CA2621057A1 - Ikk inhibitors for the treatment of endometriosis - Google Patents
Ikk inhibitors for the treatment of endometriosis Download PDFInfo
- Publication number
- CA2621057A1 CA2621057A1 CA002621057A CA2621057A CA2621057A1 CA 2621057 A1 CA2621057 A1 CA 2621057A1 CA 002621057 A CA002621057 A CA 002621057A CA 2621057 A CA2621057 A CA 2621057A CA 2621057 A1 CA2621057 A1 CA 2621057A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- aryl
- group
- alkyl
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003458 I kappa b kinase inhibitor Substances 0.000 title claims abstract description 57
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Landscapes
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- Endocrinology (AREA)
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- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71464505P | 2005-09-07 | 2005-09-07 | |
| US60/714,645 | 2005-09-07 | ||
| EP05109450.6 | 2005-10-10 | ||
| EP05109450 | 2005-10-11 | ||
| PCT/US2006/033686 WO2007030362A1 (en) | 2005-09-07 | 2006-08-28 | Ikk inhibitors for the treatment of endometriosis |
Publications (1)
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| CA2621057A1 true CA2621057A1 (en) | 2007-03-15 |
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| CA002621057A Abandoned CA2621057A1 (en) | 2005-09-07 | 2006-08-28 | Ikk inhibitors for the treatment of endometriosis |
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| Country | Link |
|---|---|
| US (1) | US20100069387A1 (enExample) |
| EP (2) | EP1931322B1 (enExample) |
| JP (1) | JP2009507073A (enExample) |
| KR (1) | KR20080052650A (enExample) |
| CN (1) | CN101304736A (enExample) |
| AU (1) | AU2006287767B2 (enExample) |
| CA (1) | CA2621057A1 (enExample) |
| EA (1) | EA200800755A1 (enExample) |
| IL (1) | IL189659A0 (enExample) |
| WO (1) | WO2007030362A1 (enExample) |
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| CA2729965A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Fused heterocyclyc inhibitor compounds |
| JP5640005B2 (ja) | 2008-07-14 | 2014-12-10 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物 |
| EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| KR20110038159A (ko) | 2008-07-28 | 2011-04-13 | 길리애드 사이언시즈, 인코포레이티드 | 사이클로알킬리덴 및 헤테로사이클로알킬리덴 히스톤 데아세틸라아제 억제제 화합물 |
| CN101503402B (zh) * | 2009-03-10 | 2014-06-25 | 沈阳药科大学 | 2-苯胺嘧啶衍生物及其制备和用途 |
| AU2010259035A1 (en) | 2009-06-08 | 2011-12-08 | Gilead Sciences, Inc. | Alkanoylamino benzamide aniline HDAC inhibitor compounds |
| CA2763167A1 (en) | 2009-06-08 | 2010-12-16 | Gilead Sciences, Inc. | Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds |
| DK2456889T3 (en) | 2009-07-24 | 2014-12-01 | Geadic Biotec Aie | Markers of endometrial cancer |
| EP3075730B1 (en) | 2010-06-04 | 2018-10-24 | Genentech, Inc. | Aminopyrimidine derivatives as lrrk2 modulators |
| ES2746134T3 (es) | 2010-11-10 | 2020-03-04 | Genentech Inc | Derivados de pirazol aminopirimidina como moduladores de LRRK2 |
| US10729693B2 (en) | 2018-03-02 | 2020-08-04 | Ponce Medical School Foundation, Inc. | Compositions and methods for the treatment of endometriosis |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| PH12022550361A1 (en) | 2019-08-14 | 2023-02-27 | Incyte Corp | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| JP7693656B2 (ja) | 2019-10-11 | 2025-06-17 | インサイト・コーポレイション | Ｃｄｋ２阻害剤としての二環式アミン |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| CN119769990B (zh) * | 2024-12-26 | 2025-09-09 | 大连医科大学附属第二医院 | 子宫内膜异位症的检测系统和治疗剂 |
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|---|---|---|---|---|
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| ATE169334T1 (de) | 1983-11-02 | 1998-08-15 | Applied Research Systems | Herstellung heterodimirer menschlicher fruchtbarkeitshormone |
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| JP2002193938A (ja) | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US20030134836A1 (en) * | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| MXPA03006817A (es) * | 2001-02-01 | 2003-11-13 | Bristol Myers Squibb Co | Metodo de tratamiento de enfermedades inflamatorias e inmunes usando inhibidores de la ikb cinasa (ikk). |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| JP2003137814A (ja) * | 2001-08-10 | 2003-05-14 | Takeda Chem Ind Ltd | ＧｎＲＨアゴニストの併用剤 |
| DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| EA200500721A1 (ru) * | 2002-11-28 | 2005-12-29 | Шеринг Акциенгезельшафт | Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств |
| WO2005034978A2 (en) * | 2003-10-02 | 2005-04-21 | Xantos Biomedicine Ag | MEDICAL USE OF IKKϵ OR OF INHIBITORS THEREOF |
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2006
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- 2006-08-28 KR KR1020087008180A patent/KR20080052650A/ko not_active Ceased
- 2006-08-28 JP JP2008530093A patent/JP2009507073A/ja active Pending
- 2006-08-28 US US11/991,578 patent/US20100069387A1/en not_active Abandoned
- 2006-08-28 EP EP06813899A patent/EP1931322B1/en active Active
- 2006-08-28 CN CNA2006800414833A patent/CN101304736A/zh active Pending
- 2006-08-28 EP EP10184024A patent/EP2266561A3/en not_active Withdrawn
- 2006-08-28 WO PCT/US2006/033686 patent/WO2007030362A1/en not_active Ceased
- 2006-08-28 CA CA002621057A patent/CA2621057A1/en not_active Abandoned
- 2006-08-28 EA EA200800755A patent/EA200800755A1/ru unknown
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2008
- 2008-02-21 IL IL189659A patent/IL189659A0/en unknown
Also Published As
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|---|---|
| US20100069387A1 (en) | 2010-03-18 |
| JP2009507073A (ja) | 2009-02-19 |
| EP2266561A3 (en) | 2011-05-18 |
| EP1931322A1 (en) | 2008-06-18 |
| EP2266561A2 (en) | 2010-12-29 |
| AU2006287767B2 (en) | 2010-05-13 |
| CN101304736A (zh) | 2008-11-12 |
| EP1931322B1 (en) | 2012-08-15 |
| IL189659A0 (en) | 2008-08-07 |
| AU2006287767A1 (en) | 2007-03-15 |
| KR20080052650A (ko) | 2008-06-11 |
| EA200800755A1 (ru) | 2008-10-30 |
| WO2007030362A1 (en) | 2007-03-15 |
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