JP2009523154A5 - - Google Patents
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- Publication number
- JP2009523154A5 JP2009523154A5 JP2008549873A JP2008549873A JP2009523154A5 JP 2009523154 A5 JP2009523154 A5 JP 2009523154A5 JP 2008549873 A JP2008549873 A JP 2008549873A JP 2008549873 A JP2008549873 A JP 2008549873A JP 2009523154 A5 JP2009523154 A5 JP 2009523154A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- asthma
- seq
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000006673 asthma Diseases 0.000 claims 24
- 239000012634 fragment Substances 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 6
- 150000003431 steroids Chemical class 0.000 claims 6
- 229950011485 pascolizumab Drugs 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000009657 Aspirin-Induced Asthma Diseases 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 208000017604 Hodgkin disease Diseases 0.000 claims 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 3
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 3
- 208000004554 Leishmaniasis Diseases 0.000 claims 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 3
- 206010039085 Rhinitis allergic Diseases 0.000 claims 3
- 208000034189 Sclerosis Diseases 0.000 claims 3
- 201000009961 allergic asthma Diseases 0.000 claims 3
- 201000010105 allergic rhinitis Diseases 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 208000029771 childhood onset asthma Diseases 0.000 claims 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000003176 fibrotic effect Effects 0.000 claims 3
- 238000005469 granulation Methods 0.000 claims 3
- 230000003179 granulation Effects 0.000 claims 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000024696 nocturnal asthma Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000000750 progressive effect Effects 0.000 claims 3
- 230000022983 regulation of cell cycle Effects 0.000 claims 3
- 201000004409 schistosomiasis Diseases 0.000 claims 3
- 230000009885 systemic effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101001076430 Homo sapiens Interleukin-13 Proteins 0.000 claims 2
- 102000019207 human interleukin-13 Human genes 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0600488.1A GB0600488D0 (en) | 2006-01-11 | 2006-01-11 | Immunoglobulins |
| PCT/EP2007/050219 WO2007080174A2 (en) | 2006-01-11 | 2007-01-10 | Chimeric and humanised anti-human il-13 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009523154A JP2009523154A (ja) | 2009-06-18 |
| JP2009523154A5 true JP2009523154A5 (https=) | 2010-02-18 |
Family
ID=35997844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008549873A Pending JP2009523154A (ja) | 2006-01-11 | 2007-01-10 | キメラおよびヒト化抗ヒトｉｌ−１３抗体 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1976881A2 (https=) |
| JP (1) | JP2009523154A (https=) |
| KR (1) | KR20080113201A (https=) |
| CN (1) | CN101370829A (https=) |
| AR (1) | AR058955A1 (https=) |
| AU (1) | AU2007204372A1 (https=) |
| BR (1) | BRPI0706481A2 (https=) |
| CA (1) | CA2635972A1 (https=) |
| CR (1) | CR10161A (https=) |
| EA (1) | EA200801520A1 (https=) |
| GB (1) | GB0600488D0 (https=) |
| IL (1) | IL192207A0 (https=) |
| MA (1) | MA30156B1 (https=) |
| NO (1) | NO20082767L (https=) |
| PE (1) | PE20081185A1 (https=) |
| TW (1) | TW200736274A (https=) |
| WO (1) | WO2007080174A2 (https=) |
| ZA (1) | ZA200805526B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007045477A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Human antibodies against il-13 and therapeutic uses |
| TWI422387B (zh) | 2006-05-25 | 2014-01-11 | Glaxo Group Ltd | 免疫球蛋白 |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| KR20110092328A (ko) * | 2008-11-26 | 2011-08-17 | 글락소 그룹 리미티드 | Ｉｌ-13에 결합하는 리간드 |
| TWI541021B (zh) * | 2009-03-05 | 2016-07-11 | 艾伯維有限公司 | Ｉｌ－１７結合蛋白 |
| GB0904214D0 (en) | 2009-03-11 | 2009-04-22 | Ucb Pharma Sa | Biological products |
| BRPI1016061A2 (pt) | 2009-05-28 | 2016-09-13 | Glaxo Group Ltd | "proteína de ligação de antígeno, célula hospedeira transfectada ou transformada recombinante, composição farmacêutica, método de tratamento de um paciente humano, uso de uma proteína de ligação de antígeno, método para a redução da agregação de um domínio variável simples de imunoglobulina, vk dab humano derivado de uma estrutura da linha germinativa, e, domínio variável simples de imunoglobulina." |
| ES2813398T3 (es) | 2009-10-20 | 2021-03-23 | Abbvie Inc | Aislamiento y purificación de anticuerpos anti-IL-13 usando cromatografía de afinidad a Proteína A |
| WO2012049278A1 (en) * | 2010-10-15 | 2012-04-19 | Medimmune Limited | Therapies for improving pulmonary function |
| RU2578468C2 (ru) | 2010-12-16 | 2016-03-27 | Дженентек, Инк. | Способы диагностики и лечения, связанные с ингибированием th2 |
| TWI719112B (zh) | 2011-03-16 | 2021-02-21 | 賽諾菲公司 | 雙重ｖ區類抗體蛋白質之用途 |
| AR098155A1 (es) | 2013-10-23 | 2016-05-04 | Genentech Inc | Métodos para diagnosticar y tratar trastornos eosinofílicos |
| UA117608C2 (uk) | 2014-02-21 | 2018-08-27 | Дженентек, Інк. | Спосіб лікування еозинофільного захворювання у пацієнта шляхом застосування біспецифічного анти-il-13/il-17 антитіла |
| CA2943326A1 (en) | 2014-04-11 | 2015-10-15 | Novartis Ag | Methods of selectively treating asthma using il-13 antagonists |
| MX2017011486A (es) | 2015-03-16 | 2018-06-15 | Genentech Inc | Métodos de detección y cuantificación de il-13 y sus usos en el diagnóstico y tratamiento de enfermedades asociadas a th2. |
| EP3433615A1 (en) | 2016-03-21 | 2019-01-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for diagnosis and treatment of solar lentigo |
| JP6871948B2 (ja) | 2016-04-27 | 2021-05-19 | アッヴィ・インコーポレイテッド | 抗ｉｌ−１３抗体を使用する、ｉｌ−１３活性が有害である疾患の治療方法 |
| US20190359722A1 (en) * | 2017-01-23 | 2019-11-28 | Toyo University | Anti-epha2 antibody and immunological detection of epha2 using same |
| CN109776677B (zh) * | 2017-11-15 | 2023-11-03 | 尚华科创投资管理（江苏）有限公司 | 一种人源化抗il-13抗体及其制备方法和应用 |
| CN107909501B (zh) * | 2017-12-05 | 2020-12-01 | 创新先进技术有限公司 | 气味与行为的关联方法、气味社交方法及装置 |
| KR20220098056A (ko) | 2018-02-09 | 2022-07-08 | 제넨테크, 인크. | 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법 |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| JP2022525703A (ja) * | 2019-03-20 | 2022-05-18 | ジャベリン・オンコロジー・インコーポレイテッド | 抗ａｄａｍ１２抗体およびキメラ抗原受容体、ならびにそれを含む組成物および方法 |
| GB201919062D0 (en) * | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Antibody |
| CN119684453A (zh) * | 2024-12-19 | 2025-03-25 | 江苏荃信生物医药股份有限公司 | 一种人il-13抗体、elisa试剂盒及其检测方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004019975A2 (en) * | 2002-08-30 | 2004-03-11 | Glaxo Group Limited | Il-14 vaccine for the treatment of asthma and atopic disorders |
| WO2004096849A2 (en) * | 2003-04-25 | 2004-11-11 | University Of Manitoba | Peptide-based cytokine/chemokine vaccines against allergy |
| PL3718564T3 (pl) * | 2003-12-23 | 2024-03-18 | Genentech, Inc. | Nowe przeciwciała anty-IL 13 i ich zastosowania |
| US7501121B2 (en) * | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| TWI307630B (en) * | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
-
2006
- 2006-01-11 GB GBGB0600488.1A patent/GB0600488D0/en not_active Ceased
-
2007
- 2007-01-09 AR ARP070100082A patent/AR058955A1/es unknown
- 2007-01-09 PE PE2007000018A patent/PE20081185A1/es not_active Application Discontinuation
- 2007-01-09 TW TW096100833A patent/TW200736274A/zh unknown
- 2007-01-10 KR KR1020087019555A patent/KR20080113201A/ko not_active Withdrawn
- 2007-01-10 EA EA200801520A patent/EA200801520A1/ru unknown
- 2007-01-10 WO PCT/EP2007/050219 patent/WO2007080174A2/en not_active Ceased
- 2007-01-10 BR BRPI0706481-0A patent/BRPI0706481A2/pt not_active IP Right Cessation
- 2007-01-10 CA CA002635972A patent/CA2635972A1/en not_active Abandoned
- 2007-01-10 EP EP07703766A patent/EP1976881A2/en not_active Withdrawn
- 2007-01-10 CN CNA2007800022973A patent/CN101370829A/zh active Pending
- 2007-01-10 AU AU2007204372A patent/AU2007204372A1/en not_active Abandoned
- 2007-01-10 JP JP2008549873A patent/JP2009523154A/ja active Pending
-
2008
- 2008-06-16 IL IL192207A patent/IL192207A0/en unknown
- 2008-06-16 NO NO20082767A patent/NO20082767L/no not_active Application Discontinuation
- 2008-06-24 ZA ZA200805526A patent/ZA200805526B/xx unknown
- 2008-07-11 MA MA31108A patent/MA30156B1/fr unknown
- 2008-07-17 CR CR10161A patent/CR10161A/es not_active Application Discontinuation
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