JP2009541240A5 - - Google Patents

Info

Publication number

JP2009541240A5

JP2009541240A5 JP2009515774A JP2009515774A JP2009541240A5 JP 2009541240 A5 JP2009541240 A5 JP 2009541240A5 JP 2009515774 A JP2009515774 A JP 2009515774A JP 2009515774 A JP2009515774 A JP 2009515774A JP 2009541240 A5 JP2009541240 A5 JP 2009541240A5

Authority

JP

Japan

Prior art keywords

hydrogen

mcl

seq

acyl

lower alkyl

Prior art date

2007-06-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• -1 hydroxy, amino Chemical group 0.000 claims 16
• 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 10
• 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 10
• 239000001257 hydrogen Substances 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 9
• 125000002252 acyl group Chemical group 0.000 claims 8
• 125000004432 carbon atom Chemical group C* 0.000 claims 7
• FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 claims 6
• 108091034117 Oligonucleotide Proteins 0.000 claims 6
• 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 6
• 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 6
• 239000000074 antisense oligonucleotide Substances 0.000 claims 6
• 238000012230 antisense oligonucleotides Methods 0.000 claims 6
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
• 239000003112 inhibitor Substances 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
• 108091030071 RNAI Proteins 0.000 claims 5
• 230000009368 gene silencing by RNA Effects 0.000 claims 5
• 150000002431 hydrogen Chemical class 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical group C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 claims 5
• 206010009944 Colon cancer Diseases 0.000 claims 4
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
• 206010025323 Lymphomas Diseases 0.000 claims 3
• 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 125000005037 alkyl phenyl group Chemical group 0.000 claims 3
• 230000000295 complement effect Effects 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 208000032839 leukemia Diseases 0.000 claims 3
• IIQIEMHSDLLZQA-QZPVEUDVSA-N n-((9s,10r,11r,13r)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1h,9h-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-n-methyl-benzamide Chemical compound CN([C@H]1[C@@]([C@]2(C)O[C@H]1N1C3=CC=CC=C3C3=C4C(=O)NCC4=C4C5=CC=CC=C5N2C4=C31)(C)OC)C(=O)C1=CC=CC=C1 IIQIEMHSDLLZQA-QZPVEUDVSA-N 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 239000013598 vector Substances 0.000 claims 3
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
• 108091027967 Small hairpin RNA Proteins 0.000 claims 2
• 125000001931 aliphatic group Chemical group 0.000 claims 2
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
• 125000005036 alkoxyphenyl group Chemical group 0.000 claims 2
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
• 125000002837 carbocyclic group Chemical group 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229910052736 halogen Inorganic materials 0.000 claims 2
• 150000002367 halogens Chemical class 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 239000004055 small Interfering RNA Substances 0.000 claims 2
• 125000000547 substituted alkyl group Chemical group 0.000 claims 2
• 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 2
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
• 239000005517 L01XE01 - Imatinib Substances 0.000 claims 1
• KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
• 229960002411 imatinib Drugs 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
• 0 BC1(C=CC(N(C)C[C@]2C(C(*)=*)=C(*=O)c3c[n](*)c4c3C=CC(*)(*)*=C4)=C2C=C1)I Chemical compound BC1(C=CC(N(C)C[C@]2C(C(*)=*)=C(*=O)c3c[n](*)c4c3C=CC(*)(*)*=C4)=C2C=C1)I 0.000 description 1