JP2009523430A5 - - Google Patents

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JP2009523430A5
JP2009523430A5 JP2008550555A JP2008550555A JP2009523430A5 JP 2009523430 A5 JP2009523430 A5 JP 2009523430A5 JP 2008550555 A JP2008550555 A JP 2008550555A JP 2008550555 A JP2008550555 A JP 2008550555A JP 2009523430 A5 JP2009523430 A5 JP 2009523430A5
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aptamer
test sample
target molecule
affinity complex
aptamer affinity
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JP2008550555A
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JP5680827B2 (ja
JP2009523430A (ja
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Priority claimed from PCT/US2007/060557 external-priority patent/WO2007084886A2/en
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JP2008550555A 2006-01-17 2007-01-16 試験試料の多重化分析 Active JP5680827B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75967506P 2006-01-17 2006-01-17
US60/759,675 2006-01-17
PCT/US2007/060557 WO2007084886A2 (en) 2006-01-17 2007-01-16 Multiplexed analyses of test samples

Related Child Applications (1)

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JP2014176974A Division JP6144654B2 (ja) 2006-01-17 2014-09-01 試験試料の多重化分析

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JP2009523430A JP2009523430A (ja) 2009-06-25
JP2009523430A5 true JP2009523430A5 (https=) 2010-01-28
JP5680827B2 JP5680827B2 (ja) 2015-03-04

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JP2008550555A Active JP5680827B2 (ja) 2006-01-17 2007-01-16 試験試料の多重化分析
JP2014176974A Active JP6144654B2 (ja) 2006-01-17 2014-09-01 試験試料の多重化分析
JP2017021895A Active JP6768547B2 (ja) 2006-01-17 2017-02-09 試験試料の多重化分析

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JP2017021895A Active JP6768547B2 (ja) 2006-01-17 2017-02-09 試験試料の多重化分析

Country Status (15)

Country Link
US (1) US20070166740A1 (https=)
EP (3) EP2952894B1 (https=)
JP (3) JP5680827B2 (https=)
KR (1) KR101149688B1 (https=)
CN (1) CN101374965B (https=)
AU (1) AU2007205974A1 (https=)
CA (1) CA2634987C (https=)
DK (1) DK1994171T3 (https=)
ES (3) ES2538121T3 (https=)
HU (1) HUE025489T2 (https=)
PL (1) PL1994171T3 (https=)
PT (1) PT1994171E (https=)
SI (1) SI1994171T1 (https=)
TW (1) TWI507528B (https=)
WO (1) WO2007084886A2 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
WO2008038696A1 (en) * 2006-09-27 2008-04-03 National University Corporation Tokyo University Of Agriculture And Technology Method of assaying target substance in sample, aptamer molecule and method of constructing the same
US7964356B2 (en) * 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US9068216B2 (en) * 2007-03-22 2015-06-30 Bret T. Barnhizer Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes
AU2013203374B2 (en) * 2007-07-17 2015-04-09 Somalogic Operating Co., Inc. Method for generating aptamers with improved off-rates
CN101802225B (zh) * 2007-07-17 2013-10-30 私募蛋白质体公司 检测样品的多元分析
AU2015261546B2 (en) * 2007-07-17 2017-09-28 Somalogic Operating Co., Inc. Multiplexed analyses of test samples
GB0719367D0 (en) 2007-10-03 2007-11-14 Procarta Biosystems Ltd Transcription factor decoys, compositions and methods
GB0906130D0 (en) * 2008-10-03 2009-05-20 Procrata Biosystems Ltd Transcription factor decoys
US8841429B2 (en) 2009-11-03 2014-09-23 Vivonics, Inc. Nucleic acid ligands against infectious prions
US8236570B2 (en) 2009-11-03 2012-08-07 Infoscitex Methods for identifying nucleic acid ligands
GB201002413D0 (en) 2010-02-12 2010-03-31 Procarta Biosystems Ltd Nucleic acid complexes
WO2011109642A1 (en) * 2010-03-03 2011-09-09 Somalogic, Inc. Aptamers to 4-1bb and their use in treating diseases and disorders
JP5901610B2 (ja) 2010-04-12 2016-04-13 ソマロジック・インコーポレーテッド ５位修飾ピリミジンとその使用
CN102608091A (zh) * 2012-03-22 2012-07-25 中国科学院广州生物医药与健康研究院 一种快速免标记检测硫离子的方法
JP6587934B2 (ja) 2012-03-28 2019-10-09 ソマロジック・インコーポレーテッド Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用
WO2013185078A1 (en) * 2012-06-07 2013-12-12 Somalogic, Inc. Aptamer-based multiplexed assays
CN104428424A (zh) * 2012-08-31 2015-03-18 东丽株式会社 目标核酸的检测方法
EP2970979B1 (en) 2013-03-14 2018-11-21 Somalogic, Inc. Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions
EP3044334B1 (en) 2013-09-09 2020-08-12 Somalogic, Inc. Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders
KR102290214B1 (ko) 2013-11-21 2021-08-18 소마로직, 인크. 시티딘-5-카르복스아미드 변형된 뉴클레오티드 조성물 및 그와 관련된 방법들
CN103616423A (zh) * 2013-12-02 2014-03-05 济南大学 一种检测土霉素的竞争型适配体传感器的制备方法及应用
KR101506147B1 (ko) * 2013-12-13 2015-03-26 삼성전자 주식회사 시약 세트, 시료 검사방법, 미세유동장치 및 검사장치
WO2015126769A1 (en) * 2014-02-18 2015-08-27 Somalogic, Inc. Compositions and methods for detecting microorganisms
CA2949537C (en) * 2014-05-23 2023-02-14 Firefly Bioworks, Inc. Substrate-mediated reactors for bioassays
NO2718257T3 (https=) * 2014-05-30 2018-04-14
EP3268011B1 (en) 2015-03-12 2020-04-22 The Regents of The University of Michigan Dek aptamers for use in treating inflammation
JP7203613B2 (ja) 2016-07-01 2023-01-13 ソマロジック オペレーティング カンパニー インコーポレイテッド 修飾ヌクレオシドを含むオリゴヌクレオチド
US11041849B2 (en) 2016-12-01 2021-06-22 Aptitude Medical Systems, Inc. Methods and systems for identifying candidate nucleic acid agent
WO2018180987A1 (ja) * 2017-03-29 2018-10-04 東洋紡株式会社 核酸の検出方法
EP4462123A3 (en) * 2017-09-27 2025-02-12 Bio-Rad Laboratories, Inc. Digital affinity linkage assay
JP7217913B2 (ja) * 2018-02-16 2023-02-06 株式会社日立ハイテクサイエンス プラスチック標準物質の製造方法
SG11202009802WA (en) * 2018-04-03 2020-11-27 The Royal Institution For The Advancement Of Learning/Mcgill Univ Colocalization-by-linkage sandwich assays
CN119491033A (zh) * 2018-06-08 2025-02-21 乌尔蒂维尤股份有限公司 复用型催化报告分子沉积
EP3810563A4 (en) * 2018-06-22 2022-03-23 Somalogic, Inc. IMPROVED PROTEOMIC MULTIPLEX TESTS
JP7153494B2 (ja) * 2018-07-27 2022-10-14 シスメックス株式会社 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット
KR102129937B1 (ko) * 2018-07-31 2020-07-03 재단법인 아산사회복지재단 종이기반 핵산검출용 키트 및 pcr 증폭산물을 분석하기 위한 방법
CN110824168B (zh) * 2018-08-10 2023-06-09 天津医科大学 一种多肽探针及其在翻译后修饰的结合蛋白鉴定中的应用
JP7316674B2 (ja) * 2018-10-25 2023-07-28 株式会社 TL Genomics 血液の前処理方法および血液中の細胞の分級方法
LU101073B1 (en) 2018-12-21 2020-06-24 Luxembourg Inst Science & Tech List Dna aptamers specific of adenovirus types
CN115380218A (zh) 2019-10-02 2022-11-22 诺米克生物公司 用于多重化的连接-共定位夹心测定
CN113624724A (zh) * 2020-05-07 2021-11-09 廖世奇 一种适配体分子信标对靶分子的多元检测分析方法
CN111735869A (zh) * 2020-05-29 2020-10-02 中山大学 一种蛋白质的检测试剂及检测方法
CN112180102B (zh) * 2020-09-29 2022-06-14 郑州安图生物工程股份有限公司 花生过敏原特异性IgE定量检测试剂、试剂盒及其应用
US20250283094A1 (en) 2021-04-13 2025-09-11 Somalogic Operating Co., Inc. Modified Nucleosides
CN113122544A (zh) * 2021-04-25 2021-07-16 杭州广科安德生物科技有限公司 一种特异性结合timp1蛋白的核酸适配体及其应用
CN113720894B (zh) * 2021-09-02 2022-07-08 清华大学 一种直接采样电离分析系统及方法、应用
JP2025536872A (ja) * 2022-10-21 2025-11-12 スタンダード バイオツールズ カナダ インコーポレイテッド 組織イメージング用レプリカ
EP4442282A1 (en) 2023-04-07 2024-10-09 POSTECH Research and Business Development Foundation Preparation of site-specific polypeptide conjugates
WO2025166038A1 (en) * 2024-02-02 2025-08-07 Illumina, Inc. Improved aptamer detection techniques

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599720A (en) * 1982-08-27 1997-02-04 Multilyte Limited Measurement of analyte concentration
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4587044A (en) * 1983-09-01 1986-05-06 The Johns Hopkins University Linkage of proteins to nucleic acids
US4737453A (en) * 1984-12-12 1988-04-12 Immunomedics, Inc. Sandwich immunoassay utilizing a separation specific binding substance
US4752566A (en) * 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
GB8803000D0 (en) * 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US4978608A (en) * 1987-09-04 1990-12-18 Molecular Devices Corporation DNA detection system
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6001577A (en) 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
ES2259800T3 (es) * 1990-06-11 2006-10-16 Gilead Sciences, Inc. Procedimientos de uso de ligandos de acido nucleico.
US6346611B1 (en) * 1990-06-11 2002-02-12 Gilead Sciences, Inc. High affinity TGfβ nucleic acid ligands and inhibitors
US6344321B1 (en) * 1990-06-11 2002-02-05 Gilead Sciences, Inc. Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
US5861254A (en) * 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5567588A (en) * 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5654151A (en) * 1990-06-11 1997-08-05 Nexstar Pharmaceuticals, Inc. High affinity HIV Nucleocapsid nucleic acid ligands
US5660985A (en) * 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5874218A (en) * 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for detecting a target compound in a substance using a nucleic acid ligand
US5688935A (en) * 1990-06-11 1997-11-18 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
JPH06508022A (ja) * 1991-02-21 1994-09-14 ギリアド　サイエンシズ，インコーポレイテッド 生体分子に特異的なアプタマーおよび生産方法
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US6007987A (en) * 1993-08-23 1999-12-28 The Trustees Of Boston University Positional sequencing by hybridization
US6458539B1 (en) * 1993-09-17 2002-10-01 Somalogic, Inc. Photoselection of nucleic acid ligands
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5658738A (en) * 1994-05-31 1997-08-19 Becton Dickinson And Company Bi-directional oligonucleotides that bind thrombin
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5908745A (en) * 1996-01-16 1999-06-01 University Of Chicago Use of continuous/contiguous stacking hybridization as a diagnostic tool
US6140098A (en) * 1996-08-30 2000-10-31 Schering Corporation Nucleic acids encoding mammalian proteinases; related reagents
ATE332368T1 (de) * 1997-01-21 2006-07-15 Gen Hospital Corp Selektion von proteinen mittels rns-protein fusionen
US6037137A (en) * 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
EP0975748B1 (en) * 1997-04-23 2006-03-29 Universität Zürich Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules
US20060057573A1 (en) * 2002-02-15 2006-03-16 Somalogic, Inc Methods and reagents for detecting target binding by nucleic acid ligands
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
EP0995798A1 (en) * 1998-10-24 2000-04-26 Novimmune Sa Transcription factor of MHC class II genes, substances capable of inhibiting this new transcription factor and medical uses of these substances
US7074586B1 (en) * 1999-06-17 2006-07-11 Source Precision Medicine, Inc. Quantitative assay for low abundance molecules
JP3463098B2 (ja) * 1999-10-08 2003-11-05 独立行政法人産業技術総合研究所 モジュレートアプタマー及びこれを用いた標的タンパク質の検出方法
SE516272C2 (sv) * 2000-02-18 2001-12-10 Ulf Landegren Metoder och kit för analytdetektion mha proximitets-probning
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
US20020037506A1 (en) * 2000-04-18 2002-03-28 Yun Lin Aptamer based two-site binding assay
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
WO2002083953A1 (en) * 2001-04-11 2002-10-24 Ptc Therapeutics, Inc. Methods for identifying small molecules that bind specific rna structural motifs
US6942972B2 (en) * 2001-10-24 2005-09-13 Beckman Coulter, Inc. Efficient synthesis of protein-oligonucleotide conjugates
AU2002314790A1 (en) 2001-12-05 2003-06-23 Dow Global Technologies Inc. Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
EP1476456A4 (en) * 2002-02-19 2007-06-20 Syntherica Corp COMPOSITIONS AND METHOD FOR SUBROGEN-ANTIBODY MODULATION OF AN IMMUNE RESPONSE AND TRANSPORT
WO2003073106A2 (en) * 2002-02-28 2003-09-04 Microsens Biophage Limited Binding of pathological forms of prion proteins
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
US20030228603A1 (en) * 2002-04-05 2003-12-11 Cload Sharon T. Compositions selective for caffeine or aspartame and methods of using same
WO2003093785A2 (en) 2002-05-02 2003-11-13 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide based hydrogels
US7045366B2 (en) 2003-09-12 2006-05-16 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
US20040216174A1 (en) * 2003-03-14 2004-10-28 Siegfried Hekimi Screening assays for targets and drugs useful in treatment and prevention of lipid metabolism disorders
US7229763B2 (en) * 2003-04-07 2007-06-12 Beckman Coulter, Inc. Assay system using labeled oligonucleotides
US7195875B2 (en) * 2003-04-18 2007-03-27 Beckman Coulter, Inc. Oligonucleotide pairs for multiplexed binding assays
JP4357284B2 (ja) 2003-05-15 2009-11-04 トヨタ自動車株式会社 内燃機関の制御装置
EP2410331B1 (en) * 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids
WO2005024042A2 (en) * 2003-09-04 2005-03-17 The Regents Of The University Of California Aptamers and methods for their in vitro selection and uses thereof
WO2005111242A2 (en) * 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
JP2006258458A (ja) 2005-03-15 2006-09-28 Sumitomo Bakelite Co Ltd 医療材料用高分子化合物及び該高分子化合物を用いたバイオチップ用基板

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