JP2009526018A5 - - Google Patents
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- Publication number
- JP2009526018A5 JP2009526018A5 JP2008553758A JP2008553758A JP2009526018A5 JP 2009526018 A5 JP2009526018 A5 JP 2009526018A5 JP 2008553758 A JP2008553758 A JP 2008553758A JP 2008553758 A JP2008553758 A JP 2008553758A JP 2009526018 A5 JP2009526018 A5 JP 2009526018A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- steroidal anti
- inflammatory agent
- pharmaceutical composition
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0602778.3 | 2006-02-10 | ||
| GBGB0602778.3A GB0602778D0 (en) | 2006-02-10 | 2006-02-10 | Novel compound |
| PCT/EP2007/051196 WO2007090859A1 (en) | 2006-02-10 | 2007-02-08 | Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{ [ (r)-2-hydroxy-2- (8-hydroxy-2-oxo-1, 2-dihydroquinolin-5-yl) eth ylaminoimethyl] } -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl ester and its use for the treatment of pulmonary disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009526018A JP2009526018A (ja) | 2009-07-16 |
| JP2009526018A5 true JP2009526018A5 (cg-RX-API-DMAC7.html) | 2010-03-18 |
| JP5616021B2 JP5616021B2 (ja) | 2014-10-29 |
Family
ID=36119909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553758A Expired - Fee Related JP5616021B2 (ja) | 2006-02-10 | 2007-02-08 | ビフェニル−２−イルカルバミン酸１−［２−（２−クロロ−４−｛［（ｒ）−２−ヒドロキシ−２−（８−ヒドロキシ−２−オキソ−１，２−ジヒドロキノリン−５−イル）エチルアミノメチル］｝−５−メトキシフェニルカルバモイル）エチル］ピペリジン−４−イルエステルのコハク酸塩および肺疾患治療におけるその使用 |
Country Status (33)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2535326T3 (es) * | 2009-04-14 | 2015-05-08 | Glaxo Group Limited | Procedimiento de preparación de un éster de ácido bifenil-2-ilcarbámico |
| HRP20130468T1 (en) | 2009-04-23 | 2013-06-30 | Theravance, Inc. | Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
| AU2015234331B2 (en) * | 2009-04-23 | 2017-08-03 | Theravance Biopharma R&D Ip, Llc | Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| AR083115A1 (es) * | 2010-09-30 | 2013-01-30 | Theravance Inc | Sales oxalato cristalinas de un compuesto diamida |
| EA026453B1 (ru) * | 2011-08-02 | 2017-04-28 | Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. | Применение окисленного авидина для ингаляции |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| AU2013360866A1 (en) * | 2012-12-18 | 2015-07-02 | Almirall, S.A. | New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activity |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| GB201500447D0 (en) * | 2015-01-12 | 2015-02-25 | Glaxosmithkline Ip Dev Ltd | Novel Combination Product |
| CN106632257B (zh) * | 2016-12-15 | 2019-02-12 | 上海市奉贤区中心医院 | Gsk961081及其中间体的合成方法 |
| WO2020047225A1 (en) | 2018-08-30 | 2020-03-05 | Theravance Biopharma R&D Ip, Llc | Methods for treating chronic obstructive pulmonary disease |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026897A (en) * | 1974-01-31 | 1977-05-31 | Otsuka Pharmaceutical Company | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives |
| DE3134590A1 (de) | 1981-09-01 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue benzo-heterocyclen |
| US4460581A (en) * | 1982-10-12 | 1984-07-17 | Boehringer Ingelheim Kg | (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones |
| ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| US4894219A (en) * | 1988-03-29 | 1990-01-16 | University Of Florida | Beta-agonist carbostyril derivatives, assay method and pharmacological composition |
| DK443489D0 (da) | 1989-09-08 | 1989-09-08 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
| SK116394A3 (en) | 1992-03-31 | 1995-04-12 | Glaxo Group Ltd | Substituted phenylcarbamates and ureas |
| CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
| WO1995006635A1 (en) | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| HUT76289A (en) | 1994-02-10 | 1997-07-28 | Yamanouchi Pharma Co Ltd | Carbamate derivative and medicinal composition containing the same |
| EP0863141B1 (en) | 1995-10-13 | 2001-09-12 | Banyu Pharmaceutical Co., Ltd. | Substituted heteroaromatic derivatives |
| PE92198A1 (es) | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| US6040344A (en) * | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| EP1047691A1 (en) | 1997-12-12 | 2000-11-02 | Smithkline Beecham Plc | Quinolinepiperazine and quinolinepiperidine derivatives, their preparation and their use as combined 5-ht1a, 5-ht1b and 5-ht1d receptor antagonists |
| US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6713651B1 (en) * | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
| EP1086066A4 (en) | 1998-06-08 | 2001-08-08 | Advanced Medicine Inc | MUSCARINIC RECEPTOR ANTAGONISTS |
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| US6593497B1 (en) * | 1999-06-02 | 2003-07-15 | Theravance, Inc. | β2-adrenergic receptor agonists |
| UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| CA2392028C (en) | 1999-12-07 | 2009-08-18 | Theravance, Inc. | Carbamate derivatives having muscarinic receptor antagonist activity |
| UA73965C2 (en) * | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| IL150524A0 (en) * | 2000-01-07 | 2003-02-12 | Transform Pharmaceuticals Inc | High-throughput formation, identification, and analysis of diverse solid-forms |
| JP2003535850A (ja) | 2000-06-05 | 2003-12-02 | アルタナ ファルマ アクチエンゲゼルシャフト | β−２−アドレナリン受容体として効果的な化合物並びにＰＤＥ４−インヒビター |
| KR100869722B1 (ko) | 2000-12-22 | 2008-11-21 | 알미랄 에이쥐 | 퀴누클리딘 카르바메이트 유도체 및 ｍ3 길항제로서 그의사용 |
| GB0103630D0 (en) | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| WO2003042160A1 (en) * | 2001-11-13 | 2003-05-22 | Theravance, Inc. | Aryl aniline beta-2 adrenergic receptor agonists |
| TWI249515B (en) * | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| JP2005529111A (ja) | 2002-04-12 | 2005-09-29 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | β模倣薬と新規な抗コリンエステラーゼ剤を含む薬剤 |
| US6747043B2 (en) * | 2002-05-28 | 2004-06-08 | Theravance, Inc. | Alkoxy aryl β2 adrenergic receptor agonists |
| GB0217225D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
| PE20040892A1 (es) | 2002-08-06 | 2004-11-19 | Glaxo Group Ltd | Antagonistas del receptor muscarinico m3 de acetilcolina |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| US7317102B2 (en) | 2003-04-01 | 2008-01-08 | Theravance, Inc. | Diarylmethyl and related compounds |
| US7358244B2 (en) * | 2003-05-28 | 2008-04-15 | Theravance, Inc. | Azabicycloalkane compounds |
| JP4851937B2 (ja) * | 2003-11-21 | 2012-01-11 | セラヴァンス， インコーポレーテッド | β２アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物 |
| US7320990B2 (en) * | 2004-02-13 | 2008-01-22 | Theravance, Inc. | Crystalline form of a biphenyl compound |
| TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| JP2008510014A (ja) * | 2004-08-16 | 2008-04-03 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
| WO2006023460A2 (en) * | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
-
2006
- 2006-02-10 GB GBGB0602778.3A patent/GB0602778D0/en not_active Ceased
-
2007
- 2007-02-08 HU HUE07704449A patent/HUE034315T2/en unknown
- 2007-02-08 TW TW096104636A patent/TWI401251B/zh not_active IP Right Cessation
- 2007-02-08 DK DK07704449.3T patent/DK1981872T3/en active
- 2007-02-08 EP EP07704449.3A patent/EP1981872B1/en active Active
- 2007-02-08 BR BRPI0707559A patent/BRPI0707559B8/pt not_active IP Right Cessation
- 2007-02-08 PL PL07704449T patent/PL1981872T3/pl unknown
- 2007-02-08 PT PT77044493T patent/PT1981872T/pt unknown
- 2007-02-08 KR KR20087022160A patent/KR101488691B1/ko not_active Expired - Fee Related
- 2007-02-08 CA CA2641769A patent/CA2641769C/en active Active
- 2007-02-08 SI SI200731963T patent/SI1981872T1/sl unknown
- 2007-02-08 SG SG201100933-9A patent/SG169404A1/en unknown
- 2007-02-08 JP JP2008553758A patent/JP5616021B2/ja not_active Expired - Fee Related
- 2007-02-08 NZ NZ570242A patent/NZ570242A/en not_active IP Right Cessation
- 2007-02-08 PE PE2007000135A patent/PE20071249A1/es not_active Application Discontinuation
- 2007-02-08 AU AU2007213767A patent/AU2007213767B2/en not_active Ceased
- 2007-02-08 AR ARP070100537A patent/AR059409A1/es not_active Application Discontinuation
- 2007-02-08 HR HRP20171304TT patent/HRP20171304T1/hr unknown
- 2007-02-08 JO JOP/2007/0037A patent/JO3389B1/ar active
- 2007-02-08 US US11/672,536 patent/US7960551B2/en active Active
- 2007-02-08 LT LTEP07704449.3T patent/LT1981872T/lt unknown
- 2007-02-08 EA EA200801691A patent/EA016580B1/ru unknown
- 2007-02-08 PE PE2010000996A patent/PE20110120A1/es active IP Right Grant
- 2007-02-08 WO PCT/EP2007/051196 patent/WO2007090859A1/en not_active Ceased
- 2007-02-08 CN CN2007800050282A patent/CN101379057B/zh not_active Expired - Fee Related
- 2007-02-08 ES ES07704449.3T patent/ES2640226T3/es active Active
- 2007-08-02 UA UAA200809940A patent/UA100364C2/ru unknown
-
2008
- 2008-07-29 IL IL193103A patent/IL193103A/en active IP Right Grant
- 2008-08-05 ZA ZA200806782A patent/ZA200806782B/xx unknown
- 2008-08-05 NO NO20083425A patent/NO341343B1/no unknown
- 2008-08-08 MY MYPI20083025A patent/MY153656A/en unknown
- 2008-08-20 CR CR10227A patent/CR10227A/es not_active Application Discontinuation
- 2008-09-10 MA MA31228A patent/MA30273B1/fr unknown
-
2016
- 2016-04-15 AR ARP160101036A patent/AR104288A2/es not_active Application Discontinuation
-
2017
- 2017-08-22 CY CY20171100887T patent/CY1119238T1/el unknown
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