JP2009507079A5 - - Google Patents
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- Publication number
- JP2009507079A5 JP2009507079A5 JP2008530175A JP2008530175A JP2009507079A5 JP 2009507079 A5 JP2009507079 A5 JP 2009507079A5 JP 2008530175 A JP2008530175 A JP 2008530175A JP 2008530175 A JP2008530175 A JP 2008530175A JP 2009507079 A5 JP2009507079 A5 JP 2009507079A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- lower alkyl
- heteroaryl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C1)=C(*)C=C(C)[C@@]1C(C(*)C(*)*)=CC*O* Chemical compound CC(C1)=C(*)C=C(C)[C@@]1C(C(*)C(*)*)=CC*O* 0.000 description 4
- YKFAFWKDOSYQIP-UHFFFAOYSA-N CCc(cc1)ccc1C(N)=O Chemical compound CCc(cc1)ccc1C(N)=O YKFAFWKDOSYQIP-UHFFFAOYSA-N 0.000 description 1
- DGAGEFUEKIORSQ-UHFFFAOYSA-N CCc1ccc(CN)cc1 Chemical compound CCc1ccc(CN)cc1 DGAGEFUEKIORSQ-UHFFFAOYSA-N 0.000 description 1
- VJXRKZJMGVSXPX-UHFFFAOYSA-N CCc1ccncc1 Chemical compound CCc1ccncc1 VJXRKZJMGVSXPX-UHFFFAOYSA-N 0.000 description 1
- MFEIKQPHQINPRI-UHFFFAOYSA-N CCc1cnccc1 Chemical compound CCc1cnccc1 MFEIKQPHQINPRI-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- FKNQCJSGGFJEIZ-UHFFFAOYSA-N Cc1ccncc1 Chemical compound Cc1ccncc1 FKNQCJSGGFJEIZ-UHFFFAOYSA-N 0.000 description 1
- ITQTTZVARXURQS-UHFFFAOYSA-N Cc1cnccc1 Chemical compound Cc1cnccc1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71532705P | 2005-09-07 | 2005-09-07 | |
| PCT/US2006/034747 WO2007030559A2 (en) | 2005-09-07 | 2006-09-06 | 1, 3-disubstituted indole derivatives for use as ppar modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009507079A JP2009507079A (ja) | 2009-02-19 |
| JP2009507079A5 true JP2009507079A5 (https=) | 2009-11-05 |
Family
ID=37685960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008530175A Pending JP2009507079A (ja) | 2005-09-07 | 2006-09-06 | Ｐｐａｒ活性化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070072904A1 (https=) |
| EP (1) | EP1943245A2 (https=) |
| JP (1) | JP2009507079A (https=) |
| KR (1) | KR20080047591A (https=) |
| CN (1) | CN101304992A (https=) |
| AU (1) | AU2006287513A1 (https=) |
| BR (1) | BRPI0615929A2 (https=) |
| CA (1) | CA2621474A1 (https=) |
| CR (1) | CR9868A (https=) |
| EC (1) | ECSP088352A (https=) |
| IL (1) | IL189776A0 (https=) |
| NO (1) | NO20081041L (https=) |
| NZ (1) | NZ567162A (https=) |
| RU (1) | RU2419618C2 (https=) |
| SG (1) | SG165362A1 (https=) |
| WO (1) | WO2007030559A2 (https=) |
| ZA (1) | ZA200802007B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080114711A (ko) * | 2006-03-02 | 2008-12-31 | 아스텔라스세이야쿠 가부시키가이샤 | 17β ＨＳＤ 타입 5 저해제 |
| JP5275236B2 (ja) | 2006-09-29 | 2013-08-28 | スミスクライン ビーチャム コーポレーション | 置換されたインドール化合物 |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| EP2121591A2 (en) * | 2007-03-08 | 2009-11-25 | Plexxikon, Inc. | Ppar active compounds |
| PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| CN101686939B (zh) * | 2007-04-17 | 2013-03-27 | 巴克斯特国际公司 | 用于肺部投送的核酸微粒 |
| WO2009012283A1 (en) | 2007-07-17 | 2009-01-22 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| FR2950053B1 (fr) * | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| ES2627911T3 (es) | 2009-11-18 | 2017-08-01 | Plexxikon, Inc. | Derivados de N-[2-fluoro-3-(4-amino-7H-pirrolo[2,3-d]pirimidin-5-carbonil)-fenil]-4-bencenosulfonamida como moduladores de la proteína quinasa Raf para el tratamiento del cáncer |
| BR112012015745A2 (pt) | 2009-12-23 | 2016-05-17 | Plexxikon Inc | compostos e métodos para a modulação de quinase, e indicações dos mesmos |
| TWI510487B (zh) | 2010-04-21 | 2015-12-01 | Plexxikon Inc | 用於激酶調節的化合物和方法及其適應症 |
| US9624213B2 (en) | 2011-02-07 | 2017-04-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP6113151B2 (ja) | 2011-05-17 | 2017-04-12 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼ調節およびその適応症 |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| EP2892534B8 (en) | 2012-09-06 | 2021-09-15 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CA2886117C (en) | 2012-10-05 | 2022-05-31 | Merck Sharp & Dohme Corp. | Indoline compounds and their use as aldosterone synthase inhibitors |
| MX365640B (es) | 2012-12-21 | 2019-06-10 | Plexxikon Inc | Compuestos y metodos para la modulacion de quinasas y sus indicaciones. |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| DK2970265T3 (en) | 2013-03-15 | 2018-10-01 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF |
| CN105228983A (zh) | 2013-05-30 | 2016-01-06 | 普莱希科公司 | 用于激酶调节的化合物及其适应症 |
| US9771369B2 (en) | 2014-03-04 | 2017-09-26 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| KR101585605B1 (ko) * | 2014-03-20 | 2016-01-21 | 현대약품 주식회사 | Pparg에 결합하되 증진제로 작용하지 않는 화합물 및 이를 유효성분으로 함유하는 pparg 관련 질병의 치료용 약학적 조성물 |
| EA036342B1 (ru) * | 2014-06-13 | 2020-10-29 | Инвентива | Применение панагониста ppar, а именно 5-хлор-1-[(6-бензотиазолил)сульфонил]-1н-индол-2-бутановой кислоты, для лечения фибротических состояний |
| ES2774177T3 (es) | 2014-09-15 | 2020-07-17 | Plexxikon Inc | Compuestos heterocíclicos y usos de estos |
| WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| ES2913048T3 (es) | 2015-09-21 | 2022-05-31 | Opna Immuno Oncology Sa | Compuestos heterocíclicos y usos de estos |
| MX2018006856A (es) | 2015-12-07 | 2018-08-01 | Plexxikon Inc | Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos. |
| WO2017109793A1 (en) * | 2015-12-21 | 2017-06-29 | Council Of Scientific & Industrial Research | Novel 1,2,3 triazole-thiazole compounds, process for preparation and use thereof |
| ES2904615T3 (es) | 2016-03-16 | 2022-04-05 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones al respecto |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| EP3558991A2 (en) | 2016-12-23 | 2019-10-30 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| WO2018165501A1 (en) * | 2017-03-10 | 2018-09-13 | Lycera Corporation | INDOLINYL SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATMENT OF DISEASE |
| JP2020511467A (ja) | 2017-03-20 | 2020-04-16 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | ブロモドメインを阻害する４−（１−（１，１−ジ（ピリジン−２−イル）エチル）−６−（３，５−ジメチルイソオキサゾール−４−イル）−１Ｈ−ピロロ［３，２−ｂ］ピリジン−３−イル）安息香酸の結晶形 |
| WO2018226846A1 (en) | 2017-06-07 | 2018-12-13 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| AU2018307910B2 (en) | 2017-07-25 | 2024-07-25 | Daiichi Sankyo Company, Limited | Formulations of a compound modulating kinases |
| US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
| AU2018354423B2 (en) | 2017-10-27 | 2024-11-07 | Plexxikon Inc. | Formulations of a compound modulating kinases |
| EP3768666A1 (en) | 2018-03-20 | 2021-01-27 | Plexxikon Inc. | Compounds and methods for ido and tdo modulation, and indications therefor |
| WO2021222442A1 (en) | 2020-04-29 | 2021-11-04 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| KR102772169B1 (ko) * | 2021-05-28 | 2025-02-26 | 서울대학교산학협력단 | 신규 인돌 감마 락탐 화합물 및 이를 유효성분으로 포함하는 저아디포넥틴혈증 관련 질환의 예방, 개선 또는 치료용 조성물 |
| CN115504925B (zh) * | 2021-06-22 | 2024-03-12 | 广东药科大学 | 一类ppar激动剂、其制备方法及其作为药物的用途 |
| WO2025019330A1 (en) | 2023-07-14 | 2025-01-23 | Pleiogenix Inc. | Methods of treating fibrotic liver diseases or conditions with indeglitazar |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489767A (en) * | 1966-01-12 | 1970-01-13 | Sumitomo Chemical Co | 1-(phenylsulfonyl)-3-indolyl aliphatic acid derivatives |
| US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| GB1573212A (en) * | 1976-04-15 | 1980-08-20 | Technicon Instr | Immunoassay for gentamicin |
| DE3246932A1 (de) * | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US4626513A (en) * | 1983-11-10 | 1986-12-02 | Massachusetts General Hospital | Method and apparatus for ligand detection |
| GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
| US5688655A (en) * | 1988-02-10 | 1997-11-18 | Ict Pharmaceuticals, Inc. | Method of screening for protein inhibitors and activators |
| US5466689A (en) * | 1993-02-08 | 1995-11-14 | Takeda Chemical Industries, Ltd. | Morpholine derivatives and their use |
| US5840485A (en) * | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
| DK0705279T3 (da) * | 1993-05-27 | 2003-06-10 | Selectide Corp | Topologisk adskilte, kodende fastfase-biblioteker |
| DE69521687T2 (de) * | 1994-03-30 | 2001-10-25 | Zeria Pharmaceutical Co., Ltd. | 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen |
| US5763198A (en) * | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
| US5747276A (en) * | 1995-09-15 | 1998-05-05 | The Scripps Research Institute | Screening methods for the identification of novel antibiotics |
| US6294330B1 (en) * | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
| AU6443498A (en) * | 1997-03-07 | 1998-09-22 | Tropix, Inc. | Protease inhibtor assay |
| US6178384B1 (en) * | 1997-09-29 | 2001-01-23 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for selecting a molecule based on conformational free energy |
| DK1042287T3 (da) * | 1997-12-24 | 2005-08-15 | Aventis Pharma Gmbh | Indolderivater som inhibitorer af faktor Xa |
| US6331537B1 (en) * | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| US6288234B1 (en) * | 1998-06-08 | 2001-09-11 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| TNSN99224A1 (fr) * | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| YU72201A (sh) * | 1999-04-28 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | Derivati di-aril kiseline kao ppar receptorski ligandi |
| US6939090B1 (en) * | 1999-08-17 | 2005-09-06 | Mitsubishi Materials Corporation | Throwaway tip and throwaway-type cutting tool |
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| CN101444496B (zh) * | 2001-06-12 | 2011-04-13 | 维尔斯达医疗公司 | 用于治疗代谢失调的化合物 |
| BR0212512A (pt) * | 2001-09-14 | 2004-10-26 | Tularik Inc | Composto, composição farmacêutica e métodos para tratar um distúrbio, condição ou doença, elevar os nìveis do colesterol hdl, reduzir os nìveis de triglicerìdeo, tratar diabete, diminuir a resistência à insulina ou diminuir a pressão arterial e modular a ppardelta |
| US7259175B2 (en) * | 2002-02-25 | 2007-08-21 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
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| ES2377318T3 (es) * | 2002-09-06 | 2012-03-26 | Cerulean Pharma Inc. | Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos |
| US7268174B2 (en) * | 2003-07-11 | 2007-09-11 | Siemens Power Generation, Inc. | Homogeneous alumoxane-LCT-epoxy polymers and methods for making the same |
| CA2532403A1 (en) * | 2003-07-17 | 2005-02-03 | James Arnold | Ppar active compounds |
| US7348338B2 (en) * | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| WO2005060958A1 (en) * | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
-
2006
- 2006-09-06 WO PCT/US2006/034747 patent/WO2007030559A2/en not_active Ceased
- 2006-09-06 EP EP06803059A patent/EP1943245A2/en not_active Withdrawn
- 2006-09-06 US US11/517,573 patent/US20070072904A1/en not_active Abandoned
- 2006-09-06 SG SG201006563-9A patent/SG165362A1/en unknown
- 2006-09-06 RU RU2008110697/04A patent/RU2419618C2/ru not_active IP Right Cessation
- 2006-09-06 CN CNA2006800396498A patent/CN101304992A/zh active Pending
- 2006-09-06 BR BRPI0615929-0A patent/BRPI0615929A2/pt not_active IP Right Cessation
- 2006-09-06 AU AU2006287513A patent/AU2006287513A1/en not_active Abandoned
- 2006-09-06 KR KR1020087008157A patent/KR20080047591A/ko not_active Ceased
- 2006-09-06 NZ NZ567162A patent/NZ567162A/en unknown
- 2006-09-06 CA CA002621474A patent/CA2621474A1/en not_active Abandoned
- 2006-09-06 JP JP2008530175A patent/JP2009507079A/ja active Pending
-
2008
- 2008-02-26 IL IL189776A patent/IL189776A0/en unknown
- 2008-02-28 NO NO20081041A patent/NO20081041L/no not_active Application Discontinuation
- 2008-03-03 ZA ZA200802007A patent/ZA200802007B/xx unknown
- 2008-04-04 CR CR9868A patent/CR9868A/es not_active Application Discontinuation
- 2008-04-07 EC EC2008008352A patent/ECSP088352A/es unknown
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