JP2009525279A5 - - Google Patents
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- Publication number
- JP2009525279A5 JP2009525279A5 JP2008552477A JP2008552477A JP2009525279A5 JP 2009525279 A5 JP2009525279 A5 JP 2009525279A5 JP 2008552477 A JP2008552477 A JP 2008552477A JP 2008552477 A JP2008552477 A JP 2008552477A JP 2009525279 A5 JP2009525279 A5 JP 2009525279A5
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- methyl
- cln
- yloxy
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000019439 ethyl acetate Nutrition 0.000 description 2
- BTTNYQZNBZNDOR-UHFFFAOYSA-N 2,4-dichloropyrimidine Chemical compound ClC1=CC=NC(Cl)=N1 BTTNYQZNBZNDOR-UHFFFAOYSA-N 0.000 description 1
- UMEDXWIHROOINS-UHFFFAOYSA-N 2-(4-chloropyrimidin-2-yl)oxy-2-methylbutanoic acid Chemical compound CCC(C(=O)O)(C)OC1=NC=CC(=N1)Cl UMEDXWIHROOINS-UHFFFAOYSA-N 0.000 description 1
- XYVQFUJDGOBPQI-UHFFFAOYSA-N Methyl-2-hydoxyisobutyric acid Chemical compound COC(=O)C(C)(C)O XYVQFUJDGOBPQI-UHFFFAOYSA-N 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- WJUMYPRGOJRUPT-UHFFFAOYSA-N methyl 2-(2-chloropyrimidin-4-yl)oxy-2-methylpropanoate Chemical compound COC(=O)C(C)(C)OC1=CC=NC(Cl)=N1 WJUMYPRGOJRUPT-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76355706P | 2006-01-30 | 2006-01-30 | |
| PCT/US2007/002315 WO2007087448A1 (en) | 2006-01-30 | 2007-01-25 | Spiro imidazole derivatives as ppar modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525279A JP2009525279A (ja) | 2009-07-09 |
| JP2009525279A5 true JP2009525279A5 (https=) | 2010-03-11 |
Family
ID=37963493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552477A Pending JP2009525279A (ja) | 2006-01-30 | 2007-01-25 | Ｐｐａｒモジュレーターとしてのスピロイミダゾール誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090137610A1 (https=) |
| EP (1) | EP1979355B1 (https=) |
| JP (1) | JP2009525279A (https=) |
| KR (1) | KR20080081359A (https=) |
| CN (1) | CN101374841A (https=) |
| AT (1) | ATE478072T1 (https=) |
| AU (1) | AU2007208156A1 (https=) |
| BR (1) | BRPI0706771A2 (https=) |
| CA (1) | CA2627692A1 (https=) |
| DE (1) | DE602007008524D1 (https=) |
| ES (1) | ES2350608T3 (https=) |
| PL (1) | PL1979355T3 (https=) |
| PT (1) | PT1979355E (https=) |
| RU (1) | RU2008135128A (https=) |
| WO (1) | WO2007087448A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008054698A2 (en) | 2006-10-30 | 2008-05-08 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| GB0720126D0 (en) * | 2007-10-15 | 2007-11-28 | Syngenta Participations Ag | Chemical compounds |
| JP2012504591A (ja) | 2008-10-02 | 2012-02-23 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| MX2011006219A (es) | 2008-12-11 | 2011-06-28 | Respivert Ltd | Inhibidores de la proteina cinasa activada por el mitogeno p38. |
| GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| FR2944524B1 (fr) * | 2009-04-17 | 2012-11-30 | Ipsen Pharma Sas | Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament |
| GB0921731D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Theraputic uses |
| GB0921730D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| GB201005589D0 (en) | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
| US9024041B2 (en) | 2010-04-08 | 2015-05-05 | Respivert Ltd. | P38 MAP kinase inhibitors |
| JP5787976B2 (ja) | 2010-04-08 | 2015-09-30 | レスピバート・リミテツド | Ｐ３８ｍａｐキナーゼ阻害剤としてのピラゾリルウレア |
| BR112012030408A2 (pt) * | 2010-05-31 | 2015-09-29 | Syngenta Participations Ag | método de melhoramento de culturas |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| WO2011163539A2 (en) * | 2010-06-25 | 2011-12-29 | The Johns Hopkins University | nAChRα7 AGONISTS AND nAChRα7 ANTAGONISTS FOR TREATING ULCERATIVE COLITIS (UC) AND CROHN'S DISEASE (CD) |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| EP2612669A4 (en) | 2010-08-31 | 2014-05-14 | Snu R&Db Foundation | USING THE FÖTAL REPROGRAMMING OF A PPAR AGONIST |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9732063B2 (en) | 2012-11-16 | 2017-08-15 | Respivert Limited | Kinase inhibitors |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN113461572B (zh) * | 2021-06-30 | 2023-09-19 | 江苏慧聚药业股份有限公司 | 2-(3-溴-5-甲基苯基)乙腈的合成 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2378179A (en) | 2001-08-03 | 2003-02-05 | Pantherix Ltd | Aromatic sulfonamides and their use in treating bacterial diseases |
| WO2004092169A1 (ja) * | 2003-04-18 | 2004-10-28 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
-
2007
- 2007-01-25 JP JP2008552477A patent/JP2009525279A/ja active Pending
- 2007-01-25 ES ES07717085T patent/ES2350608T3/es active Active
- 2007-01-25 US US12/160,302 patent/US20090137610A1/en not_active Abandoned
- 2007-01-25 BR BRPI0706771-2A patent/BRPI0706771A2/pt not_active IP Right Cessation
- 2007-01-25 RU RU2008135128/04A patent/RU2008135128A/ru not_active Application Discontinuation
- 2007-01-25 KR KR1020087018697A patent/KR20080081359A/ko not_active Ceased
- 2007-01-25 AU AU2007208156A patent/AU2007208156A1/en not_active Abandoned
- 2007-01-25 PT PT07717085T patent/PT1979355E/pt unknown
- 2007-01-25 DE DE602007008524T patent/DE602007008524D1/de active Active
- 2007-01-25 WO PCT/US2007/002315 patent/WO2007087448A1/en not_active Ceased
- 2007-01-25 CN CNA2007800031722A patent/CN101374841A/zh active Pending
- 2007-01-25 EP EP07717085A patent/EP1979355B1/en not_active Not-in-force
- 2007-01-25 AT AT07717085T patent/ATE478072T1/de active
- 2007-01-25 CA CA002627692A patent/CA2627692A1/en not_active Abandoned
- 2007-01-25 PL PL07717085T patent/PL1979355T3/pl unknown
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