JP2009256224A - エアゾール組成物 - Google Patents
エアゾール組成物 Download PDFInfo
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- JP2009256224A JP2009256224A JP2008105069A JP2008105069A JP2009256224A JP 2009256224 A JP2009256224 A JP 2009256224A JP 2008105069 A JP2008105069 A JP 2008105069A JP 2008105069 A JP2008105069 A JP 2008105069A JP 2009256224 A JP2009256224 A JP 2009256224A
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- aqueous stock
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- liquefied gas
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- 229960002607 sulconazole Drugs 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
【解決手段】水性原液と液化ガスとからなるエアゾール組成物であって、前記水性原液がたんぱく質と界面活性剤とを含有し、たんぱく質が水性原液中に2〜10重量%含有されており、前記水性原液と前記液化ガスとの配合比が50/50〜10/90(重量比)である。
【選択図】図2
Description
1)乳化
水性原液と液化ガスを充填した透明な耐圧容器(ポリエチレンテレフタレート製)を上下に振り、水性原液と液化ガスが乳化するのを目視観察し、それに要した回数を下記の水準に基づき評価した。
○:20回以内に乳化した。
△:20〜30回で乳化した。
×:30回振っても乳化しない。
得られたエアゾール組成物を25℃の恒温水槽中に1時間浸漬し、人工皮革に噴射したときの噴射状態を下記の水準に基づき評価した。
○1:スプレー状に噴射することができ、噴射物は指で押しても割れない柔軟で立体的なシャーベットを形成した。
○2:スプレー状に噴射することができ、噴射物は指で押しても割れない柔軟で平面的なシャーベットを形成した。
×1:スプレー状に噴射することができたが、噴射物は指で押すと割れる固いシャーベットを形成した。
×2:スプレー状に噴射することができたが、噴射物は発泡しシャーベットにならなかった。
×3:水性原液と液化ガスが分離した状態で噴射された。
×4:スプレー状に拡がらなかった。
垂直に立てた人工皮革に噴射して、剥がれ落ちるまたは流れ落ちるまでの時間を測定した。
○:3分以上保持することができた。
△:保持時間が1分以上3分未満であった。
×:保持時間が1分未満であった。
下記の水性原液を調製し、水性原液25gをアルミニウム製耐圧容器に充填した。アンダーカップ充填により液化石油ガス(*1)75gを充填し、耐圧容器の開口部にエアゾールバルブをクリンプした。次いでエアゾール容器を上下に振り、水性原液と液化石油ガスとを乳化させてエアゾール組成物を製造した。なお、エアゾールバルブはステム孔がφ0.4、ハウジングのアンダータップがφ1.5、ベーパータップがφ0.3であるものを用い、噴射部材は噴射孔がφ1.1であるものを用いた。評価結果を表1に示す。
ゼラチン 5.0
l−メントール 0.3
POE(20)POP(8)セチルエーテル(*2) 1.0
メチルパラベン 0.1
95%エタノール 2.5
タルク 1.0
精製水 90.1
合 計 100.0(重量%)
水性原液/液化石油ガス(*1)=25/75(重量比)
*1:イソブタンとノルマルブタンの混合物、20℃での蒸気圧が0.15(MPa)
*2:NIKKOL PBC−44(商品名)、HLB12.5、日光ケミカルズ社製
ゼラチンの配合割合を7%、精製水の配合割合を88.1%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
ゼラチンの配合割合を3%、精製水の配合割合を92.1%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
水性原液を20g、液化石油ガス(*1)80g充填したほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
水性原液を30g、液化石油ガス(*1)70g充填したほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
水性原液を40g、液化石油ガス(*1)60g充填したほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
エタノールを配合せず、精製水の配合割合を92.6%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
ゼラチンを配合せず、精製水の配合割合を95.1%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
ゼラチンの配合割合を1%、精製水の配合割合を94.1%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
ゼラチンの配合割合を12%、精製水の配合割合を83.1%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
ゼラチンの代わりにヒドロキシエチルセルロース(*3)を1%、精製水の配合割合を94.1%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
*3:HEC SE850(商品名)、ダイセル化学工業社製
ゼラチンの代わりにキサンタンガム(*4)を1%、精製水の配合割合を94.1%にしたほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
*4:エコーガム(商品名)、大日本製薬社製
ゼラチンの代わりにカルボキシビニルポリマー(*5)を0.1%、トリエタノールアミンを0.1%、精製水を94.9%配合したほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
*5:カーボポール940(商品名)、BF Goodrich社製
水性原液を5g、液化石油ガス(*1)95g充填したほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
水性原液を60g、液化石油ガス(*1)40g充填したほかは、実施例1と同じ配合で調製し、エアゾール組成物を製造した。評価結果を表1に示す。
下記の原液を調製し、原液30gをアルミニウム製耐圧容器に充填した。アンダーカップ充填により液化石油ガス70gを充填し、耐圧容器の開口部にエアゾールバルブをクリンプした。次いでエアゾール容器を上下に振り、原液と液化石油ガスとを乳化させてエアゾール組成物を製造した。
ゼラチン 5.0
ブフェキサマック 0.2
リドカイン 0.1
アクリノール 0.1
POE(20)POP(8)セチルエーテル(*2) 1.5
酸化亜鉛 3.0
タルク 1.0
メチルパラベン 0.1
精製水 89.0
合 計 100.00(重量%)
原液/液化石油ガス(*1)=30/70(重量比)
下記の原液を使用した以外は処方例1と同様にして、エアゾール組成物を製造した。
ゼラチン 5.0
尿素 10.0
塩酸ジフェンヒドラミン 1.0
グリチルリチン酸ジカリウム 0.5
酢酸トコフェロール 0.5
メチルパラベン 0.1
エタノール 10.0
製水 72.9
合 計 100.0(重量%)
原液/液化石油ガス(*1)=30/70(重量比)
下記の原液を使用した以外は処方例1と同様にして、エアゾール組成物を製造した。
ゼラチン 5.0
フェルビナク 1.0
l−メントール 0.5
エタノール 5.0
トリエタノールアミン 1.0
精製水 87.5
合 計 100.0(重量%)
原液/液化石油ガス(*1)=30/70(重量比)
1a 平坦部
1b 突出部
3 ヒビ
Claims (2)
- 水性原液と液化ガスとからなるエアゾール組成物であって、
前記水性原液がたんぱく質と界面活性剤とを含有し、
前記たんぱく質が、水性原液中に2〜10重量%含有され、
前記水性原液と前記液化ガスとの配合比が50/50〜10/90(重量比)であるエアゾール組成物。 - 前記たんぱく質が、ゼラチンである請求項1記載のエアゾール組成物。
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JP2008105069A JP5507818B2 (ja) | 2008-04-14 | 2008-04-14 | エアゾール組成物 |
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JP2008105069A JP5507818B2 (ja) | 2008-04-14 | 2008-04-14 | エアゾール組成物 |
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JP2009256224A true JP2009256224A (ja) | 2009-11-05 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018193333A (ja) * | 2017-05-18 | 2018-12-06 | 英昌化学工業株式会社 | クラッキングエアゾール組成物 |
WO2019181510A1 (ja) * | 2018-03-19 | 2019-09-26 | 株式会社マンダム | エアゾール製品 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990011068A1 (fr) * | 1989-03-17 | 1990-10-04 | Taisho Pharmaceutical Co., Ltd. | Preparation aerosol a usage externe |
JPH115715A (ja) * | 1997-06-13 | 1999-01-12 | Shiseido Co Ltd | エアゾール組成物 |
JP2000351726A (ja) * | 1999-06-08 | 2000-12-19 | Lion Corp | エアゾール製剤 |
JP2000351725A (ja) * | 1999-06-08 | 2000-12-19 | Lion Corp | エアゾール製剤 |
JP2001106611A (ja) * | 1999-07-30 | 2001-04-17 | Daizo:Kk | 発泡性エアゾール組成物 |
-
2008
- 2008-04-14 JP JP2008105069A patent/JP5507818B2/ja not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990011068A1 (fr) * | 1989-03-17 | 1990-10-04 | Taisho Pharmaceutical Co., Ltd. | Preparation aerosol a usage externe |
JPH115715A (ja) * | 1997-06-13 | 1999-01-12 | Shiseido Co Ltd | エアゾール組成物 |
JP2000351726A (ja) * | 1999-06-08 | 2000-12-19 | Lion Corp | エアゾール製剤 |
JP2000351725A (ja) * | 1999-06-08 | 2000-12-19 | Lion Corp | エアゾール製剤 |
JP2001106611A (ja) * | 1999-07-30 | 2001-04-17 | Daizo:Kk | 発泡性エアゾール組成物 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018193333A (ja) * | 2017-05-18 | 2018-12-06 | 英昌化学工業株式会社 | クラッキングエアゾール組成物 |
WO2019181510A1 (ja) * | 2018-03-19 | 2019-09-26 | 株式会社マンダム | エアゾール製品 |
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