JP2009525292A5 - - Google Patents
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- Publication number
- JP2009525292A5 JP2009525292A5 JP2008552729A JP2008552729A JP2009525292A5 JP 2009525292 A5 JP2009525292 A5 JP 2009525292A5 JP 2008552729 A JP2008552729 A JP 2008552729A JP 2008552729 A JP2008552729 A JP 2008552729A JP 2009525292 A5 JP2009525292 A5 JP 2009525292A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- pyrimidin
- alkyl
- phenylamino
- tolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06001915 | 2006-01-31 | ||
| PCT/EP2007/000725 WO2007088014A1 (en) | 2006-01-31 | 2007-01-29 | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525292A JP2009525292A (ja) | 2009-07-09 |
| JP2009525292A5 true JP2009525292A5 (https=) | 2012-01-26 |
Family
ID=36609592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552729A Ceased JP2009525292A (ja) | 2006-01-31 | 2007-01-29 | ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8058283B2 (https=) |
| EP (1) | EP1981886B1 (https=) |
| JP (1) | JP2009525292A (https=) |
| KR (1) | KR20080083046A (https=) |
| CN (1) | CN101374840B (https=) |
| AT (1) | ATE439361T1 (https=) |
| AU (1) | AU2007211684A1 (https=) |
| BR (1) | BRPI0706781A2 (https=) |
| CA (1) | CA2636981A1 (https=) |
| DE (1) | DE602007001952D1 (https=) |
| ES (1) | ES2329419T3 (https=) |
| IL (1) | IL191748A0 (https=) |
| WO (1) | WO2007088014A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009525292A (ja) | 2006-01-31 | 2009-07-09 | エフ．ホフマン−ラ ロシュ アーゲー | ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用 |
| SA111320200B1 (ar) * | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| CN104271576A (zh) | 2012-02-23 | 2015-01-07 | 艾伯维公司 | 激酶的吡啶并嘧啶酮抑制剂 |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| CN105130986B (zh) | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| CN110016026B (zh) * | 2018-01-08 | 2022-11-25 | 上海凌济生物科技有限公司 | 一类具有抗肿瘤活性的嘧啶并吡啶酮类化合物、制备方法和用途 |
| KR102747104B1 (ko) * | 2019-02-18 | 2024-12-27 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물 |
| KR102329720B1 (ko) * | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT76853A (en) | 1994-11-14 | 1997-12-29 | Warner Lambert Co | 6-aryl pyrido[2,3-d]pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation and pharmaceutical compositions containing the same |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| RS49779B (sr) * | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| AU763839B2 (en) | 1998-05-26 | 2003-07-31 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| NZ510760A (en) | 1998-10-23 | 2003-08-29 | F | Bicyclic nitrogen heterocycles |
| KR100537241B1 (ko) | 1999-10-21 | 2005-12-19 | 에프. 호프만-라 로슈 아게 | Ｐ38 단백질 키나제의 억제제로서의 알킬아미노 치환된이중고리 질소 헤테로고리 화합물 |
| DE60033307T2 (de) | 1999-10-21 | 2007-07-12 | F. Hoffmann-La Roche Ag | Heteroalkylamino-substituierte bicyclische stickstoffheterocyclen als p38-proteinkinase-inhibitoren |
| CA2420122A1 (en) | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines |
| WO2002018380A1 (en) | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| TW200413381A (en) | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| CL2004000366A1 (es) | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
| JP2006522756A (ja) | 2003-04-10 | 2006-10-05 | エフ．ホフマン−ラ ロシュ アーゲー | ピリミド化合物 |
| MXPA06001098A (es) | 2003-07-29 | 2006-04-24 | Irm Llc | Compuestos y composiciones utiles como inhibidores de proteina cinasa. |
| AU2004279427B2 (en) * | 2003-10-08 | 2008-07-03 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2006012577A2 (en) * | 2004-07-22 | 2006-02-02 | Bayer Pharmaceuticals Corporation | Quinazolinone derivatives useful for the regulation of glucose homeostasis and food intake |
| JP2009525292A (ja) | 2006-01-31 | 2009-07-09 | エフ．ホフマン−ラ ロシュ アーゲー | ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用 |
-
2007
- 2007-01-29 JP JP2008552729A patent/JP2009525292A/ja not_active Ceased
- 2007-01-29 AU AU2007211684A patent/AU2007211684A1/en not_active Abandoned
- 2007-01-29 BR BRPI0706781-0A patent/BRPI0706781A2/pt not_active IP Right Cessation
- 2007-01-29 CN CN2007800035988A patent/CN101374840B/zh not_active Expired - Fee Related
- 2007-01-29 AT AT07703091T patent/ATE439361T1/de not_active IP Right Cessation
- 2007-01-29 CA CA002636981A patent/CA2636981A1/en not_active Abandoned
- 2007-01-29 DE DE602007001952T patent/DE602007001952D1/de active Active
- 2007-01-29 ES ES07703091T patent/ES2329419T3/es active Active
- 2007-01-29 EP EP07703091A patent/EP1981886B1/en not_active Not-in-force
- 2007-01-29 WO PCT/EP2007/000725 patent/WO2007088014A1/en not_active Ceased
- 2007-01-29 KR KR1020087018893A patent/KR20080083046A/ko not_active Ceased
- 2007-01-29 US US12/087,420 patent/US8058283B2/en not_active Expired - Fee Related
-
2008
- 2008-05-27 IL IL191748A patent/IL191748A0/en unknown
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