JP2009519013A5 - - Google Patents
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- Publication number
- JP2009519013A5 JP2009519013A5 JP2008543714A JP2008543714A JP2009519013A5 JP 2009519013 A5 JP2009519013 A5 JP 2009519013A5 JP 2008543714 A JP2008543714 A JP 2008543714A JP 2008543714 A JP2008543714 A JP 2008543714A JP 2009519013 A5 JP2009519013 A5 JP 2009519013A5
- Authority
- JP
- Japan
- Prior art keywords
- egfr
- binding polypeptide
- polypeptide according
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000001301 EGF receptor Human genes 0.000 claims 73
- 108060006698 EGF receptor Proteins 0.000 claims 73
- 229920001184 polypeptide Polymers 0.000 claims 65
- 102000004196 processed proteins & peptides Human genes 0.000 claims 65
- 108090000765 processed proteins & peptides Proteins 0.000 claims 65
- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 238000001514 detection method Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 4
- 108020001580 protein domains Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 229940039227 diagnostic agent Drugs 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000005855 radiation Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000012857 radioactive material Substances 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 108700011201 Streptococcus IgG Fc-binding Proteins 0.000 claims 1
- 208000005221 X-linked episodic muscle weakness Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0524788.7 | 2005-12-05 | ||
| GBGB0524788.7A GB0524788D0 (en) | 2005-12-05 | 2005-12-05 | Polypeptides |
| PCT/EP2006/011669 WO2007065635A1 (en) | 2005-12-05 | 2006-12-05 | Polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013270874A Division JP2014087361A (ja) | 2005-12-05 | 2013-12-27 | ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519013A JP2009519013A (ja) | 2009-05-14 |
| JP2009519013A5 true JP2009519013A5 (https=) | 2010-01-28 |
| JP5898826B2 JP5898826B2 (ja) | 2016-04-06 |
Family
ID=35686099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543714A Expired - Fee Related JP5898826B2 (ja) | 2005-12-05 | 2006-12-05 | ポリペプチド |
| JP2013270874A Pending JP2014087361A (ja) | 2005-12-05 | 2013-12-27 | ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013270874A Pending JP2014087361A (ja) | 2005-12-05 | 2013-12-27 | ポリペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8247375B2 (https=) |
| EP (2) | EP1973934B1 (https=) |
| JP (2) | JP5898826B2 (https=) |
| CN (2) | CN101336250A (https=) |
| CA (1) | CA2631430C (https=) |
| DK (1) | DK2431383T3 (https=) |
| ES (1) | ES2599996T3 (https=) |
| GB (1) | GB0524788D0 (https=) |
| WO (1) | WO2007065635A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9187535B2 (en) | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| CA2711256C (en) * | 2008-01-03 | 2019-01-15 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| JP5677943B2 (ja) | 2008-06-05 | 2015-02-25 | アフィボディ・アーベーＡｆｆｉｂｏｄｙ Ａｂ | ポリペプチド |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| EP2496598B1 (en) * | 2009-11-04 | 2017-08-02 | Affibody AB | Her3 binding polypeptides |
| ES2630031T3 (es) * | 2010-09-28 | 2017-08-17 | Aegerion Pharmaceuticals, Inc. | Un polipéptido de leptina pinnípedo-humano quimérico con solubilidad aumentada |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| WO2012165544A1 (ja) * | 2011-06-03 | 2012-12-06 | 独立行政法人産業技術総合研究所 | 酸性域での親和性が低下したプロテインa変異型タンパク質及び抗体捕捉剤 |
| ES2732475T3 (es) | 2011-07-08 | 2019-11-22 | Aegerion Pharmaceuticals Inc | Polipéptidos modificados por ingeniería genética que tienen una duración potenciada de la acción y una inmunogenicidad reducida |
| TWI443108B (zh) | 2011-12-28 | 2014-07-01 | Ind Tech Res Inst | 抗人類表皮生長因子受體抗體及其應用 |
| WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
| WO2014013016A1 (en) | 2012-07-20 | 2014-01-23 | Affibody Ab | Method for determining the her2 status of a malignancy |
| US9745350B2 (en) | 2012-10-05 | 2017-08-29 | Affibody Ab | HER3 binding polypeptides |
| RS60280B1 (sr) | 2013-03-12 | 2020-06-30 | Molecular Templates Inc | Citotoksični proteini koji sadrže ciljane vezujuće regione za ćelije i regioni shiga toksina a podjedinice za selektivno ubijanje određenih vrsta ćelija |
| CN111909278B (zh) | 2014-01-27 | 2024-04-09 | 分子模板公司 | Mhc i类表位递送多肽 |
| WO2017019623A2 (en) | 2015-07-26 | 2017-02-02 | Molecular Templates, Inc. | Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes |
| ES2723774T3 (es) | 2014-03-11 | 2019-09-02 | Molecular Templates Inc | Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal |
| AU2015229583B2 (en) | 2014-03-11 | 2020-07-09 | Molecular Templates, Inc. | Proteins comprising amino-terminal proximal Shiga toxin A Subunit effector regions and cell-targeting immunoglobulin-type binding regions |
| ES2919749T3 (es) | 2014-06-11 | 2022-07-28 | Molecular Templates Inc | Moléculas dirigidas a células citotóxicas resistentes a la escisión por proteasa |
| JP7372728B2 (ja) | 2014-10-31 | 2023-11-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 改変ｔ細胞に関する方法および組成物 |
| CN108064235A (zh) * | 2015-01-12 | 2018-05-22 | 阿菲博迪公司 | Il-17a结合多肽 |
| US10521754B2 (en) * | 2016-03-08 | 2019-12-31 | Auctane, LLC | Concatenated shipping documentation processing spawning intelligent generation subprocesses |
| CN111925425B (zh) * | 2020-08-12 | 2023-03-10 | 天津科技大学 | 甲胎蛋白特异性结合多肽及应用 |
| WO2023148388A1 (en) * | 2022-02-04 | 2023-08-10 | Zytox Therapeutics Ab | Fusion protein comprising an egfr-binding domain and a masking domain |
| TW202416938A (zh) | 2022-08-10 | 2024-05-01 | 日商興和股份有限公司 | 親和體微胞(affibody micelle)藥物複合體 |
| JP2025542406A (ja) * | 2022-12-30 | 2025-12-25 | アブクロン・インコーポレイテッド | Ｃｄ１３７に特異的に結合するアフィボディ及びその用途 |
| CN117106035B (zh) * | 2023-10-25 | 2024-04-23 | 烟台药物研究所 | 一种肿瘤靶向多肽、多肽偶联药物及制备与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| SE9901379D0 (sv) * | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
| GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| SE0301936D0 (sv) * | 2003-06-30 | 2003-06-30 | Affibody Ab | New polypeptide |
| US7993650B2 (en) * | 2003-07-04 | 2011-08-09 | Affibody Ab | Polypeptides having binding affinity for HER2 |
| SE0400274D0 (sv) | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
| US20080269238A1 (en) | 2004-04-01 | 2008-10-30 | Takeda Pharmaceutical Company Limited | Thiazolopyrimidine Derivative |
| JP5634008B2 (ja) | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
| EP1736770A4 (en) * | 2004-04-16 | 2008-09-24 | Hidetoshi Okabe | METHOD FOR INVESTIGATING A NICE TUMOR |
-
2005
- 2005-12-05 GB GBGB0524788.7A patent/GB0524788D0/en not_active Ceased
-
2006
- 2006-12-05 CN CNA2006800523510A patent/CN101336250A/zh active Pending
- 2006-12-05 US US12/085,576 patent/US8247375B2/en active Active
- 2006-12-05 JP JP2008543714A patent/JP5898826B2/ja not_active Expired - Fee Related
- 2006-12-05 WO PCT/EP2006/011669 patent/WO2007065635A1/en not_active Ceased
- 2006-12-05 EP EP06829313.3A patent/EP1973934B1/en active Active
- 2006-12-05 ES ES11194071.4T patent/ES2599996T3/es active Active
- 2006-12-05 CA CA2631430A patent/CA2631430C/en active Active
- 2006-12-05 DK DK11194071.4T patent/DK2431383T3/en active
- 2006-12-05 EP EP11194071.4A patent/EP2431383B1/en active Active
- 2006-12-05 CN CN201310114471.0A patent/CN103288935B/zh not_active Expired - Fee Related
-
2012
- 2012-07-16 US US13/549,588 patent/US8598113B2/en active Active
-
2013
- 2013-10-16 US US14/055,443 patent/US9107965B2/en active Active
- 2013-12-27 JP JP2013270874A patent/JP2014087361A/ja active Pending
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