JP2009504803A5 - - Google Patents
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- JP2009504803A5 JP2009504803A5 JP2008528017A JP2008528017A JP2009504803A5 JP 2009504803 A5 JP2009504803 A5 JP 2009504803A5 JP 2008528017 A JP2008528017 A JP 2008528017A JP 2008528017 A JP2008528017 A JP 2008528017A JP 2009504803 A5 JP2009504803 A5 JP 2009504803A5
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- Prior art keywords
- alkyl
- compound according
- compound
- aryl
- substituted
- Prior art date
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71033705P | 2005-08-22 | 2005-08-22 | |
| PCT/US2006/032371 WO2007024707A2 (en) | 2005-08-22 | 2006-08-21 | Tlr agonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012254043A Division JP2013040209A (ja) | 2005-08-22 | 2012-11-20 | Tlrアゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504803A JP2009504803A (ja) | 2009-02-05 |
| JP2009504803A5 true JP2009504803A5 (https=) | 2009-10-01 |
Family
ID=37772216
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008528017A Pending JP2009504803A (ja) | 2005-08-22 | 2006-08-21 | Tlrアゴニスト |
| JP2012254043A Pending JP2013040209A (ja) | 2005-08-22 | 2012-11-20 | Tlrアゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012254043A Pending JP2013040209A (ja) | 2005-08-22 | 2012-11-20 | Tlrアゴニスト |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090324551A1 (https=) |
| EP (1) | EP1931352B1 (https=) |
| JP (2) | JP2009504803A (https=) |
| CN (1) | CN101304748A (https=) |
| CA (1) | CA2620182A1 (https=) |
| ES (1) | ES2577514T3 (https=) |
| WO (1) | WO2007024707A2 (https=) |
Families Citing this family (73)
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| MXPA05003193A (es) * | 2002-09-27 | 2005-06-08 | Sumitomo Pharma | Compuesto de adenina novedoso y uso del mismo. |
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| JPWO2007034817A1 (ja) * | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
| EP2700638A1 (en) * | 2006-05-31 | 2014-02-26 | The Regents Of the University of California | Purine analogs |
| US8138172B2 (en) | 2006-07-05 | 2012-03-20 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of TLR7 |
| TW200831105A (en) * | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| CN101790380B (zh) * | 2007-02-07 | 2013-07-10 | 加利福尼亚大学董事会 | 合成tlr激动剂的缀合物及其应用 |
| AR065372A1 (es) * | 2007-02-19 | 2009-06-03 | Smithkline Beecham Corp | Derivados de purina |
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| ES2457316T3 (es) * | 2007-03-19 | 2014-04-25 | Astrazeneca Ab | Compuestos 8-oxo-adenina 9 sustituidos como moduladores del receptor similares a toll (TLR7) |
| AR065784A1 (es) * | 2007-03-20 | 2009-07-01 | Dainippon Sumitomo Pharma Co | Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas. |
| JPWO2008114819A1 (ja) * | 2007-03-20 | 2010-07-08 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
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| WO2009034386A1 (en) * | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
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| WO2009091032A1 (ja) * | 2008-01-17 | 2009-07-23 | Dainippon Sumitomo Pharma Co., Ltd. | アデニン化合物の製造方法 |
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| UA103195C2 (uk) * | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
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| EP2391718A2 (en) * | 2009-01-30 | 2011-12-07 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of tlr9 |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
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| JP5694345B2 (ja) | 2009-10-22 | 2015-04-01 | ギリアード サイエンシーズ, インコーポレイテッド | Toll様受容体の調節因子 |
| JP2013512859A (ja) * | 2009-12-03 | 2013-04-18 | 大日本住友製薬株式会社 | トール様受容体(tlr)を介して作用するイミダゾキノリン |
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| US20120003298A1 (en) * | 2010-04-30 | 2012-01-05 | Alcide Barberis | Methods for inducing an immune response |
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| WO2012038058A1 (en) | 2010-09-21 | 2012-03-29 | Telormedix Sa | Treatment of conditions by toll-like receptor modulators |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| CN103370317B (zh) | 2010-12-16 | 2015-10-07 | 阿斯利康(瑞典)有限公司 | 可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物 |
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| EA028480B1 (ru) | 2012-11-20 | 2017-11-30 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Новые соединения |
| BR112015011439A2 (pt) | 2012-11-20 | 2017-07-11 | Glaxosmithkline Llc | composto, composição farmacêutica, composição de vacina, e, uso de um composto |
| JP6356160B2 (ja) * | 2013-02-25 | 2018-07-11 | ザ スクリプス リサーチ インスティテュート | ネオセプチン:低分子アジュバント |
| JP6522732B2 (ja) | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ, インコーポレイテッド | Hivを治療するためのトール様受容体の調節因子 |
| ES2944541T3 (es) * | 2014-08-06 | 2023-06-22 | Scripps Research Inst | Adyuvantes de molécula pequeña independientes de TLR |
| HRP20210927T1 (hr) * | 2014-08-15 | 2021-09-03 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Spojevi pirolopirimidina koje se koriste kao agonist tlr7 |
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| UA121345C2 (uk) | 2015-11-05 | 2020-05-12 | Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд. | 7-(тіазол-5-іл)піролопіримідин як агоніст рецептора tlr7 |
| CN107043379A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
| CN109843327B (zh) | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
| WO2018106945A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| AU2017376460A1 (en) | 2016-12-13 | 2019-06-20 | Bolt Biotherapeutics, Inc. | Antibody adjuvant conjugates |
| US11426566B2 (en) | 2016-12-14 | 2022-08-30 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a TLR modulator |
| WO2018191746A1 (en) | 2017-04-14 | 2018-10-18 | Bolt Biotherapeutics, Inc. | Immunoconjugate synthesis method |
| JP2021035910A (ja) * | 2017-11-01 | 2021-03-04 | 大日本住友製薬株式会社 | 置換プリン化合物 |
| WO2019196918A1 (zh) * | 2018-04-13 | 2019-10-17 | 罗欣药业(上海)有限公司 | 五元杂环并嘧啶类化合物、药物组合物及用途 |
| CA3100544A1 (en) | 2018-05-17 | 2019-11-21 | Bolt Biotherapeutics, Inc. | Immunoconjugates |
| CN109608462B (zh) * | 2018-12-15 | 2021-11-23 | 华南理工大学 | 一种7-烃基-9-烷氧/硫基嘌呤-8-酮类化合物及其合成方法与在药物中的应用 |
| WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| TWI810456B (zh) | 2019-05-22 | 2023-08-01 | 美商基利科學股份有限公司 | Tlr7調節化合物及hiv疫苗之組合 |
| CA3151662A1 (en) | 2019-09-04 | 2021-03-11 | Bolt Biotherapeutics, Inc. | Immunoconjugate synthesis method |
| WO2021174024A1 (en) | 2020-02-28 | 2021-09-02 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| JP2023532717A (ja) | 2020-07-02 | 2023-07-31 | ヴィーブ ヘルスケア カンパニー | 長期作用型抗レトロウイルス剤を用いたhivウイルス寛解の達成方法 |
| CN114787165B (zh) * | 2020-09-27 | 2023-02-28 | 上海维申医药有限公司 | 大环tlr7激动剂、其制备方法、药物组合物及其用途 |
| JP2023546205A (ja) | 2020-10-21 | 2023-11-01 | ユニヴェルザ ヴィ リュブリャナ | コンジュゲートtlr7およびnod2アゴニスト |
| CN115819215B (zh) * | 2022-11-08 | 2024-09-13 | 广东省科学院化工研究所 | 一种路易斯酸催化合成羧酸衍生物的方法 |
| WO2025040743A1 (en) | 2023-08-22 | 2025-02-27 | Univerza V Ljubljani | Conjugated tlr7 and rig-i agonists |
| WO2025093657A1 (en) | 2023-10-31 | 2025-05-08 | Univerza V Ljubljani | Conjugated tlr7 and tlr4 agonists |
| TW202602849A (zh) * | 2024-03-28 | 2026-01-16 | 日商日產化學股份有限公司 | 石墨烯連接化合物及場效電晶體生物檢測器 |
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| KR20110117705A (ko) | 2009-02-11 | 2011-10-27 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 톨-유사 수용체 조정제 및 질병의 치료 |
| JP5694345B2 (ja) | 2009-10-22 | 2015-04-01 | ギリアード サイエンシーズ, インコーポレイテッド | Toll様受容体の調節因子 |
| JP2013525431A (ja) | 2010-04-30 | 2013-06-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 合成tlr7アゴニストのリン脂質結合体の使用 |
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-
2006
- 2006-08-21 CN CNA200680038761XA patent/CN101304748A/zh active Pending
- 2006-08-21 WO PCT/US2006/032371 patent/WO2007024707A2/en not_active Ceased
- 2006-08-21 JP JP2008528017A patent/JP2009504803A/ja active Pending
- 2006-08-21 CA CA002620182A patent/CA2620182A1/en not_active Abandoned
- 2006-08-21 ES ES06813535.9T patent/ES2577514T3/es active Active
- 2006-08-21 EP EP06813535.9A patent/EP1931352B1/en not_active Not-in-force
- 2006-08-21 US US12/064,529 patent/US20090324551A1/en not_active Abandoned
-
2012
- 2012-11-20 US US13/682,208 patent/US9359360B2/en active Active
- 2012-11-20 JP JP2012254043A patent/JP2013040209A/ja active Pending
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