JP2009517412A5 - - Google Patents
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- JP2009517412A5 JP2009517412A5 JP2008542573A JP2008542573A JP2009517412A5 JP 2009517412 A5 JP2009517412 A5 JP 2009517412A5 JP 2008542573 A JP2008542573 A JP 2008542573A JP 2008542573 A JP2008542573 A JP 2008542573A JP 2009517412 A5 JP2009517412 A5 JP 2009517412A5
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- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- alkyl group
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC([C@@](*)N*)=O Chemical compound CC([C@@](*)N*)=O 0.000 description 2
- XEYUEIQAEAQUAK-UHFFFAOYSA-N CC(C)CN(C(CCCCN)COP(O)(O)=O)S(c(cc1)cc(F)c1N)(=O)=O Chemical compound CC(C)CN(C(CCCCN)COP(O)(O)=O)S(c(cc1)cc(F)c1N)(=O)=O XEYUEIQAEAQUAK-UHFFFAOYSA-N 0.000 description 1
- ZMXIYERNXPIYFR-UHFFFAOYSA-N CCc1c(cccc2)c2ccc1 Chemical compound CCc1c(cccc2)c2ccc1 ZMXIYERNXPIYFR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74064205P | 2005-11-30 | 2005-11-30 | |
| PCT/CA2006/001963 WO2007062526A1 (en) | 2005-11-30 | 2006-11-30 | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517412A JP2009517412A (ja) | 2009-04-30 |
| JP2009517412A5 true JP2009517412A5 (https=) | 2009-12-17 |
Family
ID=38091843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542573A Pending JP2009517412A (ja) | 2005-11-30 | 2006-11-30 | アスパルチルプロテアーゼ阻害物質のリジンベースのプロドラッグ及びその調製方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8227450B2 (https=) |
| EP (1) | EP1971615B1 (https=) |
| JP (1) | JP2009517412A (https=) |
| CN (1) | CN101405293B (https=) |
| AU (1) | AU2006319716B2 (https=) |
| CA (1) | CA2632095A1 (https=) |
| ES (1) | ES2452718T3 (https=) |
| WO (1) | WO2007062526A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10149030A1 (de) | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| US7388008B2 (en) | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| CN101405293B (zh) | 2005-11-30 | 2013-03-13 | 中裕新药股份有限公司 | 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法 |
| AU2007287353A1 (en) * | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| US8410300B2 (en) | 2006-09-21 | 2013-04-02 | Taimed Biologics, Inc. | Protease inhibitors |
| WO2009148600A2 (en) * | 2008-06-06 | 2009-12-10 | Concert Pharmaceuticals, Inc. | Deuterated lysine-based compounds |
| CA2762582A1 (en) | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
| WO2012055031A1 (en) | 2010-10-28 | 2012-05-03 | Merck Canada Inc. | Hiv protease inhibitors |
| EP2771332B1 (en) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| JP6704058B2 (ja) * | 2016-05-31 | 2020-06-03 | タイメド・バイオロジクス・インコーポレイテッドＴａｉＭｅｄ Ｂｉｏｌｏｇｉｃｓ Ｉｎｃ． | プロテアーゼ阻害剤の長時間作用性医薬組成物 |
| US10369129B2 (en) | 2016-05-31 | 2019-08-06 | Taimed Biologics, Inc. | Long acting pharmaceutical composition of protease inhibitor |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013861A (en) * | 1985-02-28 | 1991-05-07 | E. R. Squibb & Sons, Inc. | Ester substituted aminoalkanoylureido amino and imino acid and ester compounds |
| WO1992006998A1 (de) | 1990-10-11 | 1992-04-30 | Boehringer Ingelheim Kg | Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US5614522A (en) * | 1990-11-19 | 1997-03-25 | G.D. Searle & Co. | Retroviral protease inhibitors |
| EP0532466A3 (en) | 1991-09-12 | 1993-06-16 | Ciba-Geigy Ag | Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use |
| JP4091654B2 (ja) * | 1992-08-25 | 2008-05-28 | ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー | レトロウイルスプロテアーゼ阻害剤として有用なスルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド |
| US6022994A (en) * | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| WO1994004491A1 (en) * | 1992-08-25 | 1994-03-03 | G.D. Searle & Co. | N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors |
| JPH06321950A (ja) | 1993-05-14 | 1994-11-22 | Takeda Chem Ind Ltd | 水溶性ランカシジン誘導体 |
| WO1995006998A1 (en) | 1993-08-31 | 1995-03-09 | Stanley Kugell | Telephone billing method |
| JPH10500938A (ja) | 1994-03-07 | 1998-01-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパラチルプロテアーゼインヒビターとしてのスルホンアミド誘導体 |
| US5527829A (en) * | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US6143747A (en) * | 1995-01-20 | 2000-11-07 | G. D. Searle & Co. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
| US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5776718A (en) * | 1995-03-24 | 1998-07-07 | Arris Pharmaceutical Corporation | Reversible protease inhibitors |
| US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| HUP9901024A2 (hu) | 1996-01-26 | 1999-09-28 | Vertex Pharmaceuticals Incorporated | Telített azolok oxoszármazékai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
| AU720615B2 (en) | 1997-01-17 | 2000-06-08 | Pharmacia & Upjohn Company | Bis-sulfonomides hydroxamic acids as MMP inhibitors |
| DE59802394D1 (de) * | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
| EE200000386A (et) * | 1997-12-24 | 2001-12-17 | Vertex Pharmaceuticals Incorporated | Aspartüülproteaasi inhibiitorite eelravimid |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| US5986102A (en) | 1998-04-29 | 1999-11-16 | Pharmacopeia, Inc. | Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases |
| ES2254156T3 (es) | 1999-02-12 | 2006-06-16 | Vertex Pharmaceuticals Incorporated | Inhibidores de aspartil-proteasa. |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| EP1191929A4 (en) * | 1999-06-16 | 2005-02-16 | Univ Temple | (Z) -STYRYL ACETOXYPHENYL SULFIDES AS INHIBITORS OF CYCLO-OXYGENASE |
| US6455587B1 (en) * | 2000-03-15 | 2002-09-24 | Pharmacor Inc. | Amino acid derivatives as HIV aspartyl protease inhibitors |
| US6506786B2 (en) * | 2001-02-13 | 2003-01-14 | Pharmacor Inc. | HIV protease inhibitors based on amino acid derivatives |
| CA2374362C (en) * | 2002-03-04 | 2008-01-22 | Brent Richard Stranix | Urea derivatives as hiv aspartyl protease inhibitors |
| AU2003206588A1 (en) | 2002-03-04 | 2003-09-16 | Procyon Biopharma Inc. | Urea derivatives as hiv aspartyl protease inhibitors |
| MXPA05005773A (es) | 2002-12-16 | 2005-08-16 | Boehringer Ingelheim Int | Uso de una combinacion que contiene un inhibidor no nucleosido de transcriptasa inversa (nnrti) con un inhibidor de citocromo p450, tales como inhibidores de la proteasa. |
| US6632816B1 (en) | 2002-12-23 | 2003-10-14 | Pharmacor Inc. | Aromatic derivatives as HIV aspartyl protease inhibitors |
| JP4762917B2 (ja) | 2004-01-08 | 2011-08-31 | メディヴィル・アクチボラグ | 非ヌクレオシド逆転写酵素インヒビター |
| US7388008B2 (en) * | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| WO2006012725A1 (en) | 2004-08-02 | 2006-02-09 | Ambrilia Biopharma Inc. | Lysine based compounds |
| ES2539527T3 (es) | 2005-04-27 | 2015-07-01 | Taimed Biologics, Inc. | Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas |
| CN101405293B (zh) * | 2005-11-30 | 2013-03-13 | 中裕新药股份有限公司 | 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法 |
| AU2007287353A1 (en) | 2006-07-17 | 2008-02-28 | Ambrilia Biopharma Inc. | Method for improving pharmacokinetics |
| US8410300B2 (en) * | 2006-09-21 | 2013-04-02 | Taimed Biologics, Inc. | Protease inhibitors |
-
2006
- 2006-11-30 CN CN200680051907.4A patent/CN101405293B/zh not_active Expired - Fee Related
- 2006-11-30 EP EP06817683.3A patent/EP1971615B1/en active Active
- 2006-11-30 CA CA002632095A patent/CA2632095A1/en not_active Abandoned
- 2006-11-30 US US12/086,184 patent/US8227450B2/en not_active Expired - Fee Related
- 2006-11-30 AU AU2006319716A patent/AU2006319716B2/en not_active Ceased
- 2006-11-30 WO PCT/CA2006/001963 patent/WO2007062526A1/en not_active Ceased
- 2006-11-30 JP JP2008542573A patent/JP2009517412A/ja active Pending
- 2006-11-30 ES ES06817683.3T patent/ES2452718T3/es active Active
-
2008
- 2008-06-19 US US12/214,995 patent/US8580995B2/en not_active Expired - Fee Related
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