JP2009520766A5 - - Google Patents
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- Publication number
- JP2009520766A5 JP2009520766A5 JP2008546456A JP2008546456A JP2009520766A5 JP 2009520766 A5 JP2009520766 A5 JP 2009520766A5 JP 2008546456 A JP2008546456 A JP 2008546456A JP 2008546456 A JP2008546456 A JP 2008546456A JP 2009520766 A5 JP2009520766 A5 JP 2009520766A5
- Authority
- JP
- Japan
- Prior art keywords
- acetone
- solvent
- ethanol
- iii
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005061624.0 | 2005-12-21 | ||
| DE102005061624A DE102005061624A1 (de) | 2005-12-21 | 2005-12-21 | Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| PCT/EP2006/070034 WO2007071743A1 (en) | 2005-12-21 | 2006-12-20 | Improved process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009520766A JP2009520766A (ja) | 2009-05-28 |
| JP2009520766A5 true JP2009520766A5 (https=) | 2013-03-21 |
| JP5317702B2 JP5317702B2 (ja) | 2013-10-16 |
Family
ID=37950582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546456A Active JP5317702B2 (ja) | 2005-12-21 | 2006-12-20 | ４−（ベンゾイミダゾリルメチルアミノ）−ベンゾアミドの塩の改良された製造方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7880016B2 (https=) |
| EP (1) | EP1968949B1 (https=) |
| JP (1) | JP5317702B2 (https=) |
| KR (1) | KR101411961B1 (https=) |
| CN (1) | CN101346355B (https=) |
| AR (1) | AR058571A1 (https=) |
| AT (1) | ATE485279T1 (https=) |
| AU (1) | AU2006326980B2 (https=) |
| BR (1) | BRPI0620150A2 (https=) |
| CA (1) | CA2632310C (https=) |
| CY (1) | CY1111113T1 (https=) |
| DE (2) | DE102005061624A1 (https=) |
| DK (1) | DK1968949T3 (https=) |
| ES (1) | ES2355045T3 (https=) |
| IL (1) | IL192242A (https=) |
| NZ (1) | NZ569636A (https=) |
| PL (1) | PL1968949T3 (https=) |
| PT (1) | PT1968949E (https=) |
| RU (1) | RU2425827C2 (https=) |
| SI (1) | SI1968949T1 (https=) |
| TW (1) | TWI411608B (https=) |
| WO (1) | WO2007071743A1 (https=) |
| ZA (1) | ZA200804198B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030181488A1 (en) | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
| DE10339862A1 (de) * | 2003-08-29 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel |
| DE102005061623A1 (de) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
| DE102006054005A1 (de) * | 2006-11-16 | 2008-05-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
| US8173906B2 (en) * | 2007-02-07 | 2012-05-08 | Raytheon Company | Environmental protection coating system and method |
| US7767589B2 (en) * | 2007-02-07 | 2010-08-03 | Raytheon Company | Passivation layer for a circuit device and method of manufacture |
| RU2010143901A (ru) * | 2008-03-28 | 2012-05-10 | Бёрингер Ингельхайм Интернациональ Гмбх (De) | Способ получения композиций дабигатрана для перорального введения |
| WO2009153214A1 (en) * | 2008-06-16 | 2009-12-23 | Boehringer Ingelheim International Gmbh | Process for the manufacture of an intermediate in the synthesis of dabigatran |
| NZ588488A (en) * | 2008-06-16 | 2012-08-31 | Boehringer Ingelheim Int | Method for producing an intermediate product of dabigatran etexilate |
| BRPI0915942A2 (pt) * | 2008-07-14 | 2019-04-09 | Boehringer Ingelheim International Gmbh | método para produção de compostos medicinais contendo dabigatrana |
| JP2013510072A (ja) | 2008-11-11 | 2013-03-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 従来のワルファリン治療に対して安全性プロフィールが改善されたダビガトランエテキシレートまたはその塩を使用して血栓症を治療または予防するための方法 |
| US8399678B2 (en) | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
| JP2013521318A (ja) * | 2010-03-08 | 2013-06-10 | ラティオファルム ゲー・エム・ベー・ハー | ダビガトランエテキシラートを含有する医薬組成物 |
| WO2012077136A2 (en) * | 2010-12-06 | 2012-06-14 | Msn Laboratories Limited | Process for the preparation of benzimidazole derivatives and its salts |
| EP2522662A1 (en) | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
| EP2834224B1 (en) | 2012-04-02 | 2018-06-06 | MSN Laboratories Limited | Process for the preparation of benzimidazole derivatives and salts thereof |
| EP2890692A1 (en) | 2012-08-31 | 2015-07-08 | Ranbaxy Laboratories Limited | Process for the preparation of crystalline form i of methanesulfonate salt of dabigatran etexilate |
| US9399616B2 (en) | 2012-10-22 | 2016-07-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of 4-aminobenzoamidine dihydrochloride |
| US10077251B2 (en) | 2012-10-29 | 2018-09-18 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the synthesis of Dabigatran Etexilate and its intermediates |
| US9533971B2 (en) | 2012-10-29 | 2017-01-03 | Biophore India Pharmaceuticals Pvt. Ltd | Process for the synthesis of dabigatran and its intermediates |
| CN103275065A (zh) * | 2013-05-30 | 2013-09-04 | 上海同昌生物医药科技有限公司 | 一种新的生产达比加群酯的方法 |
| EP2835370A1 (en) | 2013-08-08 | 2015-02-11 | Medichem, S.A. | New crystals of dabigatran etexilate mesylate |
| JP6403865B2 (ja) | 2014-07-03 | 2018-10-10 | シャンハイ インスティテュート オブ ファーマシューティカル インダストリー | ダビガトランエテキシラート中間体の製造方法及び中間体化合物 |
| CN105461686A (zh) * | 2014-08-25 | 2016-04-06 | 江苏豪森药业股份有限公司 | 制备高纯度甲磺酸达比加群酯晶型的方法 |
| CN104987323B (zh) * | 2015-07-10 | 2017-08-22 | 浙江美诺华药物化学有限公司 | 一种达比加群酯的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087380A (en) * | 1949-11-24 | 2000-07-11 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions |
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| TWI248435B (en) * | 1998-07-04 | 2006-02-01 | Boehringer Ingelheim Pharma | Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions |
| US6248770B1 (en) * | 1998-07-09 | 2001-06-19 | Boehringer Ingelheim Pharma Kg | Benzimidazoles having antithrombotic activity |
| DE19962329A1 (de) * | 1999-12-23 | 2001-06-28 | Boehringer Ingelheim Pharma | Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel |
| US6451832B2 (en) * | 1999-12-23 | 2002-09-17 | Boehringer Ingelheim Pharma Kg | Benzimidazoles with antithrombotic activity |
| KR101005716B1 (ko) * | 2002-03-07 | 2011-01-05 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | ３－［（２－｛［４－（헥실옥시카보닐아미노－이미노-메틸）－페닐아미노］－메틸｝－１－메틸－１ｈ－벤즈이미다졸－５－카보닐）－피리딘－２－일－아미노］ 프로피온산 에틸에스테르의 경구 투여 형태 |
| NL1026498C2 (nl) * | 2004-06-24 | 2005-12-28 | Free Lift B V | Hellinglifteenheid met blokkeerinrichting en blokkeerinrichting bestemd voor hellinglifteenheid. |
| EP1609784A1 (de) * | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| DE102005061623A1 (de) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
-
2005
- 2005-12-21 DE DE102005061624A patent/DE102005061624A1/de not_active Withdrawn
-
2006
- 2006-12-20 AU AU2006326980A patent/AU2006326980B2/en active Active
- 2006-12-20 RU RU2008129637/04A patent/RU2425827C2/ru active
- 2006-12-20 AT AT06830756T patent/ATE485279T1/de active
- 2006-12-20 BR BRPI0620150-4A patent/BRPI0620150A2/pt not_active Application Discontinuation
- 2006-12-20 DK DK06830756.0T patent/DK1968949T3/da active
- 2006-12-20 PL PL06830756T patent/PL1968949T3/pl unknown
- 2006-12-20 EP EP06830756A patent/EP1968949B1/en active Active
- 2006-12-20 TW TW095148016A patent/TWI411608B/zh not_active IP Right Cessation
- 2006-12-20 CN CN2006800488945A patent/CN101346355B/zh active Active
- 2006-12-20 KR KR1020087017836A patent/KR101411961B1/ko active Active
- 2006-12-20 NZ NZ569636A patent/NZ569636A/en unknown
- 2006-12-20 DE DE602006017743T patent/DE602006017743D1/de active Active
- 2006-12-20 ES ES06830756T patent/ES2355045T3/es active Active
- 2006-12-20 PT PT06830756T patent/PT1968949E/pt unknown
- 2006-12-20 JP JP2008546456A patent/JP5317702B2/ja active Active
- 2006-12-20 SI SI200630879T patent/SI1968949T1/sl unknown
- 2006-12-20 CA CA2632310A patent/CA2632310C/en active Active
- 2006-12-20 WO PCT/EP2006/070034 patent/WO2007071743A1/en not_active Ceased
- 2006-12-20 AR ARP060105633A patent/AR058571A1/es not_active Application Discontinuation
- 2006-12-21 US US11/614,299 patent/US7880016B2/en active Active
-
2008
- 2008-05-15 ZA ZA200804198A patent/ZA200804198B/xx unknown
- 2008-06-17 IL IL192242A patent/IL192242A/en active IP Right Grant
-
2011
- 2011-01-14 CY CY20111100047T patent/CY1111113T1/el unknown
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