JP2009521228A5 - - Google Patents
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- Publication number
- JP2009521228A5 JP2009521228A5 JP2008547637A JP2008547637A JP2009521228A5 JP 2009521228 A5 JP2009521228 A5 JP 2009521228A5 JP 2008547637 A JP2008547637 A JP 2008547637A JP 2008547637 A JP2008547637 A JP 2008547637A JP 2009521228 A5 JP2009521228 A5 JP 2009521228A5
- Authority
- JP
- Japan
- Prior art keywords
- well
- lower chamber
- cells
- endothelial cells
- porous membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 23
- 210000002889 endothelial cell Anatomy 0.000 claims 12
- 239000000463 material Substances 0.000 claims 11
- 239000012528 membrane Substances 0.000 claims 11
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 10
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 10
- 210000002744 extracellular matrix Anatomy 0.000 claims 10
- 210000004443 dendritic cell Anatomy 0.000 claims 6
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 239000004417 polycarbonate Substances 0.000 claims 2
- 229920000515 polycarbonate Polymers 0.000 claims 2
- -1 protosan Substances 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229960000074 biopharmaceutical Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 210000003606 umbilical vein Anatomy 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75203305P | 2005-12-21 | 2005-12-21 | |
| PCT/US2006/049128 WO2007076061A1 (en) | 2005-12-21 | 2006-12-21 | A porous membrane device that promotes the differentiation of monocytes into dendritic cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009521228A JP2009521228A (ja) | 2009-06-04 |
| JP2009521228A5 true JP2009521228A5 (enExample) | 2012-04-12 |
Family
ID=37963795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008547637A Pending JP2009521228A (ja) | 2005-12-21 | 2006-12-21 | 単球の樹状細胞への分化を促進する多孔質膜デバイス |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20070178076A1 (enExample) |
| EP (2) | EP1963491B1 (enExample) |
| JP (1) | JP2009521228A (enExample) |
| AT (2) | ATE495238T1 (enExample) |
| AU (1) | AU2006330951B2 (enExample) |
| CA (2) | CA2634119C (enExample) |
| DE (1) | DE602006019638D1 (enExample) |
| IL (1) | IL192090A (enExample) |
| WO (1) | WO2007076061A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855074B2 (en) | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
| US7785806B2 (en) | 2004-04-28 | 2010-08-31 | Vaxdesign Corporation | Method for determining the immunogenicity of an antigen |
| US8298824B2 (en) | 2004-04-28 | 2012-10-30 | Sanofi Pasteur Vaxdesign Corporation | Methods of evaluating a test agent in a diseased cell model |
| US8030070B2 (en) * | 2004-04-28 | 2011-10-04 | Sanofi Pasteur Vaxdesign Corp. | Artificial lymphoid tissue equivalent |
| US7771999B2 (en) | 2004-04-28 | 2010-08-10 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
| US7709256B2 (en) * | 2004-04-28 | 2010-05-04 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
| US7785883B2 (en) | 2004-04-28 | 2010-08-31 | Vax Design Corp. | Automatable artificial immune system (AIS) |
| US8071373B2 (en) | 2004-04-28 | 2011-12-06 | Sanofi Pasteur Vaxdesign Corp. | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) |
| US8003387B2 (en) | 2005-12-21 | 2011-08-23 | Sanofi Pasteur Vaxdesign Corp. | In vitro germinal centers |
| JP2009521228A (ja) * | 2005-12-21 | 2009-06-04 | ヴァックスデザイン コーポレーション | 単球の樹状細胞への分化を促進する多孔質膜デバイス |
| ATE525093T1 (de) * | 2006-06-27 | 2011-10-15 | Sanofi Pasteur Vaxdesign Corp | Modelle für die bewertung von impfstoffen |
| US8647837B2 (en) * | 2007-07-16 | 2014-02-11 | Sanofi Pasteur Vaxdesign Corp. | Artificial tissue constructs comprising alveolar cells and methods for using the same |
| AU2010225438A1 (en) * | 2009-03-17 | 2011-10-13 | The Heart Research Institute Ltd | Method of cell differentiation and uses therefor in screening, diagnosis and therapy |
| US8802747B2 (en) * | 2009-08-26 | 2014-08-12 | Molecular Imprints, Inc. | Nanoimprint lithography processes for forming nanoparticles |
| US10731129B2 (en) | 2012-03-07 | 2020-08-04 | Children's Medical Center Corporation | Methods of evaluating immunogenicity of an agent using an artificial tissue construct |
| US9423234B2 (en) | 2012-11-05 | 2016-08-23 | The Regents Of The University Of California | Mechanical phenotyping of single cells: high throughput quantitative detection and sorting |
| FR3045664A1 (fr) * | 2015-12-17 | 2017-06-23 | Oreal | Membrane pour tissu reconstruit comprenant des pores de plusieurs diametres |
| AU2017325009B2 (en) * | 2016-09-08 | 2023-07-20 | Sanofi Pasteur Vaxdesign Corp. | In vitro neonatal biomimetic (NMIMIC) model and methods of using same |
| KR101986092B1 (ko) * | 2016-09-13 | 2019-06-05 | 대한뉴팜(주) | 유두진피 섬유아세포의 고순도 분리 방법 |
| KR102492455B1 (ko) * | 2016-11-24 | 2023-01-27 | 알베오릭스 테크놀러지스 아게 | 세포 배양 시스템 및 방법 |
| US11175282B2 (en) | 2017-06-26 | 2021-11-16 | Biohope Scientfic Solutions For Human Health S.L. | Method for predicting and monitoring clinical response to immunomodulatory therapy |
| CN112221543B (zh) * | 2019-07-15 | 2024-05-10 | 京东方科技集团股份有限公司 | 细胞片层转移器件、运输装置和转移细胞片层的方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
| US5720937A (en) * | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
| US5562910A (en) * | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
| US5188959A (en) * | 1989-09-28 | 1993-02-23 | Trustees Of Tufts College | Extracellular matrix protein adherent t cells |
| US5827641A (en) * | 1992-11-13 | 1998-10-27 | Parenteau; Nancy L. | In vitro cornea equivalent model |
| US5695996A (en) * | 1994-09-23 | 1997-12-09 | The United States Of America As Represented By The Department Of Health And Human Services | Artificial organ culture system |
| US6479258B1 (en) * | 1995-12-07 | 2002-11-12 | Diversa Corporation | Non-stochastic generation of genetic vaccines |
| US5739001A (en) * | 1996-10-29 | 1998-04-14 | E. I. Du Pont De Nemours And Company | Solid phase cell-based assay |
| US6177282B1 (en) * | 1997-08-12 | 2001-01-23 | Mcintyre John A. | Antigens embedded in thermoplastic |
| ATE428769T1 (de) * | 1997-10-27 | 2009-05-15 | Univ Rockefeller | Methode und zusammensetzung zur herstellung von reifen dendritischen zellen |
| US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| US20020155108A1 (en) * | 1998-05-04 | 2002-10-24 | Biocrystal, Ltd. | Method for ex vivo loading of antigen presenting cells with antigen, and a vaccine comprising the loaded cells |
| HK1046004B (en) * | 1999-11-12 | 2013-11-08 | Fibrogen, Inc. | Recombinant gelatins |
| EP1231836A4 (en) * | 1999-11-17 | 2004-06-02 | Univ Rochester | EX VIVO HUMAN IMMUNE SYSTEM |
| US6479064B1 (en) * | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
| US6541225B1 (en) * | 2000-01-26 | 2003-04-01 | Raven Biotechnologies, Inc. | Methods and compositions for generating human monoclonal antibodies |
| JP2004522446A (ja) * | 2001-02-07 | 2004-07-29 | コリア アトミック エネルギー リサーチ インスティテュート | 上皮細胞の分離方法、細胞を前条件付けする方法、およびバイオ人工皮膚もしくは真皮を上皮細胞または条件付けされた細胞を用いて調製する方法 |
| EP1437147B1 (en) * | 2001-09-25 | 2012-06-27 | National Institute for Environmental Studies | Method of preparing basement membrane |
| FR2833271B1 (fr) * | 2001-12-10 | 2004-09-17 | Coletica | Production de cellules dendritiques in vitro a partir de monocytes cd14+, pour notamment la realisation de modeles cellulaires et/ou tissulaires en suspension, en monocouches et tridimentionnels; utilisation de ces modeles |
| GB0130789D0 (en) * | 2001-12-21 | 2002-02-06 | King S College London | Application of spores |
| CA2480011A1 (en) * | 2002-03-18 | 2003-12-04 | Sciperio, Inc. | Dentritic cell nodes |
| EP2322928A1 (en) * | 2002-04-11 | 2011-05-18 | Cyclex, Inc. | Method for monitoring the immune response and predicting clinical outcomes in transplant recipients using ATP measurement in lymphocytes |
| US20040009943A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Pathogen vaccines and methods for using the same |
| US20050191743A1 (en) * | 2002-10-03 | 2005-09-01 | Wu J.H. D. | Three-dimensional peripheral lymphoid organ cell cultures |
| US20040109876A1 (en) * | 2002-11-25 | 2004-06-10 | Kureha Chemical Industry Co., Ltd. | Vaccine composition, HIV-infection suppression factor and method for the vaccination against HIV |
| US7785806B2 (en) * | 2004-04-28 | 2010-08-31 | Vaxdesign Corporation | Method for determining the immunogenicity of an antigen |
| US8030070B2 (en) * | 2004-04-28 | 2011-10-04 | Sanofi Pasteur Vaxdesign Corp. | Artificial lymphoid tissue equivalent |
| US8071373B2 (en) * | 2004-04-28 | 2011-12-06 | Sanofi Pasteur Vaxdesign Corp. | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) |
| WO2005104755A2 (en) * | 2004-04-28 | 2005-11-10 | Vaxdesign Corporation | Artificial immune system: methods for making and use |
| US7855074B2 (en) * | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
| US20070141552A1 (en) * | 2004-04-28 | 2007-06-21 | Warren William L | Automatable artificial immune system (AIS) |
| US20060275270A1 (en) * | 2004-04-28 | 2006-12-07 | Warren William L | In vitro mucosal tissue equivalent |
| US7771999B2 (en) * | 2004-04-28 | 2010-08-10 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
| US7785883B2 (en) * | 2004-04-28 | 2010-08-31 | Vax Design Corp. | Automatable artificial immune system (AIS) |
| JP2009521228A (ja) * | 2005-12-21 | 2009-06-04 | ヴァックスデザイン コーポレーション | 単球の樹状細胞への分化を促進する多孔質膜デバイス |
| US8003387B2 (en) * | 2005-12-21 | 2011-08-23 | Sanofi Pasteur Vaxdesign Corp. | In vitro germinal centers |
| ATE525093T1 (de) * | 2006-06-27 | 2011-10-15 | Sanofi Pasteur Vaxdesign Corp | Modelle für die bewertung von impfstoffen |
| CA2692689A1 (en) * | 2007-07-06 | 2009-01-15 | Vaxdesign Corporation | Rapid generation of t cell-independent antibody responses to t cell-dependent antigens |
-
2006
- 2006-12-21 JP JP2008547637A patent/JP2009521228A/ja active Pending
- 2006-12-21 DE DE602006019638T patent/DE602006019638D1/de active Active
- 2006-12-21 WO PCT/US2006/049128 patent/WO2007076061A1/en not_active Ceased
- 2006-12-21 US US11/642,926 patent/US20070178076A1/en not_active Abandoned
- 2006-12-21 EP EP06848082A patent/EP1963491B1/en active Active
- 2006-12-21 CA CA2634119A patent/CA2634119C/en active Active
- 2006-12-21 AT AT06848082T patent/ATE495238T1/de not_active IP Right Cessation
- 2006-12-21 CA CA2847310A patent/CA2847310A1/en not_active Abandoned
- 2006-12-21 EP EP10151003A patent/EP2199384B1/en active Active
- 2006-12-21 AU AU2006330951A patent/AU2006330951B2/en active Active
- 2006-12-21 AT AT10151003T patent/ATE531793T1/de active
-
2008
- 2008-06-12 IL IL192090A patent/IL192090A/en active IP Right Grant
-
2009
- 2009-10-30 US US12/609,060 patent/US20100105135A1/en not_active Abandoned
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