JP2009242405A5 - - Google Patents
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- Publication number
- JP2009242405A5 JP2009242405A5 JP2009133854A JP2009133854A JP2009242405A5 JP 2009242405 A5 JP2009242405 A5 JP 2009242405A5 JP 2009133854 A JP2009133854 A JP 2009133854A JP 2009133854 A JP2009133854 A JP 2009133854A JP 2009242405 A5 JP2009242405 A5 JP 2009242405A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- defined above
- here
- alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- HHLZCENAOIROSL-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCNCCN(CC(O)=O)CCN(CC(O)=O)CC1 HHLZCENAOIROSL-UHFFFAOYSA-N 0.000 description 3
- -1 phenyloxy, phenyldioxy group Chemical group 0.000 description 3
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 description 2
- 0 CCCN(C*)CCN Chemical compound CCCN(C*)CCN 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- XAMYFISTBAIHFT-UHFFFAOYSA-N 2-[1,8-bis(carboxymethyl)-1,2,5,8-tetrazecan-5-yl]acetic acid Chemical compound OC(=O)CN1CCNN(CC(O)=O)CCN(CC(O)=O)CC1 XAMYFISTBAIHFT-UHFFFAOYSA-N 0.000 description 1
- YDLDORZAYJTSMR-UHFFFAOYSA-N C=CCNCCN Chemical compound C=CCNCCN YDLDORZAYJTSMR-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001373A IT1292130B1 (it) | 1997-06-11 | 1997-06-11 | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| ITMI97A001373 | 1997-06-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50155499A Division JP4445042B2 (ja) | 1997-06-11 | 1998-06-08 | １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009242405A JP2009242405A (ja) | 2009-10-22 |
| JP2009242405A5 true JP2009242405A5 (enExample) | 2012-08-30 |
| JP5204724B2 JP5204724B2 (ja) | 2013-06-05 |
Family
ID=11377338
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50155499A Expired - Lifetime JP4445042B2 (ja) | 1997-06-11 | 1998-06-08 | １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 |
| JP2009133854A Expired - Lifetime JP5204724B2 (ja) | 1997-06-11 | 2009-06-03 | １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50155499A Expired - Lifetime JP4445042B2 (ja) | 1997-06-11 | 1998-06-08 | １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5962679A (enExample) |
| EP (1) | EP0989974B1 (enExample) |
| JP (2) | JP4445042B2 (enExample) |
| CN (2) | CN1215063C (enExample) |
| AT (1) | ATE224379T1 (enExample) |
| AU (1) | AU738506B2 (enExample) |
| DE (1) | DE69808086T2 (enExample) |
| ES (1) | ES2184302T3 (enExample) |
| IL (1) | IL131255A (enExample) |
| IN (1) | IN186470B (enExample) |
| IT (1) | IT1292130B1 (enExample) |
| NO (1) | NO312548B1 (enExample) |
| WO (1) | WO1998056776A1 (enExample) |
| ZA (1) | ZA985023B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1292130B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| US6166201A (en) * | 1999-06-25 | 2000-12-26 | Dibra S.P.A. | Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof |
| US6838557B1 (en) * | 2002-10-01 | 2005-01-04 | Board Of Regents The University Of Texas System | Process for making a chelating agent for labeling biomolecules using preformed active esters |
| US6852854B1 (en) | 2002-10-01 | 2005-02-08 | Psiloquest Inc. | Preformed carboxylated active ester for labeling biomolecules |
| US20050033106A1 (en) * | 2003-07-08 | 2005-02-10 | Wing Tak Wong | Synthesis of tris N-alkylated 1,4,7,10-tetraazacyclododecanes |
| DE102009053171B4 (de) | 2009-11-04 | 2011-07-21 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol) |
| CN103232403B (zh) * | 2013-05-09 | 2016-04-27 | 浙江凯普化工有限公司 | 一种氮杂环的制备方法 |
| CN105377309A (zh) * | 2013-05-30 | 2016-03-02 | 伯拉考成像股份公司 | 荧光固体脂质纳米颗粒组合物及其制备 |
| CN108084105B (zh) * | 2016-11-23 | 2020-07-24 | 四川科伦药物研究院有限公司 | 钆特醇中间体及其合成方法和利用该钆特醇中间体制备钆特醇的方法 |
| KR101971435B1 (ko) | 2017-08-29 | 2019-04-24 | 주식회사 엔지켐생명과학 | 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법 |
| WO2020084504A1 (en) * | 2018-10-24 | 2020-04-30 | Biophore India Pharmaceuticals Pvt. Ltd | Novel process for the preparation of macrocyclic chelant 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetra azacyclododecane-1,4,7-triyl) triacetic acid and it's complexes with paramagnetic metal ions |
| US20200397924A1 (en) * | 2019-01-28 | 2020-12-24 | Hubei Tianshu Pharmaceutical Co., Ltd | Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof |
| CN111039885B (zh) * | 2019-12-06 | 2021-03-05 | 广州康瑞泰药业有限公司 | 一种制备高纯度考布曲钙的方法 |
| KR20210114742A (ko) * | 2020-03-11 | 2021-09-24 | 주식회사 엔지켐생명과학 | 칼테리돌의 제조방법 |
| CN113549025B (zh) * | 2021-07-14 | 2023-07-25 | 江苏美迪克化学品有限公司 | 一种1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸及其钠盐的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| FR2644453A1 (fr) * | 1989-03-20 | 1990-09-21 | Centre Nat Rech Scient | Procede de preparation de tetramines cycliques monofonctionnalisees |
| IT1243801B (it) * | 1990-08-29 | 1994-06-28 | Bracco Ind Chimica Spa | Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione |
| US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
| DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
| DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
| DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
| JP3878208B2 (ja) * | 1994-04-08 | 2007-02-07 | ブラッコ インターナショナル ベスローテン フェンノートシャップ | 芳香族アミド化合物およびそれらのキレート |
| IT1292130B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| IT1292128B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
-
1997
- 1997-06-11 IT IT97MI001373A patent/IT1292130B1/it active IP Right Grant
-
1998
- 1998-06-08 IL IL13125598A patent/IL131255A/en not_active IP Right Cessation
- 1998-06-08 AU AU84369/98A patent/AU738506B2/en not_active Expired
- 1998-06-08 DE DE69808086T patent/DE69808086T2/de not_active Expired - Lifetime
- 1998-06-08 WO PCT/EP1998/003408 patent/WO1998056776A1/en not_active Ceased
- 1998-06-08 CN CNB021495890A patent/CN1215063C/zh not_active Expired - Lifetime
- 1998-06-08 CN CN98803621A patent/CN1117088C/zh not_active Expired - Lifetime
- 1998-06-08 ES ES98934925T patent/ES2184302T3/es not_active Expired - Lifetime
- 1998-06-08 EP EP98934925A patent/EP0989974B1/en not_active Expired - Lifetime
- 1998-06-08 AT AT98934925T patent/ATE224379T1/de not_active IP Right Cessation
- 1998-06-08 JP JP50155499A patent/JP4445042B2/ja not_active Expired - Lifetime
- 1998-06-10 IN IN1252MA1998 patent/IN186470B/en unknown
- 1998-06-10 US US09/095,016 patent/US5962679A/en not_active Expired - Lifetime
- 1998-06-10 ZA ZA985023A patent/ZA985023B/xx unknown
-
1999
- 1999-06-25 US US09/339,957 patent/US6054581A/en not_active Expired - Lifetime
- 1999-12-03 NO NO19995924A patent/NO312548B1/no not_active IP Right Cessation
-
2009
- 2009-06-03 JP JP2009133854A patent/JP5204724B2/ja not_active Expired - Lifetime
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