JP2009521473A5 - - Google Patents
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- Publication number
- JP2009521473A5 JP2009521473A5 JP2008547585A JP2008547585A JP2009521473A5 JP 2009521473 A5 JP2009521473 A5 JP 2009521473A5 JP 2008547585 A JP2008547585 A JP 2008547585A JP 2008547585 A JP2008547585 A JP 2008547585A JP 2009521473 A5 JP2009521473 A5 JP 2009521473A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- chlorite
- weight ratio
- unit dose
- chlorate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 13
- QBWCMBCROVPCKQ-UHFFFAOYSA-M chlorite Chemical compound [O-]Cl=O QBWCMBCROVPCKQ-UHFFFAOYSA-M 0.000 claims 10
- 229910001919 chlorite Inorganic materials 0.000 claims 10
- 229910052619 chlorite group Inorganic materials 0.000 claims 10
- XTEGARKTQYYJKE-UHFFFAOYSA-M chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 claims 8
- 239000000243 solution Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 2
- 239000008363 phosphate buffer Substances 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Claims (15)
- （ａ）亜塩素酸塩を含む水性溶液（ここで、亜塩素酸塩：塩素酸塩の重量比は１００：１．５より大きく、亜塩素酸塩の濃度は約５０ｍＭ〜約１００ｍＭであり、該溶液は約７〜約９．５のｐＨを有する）；
（ｂ）リン酸緩衝液から本質的に成る緩衝液；および
（ｃ）医薬的に許容される賦形剤、
を含む医薬組成物であって、静脈内投与用に製剤化されている、前記医薬組成物。 - 亜塩素酸塩：塩素酸塩の比が１００：０．５より大きい、請求項１に記載の組成物。
- 亜塩素酸塩：硫酸塩の重量比が１００：１６．４より大きい、請求項１に記載の組成物。
- 亜塩素酸塩：硫酸塩の重量比が１００：１．６より大きい、請求項１に記載の組成物。
- 硫酸塩が１０００重量部当り１部以下の非溶媒分子を含む、請求項１に記載の組成物。
- 亜塩素酸塩：塩素酸塩の重量比が１００：１０より大きい、請求項１に記載の組成物。
- 製剤のｐＨが、約７．０〜８．５である、請求項１に記載の組成物。
- さらに酢酸塩を含む、請求項１に記載の組成物。
- 製剤の単位用量形態であって、
（ａ）亜塩素酸塩を含む水性溶液（ここで、亜塩素酸塩：塩素酸塩の重量比は１００：１．５より大きく、亜塩素酸塩の濃度は約５０ｍＭ〜約１００ｍＭであり、該溶液は約７〜約９．５のｐＨを有する）；
（ｂ）リン酸緩衝液から本質的に成る緩衝液；および
（ｃ）医薬的に許容される賦形剤、
を含む、静脈内投与用に製剤化されている医薬組成物を、有効量にて含むことを特徴とする、前記単位用量形態。 - 前記単位用量が、被検体への投与の準備ができている、請求項９に記載の単位用量形態。
- 前記単位用量が、被検体への投与前に希釈される、請求項９に記載の単位用量形態。
- 組成物のｐＨが、約７．１〜約７．７である、請求項９に記載の単位用量形態。
- 希釈剤が食塩水溶液を含む、請求項１に記載の組成物。
- 食塩水溶液が等張性である、請求項１３に記載の組成物。
- 柔軟なパッケージ内に含まれている、請求項１に記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75349705P | 2005-12-22 | 2005-12-22 | |
| US60/753,497 | 2005-12-22 | ||
| PCT/US2006/048941 WO2007075972A2 (en) | 2005-12-22 | 2006-12-21 | Chlorite formulations, and methods of preparation and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013000170A Division JP5860821B2 (ja) | 2005-12-22 | 2013-01-04 | 亜塩素酸塩製剤、およびこの調製の方法と利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009521473A JP2009521473A (ja) | 2009-06-04 |
| JP2009521473A5 true JP2009521473A5 (ja) | 2010-02-12 |
| JP5371443B2 JP5371443B2 (ja) | 2013-12-18 |
Family
ID=38218646
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008547585A Active JP5371443B2 (ja) | 2005-12-22 | 2006-12-21 | 亜塩素酸塩製剤、およびこの調製の方法と利用 |
| JP2013000170A Expired - Fee Related JP5860821B2 (ja) | 2005-12-22 | 2013-01-04 | 亜塩素酸塩製剤、およびこの調製の方法と利用 |
| JP2014165700A Withdrawn JP2014210817A (ja) | 2005-12-22 | 2014-08-18 | 亜塩素酸塩製剤、およびこの調製の方法と利用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013000170A Expired - Fee Related JP5860821B2 (ja) | 2005-12-22 | 2013-01-04 | 亜塩素酸塩製剤、およびこの調製の方法と利用 |
| JP2014165700A Withdrawn JP2014210817A (ja) | 2005-12-22 | 2014-08-18 | 亜塩素酸塩製剤、およびこの調製の方法と利用 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8067035B2 (ja) |
| EP (1) | EP1979269A4 (ja) |
| JP (3) | JP5371443B2 (ja) |
| AU (1) | AU2006331497B2 (ja) |
| CA (2) | CA2919344C (ja) |
| WO (1) | WO2007075972A2 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110027330A1 (en) * | 2005-03-01 | 2011-02-03 | Martin Roy W | Tablet composition for the in-situ generation of chlorine dioxide for use in antimicrobial applications |
| AU2006331497B2 (en) | 2005-12-22 | 2013-07-04 | Neuraltus Pharmaceuticals, Inc. | Chlorite formulations, and methods of preparation and use thereof |
| EP2517713A3 (en) | 2007-06-01 | 2013-01-30 | Nuvo Research AG | A method of treating allergic asthma, allergic rhinitis and atopic dermatitis |
| EP2461694A4 (en) * | 2009-08-06 | 2013-06-19 | Neuraltus Pharmaceuticals Inc | TREATMENT OF DISORDERS ASSOCIATED WITH MACROPHAGES |
| CA2807723A1 (en) * | 2010-08-13 | 2012-02-16 | Servet Buyuktimkin | Foamable compositions of stabilized chlorite |
| FR2968559B1 (fr) * | 2010-12-14 | 2012-12-28 | Alexandra Fregonese | Nouvelles compositions a base d'argile et de beepollen, leur procede de preparation et leurs utilisations en nutrition et en therapeutique |
| DE102010055771A1 (de) * | 2010-12-23 | 2012-06-28 | KyroChem GmbH | Chlorithaltige Zusammensetzung |
| CA2825862A1 (en) * | 2011-02-09 | 2012-08-16 | Nuvo Research Ag | Wound dressings comprising chlorite |
| US9381214B2 (en) | 2011-03-18 | 2016-07-05 | Puricore, Inc. | Methods for treating skin irritation |
| WO2013093891A1 (en) | 2011-12-22 | 2013-06-27 | Nuvo Research Gmbh | Liposomal chlorite or chlorate compositions |
| US20140356452A1 (en) * | 2012-01-19 | 2014-12-04 | Ibt Usa Inc. | Therapeutic Uses of Tetrachlorodecaoxygen (TCDO) |
| JP2015071581A (ja) * | 2013-05-20 | 2015-04-16 | 本部三慶株式会社 | 亜塩素酸水含有ウイルス殺傷剤 |
| CN105637189B (zh) * | 2013-10-03 | 2021-11-16 | 优美科股份公司及两合公司 | 废气后处理系统 |
| WO2015181800A2 (en) * | 2014-05-30 | 2015-12-03 | Nuvo Research Ag | Methods for purifying chlorites and chlorates |
| EP3370738A2 (en) | 2015-11-02 | 2018-09-12 | Neuraltus Pharmaceuticals, Inc. | Treatment of neurodegenerative disease with sodium chlorite |
| DE102016007081A1 (de) * | 2016-06-10 | 2017-12-14 | Alethia Life Sciences Ag | Chlordioxid Desinfektionstuch |
| US20230181628A1 (en) * | 2020-05-21 | 2023-06-15 | Osaka University | Epithelial cancer therapeutic agent |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2129464A (en) * | 1937-10-06 | 1938-09-06 | Mathieson Alkali Works Inc | Recovery of sodium chloride and sodium chlorite from aqueous solutions |
| US2169066A (en) | 1938-07-01 | 1939-08-08 | Mathieson Alkali Works Inc | Preparation of sodium chlorate and sodium chlorite and the separation thereof |
| DE941665C (de) * | 1951-04-19 | 1956-04-19 | Val Mehler Segeltuchweberei Ag | Verfahren zum Bleichen von Textilien |
| US3082146A (en) | 1959-02-04 | 1963-03-19 | Chemical Res Lab Of America In | Process for the treatment of water |
| US4296103A (en) | 1980-08-08 | 1981-10-20 | Felipe Laso | Stabilized solution of chlorine oxides |
| DE3213389A1 (de) | 1982-04-10 | 1983-10-20 | Friedrich-Wilhelm Dr. 7107 Neckarsulm Kühne | Stabilisierter aktivierter sauerstoff und arzneimittel, die diesen stabilisierten aktivierten sauerstoff enthalten |
| DE3515748A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Verwendung einer isotonen chloritmatrix-loesung bei der behandlung von tumoren |
| DE3515749A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Verwendung einer stabilisierten chloritmatrixloesung bei infektioesen zustaenden |
| DE3515745A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Waessrige chloritmatrix-loesung |
| US4944920A (en) | 1986-08-01 | 1990-07-31 | University Of Southern California | Novel method to treat blood |
| US4851222A (en) | 1988-01-27 | 1989-07-25 | Oxo Chemie Gmbh | Method of promoting regeneration of bone marrow |
| US5078908A (en) * | 1989-10-02 | 1992-01-07 | Allergan, Inc. | Methods for generating chlorine dioxide and compositions for disinfecting |
| DE4208828A1 (de) * | 1992-03-19 | 1993-09-23 | Oxo Chemie Gmbh | Verwendung einer chemisch stabilisierten chloritmatrix zur herstellung von arzneimitteln zur behandlung von hiv-infektionen |
| US5622725A (en) * | 1992-03-20 | 1997-04-22 | Alcide Corporation | Wound disinfection and repair |
| GB9208731D0 (en) * | 1992-04-22 | 1992-06-10 | Squibb & Sons Inc | Hydrocolloid wound gel |
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| US5830511A (en) | 1992-06-25 | 1998-11-03 | Bioxy Inc. | Therapeutic, production and immunostimulatory uses of biocidal compositions |
| ATE241389T1 (de) | 1992-12-17 | 2003-06-15 | Advanced Medical Optics Inc | Oxidationsmittel und polyvinylpyrrolidon enthaltende desinfektionslösung für kontaktlinsen |
| JPH06230717A (ja) | 1993-02-02 | 1994-08-19 | Kanebo Ltd | 骨模型 |
| US5639295A (en) * | 1995-06-05 | 1997-06-17 | Southwest Research Institute | Method of making a composition containing a stable chlorite source |
| US5489435A (en) * | 1993-07-06 | 1996-02-06 | Ratcliff; Perry A. | Composition for treatment of abnormal conditions of the epithelium of bodily orifices |
| US5855922A (en) * | 1995-12-07 | 1999-01-05 | Bio-Cide International, Inc. | Antiseptic composition and process for prophylaxis and therapeutic treatment of dermal disorders |
| US5723095A (en) * | 1995-12-28 | 1998-03-03 | Steris Corporation | Cleaner concentrate formulation for biological waste fluid handling systems |
| US5877222A (en) | 1996-07-19 | 1999-03-02 | The Regents Of The University Of California | Method for treating aids-associated dementia |
| EP1021196B1 (en) | 1997-10-06 | 2004-02-04 | Oxo Chemie Ag | Use of a chemically-stabilized chlorite solution for inhibiting an antigen-specific immune response |
| US6132702A (en) * | 1998-02-27 | 2000-10-17 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
| US6350438B1 (en) | 1998-02-27 | 2002-02-26 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
| EP1119347B1 (en) | 1998-10-08 | 2005-03-02 | Hampar L. Karagoezian | Synergistic antimicrobial, dermatological and ophthalmic preparations containing chlorite and hydrogen peroxide |
| US20040037891A1 (en) * | 1999-10-04 | 2004-02-26 | Karagoezian Hampar L. | Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide |
| EP1234060A2 (en) | 1999-11-30 | 2002-08-28 | OXO Chemie AG | Evaluating and predicting clinical outcomes by gene expression analysis |
| DE10012340A1 (de) * | 2000-03-14 | 2001-09-20 | Merck Patent Gmbh | Verfahren zur Baeyer-Villiger-Oxidation organischer Carbonylverbindungen |
| CA2429908C (en) * | 2001-01-16 | 2011-05-17 | Joseph M. Kelley | An electrolytic process for the generation of stable solutions of chlorine dioxide |
| WO2002092028A2 (en) * | 2001-05-15 | 2002-11-21 | The Procter & Gamble Company | Oral care compositions |
| ITMI20011702A1 (it) * | 2001-08-03 | 2003-02-03 | Acraf | Soluzione disinfettante a base di ipoclorito di sodio e procedimento per prepararla |
| AU2002343609B2 (en) | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| US7105183B2 (en) | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| AU2006331497B2 (en) | 2005-12-22 | 2013-07-04 | Neuraltus Pharmaceuticals, Inc. | Chlorite formulations, and methods of preparation and use thereof |
| CN107074497B (zh) | 2014-09-09 | 2019-07-05 | 三菱电机株式会社 | 电梯的设备安装装置 |
-
2006
- 2006-12-21 AU AU2006331497A patent/AU2006331497B2/en not_active Ceased
- 2006-12-21 EP EP06847994A patent/EP1979269A4/en not_active Withdrawn
- 2006-12-21 JP JP2008547585A patent/JP5371443B2/ja active Active
- 2006-12-21 US US11/614,859 patent/US8067035B2/en not_active Expired - Fee Related
- 2006-12-21 CA CA2919344A patent/CA2919344C/en not_active Expired - Fee Related
- 2006-12-21 CA CA002634915A patent/CA2634915A1/en not_active Abandoned
- 2006-12-21 WO PCT/US2006/048941 patent/WO2007075972A2/en active Application Filing
-
2011
- 2011-05-09 US US13/103,195 patent/US8231856B2/en active Active
- 2011-09-29 US US13/249,098 patent/US9266734B2/en active Active
- 2011-09-29 US US13/249,123 patent/US8501244B2/en active Active
-
2013
- 2013-01-04 JP JP2013000170A patent/JP5860821B2/ja not_active Expired - Fee Related
-
2014
- 2014-08-18 JP JP2014165700A patent/JP2014210817A/ja not_active Withdrawn
-
2016
- 2016-01-15 US US14/996,876 patent/US9839650B2/en active Active
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