JP2009505974A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009505974A5 JP2009505974A5 JP2008525664A JP2008525664A JP2009505974A5 JP 2009505974 A5 JP2009505974 A5 JP 2009505974A5 JP 2008525664 A JP2008525664 A JP 2008525664A JP 2008525664 A JP2008525664 A JP 2008525664A JP 2009505974 A5 JP2009505974 A5 JP 2009505974A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- integer
- individually
- individually selected
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 6
- 229930189077 Rifamycin Natural products 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229960003292 rifamycin Drugs 0.000 claims 5
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 150000001721 carbon Chemical class 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical class C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- -1 methylene, carbonyl Chemical group 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70714505P | 2005-08-11 | 2005-08-11 | |
| US60/707,145 | 2005-08-11 | ||
| PCT/IB2006/004128 WO2007096703A2 (en) | 2005-08-11 | 2006-08-11 | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009505974A JP2009505974A (ja) | 2009-02-12 |
| JP2009505974A5 true JP2009505974A5 (https=) | 2011-11-24 |
| JP5368092B2 JP5368092B2 (ja) | 2013-12-18 |
Family
ID=38437733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525664A Expired - Fee Related JP5368092B2 (ja) | 2005-08-11 | 2006-08-11 | ホスホン化リファマイシン類および骨と関節感染の予防と治療のためのその投与法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8404664B2 (https=) |
| EP (1) | EP1928890B1 (https=) |
| JP (1) | JP5368092B2 (https=) |
| KR (1) | KR101327635B1 (https=) |
| CN (1) | CN101282981B (https=) |
| AU (1) | AU2006339058B2 (https=) |
| BR (1) | BRPI0614758A2 (https=) |
| CA (1) | CA2618741C (https=) |
| EA (1) | EA016059B1 (https=) |
| IL (1) | IL189270A (https=) |
| WO (1) | WO2007096703A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200809194A (en) * | 2006-05-04 | 2008-02-16 | Wyeth Corp | Determination of antibiotic concentration in bone |
| WO2010019511A2 (en) * | 2008-08-13 | 2010-02-18 | Targanta Therapeutics Corp. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
| JP6029596B2 (ja) * | 2011-02-24 | 2016-11-24 | ケイテーベー ツモルフォルシュングスゲゼルシャフト ミット ベシュレンクテル ハフツング | ビスホスホネートプロドラッグ |
| FR2973378B1 (fr) * | 2011-03-28 | 2013-10-04 | Atlanthera | Derives d'acide hydroxybisphosphonique bifonctionnels |
| LT3004162T (lt) * | 2013-05-31 | 2020-06-10 | Genentech, Inc. | Antikūnai prieš ląstelės sienelės teicho rūgštį ir konjugatai |
| BR112017011478A2 (pt) * | 2014-12-03 | 2018-02-27 | Genentech, Inc. | composto de conjugado anticorpo-antibiótico, conjugado anticorpo-antibiótico, composição farmacêutica, métodos de tratamento de uma infecção bacteriana e para exterminar staph aureus, processo para a preparação do composto, kit e intermediário antibiótico-ligante |
| HK1243931A1 (zh) * | 2014-12-03 | 2018-07-27 | F. Hoffmann-La Roche Ag | 抗金黄色葡萄球菌抗体利福霉素缀合物及其用途 |
| CN104524928A (zh) * | 2014-12-30 | 2015-04-22 | 上海锅炉厂有限公司 | 一种捕集二氧化碳的吸收剂 |
| CN107011380A (zh) * | 2016-01-28 | 2017-08-04 | 臧伟 | 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用 |
| MX386622B (es) * | 2017-06-26 | 2025-03-19 | Biofer Spa | Derivados de pirido-imidazo rifamicina como agente antibacteriano |
| CN112672787A (zh) * | 2018-07-09 | 2021-04-16 | 百奥维骨有限责任公司 | 双膦酸喹诺酮缀合物及其用途 |
| CN119291074A (zh) * | 2024-11-12 | 2025-01-10 | 重庆华邦胜凯制药有限公司 | 分离检测利福喷汀中间体z1及其杂质的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR208F (https=) | 1964-07-31 | |||
| US4261891A (en) | 1965-08-24 | 1981-04-14 | Ciba-Geigy Corporation | Antibiotically active rifamycin derivatives |
| GB1478563A (en) | 1975-03-05 | 1977-07-06 | Lepetit Spa | Rifamycin derivatives |
| IT1056272B (it) | 1975-06-13 | 1982-01-30 | Archifar Ind Chim Trentino | Prodotti derivati dalle amine aromatiche |
| AU536524B2 (en) * | 1979-06-28 | 1984-05-10 | Gruppo Lepetit S.P.A. | Water soluble hydrozones of 3-formylifamyan |
| IT1154655B (it) | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
| CA1304363C (en) | 1988-11-01 | 1992-06-30 | Takehiko Yamane | 3'-hydroxybenzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
| JP2746041B2 (ja) * | 1992-02-14 | 1998-04-28 | 三菱化学株式会社 | 新規なステロイド誘導体 |
| US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
| JPH093080A (ja) * | 1995-04-21 | 1997-01-07 | Sumitomo Pharmaceut Co Ltd | 新規な骨親和性エストロゲン誘導体 |
| US5880111A (en) * | 1995-06-07 | 1999-03-09 | Farcasiu; Dan | Therapeutic derivations of diphosphonates |
| EP0944635A4 (en) * | 1996-10-09 | 2000-07-05 | Elizanor Biopharmaceuticals In | THERAPEUTIC DIPHOSPHONATE COMPOUNDS |
| PE20020044A1 (es) * | 2000-06-16 | 2002-01-30 | Upjohn Co | Tiazina oxazolidinona |
| US6900204B2 (en) | 2001-09-06 | 2005-05-31 | Activbiotics, Inc. | Antimicrobial agents and uses thereof |
| AU2002360416A1 (en) | 2001-11-21 | 2003-06-10 | Activbiotics, Inc. | Targeted therapeutics and uses thereof |
| WO2003051299A2 (en) | 2001-12-13 | 2003-06-26 | Activbiotics, Inc. | Sulfhydryl rifamycins and uses thereof |
| US7300924B2 (en) | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| CA2536378A1 (en) | 2003-08-22 | 2005-03-10 | Activbiotics, Inc. | Rifamycin analogs and uses thereof |
| JP2007516291A (ja) | 2003-12-23 | 2007-06-21 | アクティブバイオティクス インコーポレイティッド | リファマイシンアナログおよびその使用法 |
| WO2005070940A2 (en) | 2004-01-13 | 2005-08-04 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives effective against drug-resistant microbes |
| EP1723150A1 (en) | 2004-01-13 | 2006-11-22 | Cumbre Pharmaceuticals Inc. | Rifamycin imino derivatives effective against drug-resistant microbes |
| US7256187B2 (en) | 2004-03-10 | 2007-08-14 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime derivatives effective against drug-resistant microbes |
| US7265107B2 (en) | 2004-03-10 | 2007-09-04 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes |
| US7250413B2 (en) | 2004-04-26 | 2007-07-31 | Cumbre Pharmaceuticals Inc. | C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes |
| US7202246B2 (en) | 2004-06-09 | 2007-04-10 | Cumbre Pharmaceuticals Inc. | Spiro-rifamycin derivatives targeting RNA polymerase |
| EP1781670A1 (en) | 2004-07-22 | 2007-05-09 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives for treating microbial infections |
-
2006
- 2006-08-11 US US12/063,300 patent/US8404664B2/en not_active Expired - Fee Related
- 2006-08-11 AU AU2006339058A patent/AU2006339058B2/en not_active Ceased
- 2006-08-11 CA CA2618741A patent/CA2618741C/en active Active
- 2006-08-11 EP EP06849478A patent/EP1928890B1/en active Active
- 2006-08-11 CN CN2006800373829A patent/CN101282981B/zh not_active Expired - Fee Related
- 2006-08-11 EA EA200800570A patent/EA016059B1/ru not_active IP Right Cessation
- 2006-08-11 JP JP2008525664A patent/JP5368092B2/ja not_active Expired - Fee Related
- 2006-08-11 KR KR1020087005807A patent/KR101327635B1/ko not_active Expired - Fee Related
- 2006-08-11 WO PCT/IB2006/004128 patent/WO2007096703A2/en not_active Ceased
- 2006-08-11 BR BRPI0614758-5A patent/BRPI0614758A2/pt not_active Application Discontinuation
-
2008
- 2008-02-04 IL IL189270A patent/IL189270A/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2529347A1 (en) | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections | |
| JP2009505974A5 (https=) | ||
| JP2005532287A5 (https=) | ||
| JP2007246474A5 (https=) | ||
| CA2565660A1 (en) | Ortho substituted aryl or heteroaryl amide compounds | |
| JP2005508962A5 (https=) | ||
| JP2005525294A5 (https=) | ||
| JP2007508359A5 (https=) | ||
| MY140528A (en) | Spiroketal derivatives and their use as therapeutic agents for diabetes | |
| JP2008533191A5 (https=) | ||
| CA2487542A1 (en) | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | |
| ATE556058T1 (de) | 1-(2h)-isochinolonderivat | |
| WO2007091106A3 (en) | Treatment of duchenne muscular dystrophy | |
| JP2008505117A5 (https=) | ||
| JP2005519932A5 (https=) | ||
| JP2004516314A5 (https=) | ||
| JP2005289914A5 (https=) | ||
| DE60331135D1 (de) | Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln | |
| MX2009003927A (es) | Derivado espirocetal de tioglucosa y uso del mismo como un agente terapeutico para la diabetes. | |
| TW200745034A (en) | New compounds | |
| JP2004131511A5 (https=) | ||
| JP2007530598A5 (https=) | ||
| RU2006101987A (ru) | Трициклические производные или их фармацевтически приемлемые соли, способы их получения и содержащие их фармацевтические композиции | |
| JP2011506490A5 (https=) | ||
| EP1775289A4 (en) | NEW IMIDAZOLIDINE DERIVATIVES |