ES2452718T3 - Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación - Google Patents

Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación Download PDF

Info

Publication number
ES2452718T3
ES2452718T3 ES06817683.3T ES06817683T ES2452718T3 ES 2452718 T3 ES2452718 T3 ES 2452718T3 ES 06817683 T ES06817683 T ES 06817683T ES 2452718 T3 ES2452718 T3 ES 2452718T3
Authority
ES
Spain
Prior art keywords
group
carbon atoms
compound
formula
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06817683.3T
Other languages
English (en)
Spanish (es)
Inventor
Guy Milot
Stéphane BRANCHAUD
Brent Richard Stranix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ambrilia Biopharma Inc
Taimed Biologics Inc
Original Assignee
Ambrilia Biopharma Inc
Taimed Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrilia Biopharma Inc, Taimed Biologics Inc filed Critical Ambrilia Biopharma Inc
Application granted granted Critical
Publication of ES2452718T3 publication Critical patent/ES2452718T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES06817683.3T 2005-11-30 2006-11-30 Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación Active ES2452718T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74064205P 2005-11-30 2005-11-30
US740642P 2005-11-30
PCT/CA2006/001963 WO2007062526A1 (en) 2005-11-30 2006-11-30 Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation

Publications (1)

Publication Number Publication Date
ES2452718T3 true ES2452718T3 (es) 2014-04-02

Family

ID=38091843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06817683.3T Active ES2452718T3 (es) 2005-11-30 2006-11-30 Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación

Country Status (8)

Country Link
US (2) US8227450B2 (https=)
EP (1) EP1971615B1 (https=)
JP (1) JP2009517412A (https=)
CN (1) CN101405293B (https=)
AU (1) AU2006319716B2 (https=)
CA (1) CA2632095A1 (https=)
ES (1) ES2452718T3 (https=)
WO (1) WO2007062526A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10149030A1 (de) 2001-10-05 2003-04-10 Viscum Ag Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin
US7388008B2 (en) 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
CN101405293B (zh) 2005-11-30 2013-03-13 中裕新药股份有限公司 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
AU2007287353A1 (en) * 2006-07-17 2008-02-28 Ambrilia Biopharma Inc. Method for improving pharmacokinetics
US8410300B2 (en) 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors
WO2009148600A2 (en) * 2008-06-06 2009-12-10 Concert Pharmaceuticals, Inc. Deuterated lysine-based compounds
CA2762582A1 (en) 2009-05-27 2010-12-02 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2012055031A1 (en) 2010-10-28 2012-05-03 Merck Canada Inc. Hiv protease inhibitors
EP2771332B1 (en) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
JP6704058B2 (ja) * 2016-05-31 2020-06-03 タイメド・バイオロジクス・インコーポレイテッドＴａｉＭｅｄ Ｂｉｏｌｏｇｉｃｓ Ｉｎｃ． プロテアーゼ阻害剤の長時間作用性医薬組成物
US10369129B2 (en) 2016-05-31 2019-08-06 Taimed Biologics, Inc. Long acting pharmaceutical composition of protease inhibitor

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013861A (en) * 1985-02-28 1991-05-07 E. R. Squibb & Sons, Inc. Ester substituted aminoalkanoylureido amino and imino acid and ester compounds
WO1992006998A1 (de) 1990-10-11 1992-04-30 Boehringer Ingelheim Kg Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5614522A (en) * 1990-11-19 1997-03-25 G.D. Searle & Co. Retroviral protease inhibitors
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
JP4091654B2 (ja) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー レトロウイルスプロテアーゼ阻害剤として有用なスルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド
US6022994A (en) * 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1994004491A1 (en) * 1992-08-25 1994-03-03 G.D. Searle & Co. N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
JPH06321950A (ja) 1993-05-14 1994-11-22 Takeda Chem Ind Ltd 水溶性ランカシジン誘導体
WO1995006998A1 (en) 1993-08-31 1995-03-09 Stanley Kugell Telephone billing method
JPH10500938A (ja) 1994-03-07 1998-01-27 バーテックス ファーマシューティカルズ インコーポレイテッド アスパラチルプロテアーゼインヒビターとしてのスルホンアミド誘導体
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6143747A (en) * 1995-01-20 2000-11-07 G. D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5985870A (en) * 1995-03-10 1999-11-16 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776718A (en) * 1995-03-24 1998-07-07 Arris Pharmaceutical Corporation Reversible protease inhibitors
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
HUP9901024A2 (hu) 1996-01-26 1999-09-28 Vertex Pharmaceuticals Incorporated Telített azolok oxoszármazékai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AU720615B2 (en) 1997-01-17 2000-06-08 Pharmacia & Upjohn Company Bis-sulfonomides hydroxamic acids as MMP inhibitors
DE59802394D1 (de) * 1997-05-09 2002-01-24 Hoechst Ag Substituierte Diaminocarbonsäuren
EE200000386A (et) * 1997-12-24 2001-12-17 Vertex Pharmaceuticals Incorporated Aspartüülproteaasi inhibiitorite eelravimid
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US5986102A (en) 1998-04-29 1999-11-16 Pharmacopeia, Inc. Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases
ES2254156T3 (es) 1999-02-12 2006-06-16 Vertex Pharmaceuticals Incorporated Inhibidores de aspartil-proteasa.
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
EP1191929A4 (en) * 1999-06-16 2005-02-16 Univ Temple (Z) -STYRYL ACETOXYPHENYL SULFIDES AS INHIBITORS OF CYCLO-OXYGENASE
US6455587B1 (en) * 2000-03-15 2002-09-24 Pharmacor Inc. Amino acid derivatives as HIV aspartyl protease inhibitors
US6506786B2 (en) * 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
CA2374362C (en) * 2002-03-04 2008-01-22 Brent Richard Stranix Urea derivatives as hiv aspartyl protease inhibitors
AU2003206588A1 (en) 2002-03-04 2003-09-16 Procyon Biopharma Inc. Urea derivatives as hiv aspartyl protease inhibitors
MXPA05005773A (es) 2002-12-16 2005-08-16 Boehringer Ingelheim Int Uso de una combinacion que contiene un inhibidor no nucleosido de transcriptasa inversa (nnrti) con un inhibidor de citocromo p450, tales como inhibidores de la proteasa.
US6632816B1 (en) 2002-12-23 2003-10-14 Pharmacor Inc. Aromatic derivatives as HIV aspartyl protease inhibitors
JP4762917B2 (ja) 2004-01-08 2011-08-31 メディヴィル・アクチボラグ 非ヌクレオシド逆転写酵素インヒビター
US7388008B2 (en) * 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
WO2006012725A1 (en) 2004-08-02 2006-02-09 Ambrilia Biopharma Inc. Lysine based compounds
ES2539527T3 (es) 2005-04-27 2015-07-01 Taimed Biologics, Inc. Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas
CN101405293B (zh) * 2005-11-30 2013-03-13 中裕新药股份有限公司 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
AU2007287353A1 (en) 2006-07-17 2008-02-28 Ambrilia Biopharma Inc. Method for improving pharmacokinetics
US8410300B2 (en) * 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors

Also Published As

Publication number Publication date
EP1971615B1 (en) 2014-01-01
HK1124861A1 (en) 2009-07-24
US8580995B2 (en) 2013-11-12
AU2006319716B2 (en) 2012-02-02
US20100130765A1 (en) 2010-05-27
EP1971615A4 (en) 2011-06-22
EP1971615A1 (en) 2008-09-24
CA2632095A1 (en) 2007-06-07
CN101405293B (zh) 2013-03-13
WO2007062526A8 (en) 2007-08-30
WO2007062526A1 (en) 2007-06-07
AU2006319716A1 (en) 2007-06-07
JP2009517412A (ja) 2009-04-30
US8227450B2 (en) 2012-07-24
US20090253926A1 (en) 2009-10-08
CN101405293A (zh) 2009-04-08

Similar Documents

Publication Publication Date Title
US8580995B2 (en) Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation
US8008297B2 (en) Lysine based compounds
ES2315922T3 (es) Analogos de fosfonato de compuestos inhibidores de la integrasa del vih.
ES2391813T3 (es) Derivados aromáticos como inhibidores de la proteasa de aspartilo del VIH
AU2009230800A1 (en) Lysine based compounds
CA2657316A1 (en) Method for improving pharmacokinetics
ES2539527T3 (es) Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas
HK1124861B (en) Lysme-based prodrugs of aspartyl protease inhibitors and processes for their preparation
RU2379312C2 (ru) Соединения на основе лизина, фармацевтическая композиция, содержащая эти соединения, применение указанных соединений для лечения или профилактики вич инфекции
CN102093411A (zh) 基于赖氨酸的化合物
ZA200607352B (en) Lysine based compounds
HK1105406B (en) Lysine based compounds
NZ552853A (en) Lysine based compounds
KR20070057815A (ko) 리신계 화합물