ATE538378T1 - Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten - Google Patents

Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten

Info

Publication number
ATE538378T1
ATE538378T1 AT03746717T AT03746717T ATE538378T1 AT E538378 T1 ATE538378 T1 AT E538378T1 AT 03746717 T AT03746717 T AT 03746717T AT 03746717 T AT03746717 T AT 03746717T AT E538378 T1 ATE538378 T1 AT E538378T1
Authority
AT
Austria
Prior art keywords
immune response
predicting clinical
clinical results
transplant recipients
monitoring immune
Prior art date
Application number
AT03746717T
Other languages
English (en)
Inventor
Judith Britz
Peter Sottong
Richard Kowalski
Original Assignee
Cylex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cylex Inc filed Critical Cylex Inc
Application granted granted Critical
Publication of ATE538378T1 publication Critical patent/ATE538378T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/827—Lectins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03746717T 2002-04-11 2003-04-11 Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten ATE538378T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37140202P 2002-04-11 2002-04-11
PCT/US2003/011117 WO2003086177A2 (en) 2002-04-11 2003-04-11 Method for monitoring the immune response and predicting clinical outcomes in transplant recipients

Publications (1)

Publication Number Publication Date
ATE538378T1 true ATE538378T1 (de) 2012-01-15

Family

ID=29250671

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03746717T ATE538378T1 (de) 2002-04-11 2003-04-11 Verfahren zur überwachung der immunantwort und vorhersage der klinischen resultate bei empfängern von transplantaten

Country Status (6)

Country Link
US (2) US7476514B2 (de)
EP (2) EP1495134B1 (de)
AT (1) ATE538378T1 (de)
AU (1) AU2003226067A1 (de)
ES (1) ES2379252T3 (de)
WO (1) WO2003086177A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2379252T3 (es) * 2002-04-11 2012-04-24 Cyclex, Inc. Método para monitorizar la respuesta inmunitaria y predecir los desenlaces clínicos en receptores de trasplantes
EP1800124B1 (de) * 2004-03-16 2011-12-21 Amnis Corporation Auf bildlicher darstellung beruhende quantifizierung molekularer translokation
US7771999B2 (en) * 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US8030070B2 (en) * 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
US7709256B2 (en) * 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US8298824B2 (en) 2004-04-28 2012-10-30 Sanofi Pasteur Vaxdesign Corporation Methods of evaluating a test agent in a diseased cell model
US7785806B2 (en) 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
US7785883B2 (en) * 2004-04-28 2010-08-31 Vax Design Corp. Automatable artificial immune system (AIS)
US8071373B2 (en) * 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US7855074B2 (en) * 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
US20100004738A1 (en) * 2005-04-29 2010-01-07 Atrium Medical Corporation Drug delivery coating for use with a medical device and methods of treating vascular injury
ATE531793T1 (de) * 2005-12-21 2011-11-15 Sanofi Pasteur Vaxdesign Corp Eine poröse membran gerät, das die differenzierung von monozyten in dendritische zellen fördert
WO2007075979A2 (en) 2005-12-21 2007-07-05 Vaxdesign Corporation In vitro germinal centers
EP2021493A4 (de) * 2006-05-02 2010-04-14 Therakos Inc Verfahren und reagenzien für den nachweis von anfälligkeit für transplantat-gegen-empfänger-krankheit oder transplantatbedingte mortalität
WO2008094178A2 (en) * 2006-06-27 2008-08-07 Vaxdesign Corporation Models for vaccine assessment
US20090062237A1 (en) * 2007-06-15 2009-03-05 Mayo Foundation For Medical Education And Research Evaluating immune competence
WO2009048661A1 (en) * 2007-07-16 2009-04-16 Vaxdesign Corporation Artificial tissue constructs comprising alveolar cells and methods for using the same
CN109100501B (zh) 2009-12-23 2022-05-13 塞尔雷斯蒂斯有限公司 测量细胞介导免疫反应的试验
WO2015101988A1 (en) 2013-12-31 2015-07-09 Yeda Research And Development Co. Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
US20160320384A1 (en) 2013-12-31 2016-11-03 Yeda Research And Development Co. Ltd. Methods for assaying immunological competence
WO2016139659A1 (en) 2015-03-01 2016-09-09 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677061A (en) * 1984-10-19 1987-06-30 Genetic Systems Corporation T-cell lymphocyte subset monitoring of immunologic disease
US4778750A (en) 1986-02-19 1988-10-18 Imreg, Inc. Diagnostic methods for immune function
US5292636A (en) * 1986-03-31 1994-03-08 T Cell Diagnostics, Inc. Therapeutic and diagnostic methods using soluble T cell surface molecules
CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
US4959302A (en) * 1987-08-20 1990-09-25 Endogen, Inc. Method of evaluating immune system response to allografts, viral infection and immunosuppressive therapy
US5344755A (en) * 1990-04-21 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting immune system dysfunction in asymptomatic, HIV-scropositive individuals
EP0688223A4 (de) * 1993-03-12 1998-05-13 Cellcor Inc -i(IN VITRO) 'ASSAY' ZUM MESSEN DES GRADES DER AKTIVIERUNG VON IMMUNZELLEN
WO1997036008A1 (en) * 1996-03-26 1997-10-02 Biotechnology Transfer, Inc. Methods for measurement of lymphocyte function
AU1533099A (en) * 1998-08-25 2000-03-14 Immune Response Corporation, The Methods for evaluating immune function
US6251616B1 (en) * 1999-01-14 2001-06-26 Biocrystal Ltd. Methods and assay kits for detecting altered mononuclear cell phenotype related to a pro-tumor immune response
US6150121A (en) * 1999-02-16 2000-11-21 Wisconsin Alumni Research Foundation Assessing immunological state of transplant recipients
US20020150952A1 (en) * 2001-04-17 2002-10-17 Peter Sottong Methods for measuring lymphocyte activation by mitogens and antigens
ES2379252T3 (es) * 2002-04-11 2012-04-24 Cyclex, Inc. Método para monitorizar la respuesta inmunitaria y predecir los desenlaces clínicos en receptores de trasplantes

Also Published As

Publication number Publication date
US7476514B2 (en) 2009-01-13
EP1495134A2 (de) 2005-01-12
US20030199006A1 (en) 2003-10-23
AU2003226067A8 (en) 2003-10-27
AU2003226067A1 (en) 2003-10-27
ES2379252T3 (es) 2012-04-24
US20090081716A1 (en) 2009-03-26
WO2003086177A2 (en) 2003-10-23
EP1495134B1 (de) 2011-12-21
EP2322928A1 (de) 2011-05-18
WO2003086177A3 (en) 2004-10-21
EP1495134A4 (de) 2008-02-13

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