JP2009507073A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009507073A5 JP2009507073A5 JP2008530093A JP2008530093A JP2009507073A5 JP 2009507073 A5 JP2009507073 A5 JP 2009507073A5 JP 2008530093 A JP2008530093 A JP 2008530093A JP 2008530093 A JP2008530093 A JP 2008530093A JP 2009507073 A5 JP2009507073 A5 JP 2009507073A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- aryl
- group
- heterocycloalkyl
- alkylheterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 40
- 125000002877 alkyl aryl group Chemical group 0.000 claims 28
- 125000003118 aryl group Chemical group 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 22
- -1 nitro, carboxy Chemical group 0.000 claims 22
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 125000003107 substituted aryl group Chemical group 0.000 claims 17
- 239000003458 I kappa b kinase inhibitor Substances 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000004423 acyloxy group Chemical group 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 8
- 125000002757 morpholinyl group Chemical group 0.000 claims 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 8
- 125000004193 piperazinyl group Chemical group 0.000 claims 8
- 125000003386 piperidinyl group Chemical group 0.000 claims 8
- 229940002612 prodrug Drugs 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 8
- 201000009273 Endometriosis Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 4
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 4
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 4
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 4
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 4
- 125000002883 imidazolyl group Chemical group 0.000 claims 4
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 4
- 125000001041 indolyl group Chemical group 0.000 claims 4
- 125000001786 isothiazolyl group Chemical group 0.000 claims 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims 4
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 4
- 125000002971 oxazolyl group Chemical group 0.000 claims 4
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 4
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 4
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 4
- 125000000335 thiazolyl group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 4
- 125000004306 triazinyl group Chemical group 0.000 claims 4
- 229940088597 hormone Drugs 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- YCOOGLSVZRCSMP-UHFFFAOYSA-N 1-[4-[4-[[4-(4-chlorophenyl)pyrimidin-2-yl]amino]benzoyl]piperazin-1-yl]ethanone Chemical group C1CN(C(=O)C)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=CC(C=2C=CC(Cl)=CC=2)=N1 YCOOGLSVZRCSMP-UHFFFAOYSA-N 0.000 claims 2
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 claims 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 239000003886 aromatase inhibitor Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000002834 estrogen receptor modulator Substances 0.000 claims 2
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 claims 2
- 208000000509 infertility Diseases 0.000 claims 2
- 230000036512 infertility Effects 0.000 claims 2
- 231100000535 infertility Toxicity 0.000 claims 2
- 239000002379 progesterone receptor modulator Substances 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 1
- 229940046844 aromatase inhibitors Drugs 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 239000002474 gonadorelin antagonist Substances 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71464505P | 2005-09-07 | 2005-09-07 | |
| EP05109450 | 2005-10-11 | ||
| PCT/US2006/033686 WO2007030362A1 (en) | 2005-09-07 | 2006-08-28 | Ikk inhibitors for the treatment of endometriosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009507073A JP2009507073A (ja) | 2009-02-19 |
| JP2009507073A5 true JP2009507073A5 (enExample) | 2009-10-15 |
Family
ID=37663766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008530093A Pending JP2009507073A (ja) | 2005-09-07 | 2006-08-28 | 子宮内膜症の治療のためのｉｋｋ阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100069387A1 (enExample) |
| EP (2) | EP2266561A3 (enExample) |
| JP (1) | JP2009507073A (enExample) |
| KR (1) | KR20080052650A (enExample) |
| CN (1) | CN101304736A (enExample) |
| AU (1) | AU2006287767B2 (enExample) |
| CA (1) | CA2621057A1 (enExample) |
| EA (1) | EA200800755A1 (enExample) |
| IL (1) | IL189659A0 (enExample) |
| WO (1) | WO2007030362A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| NZ590320A (en) | 2008-07-14 | 2012-12-21 | Gilead Sciences Inc | Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases |
| NZ590283A (en) | 2008-07-14 | 2012-11-30 | Gilead Sciences Inc | Imidazolylpyrimidine compounds as hdac and / or cdk inhibitors |
| MX2011001090A (es) | 2008-07-28 | 2011-03-15 | Gilead Sciences Inc | Compuestos de inhibidor de desacetilasa de histona de cicloalquilideno y heterocicloalquilideno. |
| CN101503402B (zh) * | 2009-03-10 | 2014-06-25 | 沈阳药科大学 | 2-苯胺嘧啶衍生物及其制备和用途 |
| US8283357B2 (en) | 2009-06-08 | 2012-10-09 | Gilead Sciences, Inc. | Cycloalkylcarbamate benzamide aniline HDAC inhibitor compounds |
| KR20120031170A (ko) | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| EP2848700B1 (en) | 2009-07-24 | 2017-10-04 | Geadic Biotec, AIE. | Markers for endometrial cancer |
| HUE029196T2 (en) | 2010-06-04 | 2017-02-28 | Hoffmann La Roche | Aminoprimidine derivatives as LRRK2 modulators |
| BR112013011600B1 (pt) | 2010-11-10 | 2022-01-11 | Genentech, Inc | Derivados de pirazol aminopirimidina, seu uso e composição que os compreende |
| US10729693B2 (en) | 2018-03-02 | 2020-08-04 | Ponce Medical School Foundation, Inc. | Compositions and methods for the treatment of endometriosis |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| BR112022002698A2 (pt) | 2019-08-14 | 2022-07-19 | Incyte Corp | Compostos de imidazolil pirimidinilamina como inibidores de cdk2 |
| MX2022004390A (es) | 2019-10-11 | 2022-08-08 | Incyte Corp | Aminas biciclicas como inhibidores de la cinasa dependiente de ciclina 2 (cdk2). |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| CN119769990B (zh) * | 2024-12-26 | 2025-09-09 | 大连医科大学附属第二医院 | 子宫内膜异位症的检测系统和治疗剂 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| DE3486469T2 (de) | 1983-11-02 | 1999-04-15 | Applied Research Systems Ars Holding N.V., Curacao | Herstellung heterodimirer menschlicher Fruchtbarkeitshormone |
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| JP2002193938A (ja) | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US20030134836A1 (en) * | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| CA2436770A1 (en) * | 2001-02-01 | 2002-08-08 | James R. Burke | Methods of treating inflammatory and immune diseases using inhibitors of ikb kinase (ikk) |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| EP1424080B1 (en) * | 2001-08-10 | 2011-02-16 | Takeda Pharmaceutical Company Limited | Gnrh agonist combination drugs |
| DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| EP1565446A1 (en) * | 2002-11-28 | 2005-08-24 | Schering Aktiengesellschaft | Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
| EP1670908A2 (en) * | 2003-10-02 | 2006-06-21 | Xantos Biomedicine AG | Medical use of tbk-1 or of inhibitors thereof |
-
2006
- 2006-08-28 US US11/991,578 patent/US20100069387A1/en not_active Abandoned
- 2006-08-28 EP EP10184024A patent/EP2266561A3/en not_active Withdrawn
- 2006-08-28 KR KR1020087008180A patent/KR20080052650A/ko not_active Ceased
- 2006-08-28 CA CA002621057A patent/CA2621057A1/en not_active Abandoned
- 2006-08-28 WO PCT/US2006/033686 patent/WO2007030362A1/en not_active Ceased
- 2006-08-28 EP EP06813899A patent/EP1931322B1/en active Active
- 2006-08-28 AU AU2006287767A patent/AU2006287767B2/en not_active Ceased
- 2006-08-28 EA EA200800755A patent/EA200800755A1/ru unknown
- 2006-08-28 JP JP2008530093A patent/JP2009507073A/ja active Pending
- 2006-08-28 CN CNA2006800414833A patent/CN101304736A/zh active Pending
-
2008
- 2008-02-21 IL IL189659A patent/IL189659A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009507073A5 (enExample) | ||
| AU2021282467B2 (en) | AR+ breast cancer treatment methods | |
| JP6193922B2 (ja) | ハロアルキルヘテロアリールベンズアミド化合物 | |
| RU2439068C2 (ru) | Модуляторы mglur5 | |
| JP2007519649A5 (enExample) | ||
| AU2013215251A1 (en) | Combination of a RTK inhibitor with an anti - estrogen and use thereof for the treatment of cancer | |
| AU2006287767B2 (en) | IKK inhibitors for the treatment of endometriosis | |
| RU2013143028A (ru) | Тиазолилфенилбензолсульфонамидопроизводные в качестве ингибиторов киназ | |
| JP2016512558A5 (enExample) | ||
| JP2012510989A5 (enExample) | ||
| CN103052388A (zh) | σ配体在阿片类药物诱导的痛觉过敏中的应用 | |
| CA2526908A1 (en) | Combination of histone deacetylase inhibitors with chemotherapeutic agents | |
| CA2669128A1 (en) | Treatment for multiple myeloma | |
| AR068947A1 (es) | Inhibidor de la proteina activadora de la 5- lipoxigenasa (flap), composiciones farmaceuticas, sales y solvatos | |
| JP2012515787A5 (enExample) | ||
| JP2013532709A5 (enExample) | ||
| CZ321094A3 (en) | Pharmaceutical preparation for inhibiting non-functional uterus bleeding | |
| KR20020090153A (ko) | 알콜중독 또는 알콜 의존을 위한 배합 치료 | |
| JP2009501745A5 (enExample) | ||
| JP2019182865A5 (enExample) | ||
| JP2016027024A5 (enExample) | ||
| JP2015502386A5 (enExample) | ||
| JPWO2020174283A5 (enExample) | ||
| RU2016133285A (ru) | Фармацевтические комбинации | |
| JP2017502989A5 (enExample) |