JP2009520480A5 - - Google Patents
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- Publication number
- JP2009520480A5 JP2009520480A5 JP2008546287A JP2008546287A JP2009520480A5 JP 2009520480 A5 JP2009520480 A5 JP 2009520480A5 JP 2008546287 A JP2008546287 A JP 2008546287A JP 2008546287 A JP2008546287 A JP 2008546287A JP 2009520480 A5 JP2009520480 A5 JP 2009520480A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- dimer
- polypeptide dimer
- monomer
- fragments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 239000000539 dimer Substances 0.000 claims 21
- 239000012634 fragment Substances 0.000 claims 12
- 239000000178 monomer Substances 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 125000006850 spacer group Chemical group 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000013632 covalent dimer Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000006386 Bone Resorption Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 102000005754 Cytokine Receptor gp130 Human genes 0.000 claims 1
- 108010006197 Cytokine Receptor gp130 Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 208000037147 Hypercalcaemia Diseases 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000024279 bone resorption Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000000148 hypercalcaemia Effects 0.000 claims 1
- 208000030915 hypercalcemia disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000006337 proteolytic cleavage Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05028420A EP1801121A1 (en) | 2005-12-23 | 2005-12-23 | Soluble gp130 molecule variants useful as a medicament |
| EP05028420.7 | 2005-12-23 | ||
| PCT/EP2006/012515 WO2007071449A1 (en) | 2005-12-23 | 2006-12-22 | Soluble gp130 molecule variants useful as a medicament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009520480A JP2009520480A (ja) | 2009-05-28 |
| JP2009520480A5 true JP2009520480A5 (enExample) | 2010-01-21 |
| JP5390191B2 JP5390191B2 (ja) | 2014-01-15 |
Family
ID=36233865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546287A Active JP5390191B2 (ja) | 2005-12-23 | 2006-12-22 | 医薬として有用な可溶性ｇｐ１３０分子変異体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7851182B2 (enExample) |
| EP (2) | EP1801121A1 (enExample) |
| JP (1) | JP5390191B2 (enExample) |
| AT (1) | ATE471945T1 (enExample) |
| AU (1) | AU2006328909A1 (enExample) |
| CA (1) | CA2633213A1 (enExample) |
| DE (1) | DE602006015103D1 (enExample) |
| ES (1) | ES2347694T3 (enExample) |
| WO (1) | WO2007071449A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2352561T3 (es) | 2006-06-30 | 2011-02-21 | Conaris Research Institute Ag | Dímeros de sgp 130fc mejorados. |
| JP5424330B2 (ja) * | 2007-07-26 | 2014-02-26 | 国立大学法人大阪大学 | インターロイキン６受容体阻害剤を有効成分とする眼炎症疾患治療剤 |
| EP2050759A1 (en) * | 2007-10-19 | 2009-04-22 | CONARIS research institute AG | Soluble gp 130 muteins with improved binding activity |
| RS61947B1 (sr) | 2014-12-01 | 2021-07-30 | Ferring Bv | Davanje selektivnog inhibitora il-6-trans-signalizacije |
| EP3227325B1 (en) | 2014-12-01 | 2024-04-10 | Ferring B.V. | Selective il-6-trans-signalling inhibitor compositions |
| US20190002915A1 (en) * | 2015-12-14 | 2019-01-03 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulatable antibody expression |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012520A1 (en) * | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| AU778998B2 (en) * | 1998-09-22 | 2004-12-23 | University Of Maryland At Baltimore | Cystine knot growth factor mutants |
| JP2002534962A (ja) * | 1999-01-07 | 2002-10-22 | レキシジェン ファーマシューティカルズ コーポレイション | Ｆｃ融合タンパク質としての抗肥満症タンパク質の発現および輸送 |
| ES2298106T3 (es) * | 2000-04-21 | 2008-05-16 | Conaris Research Institute Ag | Proteinas de fusion que comprenden dos moleculas gp130 solubles. |
| ATE384783T1 (de) * | 2001-10-19 | 2008-02-15 | Zymogenetics Inc | Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung |
| EP1491554A1 (en) * | 2003-06-23 | 2004-12-29 | CONARIS research institute AG | PEGylated soluble gp130-dimers useful as a medicament |
| CN1926237A (zh) * | 2004-01-28 | 2007-03-07 | 森托尼克斯制药有限公司 | 用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白 |
-
2005
- 2005-12-23 EP EP05028420A patent/EP1801121A1/en not_active Withdrawn
-
2006
- 2006-12-22 AT AT06841152T patent/ATE471945T1/de not_active IP Right Cessation
- 2006-12-22 AU AU2006328909A patent/AU2006328909A1/en not_active Abandoned
- 2006-12-22 ES ES06841152T patent/ES2347694T3/es active Active
- 2006-12-22 CA CA002633213A patent/CA2633213A1/en not_active Abandoned
- 2006-12-22 US US12/158,285 patent/US7851182B2/en active Active
- 2006-12-22 DE DE602006015103T patent/DE602006015103D1/de active Active
- 2006-12-22 EP EP06841152A patent/EP1994053B1/en active Active
- 2006-12-22 WO PCT/EP2006/012515 patent/WO2007071449A1/en not_active Ceased
- 2006-12-22 JP JP2008546287A patent/JP5390191B2/ja active Active
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