JP2009507079A5 - - Google Patents
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- Publication number
- JP2009507079A5 JP2009507079A5 JP2008530175A JP2008530175A JP2009507079A5 JP 2009507079 A5 JP2009507079 A5 JP 2009507079A5 JP 2008530175 A JP2008530175 A JP 2008530175A JP 2008530175 A JP2008530175 A JP 2008530175A JP 2009507079 A5 JP2009507079 A5 JP 2009507079A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- lower alkyl
- heteroaryl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C1)=C(*)C=C(C)[C@@]1C(C(*)C(*)*)=CC*O* Chemical compound CC(C1)=C(*)C=C(C)[C@@]1C(C(*)C(*)*)=CC*O* 0.000 description 4
- YKFAFWKDOSYQIP-UHFFFAOYSA-N CCc(cc1)ccc1C(N)=O Chemical compound CCc(cc1)ccc1C(N)=O YKFAFWKDOSYQIP-UHFFFAOYSA-N 0.000 description 1
- DGAGEFUEKIORSQ-UHFFFAOYSA-N CCc1ccc(CN)cc1 Chemical compound CCc1ccc(CN)cc1 DGAGEFUEKIORSQ-UHFFFAOYSA-N 0.000 description 1
- VJXRKZJMGVSXPX-UHFFFAOYSA-N CCc1ccncc1 Chemical compound CCc1ccncc1 VJXRKZJMGVSXPX-UHFFFAOYSA-N 0.000 description 1
- MFEIKQPHQINPRI-UHFFFAOYSA-N CCc1cnccc1 Chemical compound CCc1cnccc1 MFEIKQPHQINPRI-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- FKNQCJSGGFJEIZ-UHFFFAOYSA-N Cc1ccncc1 Chemical compound Cc1ccncc1 FKNQCJSGGFJEIZ-UHFFFAOYSA-N 0.000 description 1
- ITQTTZVARXURQS-UHFFFAOYSA-N Cc1cnccc1 Chemical compound Cc1cnccc1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71532705P | 2005-09-07 | 2005-09-07 | |
| PCT/US2006/034747 WO2007030559A2 (en) | 2005-09-07 | 2006-09-06 | 1, 3-disubstituted indole derivatives for use as ppar modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009507079A JP2009507079A (ja) | 2009-02-19 |
| JP2009507079A5 true JP2009507079A5 (https=) | 2009-11-05 |
Family
ID=37685960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008530175A Pending JP2009507079A (ja) | 2005-09-07 | 2006-09-06 | Ｐｐａｒ活性化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070072904A1 (https=) |
| EP (1) | EP1943245A2 (https=) |
| JP (1) | JP2009507079A (https=) |
| KR (1) | KR20080047591A (https=) |
| CN (1) | CN101304992A (https=) |
| AU (1) | AU2006287513A1 (https=) |
| BR (1) | BRPI0615929A2 (https=) |
| CA (1) | CA2621474A1 (https=) |
| CR (1) | CR9868A (https=) |
| EC (1) | ECSP088352A (https=) |
| IL (1) | IL189776A0 (https=) |
| NO (1) | NO20081041L (https=) |
| NZ (1) | NZ567162A (https=) |
| RU (1) | RU2419618C2 (https=) |
| SG (1) | SG165362A1 (https=) |
| WO (1) | WO2007030559A2 (https=) |
| ZA (1) | ZA200802007B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1990335A4 (en) | 2006-03-02 | 2009-11-11 | Astellas Pharma Inc | 17-BETA-HSD-type-5 INHIBITOR |
| ES2452343T3 (es) | 2006-09-29 | 2014-04-01 | Glaxosmithkline Llc | Compuestos de indol sustituidos |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| RU2009137190A (ru) * | 2007-03-08 | 2011-04-20 | Плексксикон, Инк. (Us) | Соединения, обладающие активностью в отношении ppar |
| CN101686939B (zh) * | 2007-04-17 | 2013-03-27 | 巴克斯特国际公司 | 用于肺部投送的核酸微粒 |
| JP2010533729A (ja) | 2007-07-17 | 2010-10-28 | プレキシコン，インコーポレーテッド | キナーゼ調節のための化合物と方法、及びそのための適応 |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| FR2950053B1 (fr) * | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| US8673928B2 (en) | 2009-11-18 | 2014-03-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN102753549A (zh) | 2009-12-23 | 2012-10-24 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
| KR101911972B1 (ko) | 2011-02-07 | 2018-10-25 | 플렉시콘 인코퍼레이티드 | 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 |
| AU2012255275B2 (en) | 2011-05-17 | 2016-01-28 | Plexxikon Inc. | Kinase modulation and indications therefor |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| MX2015002887A (es) | 2012-09-06 | 2015-07-06 | Plexxikon Inc | Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello. |
| EP2903615B1 (en) * | 2012-10-05 | 2021-04-07 | Merck Sharp & Dohme Corp. | 5-pyridin-3-yl-2,3-dihydro-1h-indole derivatives as aldosterone synthase (cyp11b2) inhibitors for the treatment of hypertension |
| EP2935248B1 (en) | 2012-12-21 | 2018-02-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| SG11201506687RA (en) | 2013-03-15 | 2015-09-29 | Plexxikon Inc | Heterocyclic compounds and uses thereof |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| EP3004060B1 (en) | 2013-05-30 | 2019-11-27 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
| WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| KR101585605B1 (ko) * | 2014-03-20 | 2016-01-21 | 현대약품 주식회사 | Pparg에 결합하되 증진제로 작용하지 않는 화합물 및 이를 유효성분으로 함유하는 pparg 관련 질병의 치료용 약학적 조성물 |
| JP6557684B2 (ja) | 2014-06-13 | 2019-08-07 | インベンティバ | 線維性疾患の治療に用いられるｐｐａｒ化合物 |
| CA2961356C (en) | 2014-09-15 | 2023-03-07 | Plexxikon Inc. | Heterocyclic compounds and their uses in modulating bromodomain and for treating diseases or conditions relevant thereto |
| US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN108137585B (zh) | 2015-09-21 | 2021-10-22 | 普莱希科公司 | 杂环化合物及其应用 |
| RU2018123825A (ru) | 2015-12-07 | 2020-01-15 | Плексксикон Инк. | Соединения и способы для модуляции киназ, и показания для этого |
| JP6586528B2 (ja) * | 2015-12-21 | 2019-10-02 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 新規の１，２，３−トリアゾール−チアゾール化合物とその調製方法と利用 |
| WO2017161045A1 (en) | 2016-03-16 | 2017-09-21 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| US10703757B2 (en) | 2016-12-23 | 2020-07-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| WO2018165501A1 (en) * | 2017-03-10 | 2018-09-13 | Lycera Corporation | INDOLINYL SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATMENT OF DISEASE |
| JP2020511467A (ja) | 2017-03-20 | 2020-04-16 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | ブロモドメインを阻害する４−（１−（１，１−ジ（ピリジン−２−イル）エチル）−６−（３，５−ジメチルイソオキサゾール−４−イル）−１Ｈ−ピロロ［３，２−ｂ］ピリジン−３−イル）安息香酸の結晶形 |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| BR112019028235B1 (pt) | 2017-07-25 | 2024-04-30 | Plexxikon, Inc. | Composições e seus métodos de preparação |
| JP7675519B2 (ja) | 2017-10-13 | 2025-05-13 | オプナ バイオ ソシエテ アノニム | キナーゼを調節するための化合物の固体形態 |
| WO2019084462A1 (en) | 2017-10-27 | 2019-05-02 | Plexxikon Inc. | FORMULATION OF A COMPOUND MODULATING KINASES |
| AU2019239952A1 (en) | 2018-03-20 | 2020-10-08 | Plexxikon Inc. | Compounds and methods for IDO and TDO modulation, and indications therefor |
| CN115605460A (zh) | 2020-04-29 | 2023-01-13 | 普莱希科公司（Us） | 杂环化合物的合成 |
| KR102772169B1 (ko) * | 2021-05-28 | 2025-02-26 | 서울대학교산학협력단 | 신규 인돌 감마 락탐 화합물 및 이를 유효성분으로 포함하는 저아디포넥틴혈증 관련 질환의 예방, 개선 또는 치료용 조성물 |
| CN115504925B (zh) * | 2021-06-22 | 2024-03-12 | 广东药科大学 | 一类ppar激动剂、其制备方法及其作为药物的用途 |
| WO2025019330A1 (en) | 2023-07-14 | 2025-01-23 | Pleiogenix Inc. | Methods of treating fibrotic liver diseases or conditions with indeglitazar |
Family Cites Families (34)
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| US3489767A (en) * | 1966-01-12 | 1970-01-13 | Sumitomo Chemical Co | 1-(phenylsulfonyl)-3-indolyl aliphatic acid derivatives |
| US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| GB1573212A (en) * | 1976-04-15 | 1980-08-20 | Technicon Instr | Immunoassay for gentamicin |
| DE3246932A1 (de) * | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US4626513A (en) * | 1983-11-10 | 1986-12-02 | Massachusetts General Hospital | Method and apparatus for ligand detection |
| GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
| US5688655A (en) * | 1988-02-10 | 1997-11-18 | Ict Pharmaceuticals, Inc. | Method of screening for protein inhibitors and activators |
| EP0610793A1 (en) * | 1993-02-08 | 1994-08-17 | Takeda Chemical Industries, Ltd. | Tetracyclic morpholine derivatives and their use or analgesics |
| JP3394777B2 (ja) * | 1993-05-27 | 2003-04-07 | セレクタイド コーポレーション | 位相学的に分離された、コードされた固相ライブラリー |
| US5840485A (en) * | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
| ATE203012T1 (de) * | 1994-03-30 | 2001-07-15 | Zeria Pharm Co Ltd | 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen |
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| US5747276A (en) * | 1995-09-15 | 1998-05-05 | The Scripps Research Institute | Screening methods for the identification of novel antibiotics |
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| US6178384B1 (en) * | 1997-09-29 | 2001-01-23 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for selecting a molecule based on conformational free energy |
| HU227568B1 (en) * | 1997-12-24 | 2011-08-29 | Sanofi Aventis Deutschland | Indole derivatives, as inhibitors os factor xa |
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| BRPI0314042B8 (pt) * | 2002-09-06 | 2021-05-25 | Calando Pharmaceuticals Inc | polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência |
| US7268174B2 (en) * | 2003-07-11 | 2007-09-11 | Siemens Power Generation, Inc. | Homogeneous alumoxane-LCT-epoxy polymers and methods for making the same |
| US7348338B2 (en) * | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| EP1648867B1 (en) * | 2003-07-17 | 2013-09-04 | Plexxikon Inc. | Ppar active compounds |
| WO2005060958A1 (en) * | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
-
2006
- 2006-09-06 RU RU2008110697/04A patent/RU2419618C2/ru not_active IP Right Cessation
- 2006-09-06 KR KR1020087008157A patent/KR20080047591A/ko not_active Ceased
- 2006-09-06 US US11/517,573 patent/US20070072904A1/en not_active Abandoned
- 2006-09-06 SG SG201006563-9A patent/SG165362A1/en unknown
- 2006-09-06 NZ NZ567162A patent/NZ567162A/en unknown
- 2006-09-06 WO PCT/US2006/034747 patent/WO2007030559A2/en not_active Ceased
- 2006-09-06 CN CNA2006800396498A patent/CN101304992A/zh active Pending
- 2006-09-06 AU AU2006287513A patent/AU2006287513A1/en not_active Abandoned
- 2006-09-06 JP JP2008530175A patent/JP2009507079A/ja active Pending
- 2006-09-06 EP EP06803059A patent/EP1943245A2/en not_active Withdrawn
- 2006-09-06 CA CA002621474A patent/CA2621474A1/en not_active Abandoned
- 2006-09-06 BR BRPI0615929-0A patent/BRPI0615929A2/pt not_active IP Right Cessation
-
2008
- 2008-02-26 IL IL189776A patent/IL189776A0/en unknown
- 2008-02-28 NO NO20081041A patent/NO20081041L/no not_active Application Discontinuation
- 2008-03-03 ZA ZA200802007A patent/ZA200802007B/xx unknown
- 2008-04-04 CR CR9868A patent/CR9868A/es not_active Application Discontinuation
- 2008-04-07 EC EC2008008352A patent/ECSP088352A/es unknown
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