JP2009518447A5 - - Google Patents
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- Publication number
- JP2009518447A5 JP2009518447A5 JP2008544662A JP2008544662A JP2009518447A5 JP 2009518447 A5 JP2009518447 A5 JP 2009518447A5 JP 2008544662 A JP2008544662 A JP 2008544662A JP 2008544662 A JP2008544662 A JP 2008544662A JP 2009518447 A5 JP2009518447 A5 JP 2009518447A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- antibody
- proteasome inhibitor
- fragment
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74915205P | 2005-12-09 | 2005-12-09 | |
| PCT/US2006/061786 WO2007067976A2 (en) | 2005-12-09 | 2006-12-08 | Method of using il6 antagonists with proteasome inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518447A JP2009518447A (ja) | 2009-05-07 |
| JP2009518447A5 true JP2009518447A5 (enExample) | 2009-11-12 |
Family
ID=38123650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544662A Pending JP2009518447A (ja) | 2005-12-09 | 2006-12-08 | プロテアソームインヒビターと併せたｉｌ６アンタゴニストの使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090022726A1 (enExample) |
| EP (1) | EP1954310A4 (enExample) |
| JP (1) | JP2009518447A (enExample) |
| KR (1) | KR20080072761A (enExample) |
| CN (1) | CN101325969A (enExample) |
| AR (1) | AR057227A1 (enExample) |
| AU (1) | AU2006321610A1 (enExample) |
| BR (1) | BRPI0619498A2 (enExample) |
| CA (1) | CA2632732A1 (enExample) |
| EA (1) | EA014675B1 (enExample) |
| IL (1) | IL191694A0 (enExample) |
| NO (1) | NO20082907L (enExample) |
| TW (1) | TW200803895A (enExample) |
| WO (1) | WO2007067976A2 (enExample) |
| ZA (1) | ZA200805956B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE494298T1 (de) | 2004-04-15 | 2011-01-15 | Proteolix Inc | Verbindungen zur proteasomenzymhemmung |
| US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| SI2030981T1 (sl) | 2004-05-10 | 2014-11-28 | Onyx Therapeutics, Inc. | Spojine za inhibiranje proteasomskega encima |
| RU2450830C2 (ru) | 2005-10-21 | 2012-05-20 | Чугаи Сейяку Кабусики Кайся | Средства для лечения кардиопатии |
| EP2623113B1 (en) | 2005-11-09 | 2017-05-31 | Onyx Therapeutics, Inc. | Compound for enzyme inhibition |
| AR057582A1 (es) * | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| JP5033643B2 (ja) | 2006-01-27 | 2012-09-26 | 学校法人慶應義塾 | 脈絡膜血管新生を伴う疾患の治療剤 |
| JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
| NZ597545A (en) | 2006-06-19 | 2013-07-26 | Proteolix Inc | Peptide epoxyketones for proteasome inhibition |
| MX2009007830A (es) | 2007-01-23 | 2009-10-07 | Univ Shinshu | Inhibidor de rechazo cronico. |
| EP2174667B1 (en) * | 2007-07-26 | 2017-01-04 | Osaka University | Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient |
| CA2701778C (en) | 2007-10-04 | 2018-09-11 | Onyx Therapeutics, Inc. | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
| TW201503898A (zh) | 2008-06-05 | 2015-02-01 | Chugai Pharmaceutical Co Ltd | 神經浸潤抑制劑 |
| WO2010039762A2 (en) * | 2008-10-01 | 2010-04-08 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions comprising boronic acid compounds |
| JP5675629B2 (ja) * | 2008-10-21 | 2015-02-25 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ペプチドエポキシケトンを用いた併用療法 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| KR20170060179A (ko) | 2008-11-13 | 2017-05-31 | 길리아드 칼리스토가 엘엘씨 | 혈액 종양에 대한 요법 |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| WO2011006273A1 (en) | 2009-07-15 | 2011-01-20 | Eva Kovacs-Benke | Combination of a human interleukin-6 antagonist and a human interleukin-6 receptor antagonist in therapy of tumour diseases |
| SG178190A1 (en) * | 2009-07-31 | 2012-03-29 | Shin Maeda | Cancer metastasis inhibitor |
| US7947653B1 (en) | 2009-10-09 | 2011-05-24 | Cold Spring Harbor Laboratory | Methods for treating epidermal growth factor receptor tyrosine kinase inhibitor-resistant cancers |
| US8323883B1 (en) | 2009-10-09 | 2012-12-04 | Cold Spring Harbor Laboratory | Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors |
| WO2011060179A1 (en) * | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
| AU2011223795B2 (en) | 2010-03-01 | 2015-11-05 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| RS63800B1 (sr) | 2010-05-28 | 2022-12-30 | Chugai Pharmaceutical Co Ltd | Poboljšanje antitumorskog odgovora t ćelije |
| US20140294854A1 (en) * | 2011-03-10 | 2014-10-02 | Albert Einstein College Of Medicine Of Yeshiva University | Target directed to adipocytes, methods and assays for treatment of obesity |
| WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| WO2014011695A2 (en) | 2012-07-09 | 2014-01-16 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
| KR101643041B1 (ko) * | 2014-04-25 | 2016-07-28 | 아주대학교산학협력단 | 프로테아좀 저해제 및 디히드로피리딘계 화합물을 유효성분으로 함유하는 암의 예방 또는 치료용 조성물 |
| CN108030916A (zh) * | 2015-07-03 | 2018-05-15 | 刘永庆 | 防治肿瘤和/或慢性结核病的Th2免疫反应抑制剂及其应用 |
| WO2017138008A2 (en) * | 2016-02-14 | 2017-08-17 | Yeda Research And Development Co. Ltd. | Methods of modulating protein exocytosis and uses of same in therapy |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| WO2019018410A1 (en) * | 2017-07-17 | 2019-01-24 | The General Hospital Corporation | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASES |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| TWI822728B (zh) | 2018-01-31 | 2023-11-21 | 加藤元一 | 含有il-6抑制劑的哮喘治療劑 |
| US20200165608A1 (en) * | 2018-11-23 | 2020-05-28 | Florida State University Research Foundation, Inc. | Inhibition of vascular endothelial cell-mediated phagocytic processes for treatment of demyelinating conditions |
| AU2020259884A1 (en) | 2019-04-17 | 2021-10-07 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210075A (en) * | 1990-02-16 | 1993-05-11 | Tanabe Seiyaku Co., Ltd. | Interleukin 6 antagonist peptides |
| US5340736A (en) * | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
| TW458985B (en) * | 1993-05-31 | 2001-10-11 | Chugai Pharmaceutical Co Ltd | Reconstructed human antibody against human interleukin-6 |
| US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| AU762373B2 (en) * | 1998-10-20 | 2003-06-26 | Millennium Pharmaceuticals, Inc. | Method for monitoring proteasome inhibitor drug action |
| BRPI0214168B8 (pt) * | 2001-11-14 | 2021-05-25 | Centocor Inc | anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos |
| AU2004210626A1 (en) * | 2003-02-04 | 2004-08-26 | Centocor Inc. | Use of IL-6 antagonists in combination with steroids to enhance apoptosis |
| PA8672101A1 (es) * | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
-
2006
- 2006-12-07 AR ARP060105416A patent/AR057227A1/es not_active Application Discontinuation
- 2006-12-08 CA CA002632732A patent/CA2632732A1/en not_active Abandoned
- 2006-12-08 KR KR1020087016043A patent/KR20080072761A/ko not_active Withdrawn
- 2006-12-08 TW TW095145881A patent/TW200803895A/zh unknown
- 2006-12-08 BR BRPI0619498-2A patent/BRPI0619498A2/pt not_active IP Right Cessation
- 2006-12-08 CN CNA2006800459213A patent/CN101325969A/zh active Pending
- 2006-12-08 EA EA200870029A patent/EA014675B1/ru not_active IP Right Cessation
- 2006-12-08 JP JP2008544662A patent/JP2009518447A/ja active Pending
- 2006-12-08 EP EP06840161A patent/EP1954310A4/en not_active Withdrawn
- 2006-12-08 WO PCT/US2006/061786 patent/WO2007067976A2/en not_active Ceased
- 2006-12-08 US US11/608,342 patent/US20090022726A1/en not_active Abandoned
- 2006-12-08 AU AU2006321610A patent/AU2006321610A1/en not_active Abandoned
-
2008
- 2008-05-25 IL IL191694A patent/IL191694A0/en unknown
- 2008-06-27 NO NO20082907A patent/NO20082907L/no not_active Application Discontinuation
- 2008-07-08 ZA ZA200805956A patent/ZA200805956B/xx unknown