KR101095943B1 - 과분극화 방법, 시스템 및 조성물 - Google Patents

과분극화 방법, 시스템 및 조성물 Download PDF

Info

Publication number
KR101095943B1
KR101095943B1 KR1020087023005A KR20087023005A KR101095943B1 KR 101095943 B1 KR101095943 B1 KR 101095943B1 KR 1020087023005 A KR1020087023005 A KR 1020087023005A KR 20087023005 A KR20087023005 A KR 20087023005A KR 101095943 B1 KR101095943 B1 KR 101095943B1
Authority
KR
South Korea
Prior art keywords
delete delete
hyperpolarized
solvent
hyperpolarization
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087023005A
Other languages
English (en)
Korean (ko)
Other versions
KR20080096840A (ko
Inventor
아브럼 벨저
닐 칼레초프스키
Original Assignee
밀리켈빈 테크놀로지스 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 밀리켈빈 테크놀로지스 엘엘씨 filed Critical 밀리켈빈 테크놀로지스 엘엘씨
Publication of KR20080096840A publication Critical patent/KR20080096840A/ko
Application granted granted Critical
Publication of KR101095943B1 publication Critical patent/KR101095943B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1815Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Steroid Compounds (AREA)
KR1020087023005A 2006-02-21 2007-02-21 과분극화 방법, 시스템 및 조성물 Expired - Fee Related KR101095943B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77519606P 2006-02-21 2006-02-21
US60/775,196 2006-02-21
US80269906P 2006-05-23 2006-05-23
US60/802,699 2006-05-23
PCT/US2007/004654 WO2007136439A2 (en) 2006-02-21 2007-02-21 Hyperpolarization methods, systems and compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020087023208A Division KR101321862B1 (ko) 2006-02-21 2007-02-21 과분극화 방법, 시스템 및 조성물

Publications (2)

Publication Number Publication Date
KR20080096840A KR20080096840A (ko) 2008-11-03
KR101095943B1 true KR101095943B1 (ko) 2011-12-19

Family

ID=38723740

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020087023005A Expired - Fee Related KR101095943B1 (ko) 2006-02-21 2007-02-21 과분극화 방법, 시스템 및 조성물
KR1020087023208A Expired - Fee Related KR101321862B1 (ko) 2006-02-21 2007-02-21 과분극화 방법, 시스템 및 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020087023208A Expired - Fee Related KR101321862B1 (ko) 2006-02-21 2007-02-21 과분극화 방법, 시스템 및 조성물

Country Status (8)

Country Link
US (2) US20090016964A1 (https=)
EP (1) EP1986702A4 (https=)
JP (1) JP2009527768A (https=)
KR (2) KR101095943B1 (https=)
CN (1) CN101511264A (https=)
AU (1) AU2007254464B2 (https=)
CA (1) CA2643306C (https=)
WO (1) WO2007136439A2 (https=)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5183068B2 (ja) * 2003-12-22 2013-04-17 フィンレイ,ウォーレン,エイチ 大気噴出凍結乾燥法による粉末形成
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2016089858A1 (en) * 2014-12-02 2016-06-09 Neal Kalechofsky Systems and related methods for rapdily moving materials into and out of a cryogenic environment
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US20170269180A1 (en) * 2006-02-21 2017-09-21 Millikelvin Technologies Llc Systems and related methods for rapidly moving materials into and out of a cryogenic environment
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
WO2008149118A1 (en) * 2007-06-08 2008-12-11 Oxford Instruments Molecular Biotools Limited Sample preparation method for enhancement of nmr sensitivity
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
AU2009251528B2 (en) * 2008-04-04 2014-09-18 Millikelvin Technologies Llc Manufacture, transport and delivery of material containing highly polarized nuclei
WO2010014893A2 (en) * 2008-07-31 2010-02-04 Duke University Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof
US9289518B2 (en) 2008-08-22 2016-03-22 The Brigham And Women's Hospital Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE
EP2374016B1 (en) 2008-12-10 2017-05-10 University of York Pulse sequencing with hyperpolarisable nuclei
DE212010000123U1 (de) * 2009-08-26 2012-09-13 Aspect Magnet Technologies Ltd. Mittel zur Durchführung einer Bildgebung mit hyperpolarisiertem Gas
EP2473198A4 (en) * 2009-08-31 2015-06-24 Millikelvin Technologies Llc SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF
US9222995B2 (en) 2010-02-16 2015-12-29 Koninklijke Philips N.V. Apparatus and method for dispensing a hyperpolarized fluid
WO2011116341A2 (en) * 2010-03-19 2011-09-22 Tang Joel A Longevity of hyperpolarized enhanced signals for nmr spectroscopy
WO2011124672A1 (en) * 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
US20130237803A1 (en) * 2010-11-16 2013-09-12 Aspect Imaging Ltd. System and Method for Generating Invasively Hyperpolarized Images
WO2012145733A1 (en) 2011-04-22 2012-10-26 Vanderbilt University Para-hydrogen polarizer
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
GB2498181A (en) * 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US20150234105A1 (en) * 2012-06-29 2015-08-20 Eduardo Andres Larrain Sanchez System that can be used to polarise glass, acrylic and similar automatically as required by the user
US9329246B2 (en) * 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) * 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
EP2992344B1 (en) * 2013-05-03 2020-10-07 Quantum Valley Investment Fund LP Transferring spin polarization
JP6359642B2 (ja) * 2013-05-03 2018-07-18 クオンタム ヴァリー インベストメント ファンド リミテッド パートナーシップ 効率的スピン偏極
US9606200B2 (en) 2013-08-27 2017-03-28 Bruker Biospin Corporation Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization
US9874622B2 (en) * 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
GB201412040D0 (en) * 2014-07-07 2014-08-20 Nottingham University Hospitals Nhs Trust Magnetic resonance imaging methods for the study of gastronintestinal transit
EP3174558B1 (en) * 2014-07-29 2019-03-06 Bracco Imaging S.p.A Preparation of amorphous samples for dnp from solid crystalline substrates
US10088536B2 (en) 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
US11926525B2 (en) 2015-09-07 2024-03-12 The University Of Nottingham Production of hyperpolarized gas
JP6592405B2 (ja) * 2016-06-10 2019-10-16 日本電信電話株式会社 熱可塑性ポリエステルの延性低下による寿命の推定方法
EP3544591B1 (en) * 2016-11-23 2022-04-20 Mayo Foundation for Medical Education and Research Particle-mediated delivery of biologics
GB201703658D0 (en) * 2017-03-07 2017-04-19 Univ York Hyperpolarization in aqueous media via SABRE
CN108627532B (zh) * 2017-03-23 2020-10-16 中国科学院大连化学物理研究所 一种用于原位核磁共振检测甲烷和水吸附状态的装置及方法
WO2019071090A1 (en) * 2017-10-06 2019-04-11 University Of Florida Research Foundation METHODS AND SYSTEMS FOR PRODUCTION, USE, AND ADMINISTRATION OF HYPERPOLARIZED FLUIDS
FR3074302B1 (fr) * 2017-11-28 2019-11-22 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede et appareil d'hyperpolarisation de spins, notamment electroniques
EP3756024B1 (en) * 2018-02-19 2026-04-29 BRUKER FRANCE (Société par Actions Simplifiée) Nuclear spin hyperpolarization in a porous matrix
WO2020104854A2 (en) * 2018-11-21 2020-05-28 Nvision Imaging Technologies Gmbh Systems and method for generation of hyperpolarized materials
WO2020178310A1 (en) 2019-03-04 2020-09-10 Danmarks Tekniske Universitet Cleaning of a fluid path system for hyperpolarization of a pharmaceutical product
CN111537540A (zh) * 2020-05-18 2020-08-14 中国科学院精密测量科学与技术创新研究院 一种用于低磁场下仲氢诱导极化装置及方法
EP4256357A1 (en) * 2020-12-07 2023-10-11 NVision Imaging Technologies GmbH Systems and methods for generation of hyperpolarized compounds using parahydrogen
EP4285131A2 (en) * 2021-01-30 2023-12-06 NVision Imaging Technologies GmbH Systems and methods for generation of hyperpolarized materials
US12409239B2 (en) 2021-06-25 2025-09-09 Beacon Mri Ltd Particles for use in hyperpolarization
CN119086618B (zh) * 2023-09-06 2025-10-03 中国科学院精密测量科学与技术创新研究院 用于超极化129Xe磁共振分子探针流动采样的装置及方法
WO2025111525A1 (en) * 2023-11-22 2025-05-30 University Of Wyoming Apparatus and methods for magnetically assisted alteration or transformation of organic substances
WO2025160283A1 (en) * 2024-01-24 2025-07-31 Vizma Life Sciences, Inc. Contrast agent device

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617860A (en) 1995-06-07 1997-04-08 Smithsonian Astrophysical Observatory Method and system for producing polarized 129 Xe gas
US5617859A (en) * 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
IL126347A (en) 1996-03-29 2003-11-23 Lawrence Berkeley National Lab Enhancement of nmr and mri in the presence of hyperpolarized noble gases
US5642625A (en) 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas
US5809801A (en) 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
EP0951650B1 (en) * 1997-01-08 2003-12-10 Amersham Health AS Method of magnetic resonance imaging
JP2002508687A (ja) 1997-06-19 2002-03-19 ナイコムド イメージング エーエス 磁気共鳴(mr)イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像(ormi)法
WO1999009149A1 (en) * 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Three-dimensional polymer matrices
ES2209167T3 (es) 1997-08-12 2004-06-16 Bracco Research S.A. Composiciones administrables y metodo para produccion de imagenes por resonancia magnetica.
AU1047399A (en) 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
HU222711B1 (hu) 1997-12-12 2003-09-29 Medi-Physics, Inc, Polarizált gáz akkumulátor és fżtżköpeny, eljárás polarizált gáz összegyżjtésére és felengedésére, valamint polarizált gáztermék
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
HUP0104279A3 (en) * 1998-06-17 2002-05-28 Medi Physics Inc Princeton Hyperpolarized gas transport device and associated transport method
JP2002518652A (ja) * 1998-06-17 2002-06-25 メディ‐フィジクス,インコーポレイテッド 過分極化されたガスのための弾性容器
JP2002522750A (ja) * 1998-08-05 2002-07-23 ユニバーシティ・オブ・ピッツバーグ シトクロムp450媒介反応における有機化合物の反応性のモデル化
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process
US6648130B1 (en) 1999-08-11 2003-11-18 Medi-Physics, Inc. Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets
GB0001727D0 (en) * 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
DK1330659T3 (da) 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
AU1403902A (en) 2000-11-03 2002-05-15 Amersham Health As Methods and devices for polarised nmr samples
US6869591B2 (en) * 2002-03-26 2005-03-22 Barnes-Jewish Hospital Paramagnetic particles that provide improved relaxivity
NO20025124D0 (no) * 2002-10-25 2002-10-25 Amersham Health As Metode
EP1620154A1 (en) * 2003-04-22 2006-02-01 Medi-Physics, Inc. Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
JP4405758B2 (ja) * 2003-07-01 2010-01-27 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー 磁気共鳴撮像装置
US20060124510A1 (en) * 2004-10-12 2006-06-15 Neal Kalechofsky Devices, materials and methods for sorting, separating and sizing very small particles
US20050187398A1 (en) * 2003-10-31 2005-08-25 Andrew Bell Single component cationic palladium proinitiators for the latent polymerization of cycloolefins
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
DE102004011874B4 (de) * 2004-03-11 2006-04-20 Universitätsklinikum Freiburg Verfahren zur Messung der Magnetresonanz (NMR) mittels Continuously Refocused Multiecho Spectroscopic Imaging
FR2881226B1 (fr) 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
AU2009251528B2 (en) 2008-04-04 2014-09-18 Millikelvin Technologies Llc Manufacture, transport and delivery of material containing highly polarized nuclei
EP2473198A4 (en) 2009-08-31 2015-06-24 Millikelvin Technologies Llc SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF

Also Published As

Publication number Publication date
AU2007254464B2 (en) 2013-02-21
WO2007136439A3 (en) 2008-10-23
CN101511264A (zh) 2009-08-19
US8703201B2 (en) 2014-04-22
KR20080096840A (ko) 2008-11-03
JP2009527768A (ja) 2009-07-30
US20090016964A1 (en) 2009-01-15
AU2007254464A1 (en) 2007-11-29
CA2643306C (en) 2016-05-03
WO2007136439A2 (en) 2007-11-29
KR101321862B1 (ko) 2013-10-28
KR20080091402A (ko) 2008-10-10
EP1986702A2 (en) 2008-11-05
CA2643306A1 (en) 2007-11-29
US20120114851A1 (en) 2012-05-10
EP1986702A4 (en) 2012-12-12

Similar Documents

Publication Publication Date Title
KR101095943B1 (ko) 과분극화 방법, 시스템 및 조성물
Ardenkjaer-Larsen On the present and future of dissolution-DNP
US6241966B1 (en) Magnetic resonance imaging using Hyperpolarized noble gases
JP4764548B2 (ja) 磁気共鳴調査方法
RU2186405C2 (ru) Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов
US8703102B2 (en) Systems and methods for producing hyperpolarized materials and mixtures thereof
Ho et al. A non-invasive approach to detecting organ rejection by MRI: monitoring the accumulation of immune cells at the transplanted organ
US7061237B2 (en) Remote NMR/MRI detection of laser polarized gases
Goodson Using injectable carriers of laser‐polarized noble gases for enhancing NMR and MRI
US6123919A (en) Magnetic resonance imaging using hyperpolarized noble gases
US20140223923A1 (en) Systems and methods for producing hyperpolarized materials and mixtures thereof
JP5792726B2 (ja) 過分極核を含む材料を作製する方法
AU2013205838B2 (en) Hyperpolarization Methods, Systems and Compositions
Otten Take a breath of polarized noble gas
AU2016204108A1 (en) Hyperpolarization Methods, Systems and Compositions
JP3713339B2 (ja) 被検体から磁気共鳴画像を取得する方法、磁気共鳴作像システム、並びに磁気共鳴検出システムに用いられる一体型の分極マグネット及び低磁場マグネット
Månsson Hyperpolarized Nuclei for NMR Imaging and Spectroscopy–Methodology and model studies of lung and vascular function

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

FPAY Annual fee payment

Payment date: 20141125

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20151125

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20161214

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20161214