CN101282981B - 膦酸化利福霉素及其在预防和治疗骨和关节感染中的用途 - Google Patents

膦酸化利福霉素及其在预防和治疗骨和关节感染中的用途 Download PDF

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Publication number
CN101282981B
CN101282981B CN2006800373829A CN200680037382A CN101282981B CN 101282981 B CN101282981 B CN 101282981B CN 2006800373829 A CN2006800373829 A CN 2006800373829A CN 200680037382 A CN200680037382 A CN 200680037382A CN 101282981 B CN101282981 B CN 101282981B
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bone
mmol
compound
rifamycin
acid
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Expired - Fee Related
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CN2006800373829A
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Chinese (zh)
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CN101282981A (zh
Inventor
Y·S·罗斯
S·奇布拉
T·康
A·拉费法
E·迪特里希
Y·拉方丹
R·雷迪
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Targanta Therapeutics Inc
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Targanta Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2006800373829A 2005-08-11 2006-08-11 膦酸化利福霉素及其在预防和治疗骨和关节感染中的用途 Expired - Fee Related CN101282981B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70714505P 2005-08-11 2005-08-11
US60/707,145 2005-08-11
PCT/IB2006/004128 WO2007096703A2 (en) 2005-08-11 2006-08-11 Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections

Publications (2)

Publication Number Publication Date
CN101282981A CN101282981A (zh) 2008-10-08
CN101282981B true CN101282981B (zh) 2012-09-26

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CN2006800373829A Expired - Fee Related CN101282981B (zh) 2005-08-11 2006-08-11 膦酸化利福霉素及其在预防和治疗骨和关节感染中的用途

Country Status (11)

Country Link
US (1) US8404664B2 (https=)
EP (1) EP1928890B1 (https=)
JP (1) JP5368092B2 (https=)
KR (1) KR101327635B1 (https=)
CN (1) CN101282981B (https=)
AU (1) AU2006339058B2 (https=)
BR (1) BRPI0614758A2 (https=)
CA (1) CA2618741C (https=)
EA (1) EA016059B1 (https=)
IL (1) IL189270A (https=)
WO (1) WO2007096703A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200809194A (en) * 2006-05-04 2008-02-16 Wyeth Corp Determination of antibiotic concentration in bone
WO2010019511A2 (en) * 2008-08-13 2010-02-18 Targanta Therapeutics Corp. Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
JP6029596B2 (ja) * 2011-02-24 2016-11-24 ケイテーベー ツモルフォルシュングスゲゼルシャフト ミット ベシュレンクテル ハフツング ビスホスホネートプロドラッグ
FR2973378B1 (fr) * 2011-03-28 2013-10-04 Atlanthera Derives d'acide hydroxybisphosphonique bifonctionnels
LT3004162T (lt) * 2013-05-31 2020-06-10 Genentech, Inc. Antikūnai prieš ląstelės sienelės teicho rūgštį ir konjugatai
BR112017011478A2 (pt) * 2014-12-03 2018-02-27 Genentech, Inc. composto de conjugado anticorpo-antibiótico, conjugado anticorpo-antibiótico, composição farmacêutica, métodos de tratamento de uma infecção bacteriana e para exterminar staph aureus, processo para a preparação do composto, kit e intermediário antibiótico-ligante
HK1243931A1 (zh) * 2014-12-03 2018-07-27 F. Hoffmann-La Roche Ag 抗金黄色葡萄球菌抗体利福霉素缀合物及其用途
CN104524928A (zh) * 2014-12-30 2015-04-22 上海锅炉厂有限公司 一种捕集二氧化碳的吸收剂
CN107011380A (zh) * 2016-01-28 2017-08-04 臧伟 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用
MX386622B (es) * 2017-06-26 2025-03-19 Biofer Spa Derivados de pirido-imidazo rifamicina como agente antibacteriano
CN112672787A (zh) * 2018-07-09 2021-04-16 百奥维骨有限责任公司 双膦酸喹诺酮缀合物及其用途
CN119291074A (zh) * 2024-11-12 2025-01-10 重庆华邦胜凯制药有限公司 分离检测利福喷汀中间体z1及其杂质的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US6333424B1 (en) * 1996-10-09 2001-12-25 Eliza Nor Biopharmaceuticals, Inc. Therapeutic derivatives of diphosphonates
US6605609B2 (en) * 2000-06-16 2003-08-12 Pharmacia & Upjohn Company Thizaine oxazolidinone

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR208F (https=) 1964-07-31
US4261891A (en) 1965-08-24 1981-04-14 Ciba-Geigy Corporation Antibiotically active rifamycin derivatives
GB1478563A (en) 1975-03-05 1977-07-06 Lepetit Spa Rifamycin derivatives
IT1056272B (it) 1975-06-13 1982-01-30 Archifar Ind Chim Trentino Prodotti derivati dalle amine aromatiche
AU536524B2 (en) * 1979-06-28 1984-05-10 Gruppo Lepetit S.P.A. Water soluble hydrozones of 3-formylifamyan
IT1154655B (it) 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica
CA1304363C (en) 1988-11-01 1992-06-30 Takehiko Yamane 3'-hydroxybenzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same
JP2746041B2 (ja) * 1992-02-14 1998-04-28 三菱化学株式会社 新規なステロイド誘導体
JPH093080A (ja) * 1995-04-21 1997-01-07 Sumitomo Pharmaceut Co Ltd 新規な骨親和性エストロゲン誘導体
US6900204B2 (en) 2001-09-06 2005-05-31 Activbiotics, Inc. Antimicrobial agents and uses thereof
AU2002360416A1 (en) 2001-11-21 2003-06-10 Activbiotics, Inc. Targeted therapeutics and uses thereof
WO2003051299A2 (en) 2001-12-13 2003-06-26 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
CA2536378A1 (en) 2003-08-22 2005-03-10 Activbiotics, Inc. Rifamycin analogs and uses thereof
JP2007516291A (ja) 2003-12-23 2007-06-21 アクティブバイオティクス インコーポレイティッド リファマイシンアナログおよびその使用法
WO2005070940A2 (en) 2004-01-13 2005-08-04 Cumbre Pharmaceuticals Inc. Rifamycin derivatives effective against drug-resistant microbes
EP1723150A1 (en) 2004-01-13 2006-11-22 Cumbre Pharmaceuticals Inc. Rifamycin imino derivatives effective against drug-resistant microbes
US7256187B2 (en) 2004-03-10 2007-08-14 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
US7265107B2 (en) 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
US7250413B2 (en) 2004-04-26 2007-07-31 Cumbre Pharmaceuticals Inc. C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes
US7202246B2 (en) 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
EP1781670A1 (en) 2004-07-22 2007-05-09 Cumbre Pharmaceuticals Inc. Rifamycin derivatives for treating microbial infections

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US6333424B1 (en) * 1996-10-09 2001-12-25 Eliza Nor Biopharmaceuticals, Inc. Therapeutic derivatives of diphosphonates
US6605609B2 (en) * 2000-06-16 2003-08-12 Pharmacia & Upjohn Company Thizaine oxazolidinone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Takehiko YAMANE et al..Synthesis and Biological Activity of 3"-Hydroxy-5"-aminobenzoxazinorifamycin Derivatives.《Chem.Pharm.Bull.》.1993,第41卷(第1期),第148-155页. *

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Publication number Publication date
US8404664B2 (en) 2013-03-26
AU2006339058A1 (en) 2007-08-30
EP1928890A4 (en) 2011-08-31
BRPI0614758A2 (pt) 2011-04-12
CN101282981A (zh) 2008-10-08
IL189270A0 (en) 2008-08-07
AU2006339058B2 (en) 2012-09-06
EA016059B1 (ru) 2012-01-30
CA2618741A1 (en) 2007-08-30
WO2007096703A3 (en) 2008-01-03
EP1928890B1 (en) 2013-04-03
CA2618741C (en) 2014-03-25
KR101327635B1 (ko) 2013-11-12
EA200800570A1 (ru) 2009-02-27
US20110263534A1 (en) 2011-10-27
JP5368092B2 (ja) 2013-12-18
KR20080035687A (ko) 2008-04-23
EP1928890A2 (en) 2008-06-11
WO2007096703A2 (en) 2007-08-30
JP2009505974A (ja) 2009-02-12
IL189270A (en) 2015-05-31

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