CN101505760A - 包含星形孢菌素类的组合 - Google Patents

包含星形孢菌素类的组合 Download PDF

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Publication number
CN101505760A
CN101505760A CNA200780030602XA CN200780030602A CN101505760A CN 101505760 A CN101505760 A CN 101505760A CN A200780030602X A CNA200780030602X A CN A200780030602XA CN 200780030602 A CN200780030602 A CN 200780030602A CN 101505760 A CN101505760 A CN 101505760A
Authority
CN
China
Prior art keywords
mcl
lower alkyl
typically
group
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200780030602XA
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English (en)
Chinese (zh)
Inventor
P·瓦伦特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN101505760A publication Critical patent/CN101505760A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA200780030602XA 2006-06-23 2007-06-22 包含星形孢菌素类的组合 Pending CN101505760A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0612542.1A GB0612542D0 (en) 2006-06-23 2006-06-23 Combinations comprising staurosporines
GB0612542.1 2006-06-23

Publications (1)

Publication Number Publication Date
CN101505760A true CN101505760A (zh) 2009-08-12

Family

ID=36803826

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200780030602XA Pending CN101505760A (zh) 2006-06-23 2007-06-22 包含星形孢菌素类的组合

Country Status (12)

Country Link
US (1) US20100184820A1 (enExample)
EP (1) EP2037933A2 (enExample)
JP (1) JP2009541240A (enExample)
KR (1) KR20090033874A (enExample)
CN (1) CN101505760A (enExample)
AU (1) AU2007263278A1 (enExample)
BR (1) BRPI0713730A2 (enExample)
CA (1) CA2655724A1 (enExample)
GB (1) GB0612542D0 (enExample)
MX (1) MX2008016488A (enExample)
RU (1) RU2009101972A (enExample)
WO (1) WO2007147613A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106083830A (zh) * 2016-06-01 2016-11-09 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN106146475A (zh) * 2016-06-01 2016-11-23 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN107569491A (zh) * 2017-08-30 2018-01-12 杭州科兴生物化工有限公司 一种星孢菌素类化合物的应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009143578A1 (en) * 2008-05-28 2009-12-03 The Council Of The Queensland Institute Of Medical Research Cancer drug target and methods of diagnosis and therapy
CN102101866A (zh) * 2010-11-04 2011-06-22 中国海洋大学 十字孢碱卤代衍生物及其制备方法和应用
FI20115640A0 (fi) * 2011-06-22 2011-06-22 Turun Yliopisto Yhdistelmähoito
FI20115876A0 (fi) 2011-09-06 2011-09-06 Turun Yliopisto Yhdistelmähoito
CN104619845A (zh) 2012-07-13 2015-05-13 图尔库大学 联合治疗iii
SG10201607303YA (en) 2016-09-01 2018-04-27 Agency Science Tech & Res Antisense oligonucleotides to induce exon skipping
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
EP4351564A1 (en) 2021-06-11 2024-04-17 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-cancer agents
US11931424B2 (en) 2021-06-11 2024-03-19 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-body drug conjugates
CN114437109B (zh) * 2022-03-08 2023-09-29 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种十字孢碱卤代衍生物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001992A (en) * 1999-01-07 1999-12-14 Isis Pharmaceuticals Inc. Antisense modulation of novel anti-apoptotic bcl-2-related proteins
US7973031B2 (en) * 2001-10-30 2011-07-05 Novartis Ag Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity
CA2533861A1 (en) * 2003-08-08 2005-02-17 Novartis Ag Combinations comprising staurosporines

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106083830A (zh) * 2016-06-01 2016-11-09 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN106146475A (zh) * 2016-06-01 2016-11-23 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN106146475B (zh) * 2016-06-01 2019-05-17 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN110218206A (zh) * 2016-06-01 2019-09-10 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN110218206B (zh) * 2016-06-01 2022-03-04 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
CN107569491A (zh) * 2017-08-30 2018-01-12 杭州科兴生物化工有限公司 一种星孢菌素类化合物的应用

Also Published As

Publication number Publication date
WO2007147613A3 (en) 2008-07-03
EP2037933A2 (en) 2009-03-25
KR20090033874A (ko) 2009-04-06
AU2007263278A1 (en) 2007-12-27
WO2007147613A2 (en) 2007-12-27
BRPI0713730A2 (pt) 2012-10-30
MX2008016488A (es) 2009-01-22
RU2009101972A (ru) 2010-07-27
JP2009541240A (ja) 2009-11-26
US20100184820A1 (en) 2010-07-22
CA2655724A1 (en) 2007-12-27
GB0612542D0 (en) 2006-08-02

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Application publication date: 20090812