AU2006319716B2 - Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation - Google Patents

Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation Download PDF

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Publication number
AU2006319716B2
AU2006319716B2 AU2006319716A AU2006319716A AU2006319716B2 AU 2006319716 B2 AU2006319716 B2 AU 2006319716B2 AU 2006319716 A AU2006319716 A AU 2006319716A AU 2006319716 A AU2006319716 A AU 2006319716A AU 2006319716 B2 AU2006319716 B2 AU 2006319716B2
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AU
Australia
Prior art keywords
group
carbon atoms
compound
formula
alkyl group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2006319716A
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English (en)
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AU2006319716A1 (en
Inventor
Stephane Branchaud
Guy Milot
Brent Richard Stranix
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Taimed Biologics Inc
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Taimed Biologics Inc
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Publication of AU2006319716A1 publication Critical patent/AU2006319716A1/en
Application granted granted Critical
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Assigned to TAIMED BIOLOGICS, INC. reassignment TAIMED BIOLOGICS, INC. Request for Assignment Assignors: AMBRILIA BIOPHARMA INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2006319716A 2005-11-30 2006-11-30 Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation Ceased AU2006319716B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74064205P 2005-11-30 2005-11-30
US60/740,642 2005-11-30
PCT/CA2006/001963 WO2007062526A1 (en) 2005-11-30 2006-11-30 Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation

Publications (2)

Publication Number Publication Date
AU2006319716A1 AU2006319716A1 (en) 2007-06-07
AU2006319716B2 true AU2006319716B2 (en) 2012-02-02

Family

ID=38091843

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006319716A Ceased AU2006319716B2 (en) 2005-11-30 2006-11-30 Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation

Country Status (8)

Country Link
US (2) US8227450B2 (https=)
EP (1) EP1971615B1 (https=)
JP (1) JP2009517412A (https=)
CN (1) CN101405293B (https=)
AU (1) AU2006319716B2 (https=)
CA (1) CA2632095A1 (https=)
ES (1) ES2452718T3 (https=)
WO (1) WO2007062526A1 (https=)

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US7388008B2 (en) 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
CN101405293B (zh) 2005-11-30 2013-03-13 中裕新药股份有限公司 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
AU2007287353A1 (en) * 2006-07-17 2008-02-28 Ambrilia Biopharma Inc. Method for improving pharmacokinetics
US8410300B2 (en) 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors
WO2009148600A2 (en) * 2008-06-06 2009-12-10 Concert Pharmaceuticals, Inc. Deuterated lysine-based compounds
CA2762582A1 (en) 2009-05-27 2010-12-02 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2012055031A1 (en) 2010-10-28 2012-05-03 Merck Canada Inc. Hiv protease inhibitors
EP2771332B1 (en) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
JP6704058B2 (ja) * 2016-05-31 2020-06-03 タイメド・バイオロジクス・インコーポレイテッドＴａｉＭｅｄ Ｂｉｏｌｏｇｉｃｓ Ｉｎｃ． プロテアーゼ阻害剤の長時間作用性医薬組成物
US10369129B2 (en) 2016-05-31 2019-08-06 Taimed Biologics, Inc. Long acting pharmaceutical composition of protease inhibitor

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20060025592A1 (en) * 2004-08-02 2006-02-02 Stranix Brent R Lysine based compounds

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EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
JP4091654B2 (ja) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー レトロウイルスプロテアーゼ阻害剤として有用なスルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド
US6022994A (en) * 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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JPH06321950A (ja) 1993-05-14 1994-11-22 Takeda Chem Ind Ltd 水溶性ランカシジン誘導体
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US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
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HUP9901024A2 (hu) 1996-01-26 1999-09-28 Vertex Pharmaceuticals Incorporated Telített azolok oxoszármazékai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AU720615B2 (en) 1997-01-17 2000-06-08 Pharmacia & Upjohn Company Bis-sulfonomides hydroxamic acids as MMP inhibitors
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EE200000386A (et) * 1997-12-24 2001-12-17 Vertex Pharmaceuticals Incorporated Aspartüülproteaasi inhibiitorite eelravimid
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ES2254156T3 (es) 1999-02-12 2006-06-16 Vertex Pharmaceuticals Incorporated Inhibidores de aspartil-proteasa.
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
EP1191929A4 (en) * 1999-06-16 2005-02-16 Univ Temple (Z) -STYRYL ACETOXYPHENYL SULFIDES AS INHIBITORS OF CYCLO-OXYGENASE
US6455587B1 (en) * 2000-03-15 2002-09-24 Pharmacor Inc. Amino acid derivatives as HIV aspartyl protease inhibitors
US6506786B2 (en) * 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
CA2374362C (en) * 2002-03-04 2008-01-22 Brent Richard Stranix Urea derivatives as hiv aspartyl protease inhibitors
AU2003206588A1 (en) 2002-03-04 2003-09-16 Procyon Biopharma Inc. Urea derivatives as hiv aspartyl protease inhibitors
MXPA05005773A (es) 2002-12-16 2005-08-16 Boehringer Ingelheim Int Uso de una combinacion que contiene un inhibidor no nucleosido de transcriptasa inversa (nnrti) con un inhibidor de citocromo p450, tales como inhibidores de la proteasa.
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JP4762917B2 (ja) 2004-01-08 2011-08-31 メディヴィル・アクチボラグ 非ヌクレオシド逆転写酵素インヒビター
WO2006012725A1 (en) 2004-08-02 2006-02-09 Ambrilia Biopharma Inc. Lysine based compounds
ES2539527T3 (es) 2005-04-27 2015-07-01 Taimed Biologics, Inc. Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas
CN101405293B (zh) * 2005-11-30 2013-03-13 中裕新药股份有限公司 天冬氨酰基蛋白酶抑制剂基于赖氨酸的前体药物及其制备方法
AU2007287353A1 (en) 2006-07-17 2008-02-28 Ambrilia Biopharma Inc. Method for improving pharmacokinetics
US8410300B2 (en) * 2006-09-21 2013-04-02 Taimed Biologics, Inc. Protease inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025592A1 (en) * 2004-08-02 2006-02-02 Stranix Brent R Lysine based compounds

Also Published As

Publication number Publication date
EP1971615B1 (en) 2014-01-01
HK1124861A1 (en) 2009-07-24
US8580995B2 (en) 2013-11-12
US20100130765A1 (en) 2010-05-27
EP1971615A4 (en) 2011-06-22
EP1971615A1 (en) 2008-09-24
CA2632095A1 (en) 2007-06-07
CN101405293B (zh) 2013-03-13
ES2452718T3 (es) 2014-04-02
WO2007062526A8 (en) 2007-08-30
WO2007062526A1 (en) 2007-06-07
AU2006319716A1 (en) 2007-06-07
JP2009517412A (ja) 2009-04-30
US8227450B2 (en) 2012-07-24
US20090253926A1 (en) 2009-10-08
CN101405293A (zh) 2009-04-08

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: TAIMED BIOLOGICS, INC.

Free format text: FORMER OWNER WAS: AMBRILIA BIOPHARMA INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired