JP2009500424A5 - - Google Patents
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- JP2009500424A5 JP2009500424A5 JP2008520396A JP2008520396A JP2009500424A5 JP 2009500424 A5 JP2009500424 A5 JP 2009500424A5 JP 2008520396 A JP2008520396 A JP 2008520396A JP 2008520396 A JP2008520396 A JP 2008520396A JP 2009500424 A5 JP2009500424 A5 JP 2009500424A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- aryl
- carbocycle
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 66
- 229910052739 hydrogen Inorganic materials 0.000 claims 47
- 229910052799 carbon Inorganic materials 0.000 claims 39
- 125000000623 heterocyclic group Chemical group 0.000 claims 37
- 125000003118 aryl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 32
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 22
- 229960005190 Phenylalanine Drugs 0.000 claims 22
- -1 C 3 -C 8 carbocycle Chemical group 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 4
- 229940079593 drugs Drugs 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 102000005614 monoclonal antibodies Human genes 0.000 claims 2
- 108010045030 monoclonal antibodies Proteins 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- UCKLRJLHKVCNAU-LURJTMIESA-N (2S)-2-(1,3-benzothiazol-2-ylamino)propanoic acid Chemical compound C1=CC=C2SC(N[C@@H](C)C(O)=O)=NC2=C1 UCKLRJLHKVCNAU-LURJTMIESA-N 0.000 claims 1
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2S)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims 1
- WTYDPHLGAWMABS-LURJTMIESA-N (2S)-2-(pyrrolidin-1-ylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NN1CCCC1 WTYDPHLGAWMABS-LURJTMIESA-N 0.000 claims 1
- DDCPKNYKNWXULB-YFKPBYRVSA-N (2S)-2-azaniumyl-3-[(2-methylpropan-2-yl)oxy]propanoate Chemical compound CC(C)(C)OC[C@H]([NH3+])C([O-])=O DDCPKNYKNWXULB-YFKPBYRVSA-N 0.000 claims 1
- NMJINEMBBQVPGY-RITPCOANSA-N (2S,3R)-2-azaniumyl-3-[(2-methylpropan-2-yl)oxy]butanoate Chemical compound CC(C)(C)O[C@H](C)[C@H]([NH3+])C([O-])=O NMJINEMBBQVPGY-RITPCOANSA-N 0.000 claims 1
- ONOURAAVVKGJNM-SCZZXKLOSA-N (2S,3R)-2-azaniumyl-3-phenylmethoxybutanoate Chemical compound [O-]C(=O)[C@@H]([NH3+])[C@@H](C)OCC1=CC=CC=C1 ONOURAAVVKGJNM-SCZZXKLOSA-N 0.000 claims 1
- JQNGUUYRCQQTSF-UHFFFAOYSA-N 2-(oxan-4-ylamino)acetic acid Chemical compound OC(=O)CNC1CCOCC1 JQNGUUYRCQQTSF-UHFFFAOYSA-N 0.000 claims 1
- PRSWALMQXKFZFA-UHFFFAOYSA-N 2-(piperidin-1-ylamino)acetic acid Chemical compound OC(=O)CNN1CCCCC1 PRSWALMQXKFZFA-UHFFFAOYSA-N 0.000 claims 1
- IDGQXGPQOGUGIX-UHFFFAOYSA-N 2-azaniumyl-3-phenylmethoxypropanoate Chemical compound OC(=O)C(N)COCC1=CC=CC=C1 IDGQXGPQOGUGIX-UHFFFAOYSA-N 0.000 claims 1
- UCUNFLYVYCGDHP-UHFFFAOYSA-N 2-azaniumyl-4-methylsulfonylbutanoate Chemical compound CS(=O)(=O)CCC(N)C(O)=O UCUNFLYVYCGDHP-UHFFFAOYSA-N 0.000 claims 1
- NIGWMJHCCYYCSF-UHFFFAOYSA-N 4-Chloro-3-phenyl-L-alanine Chemical group OC(=O)C(N)CC1=CC=C(Cl)C=C1 NIGWMJHCCYYCSF-UHFFFAOYSA-N 0.000 claims 1
- DPDPQQHHTHKSRN-UHFFFAOYSA-N 4-aminooxane-4-carboxylic acid Chemical compound OC(=O)C1(N)CCOCC1 DPDPQQHHTHKSRN-UHFFFAOYSA-N 0.000 claims 1
- XWHHYOYVRVGJJY-QMMMGPOBSA-N 4-fluorophenyl-L-alanine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(F)C=C1 XWHHYOYVRVGJJY-QMMMGPOBSA-N 0.000 claims 1
- GTVVZTAFGPQSPC-UHFFFAOYSA-N 4-nitrophenylalanine Chemical compound OC(=O)C(N)CC1=CC=C([N+]([O-])=O)C=C1 GTVVZTAFGPQSPC-UHFFFAOYSA-N 0.000 claims 1
- 229960001230 Asparagine Drugs 0.000 claims 1
- 229960005261 Aspartic Acid Drugs 0.000 claims 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
- 229960002989 Glutamic Acid Drugs 0.000 claims 1
- 229960000310 ISOLEUCINE Drugs 0.000 claims 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-2-aminohexanoic acid zwitterion Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 1
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid zwitterion Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims 1
- VHVGNTVUSQUXPS-JAMMHHFISA-N L-Threo-3-Phenylserine Chemical compound OC(=O)[C@@H](N)C(O)C1=CC=CC=C1 VHVGNTVUSQUXPS-JAMMHHFISA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- JTTHKOPSMAVJFE-VIFPVBQESA-N L-homophenylalanine Chemical compound OC(=O)[C@@H](N)CCC1=CC=CC=C1 JTTHKOPSMAVJFE-VIFPVBQESA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- YYFXSRHYTXNLCL-UHFFFAOYSA-N N[N-]C(O)=O Chemical compound N[N-]C(O)=O YYFXSRHYTXNLCL-UHFFFAOYSA-N 0.000 claims 1
- ZKZBPNGNEQAJSX-REOHCLBHSA-N Selenocysteine Chemical compound [SeH]C[C@H](N)C(O)=O ZKZBPNGNEQAJSX-REOHCLBHSA-N 0.000 claims 1
- 229940055619 Selenocysteine Drugs 0.000 claims 1
- FDKWRPBBCBCIGA-UWTATZPHSA-N Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 235000016491 selenocysteine Nutrition 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- QWCKQJZIFLGMSD-UHFFFAOYSA-N α-Aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims 1
- FUOOLUPWFVMBKG-UHFFFAOYSA-N α-aminoisobutanoic acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims 1
- ZGUNAGUHMKGQNY-UHFFFAOYSA-N α-phenylglycine Chemical compound OC(=O)C(N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-UHFFFAOYSA-N 0.000 claims 1
- 0 C*NCC(Cc1ccccc1)C(O)=O Chemical compound C*NCC(Cc1ccccc1)C(O)=O 0.000 description 3
- QXKFRGBDFPUSEZ-UHFFFAOYSA-N CC(N(C1)C(Cc2ccccc2)CCC1C(O)=O)=C Chemical compound CC(N(C1)C(Cc2ccccc2)CCC1C(O)=O)=C QXKFRGBDFPUSEZ-UHFFFAOYSA-N 0.000 description 1
- ZLIPGCUNOOFZML-UHFFFAOYSA-N CCN(CC(Cc1ccccc1)C1)CC1C(O)=O Chemical compound CCN(CC(Cc1ccccc1)C1)CC1C(O)=O ZLIPGCUNOOFZML-UHFFFAOYSA-N 0.000 description 1
- LXIANNUASSWOKI-UHFFFAOYSA-N CCN(CCC1Cc2ccccc2)CC1C(O)=O Chemical compound CCN(CCC1Cc2ccccc2)CC1C(O)=O LXIANNUASSWOKI-UHFFFAOYSA-N 0.000 description 1
- XWCSUERVLZIHKC-UHFFFAOYSA-N CCNCC(CC(O)=O)Cc1ccccc1 Chemical compound CCNCC(CC(O)=O)Cc1ccccc1 XWCSUERVLZIHKC-UHFFFAOYSA-N 0.000 description 1
- ZWURJJVCFRJQOY-UHFFFAOYSA-N CCNCCC(Cc1ccccc1)C(O)=O Chemical compound CCNCCC(Cc1ccccc1)C(O)=O ZWURJJVCFRJQOY-UHFFFAOYSA-N 0.000 description 1
- AOLLIWDGLAVYML-UHFFFAOYSA-N CN(C1)C(Cc2ccccc2)CC1C(O)=O Chemical compound CN(C1)C(Cc2ccccc2)CC1C(O)=O AOLLIWDGLAVYML-UHFFFAOYSA-N 0.000 description 1
- JEYBSDROLSIJQP-UHFFFAOYSA-N CN(CC1Cc2ccccc2)CC1C(O)=O Chemical compound CN(CC1Cc2ccccc2)CC1C(O)=O JEYBSDROLSIJQP-UHFFFAOYSA-N 0.000 description 1
- XDYCCVBZZUKWFY-UHFFFAOYSA-N CNC(CC(O)=O)Cc1ccccc1 Chemical compound CNC(CC(O)=O)Cc1ccccc1 XDYCCVBZZUKWFY-UHFFFAOYSA-N 0.000 description 1
- BJWPOHOQHOEKSU-UHFFFAOYSA-N CNC(CCC(O)=O)Cc1ccccc1 Chemical compound CNC(CCC(O)=O)Cc1ccccc1 BJWPOHOQHOEKSU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69776705P | 2005-07-07 | 2005-07-07 | |
| US60/697,767 | 2005-07-07 | ||
| PCT/US2006/026352 WO2007008603A1 (en) | 2005-07-07 | 2006-07-07 | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012104711A Division JP2012144576A (ja) | 2005-07-07 | 2012-05-01 | フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500424A JP2009500424A (ja) | 2009-01-08 |
| JP2009500424A5 true JP2009500424A5 (US06638906-20031028-C00029.png) | 2009-08-20 |
| JP5171621B2 JP5171621B2 (ja) | 2013-03-27 |
Family
ID=37637475
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008520396A Active JP5171621B2 (ja) | 2005-07-07 | 2006-07-07 | フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物 |
| JP2012104711A Withdrawn JP2012144576A (ja) | 2005-07-07 | 2012-05-01 | フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012104711A Withdrawn JP2012144576A (ja) | 2005-07-07 | 2012-05-01 | フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物 |
Country Status (7)
Families Citing this family (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US20110313230A1 (en) | 2001-05-11 | 2011-12-22 | Terrance Grant Johns | Specific binding proteins and uses thereof |
| EP1392359B2 (en) | 2001-05-11 | 2013-03-13 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| US20110045005A1 (en) | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| KR101438983B1 (ko) | 2003-11-06 | 2014-09-05 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| CA2586909A1 (en) | 2004-11-12 | 2006-12-14 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
| EP1912677B1 (en) * | 2005-06-20 | 2013-10-02 | Psma Development Company, L.L.C. | PSMA antibody-drug conjugates |
| US8871720B2 (en) | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| EP1917020B1 (en) | 2005-07-07 | 2016-05-25 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
| CN104013956B (zh) * | 2007-01-25 | 2018-12-18 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
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| EP2686336B1 (de) | 2011-03-16 | 2015-05-06 | Seattle Genetics, Inc. | N-carboxyalkyl-auristatine und ihre verwendung |
| CA2833477A1 (en) | 2011-04-21 | 2012-10-26 | Seattle Genetics, Inc. | Novel binder-drug conjugates (adcs) and their use |
| SI2707031T1 (sl) | 2011-05-08 | 2019-10-30 | Legochem Biosciences Inc | Konjugati protein-učinkovina in postopek za njihovo pripravo |
| UA112434C2 (uk) | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
| SG11201401815XA (en) | 2011-10-28 | 2014-05-29 | Genentech Inc | Therapeutic combinations and methods of treating melanoma |
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| CN108324943B (zh) | 2012-02-10 | 2024-03-08 | 思进股份有限公司 | Cd30+癌症的检测和治疗 |
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| RU2014148162A (ru) | 2012-05-01 | 2016-06-20 | Дженентек, Инк. | Анти-pmel17 антитела и их иммуноконъюгаты |
| JP6423340B2 (ja) | 2012-05-15 | 2018-11-14 | シアトル ジェネティクス，インコーポレイティド | 自己安定化リンカー結合体 |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
| US10132799B2 (en) | 2012-07-13 | 2018-11-20 | Innate Pharma | Screening of conjugated antibodies |
| WO2014072482A1 (en) | 2012-11-09 | 2014-05-15 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| EP2928503B1 (en) | 2012-12-10 | 2019-02-20 | Mersana Therapeutics, Inc. | Conjugates of auristatin compounds |
| CN107880126B (zh) | 2012-12-21 | 2021-03-30 | 西雅图基因公司 | 抗ntb-a抗体及相关组合物和方法 |
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| BR112015022019A2 (pt) | 2013-03-14 | 2017-08-29 | Genentech Inc | Anticorpos isolados, ácido nucleico, célula hospedeira, método de produção de anticorpos, imunoconjugado, formulação farmacêutica, métodos de tratamento de indivíduos, de inibição da proliferação de células, de detecção de b7-h4 humano e de detecção de câncer |
| EP2968582B1 (en) | 2013-03-15 | 2020-07-01 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
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2006
- 2006-07-07 EP EP06786489.2A patent/EP1917020B1/en active Active
- 2006-07-07 ES ES13190752T patent/ES2708763T3/es active Active
- 2006-07-07 CA CA2614436A patent/CA2614436C/en active Active
- 2006-07-07 EP EP13190752.9A patent/EP2722051B1/en active Active
- 2006-07-07 EP EP18200998.5A patent/EP3498289A1/en not_active Withdrawn
- 2006-07-07 US US11/994,809 patent/US8343928B2/en active Active
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- 2006-07-07 WO PCT/US2006/026352 patent/WO2007008603A1/en active Application Filing
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2012
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2018
- 2018-05-24 US US15/988,989 patent/US20180355025A1/en not_active Abandoned
