JP2009108078A5 - - Google Patents
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- Publication number
- JP2009108078A5 JP2009108078A5 JP2008290079A JP2008290079A JP2009108078A5 JP 2009108078 A5 JP2009108078 A5 JP 2009108078A5 JP 2008290079 A JP2008290079 A JP 2008290079A JP 2008290079 A JP2008290079 A JP 2008290079A JP 2009108078 A5 JP2009108078 A5 JP 2009108078A5
- Authority
- JP
- Japan
- Prior art keywords
- cys
- trp
- lys
- tyr
- cyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- ONOURAAVVKGJNM-SCZZXKLOSA-N (2s,3r)-2-azaniumyl-3-phenylmethoxybutanoate Chemical compound [O-]C(=O)[C@@H]([NH3+])[C@@H](C)OCC1=CC=CC=C1 ONOURAAVVKGJNM-SCZZXKLOSA-N 0.000 claims 32
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 8
- -1 His Chemical compound 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 3
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 3
- 150000008575 L-amino acids Chemical class 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- KAFHLONDOVSENM-HNNXBMFYSA-N O-Benzyl-L-tyrosine Chemical compound C1=CC(C[C@H](N)C(O)=O)=CC=C1OCC1=CC=CC=C1 KAFHLONDOVSENM-HNNXBMFYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13765599P | 1999-06-04 | 1999-06-04 | |
| US60/137,655 | 1999-06-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001502467A Division JP2003501443A (ja) | 1999-06-04 | 2000-06-05 | ニューロメジンｂおよびソマトスタチンレセプターアゴニスト |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011264477A Division JP5519622B2 (ja) | 1999-06-04 | 2011-12-02 | ニューロメジンｂおよびソマトスタチンレセプターアゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009108078A JP2009108078A (ja) | 2009-05-21 |
| JP2009108078A5 true JP2009108078A5 (enExample) | 2009-07-02 |
| JP5165537B2 JP5165537B2 (ja) | 2013-03-21 |
Family
ID=22478469
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001502467A Pending JP2003501443A (ja) | 1999-06-04 | 2000-06-05 | ニューロメジンｂおよびソマトスタチンレセプターアゴニスト |
| JP2008290079A Expired - Fee Related JP5165537B2 (ja) | 1999-06-04 | 2008-11-12 | ニューロメジンｂおよびソマトスタチンレセプターアゴニスト |
| JP2011264477A Expired - Fee Related JP5519622B2 (ja) | 1999-06-04 | 2011-12-02 | ニューロメジンｂおよびソマトスタチンレセプターアゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001502467A Pending JP2003501443A (ja) | 1999-06-04 | 2000-06-05 | ニューロメジンｂおよびソマトスタチンレセプターアゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011264477A Expired - Fee Related JP5519622B2 (ja) | 1999-06-04 | 2011-12-02 | ニューロメジンｂおよびソマトスタチンレセプターアゴニスト |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1189941B1 (enExample) |
| JP (3) | JP2003501443A (enExample) |
| CN (1) | CN1367793A (enExample) |
| AR (1) | AR020862A1 (enExample) |
| AU (1) | AU774096B2 (enExample) |
| BR (1) | BR0011680A (enExample) |
| CA (1) | CA2376506C (enExample) |
| CZ (1) | CZ20014297A3 (enExample) |
| ES (1) | ES2401096T3 (enExample) |
| HU (1) | HUP0202022A3 (enExample) |
| IL (1) | IL146884A0 (enExample) |
| PL (1) | PL352968A1 (enExample) |
| RU (3) | RU2263680C2 (enExample) |
| TW (1) | TWI243177B (enExample) |
| WO (1) | WO2000075186A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2433785C (en) * | 2001-01-12 | 2009-08-04 | Michael Dewitt Culler | Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof |
| CA2450446A1 (en) * | 2001-06-25 | 2003-01-03 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Pharmaceutical compositions which inhibit proliferation of pituitary adenomas and method of use thereof |
| US7189856B2 (en) | 2001-12-28 | 2007-03-13 | Gideon Shapiro | Non-peptide somatostatin receptor ligands |
| WO2003093830A1 (en) * | 2002-05-02 | 2003-11-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with neuromedin b receptor (nmb) |
| CA2647986C (en) | 2006-03-31 | 2014-07-08 | Erasmus University Medical Center Rotterdam | Compositions for tumor growth control |
| MX2008013168A (es) * | 2006-04-13 | 2008-10-27 | Sod Conseils Rech Applic | Composiciones faramaceuticas del peptido 1 similar al glucagon humano, exendina-4 y análogos de los mismos. |
| CN102083451A (zh) | 2008-06-12 | 2011-06-01 | 赛恩泰新公司 | 癌症的抑制 |
| CA2727082C (en) | 2008-06-12 | 2019-02-26 | Syntaxin Limited | Fusion proteins for use in suppression of acromegaly |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| CN102341925A (zh) | 2009-04-27 | 2012-02-01 | 东芝照明技术株式会社 | 照明装置 |
| CN108659100A (zh) * | 2017-03-28 | 2018-10-16 | 上海新生源医药集团有限公司 | 具有镇痛作用的多肽及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4505897A (en) * | 1983-04-18 | 1985-03-19 | The Administrators Of The Tulane Educational Fund | Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith |
| EP0478101B1 (en) * | 1990-09-24 | 2001-08-29 | W.R. Grace & Co.-Conn. | Therapeutic use of peptides having thrombospondin-like activity |
| HU207104B (en) * | 1991-01-25 | 1993-03-01 | Biosignal Kutato Fejlesztoe Kf | Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds |
| WO1993003056A1 (en) * | 1991-08-09 | 1993-02-18 | Winfried Kolbeck | Lanthionine bridged peptides |
| US5462926A (en) * | 1992-07-27 | 1995-10-31 | Biomeasure, Inc. | Neuromedin B receptor antagonists which demonstrate selectivity |
| WO1994005310A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of cellular adhesion |
| RU2128055C1 (ru) * | 1992-12-07 | 1999-03-27 | Такеда Кемикал Индастриз Лтд. | Фармацевтическая композиция замедленного высвобождения и способ ее получения |
| ATE330966T1 (de) * | 1996-12-04 | 2006-07-15 | Sod Conseils Rech Applic | Somatostatin-antagonisten |
| CA2289499C (en) * | 1997-05-13 | 2010-02-23 | Michael Anthony Cawthorne | Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x |
| WO1999025729A1 (fr) * | 1997-11-18 | 1999-05-27 | Chugai Seiyaku Kabushiki Kaisha | Composes possedant une activite antitumorale |
-
2000
- 2000-06-05 IL IL14688400A patent/IL146884A0/xx unknown
- 2000-06-05 WO PCT/US2000/015396 patent/WO2000075186A1/en not_active Ceased
- 2000-06-05 EP EP00939563A patent/EP1189941B1/en not_active Expired - Lifetime
- 2000-06-05 PL PL00352968A patent/PL352968A1/xx not_active Application Discontinuation
- 2000-06-05 AU AU54633/00A patent/AU774096B2/en not_active Ceased
- 2000-06-05 AR ARP000102776A patent/AR020862A1/es not_active Application Discontinuation
- 2000-06-05 JP JP2001502467A patent/JP2003501443A/ja active Pending
- 2000-06-05 HU HU0202022A patent/HUP0202022A3/hu unknown
- 2000-06-05 CN CN00811215A patent/CN1367793A/zh active Pending
- 2000-06-05 RU RU2002100069/04A patent/RU2263680C2/ru not_active IP Right Cessation
- 2000-06-05 CZ CZ20014297A patent/CZ20014297A3/cs unknown
- 2000-06-05 ES ES00939563T patent/ES2401096T3/es not_active Expired - Lifetime
- 2000-06-05 BR BR0011680-7A patent/BR0011680A/pt not_active Application Discontinuation
- 2000-06-05 CA CA2376506A patent/CA2376506C/en not_active Expired - Fee Related
- 2000-06-29 TW TW089110978A patent/TWI243177B/zh active
-
2005
- 2005-05-19 RU RU2005115449/04A patent/RU2005115449A/ru not_active Application Discontinuation
- 2005-05-19 RU RU2005115448/04A patent/RU2005115448A/ru not_active Application Discontinuation
-
2008
- 2008-11-12 JP JP2008290079A patent/JP5165537B2/ja not_active Expired - Fee Related
-
2011
- 2011-12-02 JP JP2011264477A patent/JP5519622B2/ja not_active Expired - Fee Related
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