ZA200805956B - Method of using IL6 antagonists with proteasome inhibitors - Google Patents
Method of using IL6 antagonists with proteasome inhibitorsInfo
- Publication number
- ZA200805956B ZA200805956B ZA200805956A ZA200805956A ZA200805956B ZA 200805956 B ZA200805956 B ZA 200805956B ZA 200805956 A ZA200805956 A ZA 200805956A ZA 200805956 A ZA200805956 A ZA 200805956A ZA 200805956 B ZA200805956 B ZA 200805956B
- Authority
- ZA
- South Africa
- Prior art keywords
- antagonists
- proteasome inhibitors
- proteasome
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74915205P | 2005-12-09 | 2005-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200805956B true ZA200805956B (en) | 2009-10-28 |
Family
ID=38123650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200805956A ZA200805956B (en) | 2005-12-09 | 2008-07-08 | Method of using IL6 antagonists with proteasome inhibitors |
Country Status (15)
Country | Link |
---|---|
US (1) | US20090022726A1 (xx) |
EP (1) | EP1954310A4 (xx) |
JP (1) | JP2009518447A (xx) |
KR (1) | KR20080072761A (xx) |
CN (1) | CN101325969A (xx) |
AR (1) | AR057227A1 (xx) |
AU (1) | AU2006321610A1 (xx) |
BR (1) | BRPI0619498A2 (xx) |
CA (1) | CA2632732A1 (xx) |
EA (1) | EA014675B1 (xx) |
IL (1) | IL191694A0 (xx) |
NO (1) | NO20082907L (xx) |
TW (1) | TW200803895A (xx) |
WO (1) | WO2007067976A2 (xx) |
ZA (1) | ZA200805956B (xx) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2562411A1 (en) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for enzyme inhibition |
US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
EP2030981B1 (en) | 2004-05-10 | 2014-07-09 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
RU2450830C2 (ru) * | 2005-10-21 | 2012-05-20 | Чугаи Сейяку Кабусики Кайся | Средства для лечения кардиопатии |
PT1948678E (pt) | 2005-11-09 | 2013-07-16 | Onyx Therapeutics Inc | Compostos para inibição de enzimas |
AR057582A1 (es) * | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
CA2637917C (en) * | 2006-01-27 | 2015-11-24 | Keio University | Therapeutic agents for diseases involving choroidal neovascularization |
JP5754875B2 (ja) * | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
CA2657213C (en) | 2006-06-19 | 2017-01-03 | Proteolix, Inc. | Peptide epoxyketones for proteasome inhibition |
CL2008000188A1 (es) * | 2007-01-23 | 2008-07-18 | Chugai Pharmaceutical Co Ltd | Agente para suprimir la reaccion de rechazo cronica que comprende como ingrediente activo un inhibidor de il-6; y uso del inhibidor de il-6. |
EP2174667B1 (en) * | 2007-07-26 | 2017-01-04 | Osaka University | Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient |
ES2578905T5 (es) | 2007-10-04 | 2020-03-18 | Onyx Therapeutics Inc | Inhibidores de proteasa epoxi cetona peptídicos cristalinos y la síntesis de ceto-epóxidos de aminoácidos |
EP2305306B1 (en) * | 2008-06-05 | 2016-02-10 | National Cancer Center | Neuroinvasion inhibitor |
EA201170527A1 (ru) * | 2008-10-01 | 2011-10-31 | Др. Редди'С Лабораторис Лтд. | Фармацевтические композиции, включающие соединения бороновой кислоты |
AP2011005690A0 (en) * | 2008-10-21 | 2011-06-30 | Onyx Therapeutics Inc | Combination therapy with peptide epoxyketones. |
CN104042618B (zh) | 2008-11-13 | 2018-02-16 | 吉利德卡利斯托加公司 | 恶性血液病的治疗 |
US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
EP2464666B1 (en) | 2009-07-15 | 2018-03-21 | Eva Kovacs-Benke | Combination of a human interleukin-6 antagonist and a human interleukin-6 receptor antagonist in therapy of tumour diseases |
WO2011013786A1 (ja) * | 2009-07-31 | 2011-02-03 | Maeda Shin | 癌の転移抑制剤 |
US7947653B1 (en) | 2009-10-09 | 2011-05-24 | Cold Spring Harbor Laboratory | Methods for treating epidermal growth factor receptor tyrosine kinase inhibitor-resistant cancers |
US8323883B1 (en) | 2009-10-09 | 2012-12-04 | Cold Spring Harbor Laboratory | Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors |
US8853147B2 (en) | 2009-11-13 | 2014-10-07 | Onyx Therapeutics, Inc. | Use of peptide epoxyketones for metastasis suppression |
MA34133B1 (fr) | 2010-03-01 | 2013-04-03 | Onyx Therapeutics Inc | Composes pour inhibiteurs de l'immunoproteasome |
EP2578231B1 (en) | 2010-05-28 | 2022-10-26 | Chugai Seiyaku Kabushiki Kaisha | Antitumor t cell response enhancer |
US20140294854A1 (en) * | 2011-03-10 | 2014-10-02 | Albert Einstein College Of Medicine Of Yeshiva University | Target directed to adipocytes, methods and assays for treatment of obesity |
WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
US9309283B2 (en) | 2012-07-09 | 2016-04-12 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
KR101643041B1 (ko) * | 2014-04-25 | 2016-07-28 | 아주대학교산학협력단 | 프로테아좀 저해제 및 디히드로피리딘계 화합물을 유효성분으로 함유하는 암의 예방 또는 치료용 조성물 |
CN108030916A (zh) * | 2015-07-03 | 2018-05-15 | 刘永庆 | 防治肿瘤和/或慢性结核病的Th2免疫反应抑制剂及其应用 |
US20190046497A1 (en) * | 2016-02-14 | 2019-02-14 | Yeda Research And Development Co., Ltd. | Methods of modulating protein exocytosis and uses of same in therapy |
WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法 |
US20200246488A1 (en) * | 2017-07-17 | 2020-08-06 | The Broad Institute, Inc. | Compositions and methods for treating inflammatory bowel diseases |
WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗il-6受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
US20200165608A1 (en) * | 2018-11-23 | 2020-05-28 | Florida State University Research Foundation, Inc. | Inhibition of vascular endothelial cell-mediated phagocytic processes for treatment of demyelinating conditions |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5210075A (en) * | 1990-02-16 | 1993-05-11 | Tanabe Seiyaku Co., Ltd. | Interleukin 6 antagonist peptides |
US5340736A (en) * | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
ZA943778B (en) * | 1993-05-31 | 1995-02-21 | Chugai Seiyaku Kagushiki Kaish | Reshaped human antibody to human interleukin-6 |
US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
BR9914648A (pt) * | 1998-10-20 | 2001-11-27 | Millennium Pharm Inc | Processo para monitorar ação medicamentosa deinibidor de proteasoma |
ES2624547T3 (es) * | 2001-11-14 | 2017-07-14 | Janssen Biotech, Inc. | Anticuerpos anti il 6, composiciones, métodos y usos |
AU2004210626A1 (en) * | 2003-02-04 | 2004-08-26 | Centocor Inc. | Use of IL-6 antagonists in combination with steroids to enhance apoptosis |
JO3058B1 (ar) * | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
-
2006
- 2006-12-07 AR ARP060105416A patent/AR057227A1/es not_active Application Discontinuation
- 2006-12-08 CA CA002632732A patent/CA2632732A1/en not_active Abandoned
- 2006-12-08 CN CNA2006800459213A patent/CN101325969A/zh active Pending
- 2006-12-08 KR KR1020087016043A patent/KR20080072761A/ko not_active Application Discontinuation
- 2006-12-08 JP JP2008544662A patent/JP2009518447A/ja active Pending
- 2006-12-08 TW TW095145881A patent/TW200803895A/zh unknown
- 2006-12-08 WO PCT/US2006/061786 patent/WO2007067976A2/en active Application Filing
- 2006-12-08 US US11/608,342 patent/US20090022726A1/en not_active Abandoned
- 2006-12-08 AU AU2006321610A patent/AU2006321610A1/en not_active Abandoned
- 2006-12-08 EP EP06840161A patent/EP1954310A4/en not_active Withdrawn
- 2006-12-08 BR BRPI0619498-2A patent/BRPI0619498A2/pt not_active IP Right Cessation
- 2006-12-08 EA EA200870029A patent/EA014675B1/ru not_active IP Right Cessation
-
2008
- 2008-05-25 IL IL191694A patent/IL191694A0/en unknown
- 2008-06-27 NO NO20082907A patent/NO20082907L/no not_active Application Discontinuation
- 2008-07-08 ZA ZA200805956A patent/ZA200805956B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2007067976A2 (en) | 2007-06-14 |
BRPI0619498A2 (pt) | 2011-10-04 |
EP1954310A4 (en) | 2009-04-22 |
AR057227A1 (es) | 2007-11-21 |
CN101325969A (zh) | 2008-12-17 |
AU2006321610A1 (en) | 2007-06-14 |
NO20082907L (no) | 2008-08-26 |
EA014675B1 (ru) | 2010-12-30 |
EP1954310A2 (en) | 2008-08-13 |
IL191694A0 (en) | 2008-12-29 |
KR20080072761A (ko) | 2008-08-06 |
CA2632732A1 (en) | 2007-06-14 |
TW200803895A (en) | 2008-01-16 |
EA200870029A1 (ru) | 2008-10-30 |
US20090022726A1 (en) | 2009-01-22 |
JP2009518447A (ja) | 2009-05-07 |
WO2007067976A3 (en) | 2008-02-14 |
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