JP2009519944A5 - - Google Patents

Info

Publication number

JP2009519944A5

JP2009519944A5 JP2008545835A JP2008545835A JP2009519944A5 JP 2009519944 A5 JP2009519944 A5 JP 2009519944A5 JP 2008545835 A JP2008545835 A JP 2008545835A JP 2008545835 A JP2008545835 A JP 2008545835A JP 2009519944 A5 JP2009519944 A5 JP 2009519944A5

Authority

JP

Japan

Prior art keywords

antibody

dll4

antagonist

use according

vegf

Prior art date

2006-12-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108700041286 delta Proteins 0.000 claims description 14
• 101150109170 dll4 gene Proteins 0.000 claims description 13
• 239000005557 antagonist Substances 0.000 claims description 9
• 108020001507 fusion proteins Proteins 0.000 claims description 2
• 102000037865 fusion proteins Human genes 0.000 claims description 2
• 230000002401 inhibitory effect Effects 0.000 claims description 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 5
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 5
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 4
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
• 239000003112 inhibitor Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000005748 tumor development Effects 0.000 claims 1
• 230000004614 tumor growth Effects 0.000 claims 1
• 239000002525 vasculotropin inhibitor Substances 0.000 claims 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 6
• 102000009024 Epidermal Growth Factor Human genes 0.000 description 5
• 101800003838 Epidermal growth factor Proteins 0.000 description 5
• 229940116977 epidermal growth factor Drugs 0.000 description 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 101100510615 Caenorhabditis elegans lag-2 gene Proteins 0.000 description 1
• 108010036039 Serrate-Jagged Proteins Proteins 0.000 description 1
• 102000011842 Serrate-Jagged Proteins Human genes 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 230000000694 effects Effects 0.000 description 1