JP2009541240A5 - - Google Patents
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- Publication number
- JP2009541240A5 JP2009541240A5 JP2009515774A JP2009515774A JP2009541240A5 JP 2009541240 A5 JP2009541240 A5 JP 2009541240A5 JP 2009515774 A JP2009515774 A JP 2009515774A JP 2009515774 A JP2009515774 A JP 2009515774A JP 2009541240 A5 JP2009541240 A5 JP 2009541240A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- mcl
- seq
- acyl
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 hydroxy, amino Chemical group 0.000 claims 16
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 10
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000002252 acyl group Chemical group 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 claims 6
- 108091034117 Oligonucleotide Proteins 0.000 claims 6
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 6
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 6
- 239000000074 antisense oligonucleotide Substances 0.000 claims 6
- 238000012230 antisense oligonucleotides Methods 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 108091030071 RNAI Proteins 0.000 claims 5
- 230000009368 gene silencing by RNA Effects 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical group C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- IIQIEMHSDLLZQA-QZPVEUDVSA-N n-((9s,10r,11r,13r)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1h,9h-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-n-methyl-benzamide Chemical compound CN([C@H]1[C@@]([C@]2(C)O[C@H]1N1C3=CC=CC=C3C3=C4C(=O)NCC4=C4C5=CC=CC=C5N2C4=C31)(C)OC)C(=O)C1=CC=CC=C1 IIQIEMHSDLLZQA-QZPVEUDVSA-N 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
- 229960002411 imatinib Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 0 BC1(C=CC(N(C)C[C@]2C(C(*)=*)=C(*=O)c3c[n](*)c4c3C=CC(*)(*)*=C4)=C2C=C1)I Chemical compound BC1(C=CC(N(C)C[C@]2C(C(*)=*)=C(*=O)c3c[n](*)c4c3C=CC(*)(*)*=C4)=C2C=C1)I 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0612542.1A GB0612542D0 (en) | 2006-06-23 | 2006-06-23 | Combinations comprising staurosporines |
| PCT/EP2007/005517 WO2007147613A2 (en) | 2006-06-23 | 2007-06-22 | Combinations comprising staurosprorines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009541240A JP2009541240A (ja) | 2009-11-26 |
| JP2009541240A5 true JP2009541240A5 (enExample) | 2010-08-05 |
Family
ID=36803826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515774A Pending JP2009541240A (ja) | 2006-06-23 | 2007-06-22 | スタウロスポリンを含む組み合わせ |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100184820A1 (enExample) |
| EP (1) | EP2037933A2 (enExample) |
| JP (1) | JP2009541240A (enExample) |
| KR (1) | KR20090033874A (enExample) |
| CN (1) | CN101505760A (enExample) |
| AU (1) | AU2007263278A1 (enExample) |
| BR (1) | BRPI0713730A2 (enExample) |
| CA (1) | CA2655724A1 (enExample) |
| GB (1) | GB0612542D0 (enExample) |
| MX (1) | MX2008016488A (enExample) |
| RU (1) | RU2009101972A (enExample) |
| WO (1) | WO2007147613A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143578A1 (en) * | 2008-05-28 | 2009-12-03 | The Council Of The Queensland Institute Of Medical Research | Cancer drug target and methods of diagnosis and therapy |
| CN102101866A (zh) * | 2010-11-04 | 2011-06-22 | 中国海洋大学 | 十字孢碱卤代衍生物及其制备方法和应用 |
| FI20115640A0 (fi) * | 2011-06-22 | 2011-06-22 | Turun Yliopisto | Yhdistelmähoito |
| FI20115876A0 (fi) | 2011-09-06 | 2011-09-06 | Turun Yliopisto | Yhdistelmähoito |
| CA2878873C (en) | 2012-07-13 | 2018-08-21 | Turun Yliopisto | A pharmaceutical combination including a histone deacetylase 4 (hdac4) silencing agent for treating cancer |
| CN110526903B (zh) * | 2016-06-01 | 2021-12-10 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
| CN106083830B (zh) * | 2016-06-01 | 2019-07-12 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
| SG10201607303YA (en) * | 2016-09-01 | 2018-04-27 | Agency Science Tech & Res | Antisense oligonucleotides to induce exon skipping |
| WO2019000224A1 (zh) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
| CN107569491A (zh) * | 2017-08-30 | 2018-01-12 | 杭州科兴生物化工有限公司 | 一种星孢菌素类化合物的应用 |
| TWI861509B (zh) | 2021-06-11 | 2024-11-11 | 美商基利科學股份有限公司 | Mcl-1抑制劑與抗體藥物接合物之組合 |
| JP7900421B2 (ja) | 2021-06-11 | 2026-08-04 | ギリアード サイエンシーズ， インコーポレイテッド | Ｍｃｌ－１阻害剤と抗がん剤との組み合わせ |
| CN114437109B (zh) * | 2022-03-08 | 2023-09-29 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一种十字孢碱卤代衍生物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001992A (en) * | 1999-01-07 | 1999-12-14 | Isis Pharmaceuticals Inc. | Antisense modulation of novel anti-apoptotic bcl-2-related proteins |
| PT1441737E (pt) * | 2001-10-30 | 2006-12-29 | Dana Farber Cancer Inst Inc | Derivados de estrutura como inibidores da actividade do receptor de tirosina cinase flt3 |
| EP1653973A1 (en) * | 2003-08-08 | 2006-05-10 | Novartis AG | Combinations comprising staurosporines |
-
2006
- 2006-06-23 GB GBGB0612542.1A patent/GB0612542D0/en not_active Ceased
-
2007
- 2007-06-22 CA CA002655724A patent/CA2655724A1/en not_active Abandoned
- 2007-06-22 MX MX2008016488A patent/MX2008016488A/es not_active Application Discontinuation
- 2007-06-22 US US12/305,390 patent/US20100184820A1/en not_active Abandoned
- 2007-06-22 JP JP2009515774A patent/JP2009541240A/ja active Pending
- 2007-06-22 CN CNA200780030602XA patent/CN101505760A/zh active Pending
- 2007-06-22 AU AU2007263278A patent/AU2007263278A1/en not_active Abandoned
- 2007-06-22 EP EP07764787A patent/EP2037933A2/en not_active Withdrawn
- 2007-06-22 KR KR1020097001396A patent/KR20090033874A/ko not_active Withdrawn
- 2007-06-22 BR BRPI0713730-3A patent/BRPI0713730A2/pt not_active IP Right Cessation
- 2007-06-22 WO PCT/EP2007/005517 patent/WO2007147613A2/en not_active Ceased
- 2007-06-22 RU RU2009101972/15A patent/RU2009101972A/ru unknown
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