JP5898826B2 - ポリペプチド - Google Patents
ポリペプチド Download PDFInfo
- Publication number
- JP5898826B2 JP5898826B2 JP2008543714A JP2008543714A JP5898826B2 JP 5898826 B2 JP5898826 B2 JP 5898826B2 JP 2008543714 A JP2008543714 A JP 2008543714A JP 2008543714 A JP2008543714 A JP 2008543714A JP 5898826 B2 JP5898826 B2 JP 5898826B2
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- Prior art keywords
- egfr
- binding
- amino acid
- binding polypeptide
- polypeptide according
- Prior art date
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| GB0524788.7 | 2005-12-05 | ||
| PCT/EP2006/011669 WO2007065635A1 (en) | 2005-12-05 | 2006-12-05 | Polypeptides |
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| JP (2) | JP5898826B2 (https=) |
| CN (2) | CN103288935B (https=) |
| CA (1) | CA2631430C (https=) |
| DK (1) | DK2431383T3 (https=) |
| ES (1) | ES2599996T3 (https=) |
| GB (1) | GB0524788D0 (https=) |
| WO (1) | WO2007065635A1 (https=) |
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| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| US9187535B2 (en) | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
| EP2072525A1 (en) * | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| KR101658247B1 (ko) * | 2008-01-03 | 2016-09-22 | 더 스크립스 리서치 인스티튜트 | 모듈 인식 도메인을 통한 항체 표적화 |
| US9238810B2 (en) | 2008-06-05 | 2016-01-19 | Affibody Ab | Polypeptide |
| AU2009282413B2 (en) | 2008-08-11 | 2014-07-17 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| EP2496598B1 (en) | 2009-11-04 | 2017-08-02 | Affibody AB | Her3 binding polypeptides |
| PT2621515T (pt) | 2010-09-28 | 2017-07-12 | Aegerion Pharmaceuticals Inc | Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada |
| WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| EP2728000B1 (en) * | 2011-06-03 | 2018-12-05 | National Institute of Advanced Industrial Science And Technology | Protein a mutant protein having reduced affinity in acidic region, and antibody capture agent |
| CN103957926B (zh) | 2011-07-08 | 2018-07-03 | 安米林药品有限责任公司 | 具有增强的作用持续时间和降低的免疫原性的工程改造的多肽 |
| TWI443108B (zh) | 2011-12-28 | 2014-07-01 | Ind Tech Res Inst | 抗人類表皮生長因子受體抗體及其應用 |
| EP3511339B1 (en) | 2012-02-20 | 2025-04-09 | IPC Research, LLC | Polypeptides binding to human complement c5 |
| WO2014013016A1 (en) | 2012-07-20 | 2014-01-23 | Affibody Ab | Method for determining the her2 status of a malignancy |
| JP6440618B2 (ja) | 2012-10-05 | 2018-12-19 | アフィボディ・アーベー | Ｈｅｒ３結合ポリペプチド |
| EP3666795A1 (en) | 2013-03-12 | 2020-06-17 | Molecular Templates, Inc. | Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types |
| CN112851769A (zh) | 2014-01-27 | 2021-05-28 | 分子模板公司 | 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽 |
| JP6935195B2 (ja) | 2014-03-11 | 2021-09-15 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質 |
| ES2809729T3 (es) | 2014-03-11 | 2021-03-05 | Molecular Templates Inc | Proteínas que comprenden regiones efectoras de la subunidad A de la toxina Shiga próximas al extremo amino terminal y regiones de unión de tipo inmunoglobulina de reconocimiento celular capaces de unirse específicamente a HER2/neu/ErbB2 |
| CN106604934A (zh) | 2014-06-11 | 2017-04-26 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
| CA2964958A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Methods and compositions for modified t cells |
| EP3245224B1 (en) | 2015-01-12 | 2020-07-15 | Affibody AB | Il-17a-binding polypeptides |
| KR20180030085A (ko) | 2015-07-26 | 2018-03-21 | 몰레큘러 템플레이츠, 인코퍼레이션. | 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| US10521754B2 (en) * | 2016-03-08 | 2019-12-31 | Auctane, LLC | Concatenated shipping documentation processing spawning intelligent generation subprocesses |
| CN111925425B (zh) * | 2020-08-12 | 2023-03-10 | 天津科技大学 | 甲胎蛋白特异性结合多肽及应用 |
| JP2025507294A (ja) * | 2022-02-04 | 2025-03-18 | ザイトックス セラピューティクス アクチボラゲット | Ｅｇｆｒ結合ドメインとマスキングドメインとを含む融合タンパク質 |
| TW202416938A (zh) | 2022-08-10 | 2024-05-01 | 日商興和股份有限公司 | 親和體微胞(affibody micelle)藥物複合體 |
| EP4644417A4 (en) * | 2022-12-30 | 2026-02-11 | Abclon Inc | AFFICORPS SPECIFICALLY BINDING TO CD137 AND ITS USE |
| CN117106035B (zh) * | 2023-10-25 | 2024-04-23 | 烟台药物研究所 | 一种肿瘤靶向多肽、多肽偶联药物及制备与应用 |
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| SE9400088D0 (sv) * | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| SE9901379D0 (sv) * | 1999-04-19 | 1999-04-19 | Pharmacia & Upjohn Ab | Receptor structures |
| GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| SE0301936D0 (sv) | 2003-06-30 | 2003-06-30 | Affibody Ab | New polypeptide |
| CA2531238C (en) * | 2003-07-04 | 2015-02-24 | Affibody Ab | Polypeptides having binding affinity for her2 |
| SE0400274D0 (sv) * | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
| JPWO2005095419A1 (ja) | 2004-04-01 | 2008-02-21 | 武田薬品工業株式会社 | チアゾロピリミジン誘導体 |
| JP5634008B2 (ja) | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
| JPWO2005100983A1 (ja) | 2004-04-16 | 2008-03-06 | 英俊 岡部 | 悪性腫瘍の検査方法 |
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2005
- 2005-12-05 GB GBGB0524788.7A patent/GB0524788D0/en not_active Ceased
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2006
- 2006-12-05 CN CN201310114471.0A patent/CN103288935B/zh not_active Expired - Fee Related
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- 2006-12-05 US US12/085,576 patent/US8247375B2/en active Active
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- 2006-12-05 WO PCT/EP2006/011669 patent/WO2007065635A1/en not_active Ceased
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| US20140178301A1 (en) | 2014-06-26 |
| US8598113B2 (en) | 2013-12-03 |
| CN103288935B (zh) | 2017-11-17 |
| US20090016957A1 (en) | 2009-01-15 |
| GB0524788D0 (en) | 2006-01-11 |
| JP2009519013A (ja) | 2009-05-14 |
| EP1973934B1 (en) | 2014-11-05 |
| EP1973934A1 (en) | 2008-10-01 |
| CA2631430C (en) | 2017-03-07 |
| US8247375B2 (en) | 2012-08-21 |
| CN103288935A (zh) | 2013-09-11 |
| ES2599996T3 (es) | 2017-02-06 |
| DK2431383T3 (en) | 2017-01-09 |
| EP2431383B1 (en) | 2016-09-28 |
| US9107965B2 (en) | 2015-08-18 |
| WO2007065635A1 (en) | 2007-06-14 |
| EP2431383A1 (en) | 2012-03-21 |
| CA2631430A1 (en) | 2007-06-14 |
| CN101336250A (zh) | 2008-12-31 |
| JP2014087361A (ja) | 2014-05-15 |
| US20130005653A1 (en) | 2013-01-03 |
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