JP2009523430A5 - - Google Patents

Download PDF

Info

Publication number
JP2009523430A5
JP2009523430A5 JP2008550555A JP2008550555A JP2009523430A5 JP 2009523430 A5 JP2009523430 A5 JP 2009523430A5 JP 2008550555 A JP2008550555 A JP 2008550555A JP 2008550555 A JP2008550555 A JP 2008550555A JP 2009523430 A5 JP2009523430 A5 JP 2009523430A5
Authority
JP
Japan
Prior art keywords
aptamer
test sample
target molecule
affinity complex
aptamer affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008550555A
Other languages
English (en)
Japanese (ja)
Other versions
JP5680827B2 (ja
JP2009523430A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/060557 external-priority patent/WO2007084886A2/en
Publication of JP2009523430A publication Critical patent/JP2009523430A/ja
Publication of JP2009523430A5 publication Critical patent/JP2009523430A5/ja
Application granted granted Critical
Publication of JP5680827B2 publication Critical patent/JP5680827B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008550555A 2006-01-17 2007-01-16 試験試料の多重化分析 Active JP5680827B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75967506P 2006-01-17 2006-01-17
US60/759,675 2006-01-17
PCT/US2007/060557 WO2007084886A2 (en) 2006-01-17 2007-01-16 Multiplexed analyses of test samples

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014176974A Division JP6144654B2 (ja) 2006-01-17 2014-09-01 試験試料の多重化分析

Publications (3)

Publication Number Publication Date
JP2009523430A JP2009523430A (ja) 2009-06-25
JP2009523430A5 true JP2009523430A5 (https=) 2010-01-28
JP5680827B2 JP5680827B2 (ja) 2015-03-04

Family

ID=38288365

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008550555A Active JP5680827B2 (ja) 2006-01-17 2007-01-16 試験試料の多重化分析
JP2014176974A Active JP6144654B2 (ja) 2006-01-17 2014-09-01 試験試料の多重化分析
JP2017021895A Active JP6768547B2 (ja) 2006-01-17 2017-02-09 試験試料の多重化分析

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014176974A Active JP6144654B2 (ja) 2006-01-17 2014-09-01 試験試料の多重化分析
JP2017021895A Active JP6768547B2 (ja) 2006-01-17 2017-02-09 試験試料の多重化分析

Country Status (15)

Country Link
US (1) US20070166740A1 (https=)
EP (3) EP1994171B1 (https=)
JP (3) JP5680827B2 (https=)
KR (1) KR101149688B1 (https=)
CN (1) CN101374965B (https=)
AU (1) AU2007205974A1 (https=)
CA (1) CA2634987C (https=)
DK (1) DK1994171T3 (https=)
ES (3) ES2644499T3 (https=)
HU (1) HUE025489T2 (https=)
PL (1) PL1994171T3 (https=)
PT (1) PT1994171E (https=)
SI (1) SI1994171T1 (https=)
TW (1) TWI507528B (https=)
WO (1) WO2007084886A2 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
JP5142290B2 (ja) * 2006-09-27 2013-02-13 国立大学法人東京農工大学 試料中の被検物質の測定方法並びにアプタマー分子及びその作出方法
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7964356B2 (en) * 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US9068216B2 (en) * 2007-03-22 2015-06-30 Bret T. Barnhizer Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes
AU2013203374B2 (en) * 2007-07-17 2015-04-09 Somalogic Operating Co., Inc. Method for generating aptamers with improved off-rates
DK2172566T4 (da) * 2007-07-17 2022-06-13 Somalogic Inc Fremgangsmåde til generering af aptamerer med forbedrede off-rates
AU2015261546B2 (en) * 2007-07-17 2017-09-28 Somalogic Operating Co., Inc. Multiplexed analyses of test samples
GB0719367D0 (en) 2007-10-03 2007-11-14 Procarta Biosystems Ltd Transcription factor decoys, compositions and methods
GB0906130D0 (en) * 2008-10-03 2009-05-20 Procrata Biosystems Ltd Transcription factor decoys
US8236570B2 (en) 2009-11-03 2012-08-07 Infoscitex Methods for identifying nucleic acid ligands
US8841429B2 (en) 2009-11-03 2014-09-23 Vivonics, Inc. Nucleic acid ligands against infectious prions
GB201002413D0 (en) 2010-02-12 2010-03-31 Procarta Biosystems Ltd Nucleic acid complexes
CA2808233C (en) * 2010-03-03 2017-07-11 Somalogic, Inc. Aptamers to 4-1bb and their use in treating diseases and disorders
EP3345915B1 (en) 2010-04-12 2021-11-24 Somalogic, Inc. 5-position modified pyrimidines and their use
CN102608091A (zh) * 2012-03-22 2012-07-25 中国科学院广州生物医药与健康研究院 一种快速免标记检测硫离子的方法
CA2868096C (en) 2012-03-28 2019-12-31 Somalogic, Inc. Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions
WO2013185078A1 (en) * 2012-06-07 2013-12-12 Somalogic, Inc. Aptamer-based multiplexed assays
JP6248633B2 (ja) * 2012-08-31 2017-12-20 東レ株式会社 標的核酸の検出方法
CA2902186C (en) 2013-03-14 2023-04-11 Somalogic, Inc. Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions
US9695424B2 (en) 2013-09-09 2017-07-04 Somalogic, Inc. PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
BR112016010165A2 (pt) 2013-11-21 2017-12-05 Somalogic Inc composições de nucleotídeos modificados de citidina-5-carboxamida e métodos relacionados às mesmas
CN103616423A (zh) * 2013-12-02 2014-03-05 济南大学 一种检测土霉素的竞争型适配体传感器的制备方法及应用
KR101506147B1 (ko) * 2013-12-13 2015-03-26 삼성전자 주식회사 시약 세트, 시료 검사방법, 미세유동장치 및 검사장치
CA3152415A1 (en) * 2014-02-18 2015-08-27 Somalogic Operating Co., Inc. Compositions and methods for detecting microorganisms
CN106574925B (zh) * 2014-05-23 2019-07-26 萤火虫生物股份有限公司 用于生物测定的底物介导的反应器
NO2718257T3 (https=) * 2014-05-30 2018-04-14
US10138486B2 (en) 2015-03-12 2018-11-27 The Regents Of The University Of Michigan Inhibitors of DEK protein and related methods
TWI770036B (zh) 2016-07-01 2022-07-11 美商私募蛋白質體操作有限公司 包含經修飾核苷之寡核苷酸
WO2018102115A1 (en) * 2016-12-01 2018-06-07 Aptitude Medical Systems, Inc. Methods and systems for identifying candidate nucleic acid agent
WO2018180987A1 (ja) * 2017-03-29 2018-10-04 東洋紡株式会社 核酸の検出方法
CN118376776A (zh) * 2017-09-27 2024-07-23 生物辐射实验室股份有限公司 数字化亲和连接试验
JP7217913B2 (ja) * 2018-02-16 2023-02-06 株式会社日立ハイテクサイエンス プラスチック標準物質の製造方法
BR112020020108A2 (pt) * 2018-04-03 2021-01-26 The Royal Institution For The Advancement Of Learning / Mcgill University ensaios sanduíche de colocalização por ligação
WO2019236841A1 (en) * 2018-06-08 2019-12-12 Ultivue, Inc. Multiplexed catalyzed reporter deposition
EP3810563A4 (en) * 2018-06-22 2022-03-23 Somalogic, Inc. IMPROVED PROTEOMIC MULTIPLEX TESTS
JP7153494B2 (ja) * 2018-07-27 2022-10-14 シスメックス株式会社 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット
KR102129937B1 (ko) * 2018-07-31 2020-07-03 재단법인 아산사회복지재단 종이기반 핵산검출용 키트 및 pcr 증폭산물을 분석하기 위한 방법
CN110824168B (zh) * 2018-08-10 2023-06-09 天津医科大学 一种多肽探针及其在翻译后修饰的结合蛋白鉴定中的应用
WO2020085000A1 (ja) * 2018-10-25 2020-04-30 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ 微細流路による血球の分級のための血液の前処理
LU101073B1 (en) 2018-12-21 2020-06-24 Luxembourg Inst Science & Tech List Dna aptamers specific of adenovirus types
WO2021064460A1 (en) 2019-10-02 2021-04-08 The Royal Institution For The Advancement Of Learning/Mcgill University Colocalization-by-linkage sandwich assays for multiplexing
CN113624724A (zh) * 2020-05-07 2021-11-09 廖世奇 一种适配体分子信标对靶分子的多元检测分析方法
CN111735869A (zh) * 2020-05-29 2020-10-02 中山大学 一种蛋白质的检测试剂及检测方法
CN112180102B (zh) * 2020-09-29 2022-06-14 郑州安图生物工程股份有限公司 花生过敏原特异性IgE定量检测试剂、试剂盒及其应用
EP4323374A1 (en) * 2021-04-13 2024-02-21 SomaLogic Operating Co., Inc. Modified nucleosides
CN113122544A (zh) * 2021-04-25 2021-07-16 杭州广科安德生物科技有限公司 一种特异性结合timp1蛋白的核酸适配体及其应用
CN113720894B (zh) * 2021-09-02 2022-07-08 清华大学 一种直接采样电离分析系统及方法、应用
CA3268248A1 (en) * 2022-10-21 2024-04-25 Standard Biotools Canada Inc. TISSUE IMAGING REPLICAS
KR20240150725A (ko) 2023-04-07 2024-10-16 포항공과대학교 산학협력단 위치-특이적인 폴리펩티드 컨쥬게이트의 제조
WO2025166038A1 (en) * 2024-02-02 2025-08-07 Illumina, Inc. Improved aptamer detection techniques

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599720A (en) * 1982-08-27 1997-02-04 Multilyte Limited Measurement of analyte concentration
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4587044A (en) * 1983-09-01 1986-05-06 The Johns Hopkins University Linkage of proteins to nucleic acids
US4737453A (en) * 1984-12-12 1988-04-12 Immunomedics, Inc. Sandwich immunoassay utilizing a separation specific binding substance
US4752566A (en) * 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
GB8803000D0 (en) * 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US4978608A (en) * 1987-09-04 1990-12-18 Molecular Devices Corporation DNA detection system
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6346611B1 (en) * 1990-06-11 2002-02-12 Gilead Sciences, Inc. High affinity TGfβ nucleic acid ligands and inhibitors
US5567588A (en) * 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US6344321B1 (en) * 1990-06-11 2002-02-05 Gilead Sciences, Inc. Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5874218A (en) * 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for detecting a target compound in a substance using a nucleic acid ligand
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5688935A (en) * 1990-06-11 1997-11-18 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
US6001577A (en) 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5654151A (en) * 1990-06-11 1997-08-05 Nexstar Pharmaceuticals, Inc. High affinity HIV Nucleocapsid nucleic acid ligands
US5861254A (en) * 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
EP0786469B1 (en) 1990-06-11 2006-03-01 Gilead Sciences, Inc. Methods of use of nucleic acid ligands
US5660985A (en) * 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
CA2104698A1 (en) * 1991-02-21 1992-08-22 John J. Toole Aptamers specific for biomolecules and methods of making
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US6007987A (en) * 1993-08-23 1999-12-28 The Trustees Of Boston University Positional sequencing by hybridization
US6458539B1 (en) * 1993-09-17 2002-10-01 Somalogic, Inc. Photoselection of nucleic acid ligands
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5658738A (en) * 1994-05-31 1997-08-19 Becton Dickinson And Company Bi-directional oligonucleotides that bind thrombin
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5908745A (en) * 1996-01-16 1999-06-01 University Of Chicago Use of continuous/contiguous stacking hybridization as a diagnostic tool
US6140098A (en) * 1996-08-30 2000-10-31 Schering Corporation Nucleic acids encoding mammalian proteinases; related reagents
DK1712623T3 (da) * 1997-01-21 2012-02-06 Gen Hospital Corp Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner
US6037137A (en) * 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
DE69834032T2 (de) * 1997-04-23 2006-12-07 Universität Zürich Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
EP0995798A1 (en) * 1998-10-24 2000-04-26 Novimmune Sa Transcription factor of MHC class II genes, substances capable of inhibiting this new transcription factor and medical uses of these substances
US7074586B1 (en) * 1999-06-17 2006-07-11 Source Precision Medicine, Inc. Quantitative assay for low abundance molecules
JP3463098B2 (ja) * 1999-10-08 2003-11-05 独立行政法人産業技術総合研究所 モジュレートアプタマー及びこれを用いた標的タンパク質の検出方法
SE516272C2 (sv) * 2000-02-18 2001-12-10 Ulf Landegren Metoder och kit för analytdetektion mha proximitets-probning
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
US20020037506A1 (en) * 2000-04-18 2002-03-28 Yun Lin Aptamer based two-site binding assay
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
JP2004537037A (ja) * 2001-04-11 2004-12-09 ピーティーシー セラピューティクス，インコーポレーテッド 特異的ｒｎａ構造モチーフと結合する小分子を同定する方法
US6942972B2 (en) * 2001-10-24 2005-09-13 Beckman Coulter, Inc. Efficient synthesis of protein-oligonucleotide conjugates
AU2002314790A1 (en) 2001-12-05 2003-06-23 Dow Global Technologies Inc. Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
AU2003217379A1 (en) * 2002-02-15 2003-09-09 Somalogic, Inc. Methods and reagents for detecting target binding by nucleic acid ligands
CA2476854A1 (en) * 2002-02-19 2003-08-28 Syntherica Corporation Surrogate antibodies and methods of preparation and use thereof
US7659076B2 (en) * 2002-02-28 2010-02-09 Microsens Biophage Limited Binding of pathological forms of prion proteins
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
US20030228603A1 (en) * 2002-04-05 2003-12-11 Cload Sharon T. Compositions selective for caffeine or aspartame and methods of using same
JP2005526972A (ja) 2002-05-02 2005-09-08 シファーゲン バイオシステムズ， インコーポレイテッド 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ
US7045366B2 (en) 2003-09-12 2006-05-16 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
US20040216174A1 (en) * 2003-03-14 2004-10-28 Siegfried Hekimi Screening assays for targets and drugs useful in treatment and prevention of lipid metabolism disorders
US7229763B2 (en) * 2003-04-07 2007-06-12 Beckman Coulter, Inc. Assay system using labeled oligonucleotides
US7195875B2 (en) * 2003-04-18 2007-03-27 Beckman Coulter, Inc. Oligonucleotide pairs for multiplexed binding assays
JP4357284B2 (ja) 2003-05-15 2009-11-04 トヨタ自動車株式会社 内燃機関の制御装置
JP5275566B2 (ja) * 2003-06-18 2013-08-28 ザ スクリプス リサーチ インスティチュート 反応性非天然アミノ酸遺伝コード付加
WO2005024042A2 (en) * 2003-09-04 2005-03-17 The Regents Of The University Of California Aptamers and methods for their in vitro selection and uses thereof
WO2005111242A2 (en) * 2004-05-10 2005-11-24 Parallele Bioscience, Inc. Digital profiling of polynucleotide populations
JP2006258458A (ja) 2005-03-15 2006-09-28 Sumitomo Bakelite Co Ltd 医療材料用高分子化合物及び該高分子化合物を用いたバイオチップ用基板

Similar Documents

Publication Publication Date Title
JP2009523430A5 (https=)
Cakmak et al. The prognostic value of circulating microRNAs in heart failure: preliminary results from a genome-wide expression study
JP2010533872A5 (https=)
Gopinath et al. Aptamer-based ‘point-of-care testing’
Wang et al. Prediction of DNA integrity from morphological parameters using a single‐sperm DNA fragmentation index assay
Darmanis et al. Sensitive plasma protein analysis by microparticle-based proximity ligation assays
Mederacke et al. Performance and clinical utility of a novel fully automated quantitative HCV-core antigen assay
US11713483B2 (en) Method for detection of analytes via polymer complexes
Robinson et al. Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction
JP2012525855A5 (https=)
CN113567687A (zh) 检测样品中两种生物标志物的表达水平的试剂在制备用于检测子痫前期试剂盒中的应用
Caviglia et al. Analytical and clinical evaluation of a novel assay for anti-HBc IgG measurement in serum of subjects with overt and occult HBV infection
Cox et al. Low Levels of Hepatocyte‐Specific Methylation in Cell‐Free DNA Are a Strong Negative Predictor for Acute T Cell–Mediated Rejection Requiring Treatment Following Liver Transplantation
JP2017513026A (ja) 立体障害ハイブリダイゼーションシステム、アッセイ、及びこれらに関する方法
CN104271766A (zh) 检测例如miRNA的特定核酸序列的免疫测定
Li et al. Modified high-throughput quantification of plasma microRNAs in heparinized patients with coronary artery disease using heparinase
CN107208136A (zh) 通过与免疫测定法偶联的核酸扩增的固体支持物上的分析物检测
US20160244835A1 (en) Urinary neuropilin-1 (nrp-1) as a prognostic marker for nephritis and lupus nephritis
Petrou et al. Lateral Flow Test (LFT) Detects Cell‐Free MicroRNAs Predictive of Preterm Birth Directly from Human Plasma
Chrostek et al. Serum sialic acids levels according to the severity of liver cirrhosis
CN115066616A (zh) 非酒精性脂肪性肝炎(nash)生物标志物及其用途
Li et al. Unlocking Zeptomolar Single-Molecule Detection by Synergizing Digital Microfluidics and Digital CRISPR
Liu et al. Differential Gene Expression Profile of Renin‐Angiotensin System in the Left Atrium in Mitral Regurgitation Patients
WO2018128286A1 (ko) 핵산의 신속 검출법 및 이를 이용한 질병의 신속 진단 방법
Ranjan et al. Evaluation of dried blood spots as a feasible alternative to plasma for the detection and quantification of hepatitis C virus in a tropical setting: a pilot study