JP2009502953A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009502953A5 JP2009502953A5 JP2008524168A JP2008524168A JP2009502953A5 JP 2009502953 A5 JP2009502953 A5 JP 2009502953A5 JP 2008524168 A JP2008524168 A JP 2008524168A JP 2008524168 A JP2008524168 A JP 2008524168A JP 2009502953 A5 JP2009502953 A5 JP 2009502953A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclopropyl
- dione
- quinoline
- alkyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc(c(*)c12)c(*)c(OC)c1N(*)C(SNC1=O)=C1C2=O Chemical compound Cc(c(*)c12)c(*)c(OC)c1N(*)C(SNC1=O)=C1C2=O 0.000 description 2
- DZCISUNWNZUFNA-UHFFFAOYSA-N CC(C)(C1CN(C)CC1)NC Chemical compound CC(C)(C1CN(C)CC1)NC DZCISUNWNZUFNA-UHFFFAOYSA-N 0.000 description 1
- ZBNGYAJEJQZYNL-UHFFFAOYSA-N CC1(CO)CNCC1 Chemical compound CC1(CO)CNCC1 ZBNGYAJEJQZYNL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70281105P | 2005-07-27 | 2005-07-27 | |
| US60/702,811 | 2005-07-27 | ||
| PCT/US2006/029302 WO2007014308A1 (en) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502953A JP2009502953A (ja) | 2009-01-29 |
| JP2009502953A5 true JP2009502953A5 (https=) | 2009-09-03 |
| JP5143000B2 JP5143000B2 (ja) | 2013-02-13 |
Family
ID=37106335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524168A Expired - Fee Related JP5143000B2 (ja) | 2005-07-27 | 2006-07-27 | 抗感染症薬としての８−メトキシ−９Ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8044204B2 (https=) |
| EP (1) | EP1913004B1 (https=) |
| JP (1) | JP5143000B2 (https=) |
| KR (1) | KR101272263B1 (https=) |
| CN (1) | CN101263146B (https=) |
| AT (1) | ATE482219T1 (https=) |
| AU (1) | AU2006272571B2 (https=) |
| BR (1) | BRPI0614456B8 (https=) |
| CA (1) | CA2616768C (https=) |
| DE (1) | DE602006017082D1 (https=) |
| DK (1) | DK1913004T3 (https=) |
| EA (1) | EA013244B1 (https=) |
| ES (1) | ES2352799T3 (https=) |
| IL (1) | IL189017A (https=) |
| NO (1) | NO343376B1 (https=) |
| NZ (1) | NZ566209A (https=) |
| PL (1) | PL1913004T3 (https=) |
| PT (1) | PT1913004E (https=) |
| WO (1) | WO2007014308A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008021491A2 (en) | 2006-08-16 | 2008-02-21 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones |
| WO2010115184A2 (en) * | 2009-04-03 | 2010-10-07 | Achillion Pharmaceuticals, Inc. | Hydroxythienoquinolones and related compounds as anti-infective agents |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| US9216979B2 (en) | 2009-10-16 | 2015-12-22 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| TW201726630A (zh) * | 2009-10-16 | 2017-08-01 | 梅林塔療法公司 | 抗微生物性化合物及其製造與使用方法 |
| WO2011047320A2 (en) * | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
| TN2010000566A1 (en) * | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
| CN103819401B (zh) * | 2012-11-19 | 2016-04-13 | 浙江中欣氟材股份有限公司 | 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法 |
| KR20160070066A (ko) | 2013-09-09 | 2016-06-17 | 멜린타 테라퓨틱스, 인크. | 항균 화합물, 및 이의 제조 방법 및 이용 방법 |
| EP3038623A4 (en) | 2013-09-09 | 2017-04-19 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| WO2015114317A1 (en) * | 2014-01-28 | 2015-08-06 | Redx Pharma Plc | 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds |
| CA2979342A1 (en) | 2015-03-11 | 2016-09-15 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| WO2017193016A1 (en) | 2016-05-06 | 2017-11-09 | Melinta Therapeutics, Inc. | Antimicrobials and methods of making and using same |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| CA3128224A1 (en) * | 2019-02-01 | 2020-08-06 | Aerie Pharmaceuticals, Inc. | Compounds, compositions and methods for treatment of myopia |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767762A (en) * | 1985-12-23 | 1988-08-30 | Abbott Laboratories | Tricyclic quinoline and naphthyride antibacterials |
| JPH01160985A (ja) | 1987-12-17 | 1989-06-23 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JPH01193275A (ja) | 1988-01-28 | 1989-08-03 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JP2681190B2 (ja) | 1988-04-13 | 1997-11-26 | 塩野義製薬株式会社 | ピリドン系抗菌剤 |
| CA2001203C (en) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
| US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
| JPH02174784A (ja) | 1988-12-27 | 1990-07-06 | Hokuriku Seiyaku Co Ltd | イソチアゾロキノリン誘導体 |
| JPH02243692A (ja) | 1989-03-16 | 1990-09-27 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| JPH02255687A (ja) | 1989-03-27 | 1990-10-16 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| FR2645862B1 (fr) | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
| JP2787713B2 (ja) | 1989-07-28 | 1998-08-20 | 富山化学工業株式会社 | 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩 |
| US5071848A (en) * | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
| JP2939280B2 (ja) | 1990-01-10 | 1999-08-25 | 三共株式会社 | フッ素置換メトキシキノロンカルボン酸誘導体 |
| US5580872A (en) * | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| CA2245179A1 (en) | 1996-01-31 | 1997-08-07 | Ube Industries Limited | Remedies or preventives for aids |
| JP3616454B2 (ja) | 1996-04-19 | 2005-02-02 | 栄研化学株式会社 | 生体成分測定用試薬 |
| JPH10130149A (ja) | 1996-07-12 | 1998-05-19 | Sankyo Co Ltd | Ｔｎｆ産生抑制剤 |
| DE19652219A1 (de) * | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
| ATE304539T1 (de) * | 2000-12-14 | 2005-09-15 | Procter & Gamble | Antimikrobielle chinolone |
| KR20060069836A (ko) | 2003-08-12 | 2006-06-22 | 아칠리온 파르마세우티칼스 인코포레이티드 | 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물 |
| WO2006118605A2 (en) * | 2004-11-11 | 2006-11-09 | Achillion Pharmaceuticals, Inc. | 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents |
| BRPI0607723A2 (pt) * | 2005-02-16 | 2009-10-06 | Achillion Pharmaceuticals Inc | isotiazoloquinolonas e compostos relacionados como agentes antiinfecciosos |
| WO2010115184A2 (en) | 2009-04-03 | 2010-10-07 | Achillion Pharmaceuticals, Inc. | Hydroxythienoquinolones and related compounds as anti-infective agents |
-
2006
- 2006-07-27 AU AU2006272571A patent/AU2006272571B2/en not_active Ceased
- 2006-07-27 JP JP2008524168A patent/JP5143000B2/ja not_active Expired - Fee Related
- 2006-07-27 EA EA200800444A patent/EA013244B1/ru unknown
- 2006-07-27 PT PT06800428T patent/PT1913004E/pt unknown
- 2006-07-27 EP EP06800428A patent/EP1913004B1/en active Active
- 2006-07-27 AT AT06800428T patent/ATE482219T1/de active
- 2006-07-27 DE DE602006017082T patent/DE602006017082D1/de active Active
- 2006-07-27 US US11/494,205 patent/US8044204B2/en active Active
- 2006-07-27 WO PCT/US2006/029302 patent/WO2007014308A1/en not_active Ceased
- 2006-07-27 PL PL06800428T patent/PL1913004T3/pl unknown
- 2006-07-27 DK DK06800428.2T patent/DK1913004T3/da active
- 2006-07-27 CA CA2616768A patent/CA2616768C/en not_active Expired - Fee Related
- 2006-07-27 NZ NZ566209A patent/NZ566209A/en unknown
- 2006-07-27 KR KR1020087004769A patent/KR101272263B1/ko active Active
- 2006-07-27 CN CN200680033548XA patent/CN101263146B/zh active Active
- 2006-07-27 BR BRPI0614456A patent/BRPI0614456B8/pt active IP Right Grant
- 2006-07-27 ES ES06800428T patent/ES2352799T3/es active Active
-
2008
- 2008-01-24 IL IL189017A patent/IL189017A/en active IP Right Grant
- 2008-02-27 NO NO20081005A patent/NO343376B1/no unknown
-
2011
- 2011-10-24 US US13/279,852 patent/US8946422B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009502953A5 (https=) | ||
| AU2019283921B2 (en) | Indole carboxamide compounds useful as kinase inhibitors | |
| JP6509838B2 (ja) | Ｂｔｋ阻害薬としての一級カルボキサミド類 | |
| JP6419735B2 (ja) | 四環系ブロモドメイン阻害剤 | |
| JP6423425B2 (ja) | 結晶性ブロモドメインインヒビター | |
| WO2019165073A1 (en) | Shp2 phosphatase inhibitors and methods of use thereof | |
| WO2014164771A1 (en) | Bromodomain inhibitors | |
| CA2904049A1 (en) | Fused tetracyclic bromodomain inhibitors | |
| JP2022191259A (ja) | キナーゼネットワークの阻害剤およびその使用 | |
| JP2016539970A (ja) | ブロモドメイン阻害薬として有用なジヒドロピリジノンおよびジヒドロピリダジノン誘導体 | |
| JP2014501769A (ja) | 縮合アミノジヒドロチアジン誘導体 | |
| JP2013512903A5 (https=) | ||
| WO2016065236A1 (en) | Carbazole derivatives | |
| JP2018522909A (ja) | ヒト免疫不全ウイルス複製の阻害剤としての５−（ｎ−縮合三環式アリールテトラヒドロイソキノリン−６−イル）ピリジン−３−イル酢酸誘導体 | |
| JP2008517913A5 (https=) | ||
| EP3209652A1 (en) | Tricyclic atropisomer compounds | |
| CA3191362A1 (en) | Pyrazolopyridazinone compound, and pharmaceutical composition and use thereof | |
| AU2017204748A1 (en) | (--)-Huperzine A processes and related compositions and methods of treatment | |
| JP2006511498A5 (https=) | ||
| JP2019512534A5 (https=) | ||
| RU2007112675A (ru) | ПРОИЗВОДНЫЕ ИМИДАЗО[1,5-a]ТРИАЗОЛО[1,5-d]БЕНЗОДИАЗЕПИНА ДЛЯ ЛЕЧЕНИЯ КОГНИТИВНЫХ РАССТРОЙСТВ | |
| CA2429440A1 (en) | Dehalogeno-compounds | |
| WO2005095399A3 (fr) | Derives pyrrolo (2,3-b) pyridine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases | |
| RU2012131280A (ru) | [4-(5-аминометил-2-фторфенил)пиперидин-1-ил]-(1н-пирролопиридинил)метаноны и их синтез | |
| JP2018522913A (ja) | ヒト免疫不全ウイルス複製の阻害剤としての５−（ｎ−［６，５］−縮合二環式アリールテトラヒドロイソキノリン−６−イル）ピリジン−３−イル酢酸誘導体 |