JP2009510998A5 - - Google Patents
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- JP2009510998A5 JP2009510998A5 JP2008522802A JP2008522802A JP2009510998A5 JP 2009510998 A5 JP2009510998 A5 JP 2009510998A5 JP 2008522802 A JP2008522802 A JP 2008522802A JP 2008522802 A JP2008522802 A JP 2008522802A JP 2009510998 A5 JP2009510998 A5 JP 2009510998A5
- Authority
- JP
- Japan
- Prior art keywords
- scaffold
- amino acid
- fab
- gene
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70190205P | 2005-07-22 | 2005-07-22 | |
| US60/701,902 | 2005-07-22 | ||
| US11/273,906 | 2005-11-14 | ||
| US11/273,906 US8211648B2 (en) | 2005-07-22 | 2005-11-14 | Secretion of antibodies without signal peptides from bacteria |
| PCT/US2006/026334 WO2007018853A2 (en) | 2005-07-22 | 2006-07-07 | Secretion of antibodies without signal peptides from bacteria |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009510998A JP2009510998A (ja) | 2009-03-19 |
| JP2009510998A5 true JP2009510998A5 (enExample) | 2010-05-20 |
| JP5087541B2 JP5087541B2 (ja) | 2012-12-05 |
Family
ID=37679517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522802A Expired - Fee Related JP5087541B2 (ja) | 2005-07-22 | 2006-07-07 | シグナルペプチドを用いない、細菌からの抗体分泌 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8211648B2 (enExample) |
| EP (1) | EP1907610B1 (enExample) |
| JP (1) | JP5087541B2 (enExample) |
| KR (1) | KR101014891B1 (enExample) |
| CN (1) | CN101568647B (enExample) |
| AU (1) | AU2006276823B2 (enExample) |
| CA (1) | CA2615776C (enExample) |
| IL (1) | IL188889A (enExample) |
| NZ (1) | NZ565126A (enExample) |
| SG (1) | SG177895A1 (enExample) |
| WO (1) | WO2007018853A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8211648B2 (en) * | 2005-07-22 | 2012-07-03 | Kalobios Pharmaceuticals, Inc. | Secretion of antibodies without signal peptides from bacteria |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| CN102037016B (zh) | 2008-04-28 | 2015-06-03 | 卡罗拜奥斯制药公司 | 针对粒细胞巨噬细胞集落刺激因子的抗体 |
| WO2010091189A1 (en) | 2009-02-04 | 2010-08-12 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
| WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| PT2488554T (pt) | 2009-10-14 | 2019-09-13 | Humanigen Inc | Anticorpos para epha3 |
| AR079336A1 (es) | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| KR20140006022A (ko) | 2011-02-11 | 2014-01-15 | 아이알엠 엘엘씨 | Pcsk9 길항제 |
| WO2012133119A1 (ja) * | 2011-03-28 | 2012-10-04 | 長瀬産業株式会社 | フェリチンの製造方法 |
| WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| MX2014010495A (es) * | 2012-03-02 | 2014-11-14 | Ablynx Nv | Polipeptidos que enlazan a pcrv. |
| WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
| WO2014116051A1 (ko) * | 2013-01-24 | 2014-07-31 | 스크립스코리아 항체연구원 | 단백질 조합 기반의 Fv 라이브러리 및 이의 제조 방법 |
| US10328149B2 (en) * | 2014-06-13 | 2019-06-25 | Tenboron Oy | Conjugates comprising an anti-EGFR1 antibody |
| RU2609627C2 (ru) * | 2014-09-26 | 2017-02-02 | Закрытое Акционерное Общество "Биокад" | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| IL302725A (en) * | 2016-01-13 | 2023-07-01 | Regeneron Pharma | Rodents having an engineered heavy chain diversity region |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5576184A (en) * | 1988-09-06 | 1996-11-19 | Xoma Corporation | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
| EP0967277A3 (en) | 1988-09-06 | 2003-10-15 | Xoma Corporation | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
| EP0404003A3 (en) | 1989-06-19 | 1991-10-16 | Xoma Corporation | Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen |
| US5733743A (en) * | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5914254A (en) * | 1993-08-02 | 1999-06-22 | Celtrix Pharmaceuticals, Inc. | Expression of fusion polypeptides transported out of the cytoplasm without leader sequences |
| US5563046A (en) * | 1993-08-02 | 1996-10-08 | Celtrix Pharmaceuticals, Inc. | Fusion polypeptides and proteins |
| JPH07289267A (ja) * | 1994-04-25 | 1995-11-07 | Oriental Yeast Co Ltd | 発現増強方法 |
| JPH09313191A (ja) | 1996-03-28 | 1997-12-09 | Mitsui Petrochem Ind Ltd | 蛋白質の分泌生産法 |
| US5824502A (en) * | 1996-03-28 | 1998-10-20 | Mitsui Chemicals, Inc. | Method for secretory production of protein |
| AU770952B2 (en) * | 1999-03-01 | 2004-03-11 | Genentech Inc. | Antibodies for cancer therapy and diagnosis |
| US7425328B2 (en) * | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
| DE10325026B4 (de) | 2003-06-02 | 2013-04-18 | Genencor International,Inc. | Bakterien mit erhöhter Proteinsekretion, Nukleotidsequenzen codierend für ein SecA Protein mit erhöhter Proteinsekretion sowie Verfahren zur Produktion von Proteinen |
| US20040266993A1 (en) | 2003-06-30 | 2004-12-30 | Evans Glen A. | Non-immunoglobulin binding polypeptides |
| JP2007502991A (ja) * | 2003-08-20 | 2007-02-15 | バイオサイト インコーポレイテッド | 生物活性ナトリウム利尿ペプチドを測定するための、およびその治療可能性を向上させるための方法および組成物 |
| JP4782700B2 (ja) * | 2004-01-20 | 2011-09-28 | カロバイオス ファーマシューティカルズ インコーポレイティッド | 最低限必須な結合決定基を用いた抗体特異性の移入 |
| US8211648B2 (en) * | 2005-07-22 | 2012-07-03 | Kalobios Pharmaceuticals, Inc. | Secretion of antibodies without signal peptides from bacteria |
-
2005
- 2005-11-14 US US11/273,906 patent/US8211648B2/en not_active Expired - Fee Related
-
2006
- 2006-07-07 CA CA2615776A patent/CA2615776C/en not_active Expired - Fee Related
- 2006-07-07 KR KR1020087004346A patent/KR101014891B1/ko not_active Expired - Fee Related
- 2006-07-07 EP EP06786474.4A patent/EP1907610B1/en not_active Not-in-force
- 2006-07-07 JP JP2008522802A patent/JP5087541B2/ja not_active Expired - Fee Related
- 2006-07-07 CN CN200680034693XA patent/CN101568647B/zh not_active Expired - Fee Related
- 2006-07-07 AU AU2006276823A patent/AU2006276823B2/en not_active Ceased
- 2006-07-07 NZ NZ565126A patent/NZ565126A/en not_active IP Right Cessation
- 2006-07-07 SG SG2011092400A patent/SG177895A1/en unknown
- 2006-07-07 WO PCT/US2006/026334 patent/WO2007018853A2/en not_active Ceased
-
2008
- 2008-01-20 IL IL188889A patent/IL188889A/en not_active IP Right Cessation
-
2012
- 2012-05-07 US US13/506,653 patent/US9127046B2/en not_active Expired - Fee Related
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