CN101405293B - 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法 - Google Patents

天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法 Download PDF

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Publication number
CN101405293B
CN101405293B CN200680051907.4A CN200680051907A CN101405293B CN 101405293 B CN101405293 B CN 101405293B CN 200680051907 A CN200680051907 A CN 200680051907A CN 101405293 B CN101405293 B CN 101405293B
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compound
group
formula
carbon atoms
hydrogen
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Expired - Fee Related
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CN200680051907.4A
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English (en)
Chinese (zh)
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CN101405293A (zh
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G·米洛特
S·布兰乔德
B·R·斯特瑞克斯
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Taimed Biologics Inc
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Ambrilia Biopharma Inc
Taimed Biologics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200680051907.4A 2005-11-30 2006-11-30 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法 Expired - Fee Related CN101405293B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74064205P 2005-11-30 2005-11-30
US60/740,642 2005-11-30
PCT/CA2006/001963 WO2007062526A1 (en) 2005-11-30 2006-11-30 Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation

Publications (2)

Publication Number Publication Date
CN101405293A CN101405293A (zh) 2009-04-08
CN101405293B true CN101405293B (zh) 2013-03-13

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CN200680051907.4A Expired - Fee Related CN101405293B (zh) 2005-11-30 2006-11-30 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法

Country Status (8)

Country Link
US (2) US8227450B2 (https=)
EP (1) EP1971615B1 (https=)
JP (1) JP2009517412A (https=)
CN (1) CN101405293B (https=)
AU (1) AU2006319716B2 (https=)
CA (1) CA2632095A1 (https=)
ES (1) ES2452718T3 (https=)
WO (1) WO2007062526A1 (https=)

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CN101405293B (zh) 2005-11-30 2013-03-13 中裕新药股份有限公司 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
AU2007287353A1 (en) * 2006-07-17 2008-02-28 Ambrilia Biopharma Inc. Method for improving pharmacokinetics
US8410300B2 (en) 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors
WO2009148600A2 (en) * 2008-06-06 2009-12-10 Concert Pharmaceuticals, Inc. Deuterated lysine-based compounds
CA2762582A1 (en) 2009-05-27 2010-12-02 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2012055031A1 (en) 2010-10-28 2012-05-03 Merck Canada Inc. Hiv protease inhibitors
EP2771332B1 (en) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
JP6704058B2 (ja) * 2016-05-31 2020-06-03 タイメド・バイオロジクス・インコーポレイテッドＴａｉＭｅｄ Ｂｉｏｌｏｇｉｃｓ Ｉｎｃ． プロテアーゼ阻害剤の長時間作用性医薬組成物
US10369129B2 (en) 2016-05-31 2019-08-06 Taimed Biologics, Inc. Long acting pharmaceutical composition of protease inhibitor

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AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
EP1191929A4 (en) * 1999-06-16 2005-02-16 Univ Temple (Z) -STYRYL ACETOXYPHENYL SULFIDES AS INHIBITORS OF CYCLO-OXYGENASE
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US6506786B2 (en) * 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
CA2374362C (en) * 2002-03-04 2008-01-22 Brent Richard Stranix Urea derivatives as hiv aspartyl protease inhibitors
AU2003206588A1 (en) 2002-03-04 2003-09-16 Procyon Biopharma Inc. Urea derivatives as hiv aspartyl protease inhibitors
MXPA05005773A (es) 2002-12-16 2005-08-16 Boehringer Ingelheim Int Uso de una combinacion que contiene un inhibidor no nucleosido de transcriptasa inversa (nnrti) con un inhibidor de citocromo p450, tales como inhibidores de la proteasa.
JP4762917B2 (ja) 2004-01-08 2011-08-31 メディヴィル・アクチボラグ 非ヌクレオシド逆転写酵素インヒビター
US7388008B2 (en) * 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
WO2006012725A1 (en) 2004-08-02 2006-02-09 Ambrilia Biopharma Inc. Lysine based compounds
ES2539527T3 (es) 2005-04-27 2015-07-01 Taimed Biologics, Inc. Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas
CN101405293B (zh) * 2005-11-30 2013-03-13 中裕新药股份有限公司 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
AU2007287353A1 (en) 2006-07-17 2008-02-28 Ambrilia Biopharma Inc. Method for improving pharmacokinetics
US8410300B2 (en) * 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632816B1 (en) * 2002-12-23 2003-10-14 Pharmacor Inc. Aromatic derivatives as HIV aspartyl protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
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Also Published As

Publication number Publication date
EP1971615B1 (en) 2014-01-01
HK1124861A1 (en) 2009-07-24
US8580995B2 (en) 2013-11-12
AU2006319716B2 (en) 2012-02-02
US20100130765A1 (en) 2010-05-27
EP1971615A4 (en) 2011-06-22
EP1971615A1 (en) 2008-09-24
CA2632095A1 (en) 2007-06-07
ES2452718T3 (es) 2014-04-02
WO2007062526A8 (en) 2007-08-30
WO2007062526A1 (en) 2007-06-07
AU2006319716A1 (en) 2007-06-07
JP2009517412A (ja) 2009-04-30
US8227450B2 (en) 2012-07-24
US20090253926A1 (en) 2009-10-08
CN101405293A (zh) 2009-04-08

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Effective date: 20130128

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Granted publication date: 20130313

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