JP2007532625A5 - - Google Patents
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- Publication number
- JP2007532625A5 JP2007532625A5 JP2007507864A JP2007507864A JP2007532625A5 JP 2007532625 A5 JP2007532625 A5 JP 2007532625A5 JP 2007507864 A JP2007507864 A JP 2007507864A JP 2007507864 A JP2007507864 A JP 2007507864A JP 2007532625 A5 JP2007532625 A5 JP 2007532625A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- groups
- aryl
- independently selected
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003118 aryl group Chemical group 0.000 claims 69
- 150000001875 compounds Chemical class 0.000 claims 55
- 229910052799 carbon Inorganic materials 0.000 claims 53
- 229910052739 hydrogen Inorganic materials 0.000 claims 43
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000003710 aryl alkyl group Chemical group 0.000 claims 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 20
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 15
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 15
- 125000000732 arylene group Chemical group 0.000 claims 14
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 13
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 9
- 125000002947 alkylene group Chemical group 0.000 claims 9
- 125000005549 heteroarylene group Chemical group 0.000 claims 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000006587 (C5-C10) heteroarylene group Chemical group 0.000 claims 6
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 4
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 4
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- -1 thiol compound Chemical class 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 206010062519 Poor quality sleep Diseases 0.000 claims 1
- 208000032140 Sleepiness Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 208000033914 shift work type circadian rhythm sleep disease Diseases 0.000 claims 1
- 230000037321 sleepiness Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04290983A EP1586560A1 (en) | 2004-04-13 | 2004-04-13 | Thio-substituted arylmethanesulfinyl derivatives |
| EP04290983.8 | 2004-04-13 | ||
| US56899104P | 2004-05-07 | 2004-05-07 | |
| US60/568,991 | 2004-05-07 | ||
| US11/104,074 | 2005-04-12 | ||
| US11/104,074 US7297817B2 (en) | 2004-04-13 | 2005-04-12 | Thio-substituted arylmethanesulfinyl derivatives |
| PCT/IB2005/000964 WO2005100310A1 (en) | 2004-04-13 | 2005-04-13 | Thio-substituted arylmethanesulfinyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007532625A JP2007532625A (ja) | 2007-11-15 |
| JP2007532625A5 true JP2007532625A5 (https=) | 2008-06-26 |
| JP4972542B2 JP4972542B2 (ja) | 2012-07-11 |
Family
ID=34964553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507864A Expired - Fee Related JP4972542B2 (ja) | 2004-04-13 | 2005-04-13 | チオ置換アリールメタンスルフィニル誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7297817B2 (https=) |
| EP (1) | EP1740535B1 (https=) |
| JP (1) | JP4972542B2 (https=) |
| CN (1) | CN1972909B (https=) |
| AT (1) | ATE524439T1 (https=) |
| AU (1) | AU2005232961B2 (https=) |
| CA (1) | CA2562554C (https=) |
| ES (1) | ES2373667T3 (https=) |
| MX (1) | MXPA06011779A (https=) |
| NZ (1) | NZ550583A (https=) |
| WO (1) | WO2005100310A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| US7314875B2 (en) * | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| EP1702915A1 (en) * | 2005-03-14 | 2006-09-20 | Cephalon France | Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation |
| CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| ES2645483T3 (es) | 2014-08-13 | 2017-12-05 | Red Bull Gmbh | Compuestos heterocíclicos con actividad de mejora de la memoria de trabajo |
| WO2016023997A1 (en) | 2014-08-13 | 2016-02-18 | Red Bull Gmbh | Heterocyclic compounds with working memory enhancing activity |
| WO2017223284A1 (en) | 2016-06-23 | 2017-12-28 | University Of Maryland, Baltimore | NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF |
| AU2019392904B9 (en) | 2018-12-07 | 2022-12-22 | University Of Maryland, Baltimore | Non-ATP/catalytic site p38 mitogen activated protein kinase inhibitors |
| EP4153303A1 (en) * | 2020-05-18 | 2023-03-29 | GEN1E Lifesciences Inc. | P38alpha mitogen-activated protein kinase inhibitors |
| EP4237415A1 (en) | 2020-10-29 | 2023-09-06 | GEN1E Lifesciences Inc. | Crystalline 5-(dimethylamino)-n-(4-(morpholinomethyl)phenyl) naphthalene-1-sulfonamide di-hydrochloride di-hydrate |
| WO2022204046A1 (en) | 2021-03-23 | 2022-09-29 | Gen1E Lifesciences Inc. | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE150366C (https=) | ||||
| US3689567A (en) | 1966-08-01 | 1972-09-05 | Tsung Ying Shen | Benzyl methyl sulfones and process for preparing same |
| US3950542A (en) * | 1967-02-21 | 1976-04-13 | L'oreal | Cysteamine derivatives for oral treatment of seborrhea |
| US3976694A (en) | 1973-05-10 | 1976-08-24 | Smithkline Corporation | α-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylphenyl ketones |
| US4006183A (en) | 1975-07-08 | 1977-02-01 | Sandoz, Inc. | Substituted α-methylsulfinyl-o-toluidines |
| GB1520812A (en) | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
| GB1570982A (en) | 1976-03-05 | 1980-07-09 | Shell Int Research | Substituted benzyl ethers and thioethers |
| GB1584462A (en) | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
| GB1600840A (en) | 1978-05-30 | 1981-10-21 | Wellcome Found | Diphenylether derivatives useful as flukicidal agents |
| DE3100387A1 (de) * | 1981-01-09 | 1982-09-02 | Basf Ag, 6700 Ludwigshafen | Substituierte diphenylether, diese enthaltende herbizide und ihre anwendung als herbizide |
| FR2593809B1 (fr) | 1986-01-31 | 1988-07-22 | Lafon Labor | Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique |
| DE3872937T2 (de) | 1987-05-11 | 1993-01-21 | Ono Pharmaceutical Co | Benzoylaminophenoxybuttersaeure-derivate. |
| US4935240A (en) | 1987-06-04 | 1990-06-19 | Ono Pharmaceutical Co., Ltd. | Benzoylaminophenoxybutanoic acid derivatives |
| DE3901706A1 (de) * | 1988-05-17 | 1989-11-30 | Bayer Ag | Halogensubstituierte phenoxybenzyl(thi)ol-derivate |
| JPH02229175A (ja) * | 1989-03-02 | 1990-09-11 | Hokko Chem Ind Co Ltd | 環状アシルヒドロキシルアミン誘導体およびその製法 |
| FR2663225B1 (fr) | 1990-06-14 | 1994-11-04 | Lafon Labor | Nouvelle utilisation du modafinil. |
| US5563169A (en) | 1991-09-13 | 1996-10-08 | Sankyo Company, Limited | Tricyclic heterocyclic compound |
| FR2684875B1 (fr) | 1991-12-13 | 1995-05-24 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique. |
| AU3276793A (en) * | 1991-12-20 | 1993-07-28 | Agouron Pharmaceuticals, Inc. | Antifolate quinazolines |
| FR2697162B1 (fr) | 1992-10-23 | 1995-01-13 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux. |
| FR2706767B1 (https=) | 1993-06-22 | 1995-09-08 | Lafon Labor | |
| FR2708201B1 (fr) | 1993-06-30 | 1995-10-20 | Lafon Labor | Utilisation de dérivés d'acétamide pour la fabrication de médicaments. |
| FR2707637B1 (fr) | 1993-06-30 | 1995-10-06 | Lafon Labor | Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique. |
| DK0723956T3 (da) * | 1995-01-30 | 2000-04-17 | Hoechst Ag | Basisk substituerede benzoylguanidiner, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemiddel eller diagnos |
| EP0752421B1 (en) * | 1995-07-07 | 2005-10-12 | AstraZeneca AB | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists |
| EP0923377A1 (en) * | 1996-05-17 | 1999-06-23 | Magainin Pharmaceuticals Inc. | Therapeutic uses for an aminosterol compound |
| JP3608021B2 (ja) * | 1996-09-05 | 2005-01-05 | 参天製薬株式会社 | 新規含硫黄アミノ酸誘導体 |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| WO1999011255A1 (en) * | 1997-08-28 | 1999-03-11 | Ono Pharmaceutical Co., Ltd. | Peroxisome proliferator-activated receptor controllers |
| FR2771004B1 (fr) | 1997-11-19 | 2000-02-18 | Inst Curie | Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse |
| ATE451346T1 (de) * | 1998-03-10 | 2009-12-15 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| NZ515086A (en) * | 1999-04-28 | 2003-10-31 | Aventis Pharma Gmbh | Di-aryl acid derivatives as PPAR receptor ligands |
| US6346548B1 (en) | 1999-08-16 | 2002-02-12 | Cephalon, Inc. | Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue |
| US6455588B1 (en) | 1999-08-20 | 2002-09-24 | Cephalon, Inc. | Compositions including modafinil for treatment of eating disorders and for appetite stimulation |
| HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| US6492396B2 (en) | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
| US6670358B2 (en) | 2000-05-16 | 2003-12-30 | Cephalon, Inc. | Substituted thioacetamides |
| CZ2003529A3 (cs) | 2000-07-27 | 2003-09-17 | Teva Pharmaceutical Industries Ltd. | Krystalický a čistý modafinil a postup jeho přípravy |
| JP2002212177A (ja) * | 2000-11-14 | 2002-07-31 | Takeda Chem Ind Ltd | 脂質代謝改善剤 |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| MXPA03011558A (es) * | 2001-06-12 | 2004-03-26 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de desordenes metabolicos. |
| ES2296979T3 (es) * | 2001-06-27 | 2008-05-01 | Smithkline Beecham Corporation | Fluoropirrolidinas como inhibidores de dipeptidil peptidasa. |
| AU2003261935A1 (en) * | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| US7119214B2 (en) | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7449481B2 (en) | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| US7314875B2 (en) | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| EP1586560A1 (en) | 2004-04-13 | 2005-10-19 | Cephalon, Inc. | Thio-substituted arylmethanesulfinyl derivatives |
-
2005
- 2005-04-12 US US11/104,074 patent/US7297817B2/en not_active Expired - Lifetime
- 2005-04-13 CN CN2005800194167A patent/CN1972909B/zh not_active Expired - Fee Related
- 2005-04-13 MX MXPA06011779A patent/MXPA06011779A/es active IP Right Grant
- 2005-04-13 JP JP2007507864A patent/JP4972542B2/ja not_active Expired - Fee Related
- 2005-04-13 CA CA2562554A patent/CA2562554C/en not_active Expired - Fee Related
- 2005-04-13 NZ NZ550583A patent/NZ550583A/en not_active IP Right Cessation
- 2005-04-13 WO PCT/IB2005/000964 patent/WO2005100310A1/en not_active Ceased
- 2005-04-13 AT AT05718427T patent/ATE524439T1/de not_active IP Right Cessation
- 2005-04-13 ES ES05718427T patent/ES2373667T3/es not_active Expired - Lifetime
- 2005-04-13 EP EP05718427A patent/EP1740535B1/en not_active Expired - Lifetime
- 2005-04-13 AU AU2005232961A patent/AU2005232961B2/en not_active Ceased
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