JP2009509952A5 - - Google Patents
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- Publication number
- JP2009509952A5 JP2009509952A5 JP2008531815A JP2008531815A JP2009509952A5 JP 2009509952 A5 JP2009509952 A5 JP 2009509952A5 JP 2008531815 A JP2008531815 A JP 2008531815A JP 2008531815 A JP2008531815 A JP 2008531815A JP 2009509952 A5 JP2009509952 A5 JP 2009509952A5
- Authority
- JP
- Japan
- Prior art keywords
- pdgf
- group
- complex according
- complex
- amphiphilic polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims 12
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 11
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 11
- 239000002253 acid Substances 0.000 claims 7
- 239000002131 composite material Substances 0.000 claims 6
- 150000004804 polysaccharides Chemical class 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 229920001282 polysaccharide Polymers 0.000 claims 4
- 239000005017 polysaccharide Substances 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 229920002307 Dextran Polymers 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 235000010980 cellulose Nutrition 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000001165 hydrophobic group Chemical group 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 150000004781 alginic acids Chemical class 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 150000008131 glucosides Chemical class 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 2
- 108010081589 Becaplermin Proteins 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- IBARXVLAFNRWSF-UHFFFAOYSA-N O=CN=CCC1=CC=CC=C1 Chemical group O=CN=CCC1=CC=CC=C1 IBARXVLAFNRWSF-UHFFFAOYSA-N 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 108010020346 Polyglutamic Acid Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 150000003939 benzylamines Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- 229940107200 chondroitin sulfates Drugs 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000007515 enzymatic degradation Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims 1
- 229930182478 glucoside Natural products 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- -1 methyl carboxyl group Chemical group 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000002989 phenols Chemical class 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 108010064470 polyaspartate Proteins 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000019635 sulfation Effects 0.000 claims 1
- 238000005670 sulfation reaction Methods 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR05/09803 | 2005-09-26 | ||
| FR0509803A FR2891149B1 (fr) | 2005-09-26 | 2005-09-26 | Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes. |
| PCT/IB2006/002666 WO2007034320A2 (fr) | 2005-09-26 | 2006-09-26 | Complexe polymere amphiphile-pdgf |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009509952A JP2009509952A (ja) | 2009-03-12 |
| JP2009509952A5 true JP2009509952A5 (enExample) | 2009-11-12 |
| JP5438968B2 JP5438968B2 (ja) | 2014-03-12 |
Family
ID=36685952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008531815A Expired - Fee Related JP5438968B2 (ja) | 2005-09-26 | 2006-09-26 | 両親媒性ポリマー−ｐｄｇｆ複合体 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20090221805A1 (enExample) |
| EP (2) | EP1940448B1 (enExample) |
| JP (1) | JP5438968B2 (enExample) |
| KR (1) | KR101506593B1 (enExample) |
| CN (3) | CN101316607A (enExample) |
| AU (1) | AU2006293613B2 (enExample) |
| BR (1) | BRPI0616439A2 (enExample) |
| CA (1) | CA2623529C (enExample) |
| DK (1) | DK1940448T3 (enExample) |
| ES (1) | ES2406229T3 (enExample) |
| FR (1) | FR2891149B1 (enExample) |
| IL (1) | IL190400A (enExample) |
| PL (1) | PL1940448T3 (enExample) |
| PT (1) | PT1940448E (enExample) |
| RU (1) | RU2424824C2 (enExample) |
| WO (2) | WO2007034321A2 (enExample) |
| ZA (2) | ZA200803500B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2822834B1 (fr) * | 2001-04-02 | 2005-02-25 | Flamel Tech Sa | Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation |
| FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
| FR2843117B1 (fr) * | 2002-07-30 | 2004-10-15 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques |
| FR2860516B1 (fr) * | 2003-10-03 | 2006-01-13 | Flamel Tech Sa | Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
| FR2862536B1 (fr) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
| FR2914305B1 (fr) * | 2007-03-29 | 2009-07-03 | Proteins & Peptides Man | Dextran fonctionnalise par des amino-acides hydrophobes. |
| US20120041079A1 (en) * | 2006-09-26 | 2012-02-16 | Adocia | Dextran functionalized by hydrophobic amino acids |
| FR2908414B1 (fr) | 2006-11-13 | 2012-01-20 | Centre Nat Rech Scient | Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile |
| RU2542471C2 (ru) | 2006-11-15 | 2015-02-20 | Коуда Терапьютикс, Инк. | Улучшенные способы и композиции для заживления ран |
| FR2914191A1 (fr) * | 2007-03-29 | 2008-10-03 | Proteins & Peptides Man | Composition angiogenique. |
| FR2919188B1 (fr) * | 2007-07-27 | 2010-02-26 | Proteins & Peptides Man | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
| US20090291114A1 (en) * | 2008-04-14 | 2009-11-26 | Adocia | Osteogenic composition comprising a growth factor/amphiphilic polymer complex, a soluble cation salt and an organic support |
| FR2934999B1 (fr) * | 2008-08-13 | 2011-07-29 | Adocia | Polysaccharides fonctionnalises par des derives du tryptophane |
| BRPI0913684A2 (pt) * | 2008-09-26 | 2015-10-20 | Adocia | complexo composto por um polissacarídeo substituído por um triptofano ou um derivado de triptofano a partir de uma proteína ligadora à heparina, composição farmacêutica e seus usos |
| FR2936800B1 (fr) * | 2008-10-06 | 2010-12-31 | Adocia | Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe |
| US8426382B2 (en) * | 2008-10-06 | 2013-04-23 | Adocia | Polysaccharides comprising carboxyl functional groups substituted by a hydrophobic alcohol derivative |
| FR2943538B1 (fr) * | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
| FR2958646B1 (fr) * | 2010-04-07 | 2012-05-18 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'acide hydrophobe. |
| WO2011098962A2 (fr) * | 2010-02-09 | 2011-08-18 | Adocia | Polysaccharides anioniques fonctionnalisés par au moins deux groupements hydrophobes portés par un spacer au moins trivalent |
| FR2966248B1 (fr) | 2010-10-18 | 2020-05-01 | Centre National De La Recherche Scientifique (Cnrs) | Procede de fonctionnalisation de surfaces pour la detection d'analytes |
| US20120295833A1 (en) * | 2011-05-10 | 2012-11-22 | Adocia | Polysaccharides having an adjustable degree of functionalization |
| US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
| KR101466511B1 (ko) * | 2012-11-12 | 2014-11-27 | 성균관대학교산학협력단 | 저산소증 관련 질환의 진단 및 치료용 저산소 감응형 나노입자 |
| EA201590937A1 (ru) * | 2012-11-13 | 2016-04-29 | Адосиа | Замещенные анионные соединения, имеющие скелет, образованный из небольшого числа сахаридных звеньев |
| EP2919804B1 (fr) * | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| WO2016029191A2 (en) | 2014-08-22 | 2016-02-25 | Auckland Uniservices Limited | Channel modulators |
| FR3025428A1 (fr) | 2014-09-08 | 2016-03-11 | Adocia | Composition pharmaceutique stable comprenant du pdgf |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
| CN106188649B (zh) * | 2016-07-04 | 2019-06-25 | 宁波国际材料基因工程研究院有限公司 | 一种药物缓释载体水凝胶及其制备方法 |
| CN111171174B (zh) * | 2020-01-14 | 2022-02-01 | 上海图珐医药科技有限公司 | 葡聚糖衍生物及其制备方法和用于制备药剂的附加剂 |
| CN111253569B (zh) * | 2020-02-26 | 2021-06-01 | 山东大学 | 一种聚合物、其制剂及其制备方法和应用 |
| US12667586B2 (en) | 2023-03-07 | 2026-06-30 | Glaukos Corporation | Treatments for ocular surface disorders |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US183282A (en) * | 1876-10-17 | Improvement in striping implements | ||
| US169120A (en) * | 1875-10-26 | Improvement in machines for bending scythe-snaths | ||
| US2808405A (en) * | 1955-03-11 | 1957-10-01 | Ohio Commw Eng Co | Acylated amino acid esters of dextran products and method of making same |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4717717A (en) | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
| US5705485A (en) | 1987-09-18 | 1998-01-06 | Ethicon, Inc. | Gel formulations containing growth factors |
| US5457093A (en) * | 1987-09-18 | 1995-10-10 | Ethicon, Inc. | Gel formulations containing growth factors |
| WO1992001716A1 (en) * | 1990-07-23 | 1992-02-06 | Zymogenetics, Inc. | Protease resistant pdgf and methods of use |
| US5234908A (en) * | 1991-04-12 | 1993-08-10 | Creative Biomolecules, Inc. | Method of treating gastrointestinal ulcers with platelet derived growth factor |
| JPH0543453A (ja) * | 1991-08-20 | 1993-02-23 | Sumitomo Pharmaceut Co Ltd | 創傷治癒促進用局所用徐放性製剤 |
| WO1993008825A1 (en) | 1991-11-04 | 1993-05-13 | Zymogenetics, Inc. | Pdgf gel formulation |
| DE4136324A1 (de) * | 1991-11-05 | 1993-05-13 | Hoechst Ag | Dextranderivate als adsorptionsmittel fuer gallensaeuren, mit gallensaeuren beladene dextranderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel |
| GB9301258D0 (en) * | 1993-01-22 | 1993-03-17 | Courtaulds Plc | Use of absorbent fibre |
| US5612321A (en) * | 1995-06-22 | 1997-03-18 | Hercules Incorporated | Antioxidant grafted polysaccharides |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| PT948538E (pt) | 1996-12-13 | 2008-08-05 | Novartis Vaccines & Diagnostic | Análise e separação de proteínas do factor de crescimento derivado de plaquetas |
| AU7466998A (en) * | 1997-04-14 | 1998-11-11 | Byron E. Anderson | Method and material for inhibiting complement |
| FR2772382B1 (fr) * | 1997-12-11 | 2000-03-03 | Solutions | Derives de dextrane, leur procede de preparation et leurs applications comme medicaments a action biologique specifique |
| FR2794649B1 (fr) * | 1999-06-11 | 2003-04-11 | Solutions | Biomateriau a base d'un derive de dextrane insolubilise et d'un facteur de croissance, son procede de preparation et ses applications |
| FR2794976B1 (fr) * | 1999-06-16 | 2004-05-07 | Solutions | Compositions pharmaceutiques a action cicatrisante ou anti-complementaire comprenant un derive de dextrane |
| CA2436076A1 (en) * | 2001-01-26 | 2002-08-01 | Genetix Pharmaceuticals, Inc. | Use of compositions containing pdgf-bb for promoting angiogenesis |
| DE10140623A1 (de) * | 2001-08-18 | 2003-03-06 | Nawa Heilmittel Gmbh | Pharmazeutisches Präparat zur Behandlung von Wunden |
| US7368125B2 (en) * | 2002-06-05 | 2008-05-06 | Ethicon, Inc. | Amphiphilic polymers for medical applications |
| FR2840614B1 (fr) * | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
| CN1506112A (zh) * | 2002-12-09 | 2004-06-23 | 北京金赛狮生物制药技术开发有限责任 | 重组血小板源生长因子的水凝胶制剂 |
| CN1506113A (zh) * | 2002-12-09 | 2004-06-23 | 北京金赛狮生物制药技术开发有限责任 | 重组血小板源生长因子水凝胶制剂的制备方法 |
| CN1508259A (zh) * | 2002-12-19 | 2004-06-30 | 北京金赛狮生物制药技术开发有限责任 | 重组人血小板源生长因子的发酵方法 |
| WO2005075455A2 (en) | 2004-01-30 | 2005-08-18 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
| WO2007013100A1 (en) | 2005-07-26 | 2007-02-01 | Virchow Biotech Private Limited | Gel formulation comprising platelet derived growth factor |
| CN101460523A (zh) * | 2006-04-07 | 2009-06-17 | 阿道恰公司 | 双官能化多糖 |
-
2005
- 2005-09-26 FR FR0509803A patent/FR2891149B1/fr not_active Expired - Fee Related
-
2006
- 2006-09-26 ES ES06808894T patent/ES2406229T3/es active Active
- 2006-09-26 RU RU2008116585/05A patent/RU2424824C2/ru not_active IP Right Cessation
- 2006-09-26 EP EP06808894A patent/EP1940448B1/fr not_active Not-in-force
- 2006-09-26 WO PCT/IB2006/002667 patent/WO2007034321A2/fr not_active Ceased
- 2006-09-26 KR KR1020087009706A patent/KR101506593B1/ko not_active Expired - Fee Related
- 2006-09-26 AU AU2006293613A patent/AU2006293613B2/en not_active Ceased
- 2006-09-26 CN CNA2006800442335A patent/CN101316607A/zh active Pending
- 2006-09-26 DK DK06808894.7T patent/DK1940448T3/da active
- 2006-09-26 PL PL06808894T patent/PL1940448T3/pl unknown
- 2006-09-26 CA CA2623529A patent/CA2623529C/fr not_active Expired - Fee Related
- 2006-09-26 EP EP06808895A patent/EP1940449A2/fr not_active Withdrawn
- 2006-09-26 CN CN201310120297.0A patent/CN103203023B/zh not_active Expired - Fee Related
- 2006-09-26 JP JP2008531815A patent/JP5438968B2/ja not_active Expired - Fee Related
- 2006-09-26 PT PT68088947T patent/PT1940448E/pt unknown
- 2006-09-26 US US11/526,735 patent/US20090221805A1/en not_active Abandoned
- 2006-09-26 US US11/526,678 patent/US20070254828A1/en not_active Abandoned
- 2006-09-26 BR BRPI0616439-0A patent/BRPI0616439A2/pt not_active IP Right Cessation
- 2006-09-26 WO PCT/IB2006/002666 patent/WO2007034320A2/fr not_active Ceased
-
2007
- 2007-09-26 CN CN2007800356669A patent/CN101631804B/zh not_active Expired - Fee Related
-
2008
- 2008-03-24 IL IL190400A patent/IL190400A/en active IP Right Grant
- 2008-04-21 ZA ZA2008/03500A patent/ZA200803500B/en unknown
-
2009
- 2009-03-20 ZA ZA200902008A patent/ZA200902008B/xx unknown
-
2011
- 2011-05-23 US US13/067,299 patent/US8241620B2/en not_active Expired - Fee Related
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