KR101272263B1 - 감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물 - Google Patents

감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물 Download PDF

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KR101272263B1
KR101272263B1 KR1020087004769A KR20087004769A KR101272263B1 KR 101272263 B1 KR101272263 B1 KR 101272263B1 KR 1020087004769 A KR1020087004769 A KR 1020087004769A KR 20087004769 A KR20087004769 A KR 20087004769A KR 101272263 B1 KR101272263 B1 KR 101272263B1
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alkyl
cyclopropyl
quinoline
dione
fluoro
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KR20080035661A (ko
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바튼 제임스 브래드버리
제이슨 앨런 윌레스
퀴핑 왕
아키히로 하시모토
에들라인 루시엔
고드윈 클래런스 길로이 파이스
밀린드 데쉬팬드
미카엘 존 푸치
김하영
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아칠리온 파르마세우티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020087004769A 2005-07-27 2006-07-27 감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물 Active KR101272263B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70281105P 2005-07-27 2005-07-27
US60/702,811 2005-07-27
PCT/US2006/029302 WO2007014308A1 (en) 2005-07-27 2006-07-27 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Publications (2)

Publication Number Publication Date
KR20080035661A KR20080035661A (ko) 2008-04-23
KR101272263B1 true KR101272263B1 (ko) 2013-06-13

Family

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KR1020087004769A Active KR101272263B1 (ko) 2005-07-27 2006-07-27 감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물

Country Status (19)

Country Link
US (2) US8044204B2 (https=)
EP (1) EP1913004B1 (https=)
JP (1) JP5143000B2 (https=)
KR (1) KR101272263B1 (https=)
CN (1) CN101263146B (https=)
AT (1) ATE482219T1 (https=)
AU (1) AU2006272571B2 (https=)
BR (1) BRPI0614456B8 (https=)
CA (1) CA2616768C (https=)
DE (1) DE602006017082D1 (https=)
DK (1) DK1913004T3 (https=)
EA (1) EA013244B1 (https=)
ES (1) ES2352799T3 (https=)
IL (1) IL189017A (https=)
NO (1) NO343376B1 (https=)
NZ (1) NZ566209A (https=)
PL (1) PL1913004T3 (https=)
PT (1) PT1913004E (https=)
WO (1) WO2007014308A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008021491A2 (en) 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US9216979B2 (en) 2009-10-16 2015-12-22 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
TW201726630A (zh) * 2009-10-16 2017-08-01 梅林塔療法公司 抗微生物性化合物及其製造與使用方法
WO2011047320A2 (en) * 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
KR20160070066A (ko) 2013-09-09 2016-06-17 멜린타 테라퓨틱스, 인크. 항균 화합물, 및 이의 제조 방법 및 이용 방법
EP3038623A4 (en) 2013-09-09 2017-04-19 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2015114317A1 (en) * 2014-01-28 2015-08-06 Redx Pharma Plc 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds
CA2979342A1 (en) 2015-03-11 2016-09-15 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2017193016A1 (en) 2016-05-06 2017-11-09 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3454856B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
ES2990061T3 (es) 2016-05-10 2024-11-28 C4 Therapeutics Inc Degronímeros espirocíclicos para la degradación de proteínas diana
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
CA3128224A1 (en) * 2019-02-01 2020-08-06 Aerie Pharmaceuticals, Inc. Compounds, compositions and methods for treatment of myopia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029894A1 (en) 1994-04-28 1995-11-09 The Procter & Gamble Company Novel quinolone 5-(n-heterosubstituted amino) antimicrobials
WO2002048138A1 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
JPH01160985A (ja) 1987-12-17 1989-06-23 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH01193275A (ja) 1988-01-28 1989-08-03 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JP2681190B2 (ja) 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
JPH02174784A (ja) 1988-12-27 1990-07-06 Hokuriku Seiyaku Co Ltd イソチアゾロキノリン誘導体
JPH02243692A (ja) 1989-03-16 1990-09-27 Dainippon Pharmaceut Co Ltd 三環式化合物
JPH02255687A (ja) 1989-03-27 1990-10-16 Dainippon Pharmaceut Co Ltd 三環式化合物
FR2645862B1 (fr) 1989-04-18 1991-07-12 Esteve Labor Dr Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
JP2787713B2 (ja) 1989-07-28 1998-08-20 富山化学工業株式会社 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
US5071848A (en) * 1989-10-23 1991-12-10 Abbott Laboratories Tricyclic quinoline antineoplastic agents
JP2939280B2 (ja) 1990-01-10 1999-08-25 三共株式会社 フッ素置換メトキシキノロンカルボン酸誘導体
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
CA2245179A1 (en) 1996-01-31 1997-08-07 Ube Industries Limited Remedies or preventives for aids
JP3616454B2 (ja) 1996-04-19 2005-02-02 栄研化学株式会社 生体成分測定用試薬
JPH10130149A (ja) 1996-07-12 1998-05-19 Sankyo Co Ltd Ｔｎｆ産生抑制剤
DE19652219A1 (de) * 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
KR20060069836A (ko) 2003-08-12 2006-06-22 아칠리온 파르마세우티칼스 인코포레이티드 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물
WO2006118605A2 (en) * 2004-11-11 2006-11-09 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
BRPI0607723A2 (pt) * 2005-02-16 2009-10-06 Achillion Pharmaceuticals Inc isotiazoloquinolonas e compostos relacionados como agentes antiinfecciosos
WO2010115184A2 (en) 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029894A1 (en) 1994-04-28 1995-11-09 The Procter & Gamble Company Novel quinolone 5-(n-heterosubstituted amino) antimicrobials
WO2002048138A1 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones

Also Published As

Publication number Publication date
WO2007014308A1 (en) 2007-02-01
AU2006272571A1 (en) 2007-02-01
IL189017A0 (en) 2008-08-07
IL189017A (en) 2014-01-30
BRPI0614456A2 (pt) 2011-03-29
EP1913004A1 (en) 2008-04-23
US8946422B2 (en) 2015-02-03
DK1913004T3 (da) 2011-01-10
NO343376B1 (no) 2019-02-11
NO20081005L (no) 2008-04-09
JP5143000B2 (ja) 2013-02-13
ES2352799T3 (es) 2011-02-23
BRPI0614456B1 (pt) 2019-08-27
ATE482219T1 (de) 2010-10-15
NZ566209A (en) 2011-03-31
JP2009502953A (ja) 2009-01-29
EA013244B1 (ru) 2010-04-30
US8044204B2 (en) 2011-10-25
CN101263146A (zh) 2008-09-10
HK1122024A1 (en) 2009-05-08
CN101263146B (zh) 2012-12-05
KR20080035661A (ko) 2008-04-23
US20120040959A1 (en) 2012-02-16
PL1913004T3 (pl) 2011-03-31
PT1913004E (pt) 2010-12-09
AU2006272571B2 (en) 2012-03-08
EP1913004B1 (en) 2010-09-22
EA200800444A1 (ru) 2008-06-30
DE602006017082D1 (de) 2010-11-04
CA2616768A1 (en) 2007-02-01
US20070049586A1 (en) 2007-03-01
BRPI0614456B8 (pt) 2021-05-25
CA2616768C (en) 2014-05-06

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