JP2009504762A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009504762A5 JP2009504762A5 JP2008527122A JP2008527122A JP2009504762A5 JP 2009504762 A5 JP2009504762 A5 JP 2009504762A5 JP 2008527122 A JP2008527122 A JP 2008527122A JP 2008527122 A JP2008527122 A JP 2008527122A JP 2009504762 A5 JP2009504762 A5 JP 2009504762A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- indol
- phenyl
- alkyl
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 14
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims 10
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 229960005190 phenylalanine Drugs 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- -1 1,1′-biphenyl-4-ylsulfonyl Chemical group 0.000 claims 6
- 150000002148 esters Chemical group 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 208000024172 Cardiovascular disease Diseases 0.000 claims 4
- 208000007536 Thrombosis Diseases 0.000 claims 4
- 206010047249 Venous thrombosis Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010003178 Arterial thrombosis Diseases 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 2
- 206010008132 Cerebral thrombosis Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
- 201000001429 Intracranial Thrombosis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 230000036778 atheroma formation Effects 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000003527 fibrinolytic agent Substances 0.000 claims 2
- 230000003480 fibrinolytic effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 201000002793 renal fibrosis Diseases 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 230000009424 thromboembolic effect Effects 0.000 claims 2
- FTXPWRLJYLZQJJ-VWLOTQADSA-N (2s)-2-[[2-[5-[(4-tert-butylphenyl)sulfonylamino]indol-1-yl]acetyl]amino]-3-phenylpropanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1S(=O)(=O)NC1=CC=C(N(CC(=O)N[C@@H](CC=2C=CC=CC=2)C(O)=O)C=C2)C2=C1 FTXPWRLJYLZQJJ-VWLOTQADSA-N 0.000 claims 1
- YGUPESDIHPDIOR-UHFFFAOYSA-N 1-[2-[5-(quinolin-8-ylsulfonylamino)indol-1-yl]acetyl]piperidine-4-carboxylic acid Chemical compound C1CC(C(=O)O)CCN1C(=O)CN1C2=CC=C(NS(=O)(=O)C=3C4=NC=CC=C4C=CC=3)C=C2C=C1 YGUPESDIHPDIOR-UHFFFAOYSA-N 0.000 claims 1
- CRYVNOZRRWLQHX-UHFFFAOYSA-N 1-[2-[5-[(4-phenylphenyl)sulfonylamino]indol-1-yl]acetyl]piperidine-4-carboxylic acid Chemical compound C1CC(C(=O)O)CCN1C(=O)CN1C2=CC=C(NS(=O)(=O)C=3C=CC(=CC=3)C=3C=CC=CC=3)C=C2C=C1 CRYVNOZRRWLQHX-UHFFFAOYSA-N 0.000 claims 1
- YWSBPHIYNIBKSZ-UHFFFAOYSA-N 1-[2-[5-[(4-tert-butylphenyl)sulfonylamino]indol-1-yl]acetyl]piperidine-4-carboxylic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1S(=O)(=O)NC1=CC=C(N(CC(=O)N2CCC(CC2)C(O)=O)C=C2)C2=C1 YWSBPHIYNIBKSZ-UHFFFAOYSA-N 0.000 claims 1
- AIXNRFHZGPUJNS-UHFFFAOYSA-N 1-[2-[5-[[4-(trifluoromethoxy)phenyl]sulfonylamino]indol-1-yl]acetyl]piperidine-4-carboxylic acid Chemical compound C1CC(C(=O)O)CCN1C(=O)CN1C2=CC=C(NS(=O)(=O)C=3C=CC(OC(F)(F)F)=CC=3)C=C2C=C1 AIXNRFHZGPUJNS-UHFFFAOYSA-N 0.000 claims 1
- DBUIDJJRUFCYED-UHFFFAOYSA-N 1-[4-[[5-[(4-tert-butylphenyl)sulfonylamino]indol-1-yl]methyl]benzoyl]piperidine-4-carboxylic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1S(=O)(=O)NC1=CC=C(N(CC=2C=CC(=CC=2)C(=O)N2CCC(CC2)C(O)=O)C=C2)C2=C1 DBUIDJJRUFCYED-UHFFFAOYSA-N 0.000 claims 1
- FAMBBSVOBIDVIF-UHFFFAOYSA-N 2-[4-[[5-[(4-phenylphenyl)sulfonylamino]indol-1-yl]methyl]phenoxy]acetic acid Chemical compound C1=CC(OCC(=O)O)=CC=C1CN1C2=CC=C(NS(=O)(=O)C=3C=CC(=CC=3)C=3C=CC=CC=3)C=C2C=C1 FAMBBSVOBIDVIF-UHFFFAOYSA-N 0.000 claims 1
- GNMGWUDVNYDOGY-UHFFFAOYSA-N 2-[4-[[5-[(4-tert-butylphenyl)sulfonylamino]indol-1-yl]methyl]phenoxy]acetic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1S(=O)(=O)NC1=CC=C(N(CC=2C=CC(OCC(O)=O)=CC=2)C=C2)C2=C1 GNMGWUDVNYDOGY-UHFFFAOYSA-N 0.000 claims 1
- CBFIFFDFJSHQHE-UHFFFAOYSA-N 2-[5-[(4-phenylphenyl)sulfonylamino]indol-1-yl]acetic acid Chemical compound C=1C=C2N(CC(=O)O)C=CC2=CC=1NS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 CBFIFFDFJSHQHE-UHFFFAOYSA-N 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- MXOJUHPZFHCXGO-UHFFFAOYSA-N 3-[[1-[(4-tert-butylphenyl)methyl]indol-5-yl]carbamoylamino]benzoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1CN1C2=CC=C(NC(=O)NC=3C=C(C=CC=3)C(O)=O)C=C2C=C1 MXOJUHPZFHCXGO-UHFFFAOYSA-N 0.000 claims 1
- WHGUVQSEODAYAE-UHFFFAOYSA-N 3-[[1-[(4-tert-butylphenyl)methyl]indol-5-yl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1CN1C2=CC=C(NS(=O)(=O)C=3C=C(C=CC=3)C(O)=O)C=C2C=C1 WHGUVQSEODAYAE-UHFFFAOYSA-N 0.000 claims 1
- KDQPNMXYQDSYGR-UHFFFAOYSA-N 3-[[4-[[5-[(4-phenylphenyl)sulfonylamino]indol-1-yl]methyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1CN1C2=CC=C(NS(=O)(=O)C=3C=CC(=CC=3)C=3C=CC=CC=3)C=C2C=C1 KDQPNMXYQDSYGR-UHFFFAOYSA-N 0.000 claims 1
- HAQHOVYIUNKXGN-UHFFFAOYSA-N 3-[[4-[[5-[(4-tert-butylphenyl)sulfonylamino]indol-1-yl]methyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1S(=O)(=O)NC1=CC=C(N(CC=2C=CC(=CC=2)C(=O)NCCC(O)=O)C=C2)C2=C1 HAQHOVYIUNKXGN-UHFFFAOYSA-N 0.000 claims 1
- IZCFZONLKDLOKI-UHFFFAOYSA-N 3-[[4-[[5-[[4-(trifluoromethoxy)phenyl]sulfonylamino]indol-1-yl]methyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1CN1C2=CC=C(NS(=O)(=O)C=3C=CC(OC(F)(F)F)=CC=3)C=C2C=C1 IZCFZONLKDLOKI-UHFFFAOYSA-N 0.000 claims 1
- XJAHKKNQXJBNFK-UHFFFAOYSA-N 3-phenyl-2-[5-[[4-(trifluoromethoxy)phenyl]sulfonylamino]indol-1-yl]propanoic acid Chemical compound C1=CC2=CC(NS(=O)(=O)C=3C=CC(OC(F)(F)F)=CC=3)=CC=C2N1C(C(=O)O)CC1=CC=CC=C1 XJAHKKNQXJBNFK-UHFFFAOYSA-N 0.000 claims 1
- HYZWGJLDBHISIG-UHFFFAOYSA-N 4-[[1-[(4-tert-butylphenyl)methyl]indol-5-yl]sulfamoyl]benzoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1CN1C2=CC=C(NS(=O)(=O)C=3C=CC(=CC=3)C(O)=O)C=C2C=C1 HYZWGJLDBHISIG-UHFFFAOYSA-N 0.000 claims 1
- QODVSVPDRWYDJM-UHFFFAOYSA-N 4-[[benzenesulfonyl-[1-[(4-tert-butylphenyl)methyl]indol-5-yl]amino]methyl]benzoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1CN1C2=CC=C(N(CC=3C=CC(=CC=3)C(O)=O)S(=O)(=O)C=3C=CC=CC=3)C=C2C=C1 QODVSVPDRWYDJM-UHFFFAOYSA-N 0.000 claims 1
- 125000003352 4-tert-butyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70883405P | 2005-08-17 | 2005-08-17 | |
| PCT/US2006/032066 WO2007022321A2 (en) | 2005-08-17 | 2006-08-16 | Substituted indoles and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504762A JP2009504762A (ja) | 2009-02-05 |
| JP2009504762A5 true JP2009504762A5 (https=) | 2009-09-24 |
Family
ID=37691771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008527122A Withdrawn JP2009504762A (ja) | 2005-08-17 | 2006-08-16 | 置換インドール類およびそれらの使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7683091B2 (https=) |
| EP (1) | EP1919866A2 (https=) |
| JP (1) | JP2009504762A (https=) |
| CN (1) | CN101263115A (https=) |
| AU (1) | AU2006279496A1 (https=) |
| BR (1) | BRPI0614340A2 (https=) |
| CA (1) | CA2617372A1 (https=) |
| MX (1) | MX2008002117A (https=) |
| WO (1) | WO2007022321A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059629A1 (es) * | 2006-02-27 | 2008-04-16 | Wyeth Corp | Inhibidores del inhibidor del activador de plasminogeno (pai- 1) para el tratamiento de trastornos musculares |
| CN102429901B (zh) * | 2011-11-03 | 2013-11-06 | 合肥博太医药生物技术发展有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备防治肾纤维化药物中的应用 |
| EP2844247A4 (en) * | 2012-04-20 | 2015-11-25 | Anderson Gaweco | ROR MODULATORS AND ITS USES |
| CN106890324A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
| DK3395354T3 (da) | 2015-12-18 | 2024-06-03 | Talengen Int Ltd | Plasminogen til anvendelse i behandling af diabetisk nefropati |
| CA3010615C (en) | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| TWI763705B (zh) * | 2016-09-06 | 2022-05-11 | 比利時商健生藥品公司 | 可作為升糖素受體拮抗劑之吲哚衍生物 |
| CN110198732A (zh) | 2016-12-15 | 2019-09-03 | 泰伦基国际有限公司 | 一种促进胰岛素受体底物-2表达的方法 |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3026325A (en) * | 1959-01-26 | 1962-03-20 | Upjohn Co | 5-hydroxy-alpha-alkyltryptophans |
| US3476770A (en) * | 1967-04-14 | 1969-11-04 | Parke Davis & Co | 2-methyl-7-phenylindole-3-acetic acid compounds |
| GB1321433A (en) | 1968-01-11 | 1973-06-27 | Roussel Uclaf | 1,2,3,6-tetrasubstituted indoles |
| US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| FR2244499A1 (en) | 1973-06-07 | 1975-04-18 | Delalande Sa | Indol-3-ylformaldoxime carbamates - for treating anxiety epilepsy, cardiac arrhythmias, asthma, intestinal spasm, peptic ulcer, cardiac insufficiency |
| DE3147276A1 (de) | 1981-11-28 | 1983-06-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole |
| FR2525474A1 (fr) * | 1982-04-26 | 1983-10-28 | Roussel Uclaf | Nouvelle forme pharmaceutique orale de clometacine |
| GB8524157D0 (en) | 1984-10-19 | 1985-11-06 | Ici America Inc | Heterocyclic amides |
| DE3531658A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
| PT83559B (pt) | 1985-10-17 | 1989-05-31 | Ici America Inc | Processo para a preparacao de novos derivados de indol e indazol-ceto-sulfona e de composicoes farmaceuticas que os contem |
| US5164372A (en) * | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
| IE903206A1 (en) | 1989-09-07 | 1991-03-13 | Abbott Lab | Indole-, benzofuran-, and benzothiophene-containing¹lipoxygenase-inhibiting compounds |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5151435A (en) | 1991-04-08 | 1992-09-29 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating an indole or dihydroindole |
| IL101785A0 (en) | 1991-05-10 | 1992-12-30 | Fujisawa Pharmaceutical Co | Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| GB9123396D0 (en) | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| US5502187A (en) * | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| DE4242675A1 (de) | 1992-12-17 | 1994-06-23 | Basf Ag | Neue Hydroxyiminoalkylindolcarbonsäure-Derivate, ihre Herstellung und Verwendung |
| ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| IL109568A0 (en) | 1993-05-19 | 1994-08-26 | Fujisawa Pharmaceutical Co | Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| DE4338770A1 (de) | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
| CA2134192A1 (en) | 1993-11-12 | 1995-05-13 | Michael L. Denney | 5, 6-bicyclic glycoprotein iib/iiia antagonists |
| JPH07206817A (ja) | 1994-01-20 | 1995-08-08 | Kyowa Hakko Kogyo Co Ltd | 尿素誘導体 |
| US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5482960A (en) * | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| IL117208A0 (en) | 1995-02-23 | 1996-06-18 | Nissan Chemical Ind Ltd | Indole type thiazolidines |
| CA2217707A1 (en) | 1995-04-10 | 1996-10-17 | Fujisawa Pharmaceutial Co., Ltd. | Indole derivatives as cgmp-pde inhibitors |
| US5728724A (en) | 1995-08-17 | 1998-03-17 | Eli Lilly And Company | Benzothiophene compounds |
| IL120724A0 (en) | 1995-09-01 | 1997-08-14 | Lilly Co Eli | Indolyl neuropeptide Y receptor antagonists |
| DE19543639A1 (de) | 1995-11-23 | 1997-05-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| GB9609641D0 (en) | 1996-05-09 | 1996-07-10 | Pfizer Ltd | Compounds useful in therapy |
| JP4373497B2 (ja) * | 1996-06-19 | 2009-11-25 | ローン−プーラン・ロレ・リミテツド | 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用 |
| CA2207083A1 (en) | 1996-07-15 | 1998-01-15 | Brian William Grinnell | Benzothiophene compounds, and uses and formulations thereof |
| EP0822185A1 (en) | 1996-07-31 | 1998-02-04 | Pfizer Inc. | B-3-adrenergic agonists as antidiabetic and antiobesity agents |
| JP2000516958A (ja) | 1996-08-26 | 2000-12-19 | ジェネティックス・インスチチュート・インコーポレーテッド | ホスホリパーゼ酵素の阻害剤 |
| AU7237998A (en) | 1997-05-16 | 1998-12-08 | Chugai Seiyaku Kabushiki Kaisha | Indole derivatives and mono- and diazaindole derivatives |
| DE19727117A1 (de) * | 1997-06-26 | 1999-01-07 | Boehringer Ingelheim Pharma | Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
| HUP0100156A3 (en) | 1998-02-25 | 2002-12-28 | Genetics Inst Inc Cambridge | Indole derivatives as inhibitors of phospholipase a2 and use of them for producing pharmaceutical compositions |
| SK12752000A3 (sk) | 1998-02-25 | 2001-03-12 | Genetics Institute, Inc. | Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie |
| US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| EA200000868A1 (ru) | 1998-02-25 | 2001-04-23 | Дженетикс Инститьют, Инк. | Ингибиторы фосфолипаз |
| SE9800836D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| FR2777886B1 (fr) * | 1998-04-27 | 2002-05-31 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6251936B1 (en) * | 1998-05-12 | 2001-06-26 | American Home Products Corporation | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia |
| US6232322B1 (en) * | 1998-05-12 | 2001-05-15 | American Home Products Corporation | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
| US6166069A (en) * | 1998-05-12 | 2000-12-26 | American Home Products Corporation | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
| HRP20000767A2 (en) | 1998-05-12 | 2001-10-31 | American Home Prod | Benzothiophenes, benzofurans and indoles useful in the treatment of insulin resistance and hyperglycemia |
| JP2002514636A (ja) | 1998-05-12 | 2002-05-21 | アメリカン・ホーム・プロダクツ・コーポレイション | インスリン抵抗性または高血糖症の治療に有用なフェニルオキソ−酢酸類 |
| US6110963A (en) * | 1998-05-12 | 2000-08-29 | American Home Products Corporation | Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
| TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| JP3827530B2 (ja) * | 1998-12-16 | 2006-09-27 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 置換アリール誘導体及び置換ヘテロアリール誘導体、それらの調製及び薬物としてのそれらの使用 |
| AU2319100A (en) | 1999-01-28 | 2000-08-18 | Nippon Shinyaku Co. Ltd. | Amide derivatives and drug compositions |
| GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| YU72201A (sh) | 1999-04-28 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | Derivati di-aril kiseline kao ppar receptorski ligandi |
| PL351470A1 (en) | 1999-04-28 | 2003-04-22 | Aventis Pharma Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
| DE19919793A1 (de) * | 1999-04-30 | 2000-11-02 | Bayer Ag | Neue Sulfonamide |
| GB9919411D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
| GB9919413D0 (en) * | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
| FR2799756B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19963178A1 (de) | 1999-12-27 | 2001-07-05 | Gruenenthal Gmbh | Substituierte Indol-Mannichbasen |
| US6410734B1 (en) * | 2000-07-17 | 2002-06-25 | Wyeth | 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists |
| AU2002211901A1 (en) | 2000-10-10 | 2002-04-22 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents |
| DE10053813A1 (de) | 2000-10-30 | 2002-05-08 | Bayer Ag | Neue Verwendung von Sulfonamiden |
| WO2002072549A1 (en) | 2001-03-12 | 2002-09-19 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
| FR2825706B1 (fr) * | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
| US7291639B2 (en) * | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| TWI240723B (en) * | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| US7074817B2 (en) | 2001-06-20 | 2006-07-11 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| KR100810468B1 (ko) * | 2001-10-10 | 2008-03-07 | 씨제이제일제당 (주) | 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난1ｈ-인돌 유도체 |
| JP4445266B2 (ja) | 2002-02-12 | 2010-04-07 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | Ａｈ受容体のリガンドとしてのインドールチアゾール化合物の合成 |
| WO2003087087A2 (en) | 2002-04-09 | 2003-10-23 | Astex Technology Limited | Heterocyclic compounds and their use as modulators of p38 map kinase |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| DE60324183D1 (en) | 2002-12-10 | 2008-11-27 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| CA2509222A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| CA2509170A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| EP1569900B1 (en) | 2002-12-10 | 2006-06-28 | Wyeth | Substituted 3-carbonyl-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| MXPA05010174A (es) | 2003-04-25 | 2005-11-08 | Lundbeck & Co As H | Derivados de indol e indolina sustituidos. |
| US7420083B2 (en) * | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US20050215626A1 (en) * | 2003-09-25 | 2005-09-29 | Wyeth | Substituted benzofuran oximes |
| US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| WO2006023865A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
| CN101044127A (zh) * | 2004-08-23 | 2007-09-26 | 惠氏公司 | 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸 |
| AU2005277137A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as PAI-1 inhibitors |
-
2006
- 2006-08-16 BR BRPI0614340-7A patent/BRPI0614340A2/pt not_active Application Discontinuation
- 2006-08-16 US US11/505,527 patent/US7683091B2/en not_active Expired - Fee Related
- 2006-08-16 EP EP06801683A patent/EP1919866A2/en not_active Withdrawn
- 2006-08-16 JP JP2008527122A patent/JP2009504762A/ja not_active Withdrawn
- 2006-08-16 CA CA002617372A patent/CA2617372A1/en not_active Abandoned
- 2006-08-16 MX MX2008002117A patent/MX2008002117A/es not_active Application Discontinuation
- 2006-08-16 AU AU2006279496A patent/AU2006279496A1/en not_active Abandoned
- 2006-08-16 CN CNA2006800298940A patent/CN101263115A/zh active Pending
- 2006-08-16 WO PCT/US2006/032066 patent/WO2007022321A2/en not_active Ceased
-
2010
- 2010-01-29 US US12/696,648 patent/US20100137363A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2494095C2 (ru) | Модифицированные миметики лизина | |
| JP5586484B2 (ja) | ピロリジン誘導体 | |
| JP2008519761A5 (https=) | ||
| JP2008502700A5 (https=) | ||
| US7696231B2 (en) | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs) | |
| JP2007536224A5 (https=) | ||
| JP2014502979A5 (https=) | ||
| JP2005513123A5 (https=) | ||
| CA2436526A1 (en) | Heterocyclic sulfonamide inhibitors of beta amyloid production | |
| JP2004508304A5 (https=) | ||
| JP2006510673A5 (https=) | ||
| CN1304447A (zh) | 通过抑制木瓜蛋白酶超家族的半胱氨酸蛋白酶治疗寄生虫病 | |
| US20110118314A1 (en) | Piperidine analogs as glycogen synthase activators | |
| JP2007502265A5 (https=) | ||
| JP2013509376A5 (https=) | ||
| RU2007119427A (ru) | Соединения, являющиеся ингибиторами гликогенфосфорилазы, и фармацевтические композиции на их основе | |
| JP2003535900A (ja) | ベンズアミド誘導体の治療薬としての使用 | |
| JP2007522135A5 (https=) | ||
| JP2008502614A5 (https=) | ||
| JP2005511656A5 (https=) | ||
| KR20150136294A (ko) | 인자 ＸＩａ 억제 활성을 가지는 신규한 화합물 | |
| AU2002342859A1 (en) | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPS) | |
| JP2009504762A5 (https=) | ||
| JP2005272321A (ja) | 含窒素複素環化合物およびその医薬用途 | |
| EP1666469A1 (en) | Plasminogen activator inhibitor-1 inhibitor |