method of magnetic resonance imaging
JP2002508687A (ja) 1997-06-19 2002-03-19 ナイコムド イメージング エーエス 磁気共鳴（ｍｒ）イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像（ｏｒｍｉ）法
WO1999009149A1 (en) * 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Three-dimensional polymer matrices
ES2209167T3 (es) 1997-08-12 2004-06-16 Bracco Research S.A. Composiciones administrables y metodo para produccion de imagenes por resonancia magnetica.
AU1047399A (en) 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
HU222711B1 (hu) 1997-12-12 2003-09-29 Medi-Physics, Inc, Polarizált gáz akkumulátor és fżtżköpeny, eljárás polarizált gáz összegyżjtésére és felengedésére, valamint polarizált gáztermék
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
HUP0104279A3 (en) * 1998-06-17 2002-05-28 Medi Physics Inc Princeton Hyperpolarized gas transport device and associated transport method
JP2002518652A (ja) * 1998-06-17 2002-06-25 メディ‐フィジクス，インコーポレイテッド 過分極化されたガスのための弾性容器
JP2002522750A (ja) * 1998-08-05 2002-07-23 ユニバーシティ・オブ・ピッツバーグ シトクロムｐ４５０媒介反応における有機化合物の反応性のモデル化
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process
US6648130B1 (en) 1999-08-11 2003-11-18 Medi-Physics, Inc. Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets
GB0001727D0 (en) * 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
DK1330659T3 (da) 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
AU1403902A (en) 2000-11-03 2002-05-15 Amersham Health As Methods and devices for polarised nmr samples
NO20025124D0 (no) * 2002-10-25 2002-10-25 Amersham Health As Metode
EP1620154A1 (en) * 2003-04-22 2006-02-01 Medi-Physics, Inc. Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
JP4405758B2 (ja) * 2003-07-01 2010-01-27 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー 磁気共鳴撮像装置
US20060124510A1 (en) * 2004-10-12 2006-06-15 Neal Kalechofsky Devices, materials and methods for sorting, separating and sizing very small particles
US20050187398A1 (en) * 2003-10-31 2005-08-25 Andrew Bell Single component cationic palladium proinitiators for the latent polymerization of cycloolefins
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
DE102004011874B4 (de) * 2004-03-11 2006-04-20 Universitätsklinikum Freiburg Verfahren zur Messung der Magnetresonanz (NMR) mittels Continuously Refocused Multiecho Spectroscopic Imaging
FR2881226B1 (fr) 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
AU2009251528B2 (en) 2008-04-04 2014-09-18 Millikelvin Technologies Llc Manufacture, transport and delivery of material containing highly polarized nuclei
EP2473198A4 (en) 2009-08-31 2015-06-24 Millikelvin Technologies Llc SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017110A1 (en) * 1996-03-29 2003-01-23 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
US20030185760A1 (en) * 2002-03-26 2003-10-02 Gregory Lanza Paramagnetic particles that provide improved relaxivity

Also Published As

Publication number Publication date
WO2007136439A3 (en) 2008-10-23
CN101511264A (zh) 2009-08-19
KR101095943B1 (ko) 2011-12-19
US8703201B2 (en) 2014-04-22
KR20080096840A (ko) 2008-11-03
JP2009527768A (ja) 2009-07-30
US20090016964A1 (en) 2009-01-15
AU2007254464A1 (en) 2007-11-29
CA2643306C (en) 2016-05-03
WO2007136439A2 (en) 2007-11-29
KR101321862B1 (ko) 2013-10-28
KR20080091402A (ko) 2008-10-10
EP1986702A2 (en) 2008-11-05
CA2643306A1 (en) 2007-11-29
US20120114851A1 (en) 2012-05-10
EP1986702A4 (en) 2012-12-12

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