DE602006019638D1 - Iin vitro methode um eine potentielle reaktion eines tieres an einen agenten zu bestimmen - Google Patents
Iin vitro methode um eine potentielle reaktion eines tieres an einen agenten zu bestimmenInfo
- Publication number
- DE602006019638D1 DE602006019638D1 DE602006019638T DE602006019638T DE602006019638D1 DE 602006019638 D1 DE602006019638 D1 DE 602006019638D1 DE 602006019638 T DE602006019638 T DE 602006019638T DE 602006019638 T DE602006019638 T DE 602006019638T DE 602006019638 D1 DE602006019638 D1 DE 602006019638D1
- Authority
- DE
- Germany
- Prior art keywords
- dcs
- cultured
- transwell
- populations
- blood monocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000004443 dendritic cell Anatomy 0.000 abstract 5
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 230000005867 T cell response Effects 0.000 abstract 1
- 230000000139 costimulatory effect Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4641—Fungal antigens, e.g. Trichophyton, Aspergillus or Candida
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Clinical Laboratory Science (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75203305P | 2005-12-21 | 2005-12-21 | |
PCT/US2006/049128 WO2007076061A1 (en) | 2005-12-21 | 2006-12-21 | A porous membrane device that promotes the differentiation of monocytes into dendritic cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006019638D1 true DE602006019638D1 (de) | 2011-02-24 |
Family
ID=37963795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006019638T Active DE602006019638D1 (de) | 2005-12-21 | 2006-12-21 | Iin vitro methode um eine potentielle reaktion eines tieres an einen agenten zu bestimmen |
Country Status (9)
Country | Link |
---|---|
US (2) | US20070178076A1 (de) |
EP (2) | EP2199384B1 (de) |
JP (1) | JP2009521228A (de) |
AT (2) | ATE495238T1 (de) |
AU (1) | AU2006330951B2 (de) |
CA (2) | CA2847310A1 (de) |
DE (1) | DE602006019638D1 (de) |
IL (1) | IL192090A (de) |
WO (1) | WO2007076061A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7785883B2 (en) | 2004-04-28 | 2010-08-31 | Vax Design Corp. | Automatable artificial immune system (AIS) |
US7855074B2 (en) | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
US7771999B2 (en) * | 2004-04-28 | 2010-08-10 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
US7785806B2 (en) | 2004-04-28 | 2010-08-31 | Vaxdesign Corporation | Method for determining the immunogenicity of an antigen |
US8030070B2 (en) * | 2004-04-28 | 2011-10-04 | Sanofi Pasteur Vaxdesign Corp. | Artificial lymphoid tissue equivalent |
US8298824B2 (en) | 2004-04-28 | 2012-10-30 | Sanofi Pasteur Vaxdesign Corporation | Methods of evaluating a test agent in a diseased cell model |
US8071373B2 (en) | 2004-04-28 | 2011-12-06 | Sanofi Pasteur Vaxdesign Corp. | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) |
US7709256B2 (en) * | 2004-04-28 | 2010-05-04 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
US20070178076A1 (en) * | 2005-12-21 | 2007-08-02 | Drake Donald Iii | Porous membrane device that promotes the differentiation of monocytes into dendritic cells |
WO2007075979A2 (en) | 2005-12-21 | 2007-07-05 | Vaxdesign Corporation | In vitro germinal centers |
EP2409715A1 (de) * | 2006-06-27 | 2012-01-25 | Sanofi Pasteur VaxDesign Corporation | Modelle für die Bewertung von Impfstoffen |
WO2009048661A1 (en) | 2007-07-16 | 2009-04-16 | Vaxdesign Corporation | Artificial tissue constructs comprising alveolar cells and methods for using the same |
WO2010105285A1 (en) * | 2009-03-17 | 2010-09-23 | The Heart Research Institute | Method of cell differentiation and uses therefor in screening, diagnosis and therapy |
EP2529274B1 (de) * | 2010-01-29 | 2014-10-08 | Canon Nanotechnologies, Inc. | Nanoimprintverfahren zur herstellung von nanopartikeln |
WO2013134464A1 (en) | 2012-03-07 | 2013-09-12 | Children's Medical Center Corporation | Tissue constructs and uses thereof |
US9423234B2 (en) | 2012-11-05 | 2016-08-23 | The Regents Of The University Of California | Mechanical phenotyping of single cells: high throughput quantitative detection and sorting |
FR3045664A1 (fr) | 2015-12-17 | 2017-06-23 | Oreal | Membrane pour tissu reconstruit comprenant des pores de plusieurs diametres |
EP3510143B1 (de) * | 2016-09-08 | 2023-03-01 | Sanofi Pasteur Vaxdesign Corp. | Neonatales biomimetisches (nmimic) in-vitro-modell und verfahren zur verwendung davon |
KR101986092B1 (ko) * | 2016-09-13 | 2019-06-05 | 대한뉴팜(주) | 유두진피 섬유아세포의 고순도 분리 방법 |
US11175282B2 (en) | 2017-06-26 | 2021-11-16 | Biohope Scientfic Solutions For Human Health S.L. | Method for predicting and monitoring clinical response to immunomodulatory therapy |
CN112221543B (zh) * | 2019-07-15 | 2024-05-10 | 京东方科技集团股份有限公司 | 细胞片层转移器件、运输装置和转移细胞片层的方法 |
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US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
US5720937A (en) * | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
US5562910A (en) * | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
US5188959A (en) * | 1989-09-28 | 1993-02-23 | Trustees Of Tufts College | Extracellular matrix protein adherent t cells |
US5827641A (en) * | 1992-11-13 | 1998-10-27 | Parenteau; Nancy L. | In vitro cornea equivalent model |
US5695996A (en) * | 1994-09-23 | 1997-12-09 | The United States Of America As Represented By The Department Of Health And Human Services | Artificial organ culture system |
US6479258B1 (en) * | 1995-12-07 | 2002-11-12 | Diversa Corporation | Non-stochastic generation of genetic vaccines |
US5739001A (en) * | 1996-10-29 | 1998-04-14 | E. I. Du Pont De Nemours And Company | Solid phase cell-based assay |
US6177282B1 (en) * | 1997-08-12 | 2001-01-23 | Mcintyre John A. | Antigens embedded in thermoplastic |
DE69840739D1 (de) * | 1997-10-27 | 2009-05-28 | Merix Bioscience Inc | Methode und Zusammensetzung zur Herstellung von reifen dendritischen Zellen |
US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
US20020155108A1 (en) * | 1998-05-04 | 2002-10-24 | Biocrystal, Ltd. | Method for ex vivo loading of antigen presenting cells with antigen, and a vaccine comprising the loaded cells |
JP2003513988A (ja) * | 1999-11-12 | 2003-04-15 | ファイブローゲン、インコーポレーテッド | ワクチンに含まれる組換えゼラチン |
EP1231836A4 (de) * | 1999-11-17 | 2004-06-02 | Univ Rochester | Menschliches ex vivo immunsystem |
US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
US6541225B1 (en) * | 2000-01-26 | 2003-04-01 | Raven Biotechnologies, Inc. | Methods and compositions for generating human monoclonal antibodies |
WO2002062971A1 (en) * | 2001-02-07 | 2002-08-15 | Korea Atomic Energy Research Institute | Method of isolating epithelial cells, method of preconditioning cells, and methods of preparing bioartificial skin and dermis with the epithelial cells or the preconditioned cells |
WO2003026712A1 (fr) * | 2001-09-25 | 2003-04-03 | Japan Science And Technology Agency | Procede de formation de membrane basale, procede d'elaboration d'echantillon de membrane basale, tissu artificiel reconstitue utilisant cet echantillon, et procede d'elaboration de ce tissu |
FR2833271B1 (fr) * | 2001-12-10 | 2004-09-17 | Coletica | Production de cellules dendritiques in vitro a partir de monocytes cd14+, pour notamment la realisation de modeles cellulaires et/ou tissulaires en suspension, en monocouches et tridimentionnels; utilisation de ces modeles |
GB0130789D0 (en) * | 2001-12-21 | 2002-02-06 | King S College London | Application of spores |
CA2480011A1 (en) * | 2002-03-18 | 2003-12-04 | Sciperio, Inc. | Dentritic cell nodes |
ATE538378T1 (de) * | 2002-04-11 | 2012-01-15 | Cylex Inc | Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten |
US20040009943A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Pathogen vaccines and methods for using the same |
AU2003275421A1 (en) * | 2002-10-03 | 2004-04-23 | Andrea Bottaro | Three-dimensional peripheral lymphoid organ cell cultures |
US20040109876A1 (en) * | 2002-11-25 | 2004-06-10 | Kureha Chemical Industry Co., Ltd. | Vaccine composition, HIV-infection suppression factor and method for the vaccination against HIV |
US7785806B2 (en) * | 2004-04-28 | 2010-08-31 | Vaxdesign Corporation | Method for determining the immunogenicity of an antigen |
US7785883B2 (en) * | 2004-04-28 | 2010-08-31 | Vax Design Corp. | Automatable artificial immune system (AIS) |
US7771999B2 (en) * | 2004-04-28 | 2010-08-10 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
US20070141552A1 (en) * | 2004-04-28 | 2007-06-21 | Warren William L | Automatable artificial immune system (AIS) |
US20060275270A1 (en) * | 2004-04-28 | 2006-12-07 | Warren William L | In vitro mucosal tissue equivalent |
US7855074B2 (en) * | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
US8030070B2 (en) * | 2004-04-28 | 2011-10-04 | Sanofi Pasteur Vaxdesign Corp. | Artificial lymphoid tissue equivalent |
US8071373B2 (en) * | 2004-04-28 | 2011-12-06 | Sanofi Pasteur Vaxdesign Corp. | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) |
EP1758985B1 (de) * | 2004-04-28 | 2015-06-03 | Sanofi Pasteur VaxDesign Corporation | Künstliches immunsystem: verfahren zur herstellung und verwendung |
WO2007075979A2 (en) * | 2005-12-21 | 2007-07-05 | Vaxdesign Corporation | In vitro germinal centers |
US20070178076A1 (en) * | 2005-12-21 | 2007-08-02 | Drake Donald Iii | Porous membrane device that promotes the differentiation of monocytes into dendritic cells |
EP2409715A1 (de) * | 2006-06-27 | 2012-01-25 | Sanofi Pasteur VaxDesign Corporation | Modelle für die Bewertung von Impfstoffen |
EP2420516A1 (de) * | 2007-07-06 | 2012-02-22 | Sanofi Pasteur VaxDesign Corporation | Schnelle Erzeugung von T-Zellen-unabhängigen Antikörper-Reaktionen auf T-Zellen-abhängige Antigene |
-
2006
- 2006-12-21 US US11/642,926 patent/US20070178076A1/en not_active Abandoned
- 2006-12-21 CA CA2847310A patent/CA2847310A1/en not_active Abandoned
- 2006-12-21 EP EP10151003A patent/EP2199384B1/de active Active
- 2006-12-21 AT AT06848082T patent/ATE495238T1/de not_active IP Right Cessation
- 2006-12-21 WO PCT/US2006/049128 patent/WO2007076061A1/en active Application Filing
- 2006-12-21 EP EP06848082A patent/EP1963491B1/de active Active
- 2006-12-21 CA CA2634119A patent/CA2634119C/en active Active
- 2006-12-21 AT AT10151003T patent/ATE531793T1/de active
- 2006-12-21 AU AU2006330951A patent/AU2006330951B2/en active Active
- 2006-12-21 DE DE602006019638T patent/DE602006019638D1/de active Active
- 2006-12-21 JP JP2008547637A patent/JP2009521228A/ja active Pending
-
2008
- 2008-06-12 IL IL192090A patent/IL192090A/en active IP Right Grant
-
2009
- 2009-10-30 US US12/609,060 patent/US20100105135A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2199384A1 (de) | 2010-06-23 |
CA2847310A1 (en) | 2007-07-05 |
AU2006330951B2 (en) | 2012-04-05 |
CA2634119A1 (en) | 2007-07-05 |
EP1963491A1 (de) | 2008-09-03 |
EP2199384B1 (de) | 2011-11-02 |
JP2009521228A (ja) | 2009-06-04 |
US20070178076A1 (en) | 2007-08-02 |
US20100105135A1 (en) | 2010-04-29 |
ATE531793T1 (de) | 2011-11-15 |
IL192090A0 (en) | 2008-12-29 |
EP1963491B1 (de) | 2011-01-12 |
IL192090A (en) | 2012-01-31 |
CA2634119C (en) | 2015-02-24 |
AU2006330951A1 (en) | 2007-07-05 |
ATE495238T1 (de) | 2011-01-15 |
WO2007076061A1 (en) | 2007-07-05 |
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