JP2009513681A5 - - Google Patents
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- Publication number
- JP2009513681A5 JP2009513681A5 JP2008538212A JP2008538212A JP2009513681A5 JP 2009513681 A5 JP2009513681 A5 JP 2009513681A5 JP 2008538212 A JP2008538212 A JP 2008538212A JP 2008538212 A JP2008538212 A JP 2008538212A JP 2009513681 A5 JP2009513681 A5 JP 2009513681A5
- Authority
- JP
- Japan
- Prior art keywords
- test sample
- polypeptide
- substrate
- fusion protein
- contacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000523 sample Substances 0.000 claims 40
- 229920001184 polypeptide Polymers 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 238000002165 resonance energy transfer Methods 0.000 claims 24
- 239000000758 substrate Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 18
- 108020001507 fusion proteins Proteins 0.000 claims 17
- 102000037865 fusion proteins Human genes 0.000 claims 17
- 230000000694 effects Effects 0.000 claims 16
- 102000044159 Ubiquitin Human genes 0.000 claims 15
- 108090000848 Ubiquitin Proteins 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 15
- 102000001477 Deubiquitinating Enzymes Human genes 0.000 claims 10
- 108010093668 Deubiquitinating Enzymes Proteins 0.000 claims 10
- 230000009504 deubiquitination Effects 0.000 claims 8
- 230000034512 ubiquitination Effects 0.000 claims 8
- 238000010798 ubiquitination Methods 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims 4
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims 4
- 230000004481 post-translational protein modification Effects 0.000 claims 4
- 150000004696 coordination complex Chemical class 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 102100024542 Small ubiquitin-related modifier 2 Human genes 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 102000012035 Autophagy-Related Protein 12 Human genes 0.000 claims 1
- 108010061408 Autophagy-Related Protein 12 Proteins 0.000 claims 1
- 102000007353 Autophagy-Related Protein 8 Family Human genes 0.000 claims 1
- 108010032769 Autophagy-Related Protein 8 Family Proteins 0.000 claims 1
- 102100034003 FAU ubiquitin-like and ribosomal protein S30 Human genes 0.000 claims 1
- 101000732045 Homo sapiens FAU ubiquitin-like and ribosomal protein S30 Proteins 0.000 claims 1
- 101000759918 Homo sapiens Ubiquitin carboxyl-terminal hydrolase isozyme L3 Proteins 0.000 claims 1
- 101000772767 Homo sapiens Ubiquitin-like protein 5 Proteins 0.000 claims 1
- 101000941158 Homo sapiens Ubiquitin-related modifier 1 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100031911 NEDD8 Human genes 0.000 claims 1
- 108700004934 NEDD8 Proteins 0.000 claims 1
- 101150107958 NEDD8 gene Proteins 0.000 claims 1
- 101100532088 Oryza sativa subsp. japonica RUB2 gene Proteins 0.000 claims 1
- 101100532090 Oryza sativa subsp. japonica RUB3 gene Proteins 0.000 claims 1
- 102100026940 Small ubiquitin-related modifier 1 Human genes 0.000 claims 1
- 101710081623 Small ubiquitin-related modifier 1 Proteins 0.000 claims 1
- 101710081711 Small ubiquitin-related modifier 2 Proteins 0.000 claims 1
- 101710081626 Small ubiquitin-related modifier 3 Proteins 0.000 claims 1
- 102100024535 Small ubiquitin-related modifier 4 Human genes 0.000 claims 1
- 101710081624 Small ubiquitin-related modifier 4 Proteins 0.000 claims 1
- 101150066810 URM1 gene Proteins 0.000 claims 1
- 102100025040 Ubiquitin carboxyl-terminal hydrolase isozyme L3 Human genes 0.000 claims 1
- 102100030580 Ubiquitin-like protein 5 Human genes 0.000 claims 1
- 102100031319 Ubiquitin-related modifier 1 Human genes 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- 101150024074 rub1 gene Proteins 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73131005P | 2005-10-28 | 2005-10-28 | |
| US73581205P | 2005-11-14 | 2005-11-14 | |
| US75954506P | 2006-01-18 | 2006-01-18 | |
| US77423606P | 2006-02-17 | 2006-02-17 | |
| US83211406P | 2006-07-21 | 2006-07-21 | |
| PCT/US2006/060373 WO2007051207A2 (en) | 2005-10-28 | 2006-10-30 | Kinase and ubiquination assays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009513681A JP2009513681A (ja) | 2009-04-02 |
| JP2009513681A5 true JP2009513681A5 (enExample) | 2010-12-24 |
Family
ID=37968695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538212A Withdrawn JP2009513681A (ja) | 2005-10-28 | 2006-10-30 | キナーゼおよびユビキネーションアッセイ法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20070264678A1 (enExample) |
| EP (2) | EP1955071A4 (enExample) |
| JP (1) | JP2009513681A (enExample) |
| WO (1) | WO2007051207A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| JP2007505315A (ja) * | 2003-09-12 | 2007-03-08 | インヴィトロジェン コーポレーション | 多重結合および活性アッセイ |
| EP1955071A4 (en) | 2005-10-28 | 2009-03-18 | Invitrogen Corp | ASSAYS OF ACTIVITY KINASE AND UBIQUITINATION |
| JP2009215238A (ja) * | 2008-03-11 | 2009-09-24 | Osaka Univ | 希土類発光プローブ |
| JP5774471B2 (ja) | 2008-03-27 | 2015-09-09 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | シアノベンゾチアゾールコンジュゲートによるタンパク質標識 |
| DE102008024567A1 (de) * | 2008-05-21 | 2009-12-03 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | Verfahren zur Messung einer Konzentration einer Messsubstanz in einer biologischen Probe |
| EP2154533A1 (en) * | 2008-08-04 | 2010-02-17 | Medizinische Hochschule Hannover | Method for determining SUMOylation |
| WO2010044892A1 (en) * | 2008-10-17 | 2010-04-22 | President And Fellows Of Harvard College | Diagnostic method based on large scale identification of post-translational modification of proteins |
| WO2010127980A1 (en) * | 2009-05-05 | 2010-11-11 | F. Hoffmann-La Roche Ag | Fret-based binding assay |
| WO2011090159A1 (ja) * | 2010-01-22 | 2011-07-28 | 独立行政法人科学技術振興機構 | 蛋白質の分解活性を測定するためのプローブ試薬 |
| US20140178895A1 (en) * | 2011-03-23 | 2014-06-26 | Saurabh Rajendra Nirantar | Recombinant protein biosensors and a method for detecting the presence of an analyte molecule |
| JP2014527087A (ja) * | 2011-03-31 | 2014-10-09 | エンバイロメンタル テクノロジー ソリューションズ エルエルシー | 変化検出能力を高めるためのポリマーおよび役割に応じて官能化されたポリマー |
| WO2014179494A1 (en) * | 2013-04-30 | 2014-11-06 | Colorado State University Research Foundation | Sensors and assays for ubiquitin or ubiquitin-like proteins |
| GB201417288D0 (en) | 2014-09-30 | 2014-11-12 | Univ Dundee | Cysteine labelling |
| US10167496B2 (en) | 2015-10-01 | 2019-01-01 | The Uab Research Foundation | SUMOylation assay and related reagents |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
| US5220012A (en) | 1984-09-26 | 1993-06-15 | Compagnie Oris Industrie Sa | Macropolycyclic rare earth complexes and application as fluorescent tracers |
| US5162508A (en) | 1987-12-18 | 1992-11-10 | Compagnie Oris Industrie | Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers |
| US5571897A (en) | 1991-12-05 | 1996-11-05 | Wallac Oy | Luminescent lanthanide chelates |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5622821A (en) | 1994-06-29 | 1997-04-22 | The Regents Of The University Of California | Luminescent lanthanide chelates and methods of use |
| US6162931A (en) | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
| AU768859B2 (en) | 1999-07-29 | 2004-01-08 | Dyax Corp. | Binding moieties for fibrin |
| JP2003505519A (ja) | 1999-07-29 | 2003-02-12 | エピックス メディカル， インコーポレイテッド | 多座結合を介した多量体画像化剤の標的化 |
| GB9927331D0 (en) * | 1999-11-18 | 2000-01-12 | Fluorescience Ltd | Assay for measuring enzyme activity in vivo |
| US20040214227A1 (en) | 1999-12-22 | 2004-10-28 | Erik Joly | Bioluminescence resonance energy transfer (bret) fusion molecule and method of use |
| GB0007915D0 (en) * | 2000-03-31 | 2000-05-17 | Univ Bristol | Protein kinase assay |
| DE10029210A1 (de) * | 2000-06-14 | 2002-01-31 | Vasopharm Biotech Gmbh & Co Kg | Testsystem sowie dessen Verwendung |
| TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| US20040053324A1 (en) * | 2002-08-30 | 2004-03-18 | Brian Wong | Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents |
| EP1498133A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma Deutschland GmbH | Use of a pak inhibitor for the treatment of a joint disease |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| JP2007505315A (ja) * | 2003-09-12 | 2007-03-08 | インヴィトロジェン コーポレーション | 多重結合および活性アッセイ |
| EP1955071A4 (en) | 2005-10-28 | 2009-03-18 | Invitrogen Corp | ASSAYS OF ACTIVITY KINASE AND UBIQUITINATION |
-
2006
- 2006-10-30 EP EP06839622A patent/EP1955071A4/en not_active Withdrawn
- 2006-10-30 WO PCT/US2006/060373 patent/WO2007051207A2/en not_active Ceased
- 2006-10-30 JP JP2008538212A patent/JP2009513681A/ja not_active Withdrawn
- 2006-10-30 US US11/554,553 patent/US20070264678A1/en not_active Abandoned
- 2006-10-30 EP EP09180259A patent/EP2221385A3/en not_active Withdrawn
-
2009
- 2009-07-23 US US12/508,513 patent/US8642256B2/en active Active
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