KR101272263B1 - 감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물 - Google Patents

감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물 Download PDF

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KR101272263B1
KR101272263B1 KR1020087004769A KR20087004769A KR101272263B1 KR 101272263 B1 KR101272263 B1 KR 101272263B1 KR 1020087004769 A KR1020087004769 A KR 1020087004769A KR 20087004769 A KR20087004769 A KR 20087004769A KR 101272263 B1 KR101272263 B1 KR 101272263B1
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alkyl
cyclopropyl
quinoline
dione
fluoro
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KR20080035661A (ko
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바튼 제임스 브래드버리
제이슨 앨런 윌레스
퀴핑 왕
아키히로 하시모토
에들라인 루시엔
고드윈 클래런스 길로이 파이스
밀린드 데쉬팬드
미카엘 존 푸치
김하영
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아칠리온 파르마세우티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020087004769A 2005-07-27 2006-07-27 감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물 Active KR101272263B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70281105P 2005-07-27 2005-07-27
US60/702,811 2005-07-27
PCT/US2006/029302 WO2007014308A1 (en) 2005-07-27 2006-07-27 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Publications (2)

Publication Number Publication Date
KR20080035661A KR20080035661A (ko) 2008-04-23
KR101272263B1 true KR101272263B1 (ko) 2013-06-13

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KR1020087004769A Active KR101272263B1 (ko) 2005-07-27 2006-07-27 감염 방지제로서 사용되는8-메톡시-9ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및관련 화합물

Country Status (19)

Country Link
US (2) US8044204B2 (https=)
EP (1) EP1913004B1 (https=)
JP (1) JP5143000B2 (https=)
KR (1) KR101272263B1 (https=)
CN (1) CN101263146B (https=)
AT (1) ATE482219T1 (https=)
AU (1) AU2006272571B2 (https=)
BR (1) BRPI0614456B8 (https=)
CA (1) CA2616768C (https=)
DE (1) DE602006017082D1 (https=)
DK (1) DK1913004T3 (https=)
EA (1) EA013244B1 (https=)
ES (1) ES2352799T3 (https=)
IL (1) IL189017A (https=)
NO (1) NO343376B1 (https=)
NZ (1) NZ566209A (https=)
PL (1) PL1913004T3 (https=)
PT (1) PT1913004E (https=)
WO (1) WO2007014308A1 (https=)

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US7902365B2 (en) 2006-08-16 2011-03-08 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones
EA201101451A1 (ru) * 2009-04-03 2012-03-30 Ачиллион Фармасьютикалз, Инк. Гидрокситиенохинолоны и родственные соединения как противоинфекционные средства
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
NZ599290A (en) 2009-10-16 2014-10-31 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
CN108456211A (zh) * 2009-10-16 2018-08-28 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
MX2012004341A (es) * 2009-10-16 2012-10-05 Rib X Pharmaceuticals Inc Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
EP3038623A4 (en) 2013-09-09 2017-04-19 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
CA2923214A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2015114317A1 (en) * 2014-01-28 2015-08-06 Redx Pharma Plc 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds
HK1249758A1 (zh) 2015-03-11 2018-11-09 Melinta Therapeutics, Inc. 抗微生物化合物及其制备和使用方法
US11098047B2 (en) 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
JP7665519B2 (ja) * 2019-02-01 2025-04-21 アルコン インコーポレイティド 近視を治療するための化合物、組成物及び医薬組成物

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WO2002048138A1 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones

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Also Published As

Publication number Publication date
EP1913004B1 (en) 2010-09-22
CA2616768C (en) 2014-05-06
JP2009502953A (ja) 2009-01-29
AU2006272571B2 (en) 2012-03-08
PL1913004T3 (pl) 2011-03-31
NO343376B1 (no) 2019-02-11
EA200800444A1 (ru) 2008-06-30
CN101263146A (zh) 2008-09-10
CA2616768A1 (en) 2007-02-01
ES2352799T3 (es) 2011-02-23
DK1913004T3 (da) 2011-01-10
EP1913004A1 (en) 2008-04-23
JP5143000B2 (ja) 2013-02-13
EA013244B1 (ru) 2010-04-30
US8044204B2 (en) 2011-10-25
IL189017A0 (en) 2008-08-07
US20120040959A1 (en) 2012-02-16
KR20080035661A (ko) 2008-04-23
US8946422B2 (en) 2015-02-03
BRPI0614456B8 (pt) 2021-05-25
NZ566209A (en) 2011-03-31
ATE482219T1 (de) 2010-10-15
PT1913004E (pt) 2010-12-09
HK1122024A1 (en) 2009-05-08
CN101263146B (zh) 2012-12-05
BRPI0614456A2 (pt) 2011-03-29
US20070049586A1 (en) 2007-03-01
NO20081005L (no) 2008-04-09
IL189017A (en) 2014-01-30
BRPI0614456B1 (pt) 2019-08-27
DE602006017082D1 (de) 2010-11-04
WO2007014308A1 (en) 2007-02-01
AU2006272571A1 (en) 2007-02-01

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