JP2009521228A - 単球の樹状細胞への分化を促進する多孔質膜デバイス - Google Patents

単球の樹状細胞への分化を促進する多孔質膜デバイス Download PDF

Info

Publication number
JP2009521228A
JP2009521228A JP2008547637A JP2008547637A JP2009521228A JP 2009521228 A JP2009521228 A JP 2009521228A JP 2008547637 A JP2008547637 A JP 2008547637A JP 2008547637 A JP2008547637 A JP 2008547637A JP 2009521228 A JP2009521228 A JP 2009521228A
Authority
JP
Japan
Prior art keywords
cells
well
porous membrane
endothelial cells
endothelial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008547637A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009521228A5 (enExample
Inventor
ドナルド サード ドレイク
デイヴィッド モー
コナン リー
ヘザー ファーレンカンプ
ガズマン サンチェス−シュミッツ
ラッセル ヒグビー
ロバート パークヒル
ウィリアム エル. ウォーレン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VaxDesign Corp
Original Assignee
VaxDesign Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VaxDesign Corp filed Critical VaxDesign Corp
Publication of JP2009521228A publication Critical patent/JP2009521228A/ja
Publication of JP2009521228A5 publication Critical patent/JP2009521228A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0639Dendritic cells, e.g. Langherhans cells in the epidermis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/19Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/44Fungal antigens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/12Well or multiwell plates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/20Material Coatings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02Membranes; Filters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/28Vascular endothelial cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00Use of cells in diagnostics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2008547637A 2005-12-21 2006-12-21 単球の樹状細胞への分化を促進する多孔質膜デバイス Pending JP2009521228A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75203305P 2005-12-21 2005-12-21
PCT/US2006/049128 WO2007076061A1 (en) 2005-12-21 2006-12-21 A porous membrane device that promotes the differentiation of monocytes into dendritic cells

Publications (2)

Publication Number Publication Date
JP2009521228A true JP2009521228A (ja) 2009-06-04
JP2009521228A5 JP2009521228A5 (enExample) 2012-04-12

Family

ID=37963795

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547637A Pending JP2009521228A (ja) 2005-12-21 2006-12-21 単球の樹状細胞への分化を促進する多孔質膜デバイス

Country Status (9)

Country Link
US (2) US20070178076A1 (enExample)
EP (2) EP1963491B1 (enExample)
JP (1) JP2009521228A (enExample)
AT (2) ATE495238T1 (enExample)
AU (1) AU2006330951B2 (enExample)
CA (2) CA2634119C (enExample)
DE (1) DE602006019638D1 (enExample)
IL (1) IL192090A (enExample)
WO (1) WO2007076061A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018537116A (ja) * 2015-12-17 2018-12-20 ロレアル いくつかの直径の細孔を含む再構築された組織のための膜
JP2019531717A (ja) * 2016-09-08 2019-11-07 サノフィ パスツール ヴァックスデザイン コーポレーション インビトロの新生児バイオミメティック(nmimic)モデル及び方法、並びにその使用
US12359153B2 (en) * 2016-11-24 2025-07-15 AlveoliX Technologies AG Cell culturing system and method

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7855074B2 (en) 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
US7785806B2 (en) 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
US8298824B2 (en) 2004-04-28 2012-10-30 Sanofi Pasteur Vaxdesign Corporation Methods of evaluating a test agent in a diseased cell model
US8030070B2 (en) * 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
US7771999B2 (en) 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US7709256B2 (en) * 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US7785883B2 (en) 2004-04-28 2010-08-31 Vax Design Corp. Automatable artificial immune system (AIS)
US8071373B2 (en) 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US8003387B2 (en) 2005-12-21 2011-08-23 Sanofi Pasteur Vaxdesign Corp. In vitro germinal centers
JP2009521228A (ja) * 2005-12-21 2009-06-04 ヴァックスデザイン コーポレーション 単球の樹状細胞への分化を促進する多孔質膜デバイス
ATE525093T1 (de) * 2006-06-27 2011-10-15 Sanofi Pasteur Vaxdesign Corp Modelle für die bewertung von impfstoffen
US8647837B2 (en) * 2007-07-16 2014-02-11 Sanofi Pasteur Vaxdesign Corp. Artificial tissue constructs comprising alveolar cells and methods for using the same
AU2010225438A1 (en) * 2009-03-17 2011-10-13 The Heart Research Institute Ltd Method of cell differentiation and uses therefor in screening, diagnosis and therapy
US8802747B2 (en) * 2009-08-26 2014-08-12 Molecular Imprints, Inc. Nanoimprint lithography processes for forming nanoparticles
US10731129B2 (en) 2012-03-07 2020-08-04 Children's Medical Center Corporation Methods of evaluating immunogenicity of an agent using an artificial tissue construct
US9423234B2 (en) 2012-11-05 2016-08-23 The Regents Of The University Of California Mechanical phenotyping of single cells: high throughput quantitative detection and sorting
KR101986092B1 (ko) * 2016-09-13 2019-06-05 대한뉴팜(주) 유두진피 섬유아세포의 고순도 분리 방법
US11175282B2 (en) 2017-06-26 2021-11-16 Biohope Scientfic Solutions For Human Health S.L. Method for predicting and monitoring clinical response to immunomodulatory therapy
CN112221543B (zh) * 2019-07-15 2024-05-10 京东方科技集团股份有限公司 细胞片层转移器件、运输装置和转移细胞片层的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10508522A (ja) * 1994-11-08 1998-08-25 オーガノジェネシス・インコーポレーテッド イン・ビトロ組織および器官相当モデル
WO2005104755A2 (en) * 2004-04-28 2005-11-10 Vaxdesign Corporation Artificial immune system: methods for making and use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5720937A (en) * 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
US5008116A (en) * 1988-11-14 1991-04-16 Frederick Cahn Immunostimulatory microsphere
US5562910A (en) * 1989-09-25 1996-10-08 University Of Utah Research Foundation Vaccine compositions and method for enhancing an immune response
US5188959A (en) * 1989-09-28 1993-02-23 Trustees Of Tufts College Extracellular matrix protein adherent t cells
US5695996A (en) * 1994-09-23 1997-12-09 The United States Of America As Represented By The Department Of Health And Human Services Artificial organ culture system
US6479258B1 (en) * 1995-12-07 2002-11-12 Diversa Corporation Non-stochastic generation of genetic vaccines
US5739001A (en) * 1996-10-29 1998-04-14 E. I. Du Pont De Nemours And Company Solid phase cell-based assay
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
ATE428769T1 (de) * 1997-10-27 2009-05-15 Univ Rockefeller Methode und zusammensetzung zur herstellung von reifen dendritischen zellen
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US20020155108A1 (en) * 1998-05-04 2002-10-24 Biocrystal, Ltd. Method for ex vivo loading of antigen presenting cells with antigen, and a vaccine comprising the loaded cells
HK1046004B (en) * 1999-11-12 2013-11-08 Fibrogen, Inc. Recombinant gelatins
EP1231836A4 (en) * 1999-11-17 2004-06-02 Univ Rochester EX VIVO HUMAN IMMUNE SYSTEM
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US6541225B1 (en) * 2000-01-26 2003-04-01 Raven Biotechnologies, Inc. Methods and compositions for generating human monoclonal antibodies
JP2004522446A (ja) * 2001-02-07 2004-07-29 コリア アトミック エネルギー リサーチ インスティテュート 上皮細胞の分離方法、細胞を前条件付けする方法、およびバイオ人工皮膚もしくは真皮を上皮細胞または条件付けされた細胞を用いて調製する方法
EP1437147B1 (en) * 2001-09-25 2012-06-27 National Institute for Environmental Studies Method of preparing basement membrane
FR2833271B1 (fr) * 2001-12-10 2004-09-17 Coletica Production de cellules dendritiques in vitro a partir de monocytes cd14+, pour notamment la realisation de modeles cellulaires et/ou tissulaires en suspension, en monocouches et tridimentionnels; utilisation de ces modeles
GB0130789D0 (en) * 2001-12-21 2002-02-06 King S College London Application of spores
CA2480011A1 (en) * 2002-03-18 2003-12-04 Sciperio, Inc. Dentritic cell nodes
EP2322928A1 (en) * 2002-04-11 2011-05-18 Cyclex, Inc. Method for monitoring the immune response and predicting clinical outcomes in transplant recipients using ATP measurement in lymphocytes
US20040009943A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Pathogen vaccines and methods for using the same
US20050191743A1 (en) * 2002-10-03 2005-09-01 Wu J.H. D. Three-dimensional peripheral lymphoid organ cell cultures
US20040109876A1 (en) * 2002-11-25 2004-06-10 Kureha Chemical Industry Co., Ltd. Vaccine composition, HIV-infection suppression factor and method for the vaccination against HIV
US7785806B2 (en) * 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
US8030070B2 (en) * 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
US8071373B2 (en) * 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US7855074B2 (en) * 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
US20070141552A1 (en) * 2004-04-28 2007-06-21 Warren William L Automatable artificial immune system (AIS)
US20060275270A1 (en) * 2004-04-28 2006-12-07 Warren William L In vitro mucosal tissue equivalent
US7771999B2 (en) * 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US7785883B2 (en) * 2004-04-28 2010-08-31 Vax Design Corp. Automatable artificial immune system (AIS)
JP2009521228A (ja) * 2005-12-21 2009-06-04 ヴァックスデザイン コーポレーション 単球の樹状細胞への分化を促進する多孔質膜デバイス
US8003387B2 (en) * 2005-12-21 2011-08-23 Sanofi Pasteur Vaxdesign Corp. In vitro germinal centers
ATE525093T1 (de) * 2006-06-27 2011-10-15 Sanofi Pasteur Vaxdesign Corp Modelle für die bewertung von impfstoffen
CA2692689A1 (en) * 2007-07-06 2009-01-15 Vaxdesign Corporation Rapid generation of t cell-independent antibody responses to t cell-dependent antigens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10508522A (ja) * 1994-11-08 1998-08-25 オーガノジェネシス・インコーポレーテッド イン・ビトロ組織および器官相当モデル
WO2005104755A2 (en) * 2004-04-28 2005-11-10 Vaxdesign Corporation Artificial immune system: methods for making and use

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN6012017130; 血液フロンティア Vol.11, No.8, 2001, p.47-52 *
JPN6012017132; Science Vol.282, 1998, p.480-483 *
JPN6012017134; Blood Vol.106, 20050719, p.2818-2826 *
JPN6012017136; Arthritis Rheumatism Vol.52, No.11, 200511, p.3460-3469 *
JPN6013000799; J.Immunol. Vol.160, 1998, p.2675-2683 *
JPN6013000802; Immunity Vol.13, 2000, p.323-332 *
JPN6013000805; Eur.J.Immunol. Vol.26, 1996, p.759-767 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018537116A (ja) * 2015-12-17 2018-12-20 ロレアル いくつかの直径の細孔を含む再構築された組織のための膜
JP2019531717A (ja) * 2016-09-08 2019-11-07 サノフィ パスツール ヴァックスデザイン コーポレーション インビトロの新生児バイオミメティック(nmimic)モデル及び方法、並びにその使用
JP2021180673A (ja) * 2016-09-08 2021-11-25 サノフィ パスツール ヴァックスデザイン コーポレーション インビトロの新生児バイオミメティック(nmimic)モデル及び方法、並びにその使用
JP7274540B2 (ja) 2016-09-08 2023-05-16 サノフィ パスツール ヴァックスデザイン コーポレーション インビトロの新生児バイオミメティック(nmimic)モデル及び方法、並びにその使用
US12359153B2 (en) * 2016-11-24 2025-07-15 AlveoliX Technologies AG Cell culturing system and method

Also Published As

Publication number Publication date
AU2006330951A1 (en) 2007-07-05
DE602006019638D1 (de) 2011-02-24
IL192090A (en) 2012-01-31
IL192090A0 (en) 2008-12-29
CA2634119A1 (en) 2007-07-05
ATE531793T1 (de) 2011-11-15
ATE495238T1 (de) 2011-01-15
EP2199384B1 (en) 2011-11-02
WO2007076061A1 (en) 2007-07-05
US20100105135A1 (en) 2010-04-29
AU2006330951B2 (en) 2012-04-05
CA2847310A1 (en) 2007-07-05
CA2634119C (en) 2015-02-24
EP1963491B1 (en) 2011-01-12
EP1963491A1 (en) 2008-09-03
EP2199384A1 (en) 2010-06-23
US20070178076A1 (en) 2007-08-02

Similar Documents

Publication Publication Date Title
US20100105135A1 (en) Porous membrane device that promotes the differentiation of monocytes into dendritic cells
JP5101559B2 (ja) invitroにおけるCD14陽性単球からの樹状細胞の産出
JP5795699B2 (ja) 人工免疫システム:作製および使用方法
US5766944A (en) T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
US7855074B2 (en) Artificial immune system: methods for making and use
IL191930A (en) Methods for producing activated dendritic cells
US20060275270A1 (en) In vitro mucosal tissue equivalent
US12291702B2 (en) System and methods for immune cells expansion and activation in large scale
Schanen et al. A novel approach for the generation of human dendritic cells from blood monocytes in the absence of exogenous factors
Paulnock Macrophages: Practical Approach Series
KR20090049620A (ko) Cd14+ 단구로부터 랑게르한스 세포 및/또는 진피/간질성 수지상 세포를 생성시키는 방법
Koch et al. Isolation, enrichment, and culture of murine epidermal langerhans cells
EP3510143B1 (en) In vitro neonatal biomimetic (nmimic) model and methods of using same

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091221

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091221

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20110726

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20111129

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120222

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120403

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130415

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130422

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140627