JP2009508818A5 - - Google Patents
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- Publication number
- JP2009508818A5 JP2009508818A5 JP2008529335A JP2008529335A JP2009508818A5 JP 2009508818 A5 JP2009508818 A5 JP 2009508818A5 JP 2008529335 A JP2008529335 A JP 2008529335A JP 2008529335 A JP2008529335 A JP 2008529335A JP 2009508818 A5 JP2009508818 A5 JP 2009508818A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- optionally substituted
- substituents
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(c1c(*)c(*)c(*)c(*)c11)S)N(*)C(*)C1I Chemical compound *C(C(c1c(*)c(*)c(*)c(*)c11)S)N(*)C(*)C1I 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71349505P | 2005-09-01 | 2005-09-01 | |
| US60/713,495 | 2005-09-01 | ||
| PCT/US2006/034334 WO2007028082A1 (en) | 2005-09-01 | 2006-09-01 | 6-substituted- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009508818A JP2009508818A (ja) | 2009-03-05 |
| JP2009508818A5 true JP2009508818A5 (enExample) | 2009-10-15 |
| JP5165568B2 JP5165568B2 (ja) | 2013-03-21 |
Family
ID=37499682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529335A Expired - Fee Related JP5165568B2 (ja) | 2005-09-01 | 2006-09-01 | ５−ＨＴ２Ｃ受容体アゴニストとしての６−置換−２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7994163B2 (enExample) |
| EP (1) | EP1924560B1 (enExample) |
| JP (1) | JP5165568B2 (enExample) |
| AT (1) | ATE438627T1 (enExample) |
| CA (1) | CA2619566C (enExample) |
| CY (1) | CY1110531T1 (enExample) |
| DE (1) | DE602006008323D1 (enExample) |
| DK (1) | DK1924560T3 (enExample) |
| ES (1) | ES2328520T3 (enExample) |
| PL (1) | PL1924560T3 (enExample) |
| PT (1) | PT1924560E (enExample) |
| SI (1) | SI1924560T1 (enExample) |
| WO (1) | WO2007028082A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008002180A (es) * | 2005-09-01 | 2008-04-22 | Lilly Co Eli | 2,3,4,5-tetrahidro-1h-benzo[d]azepinas 6-sustituidas como agonistas de receptor 5-ht2c. |
| JP5249031B2 (ja) * | 2005-09-01 | 2013-07-31 | イーライ リリー アンド カンパニー | ５−ＨＴ２Ｃ受容体アゴニストとしての６−Ｎ結合型へテロ環置換された２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン |
| JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| US7897595B2 (en) | 2006-05-26 | 2011-03-01 | Forest Laboratories Holdings Limited | Pyridoazepine derivatives |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| EP3725775A1 (en) | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- and pyrimidinecarboxamides as cxcr2 modulators |
| US8779149B2 (en) | 2010-08-23 | 2014-07-15 | Syntrix Biosystems, Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| WO2012030938A1 (en) * | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
| US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| US9365521B2 (en) * | 2010-09-01 | 2016-06-14 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-HT2C agonists |
| JP2013536858A (ja) * | 2010-09-01 | 2013-09-26 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストの速く溶解する剤形 |
| EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CN105622511B (zh) * | 2014-11-03 | 2018-01-23 | 北京瑞都医药科技有限公司 | 一种减肥药物及其制备方法 |
| EP3733204A4 (en) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4265890A (en) * | 1978-07-07 | 1981-05-05 | Smithkline Corporation | 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines |
| EP0285287A3 (en) | 1987-03-23 | 1990-08-16 | Smithkline Beecham Corporation | 3-benzazepine compounds for use in treating gastrointestinal motility disorders |
| US4985352A (en) * | 1988-02-29 | 1991-01-15 | The Trustees Of Columbia University In The City Of New York | DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof |
| GB9116824D0 (en) | 1991-08-05 | 1991-09-18 | Smithkline Beecham Corp | Chemical compounds |
| US5639748A (en) * | 1991-08-05 | 1997-06-17 | Smithkline Beecham Corporation | 6,9-disubstituted benzazepines having α-adrenoceptor blocking activity |
| DE69224618T2 (de) | 1991-09-11 | 1998-07-16 | Canon Kk | Säuberungsglied für einen tintenstrahlkopf und mit solchem säuberungsglied ausgestattetes tintenstrahlgerät |
| GB9119467D0 (en) * | 1991-09-12 | 1991-10-23 | Smithkline Beecham Corp | Chemical compounds |
| US5698766A (en) * | 1995-04-05 | 1997-12-16 | The Regents Of The University Of California | Transgenic animal model for testing drugs for treating eating disorders and epilepsy |
| EP1213017A3 (en) | 2000-12-05 | 2003-11-12 | Akzo Nobel N.V. | Use of a 5-HT2C receptor agonist for the treatment of hot flushes |
| JPWO2002074746A1 (ja) * | 2001-03-16 | 2004-07-08 | 山之内製薬株式会社 | ベンゾアゼピン誘導体 |
| DK1406902T3 (da) | 2001-07-13 | 2006-01-30 | Pharmacia & Upjohn Co Llc | Hexahydroazepino[4,5-g]indoler og -indoliner som 5-HT-receptor-ligander |
| US6861420B2 (en) * | 2001-11-28 | 2005-03-01 | Pharmacia & Upjohn Company | N-substituted 1,2,4,5-tetrahydro-1H-benzo[d]azepine compounds |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| HUE028976T2 (en) | 2003-06-17 | 2017-02-28 | Arena Pharm Inc | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
| CN1805939B (zh) | 2003-06-17 | 2010-10-13 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物 |
| TW200510324A (en) | 2003-08-11 | 2005-03-16 | Lilly Co Eli | 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist |
| US20080009478A1 (en) * | 2003-10-22 | 2008-01-10 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases |
| WO2005042490A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
| EP2479168B1 (en) * | 2004-02-25 | 2014-04-09 | Eli Lilly And Company | 6-Substituted 2,3,4,5-Tetrahydro-1H-Benzo [d]Azepines as 5-HT2C Receptor Agonists |
| JP5270167B2 (ja) | 2004-12-21 | 2013-08-21 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
| KR20130087622A (ko) | 2004-12-23 | 2013-08-06 | 아레나 파마슈티칼스, 인크. | 5ｈｔ２ｃ 수용체 조정물질 조성물 및 그의 사용 방법 |
| MX2008002180A (es) * | 2005-09-01 | 2008-04-22 | Lilly Co Eli | 2,3,4,5-tetrahidro-1h-benzo[d]azepinas 6-sustituidas como agonistas de receptor 5-ht2c. |
-
2006
- 2006-09-01 DK DK06802858T patent/DK1924560T3/da active
- 2006-09-01 JP JP2008529335A patent/JP5165568B2/ja not_active Expired - Fee Related
- 2006-09-01 AT AT06802858T patent/ATE438627T1/de active
- 2006-09-01 ES ES06802858T patent/ES2328520T3/es active Active
- 2006-09-01 DE DE602006008323T patent/DE602006008323D1/de active Active
- 2006-09-01 US US11/996,457 patent/US7994163B2/en not_active Expired - Fee Related
- 2006-09-01 WO PCT/US2006/034334 patent/WO2007028082A1/en not_active Ceased
- 2006-09-01 SI SI200630458T patent/SI1924560T1/sl unknown
- 2006-09-01 CA CA2619566A patent/CA2619566C/en not_active Expired - Fee Related
- 2006-09-01 PL PL06802858T patent/PL1924560T3/pl unknown
- 2006-09-01 EP EP06802858A patent/EP1924560B1/en not_active Not-in-force
- 2006-09-01 PT PT06802858T patent/PT1924560E/pt unknown
-
2009
- 2009-10-02 CY CY20091101025T patent/CY1110531T1/el unknown