EA200400603A1 - Новые пептиды - аналоги гормона высвобождения гормона роста человека - Google Patents
Новые пептиды - аналоги гормона высвобождения гормона роста человекаInfo
- Publication number
- EA200400603A1 EA200400603A1 EA200400603A EA200400603A EA200400603A1 EA 200400603 A1 EA200400603 A1 EA 200400603A1 EA 200400603 A EA200400603 A EA 200400603A EA 200400603 A EA200400603 A EA 200400603A EA 200400603 A1 EA200400603 A1 EA 200400603A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- guanidine
- aminobutyric acid
- acid
- homoarginine
- leu
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 102000002265 Human Growth Hormone Human genes 0.000 title 1
- 108010000521 Human Growth Hormone Proteins 0.000 title 1
- 239000000854 Human Growth Hormone Substances 0.000 title 1
- 230000003054 hormonal effect Effects 0.000 title 1
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 abstract 6
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 abstract 4
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 2
- 108010051696 Growth Hormone Proteins 0.000 abstract 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 239000000122 growth hormone Substances 0.000 abstract 2
- 229960003104 ornithine Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
- 229930028154 D-arginine Natural products 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000007515 enzymatic degradation Effects 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000307 polymer substrate Polymers 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Новые пептиды - аналоги гормона высвобождения гормона роста, имеющие последовательность аминокислот формулы Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-R-R-Val-Leu-Ala-Gln-Leu-Ser-Ala-R-R-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R-NH(I), в которой Rпредставляет собой гомоаргинин, 4-гуанидин-2-аминомасляную кислоту или 3-гуанидин-2-аминомасляную кислоту; Rпредставляет собой гомоаргинин, орнитин, 4-гуанидин-2-аминомасляную кислоту или 3-гуанидин-2-аминомасляную кислоту; Rпредставляет собой гомоаргинин, 4-гуанидин-2-аминомасляную кислоту или 3-гуанидин-2-аминомасляную кислоту; Rпредставляет собой гомоаргинин, орнитин, 4-гуанидин-2-аминомасляную кислоту или 3-гуанидин-2-аминомасляную кислоту; Rпредставляет собой D-аргинин, гомоаргинин, 4-гуанидин-2-аминомасляную кислоту или 3-гуанидин-2-аминомасляную кислоту; а также их фармацевтически приемлемые соли являются мощными и селективными стимуляторами высвобождения гормона роста и обладают высокой стойкостью к ферментному расщеплению. Новые пептиды получают с использованием способа твердофазного синтеза, включающего: введение подходящих заместителей лизина, 2,4-диаминомасляной кислоты или 2,3-диаминопропионовой кислоты на соответствующие позиции в пептидной цепи, присоединенной к полимерной подложке, снятие защиты с боковых аминогрупп и взаимодействие свободных аминогрупп с гуанидирующим агентом, удаление всех остальных защитных трет-бутилоксикарбонильных групп, а также отделение синтезированного пептида от указанной подложки с последующей его очисткой и необязательное превращение указанного пептида в фармацевтически приемлемую соль.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL350463A PL195917B1 (pl) | 2001-10-31 | 2001-10-31 | Nowe peptydy - analogi ludzkiego hormonu uwalniającego hormon wzrostu |
| PCT/PL2002/000080 WO2003037928A2 (en) | 2001-10-31 | 2002-10-30 | Analogs of human growth hormone-releasing hormone, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200400603A1 true EA200400603A1 (ru) | 2006-06-30 |
| EA007841B1 EA007841B1 (ru) | 2007-02-27 |
Family
ID=20079564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200400603A EA007841B1 (ru) | 2001-10-31 | 2002-10-30 | Новые пептиды - аналоги гормона высвобождения гормона роста человека |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7928063B2 (ru) |
| EP (1) | EP1442059B1 (ru) |
| JP (1) | JP4401170B2 (ru) |
| AT (1) | ATE353917T1 (ru) |
| AU (1) | AU2002351536A1 (ru) |
| CA (1) | CA2465667C (ru) |
| DE (1) | DE60218199T2 (ru) |
| EA (1) | EA007841B1 (ru) |
| ES (1) | ES2282494T3 (ru) |
| HU (1) | HU229220B1 (ru) |
| PL (1) | PL195917B1 (ru) |
| SI (1) | SI1442059T1 (ru) |
| UA (1) | UA79440C2 (ru) |
| WO (1) | WO2003037928A2 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05002991A (es) * | 2002-09-18 | 2005-10-05 | Univ Montreal Ct Hospitalier Chum | Analogos de ghrh. |
| US8980249B2 (en) | 2010-06-03 | 2015-03-17 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| US20130261058A1 (en) * | 2010-09-16 | 2013-10-03 | University Of Miami | Acceleration of wound healing by growth hormone releasing hormone and its agonists |
| WO2012068187A1 (en) * | 2010-11-19 | 2012-05-24 | Merck Sharp & Dohme Corp. | Poly(amide) polymers for the delivery of oligonucleotides |
| JP6342808B2 (ja) * | 2011-10-18 | 2018-06-13 | エイルロン セラピューティクス，インコーポレイテッド | ペプチドミメティック大環状化合物 |
| US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| US9855312B2 (en) | 2012-12-21 | 2018-01-02 | University Of Miami | GHRH agonists for the treatment of ischemic disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5416073A (en) * | 1983-08-10 | 1995-05-16 | The Adminstrators Of The Tulane Educational Fund | Growth hormone-releasing peptides and method of treating animals, therewith |
| US5792747A (en) * | 1995-01-24 | 1998-08-11 | The Administrators Of The Tulane Educational Fund | Highly potent agonists of growth hormone releasing hormone |
| US6072075A (en) * | 1997-05-22 | 2000-06-06 | The Regents Of The University Of California | Guanidinylation reagents |
-
2001
- 2001-10-31 PL PL350463A patent/PL195917B1/pl unknown
-
2002
- 2002-10-30 WO PCT/PL2002/000080 patent/WO2003037928A2/en active IP Right Grant
- 2002-10-30 EA EA200400603A patent/EA007841B1/ru not_active IP Right Cessation
- 2002-10-30 CA CA2465667A patent/CA2465667C/en not_active Expired - Fee Related
- 2002-10-30 UA UA20040504092A patent/UA79440C2/ru unknown
- 2002-10-30 JP JP2003540209A patent/JP4401170B2/ja not_active Expired - Fee Related
- 2002-10-30 AU AU2002351536A patent/AU2002351536A1/en not_active Abandoned
- 2002-10-30 DE DE60218199T patent/DE60218199T2/de not_active Expired - Lifetime
- 2002-10-30 SI SI200230531T patent/SI1442059T1/sl unknown
- 2002-10-30 US US10/494,218 patent/US7928063B2/en not_active Expired - Fee Related
- 2002-10-30 AT AT02786274T patent/ATE353917T1/de not_active IP Right Cessation
- 2002-10-30 EP EP02786274A patent/EP1442059B1/en not_active Expired - Lifetime
- 2002-10-30 ES ES02786274T patent/ES2282494T3/es not_active Expired - Lifetime
- 2002-10-30 HU HU0401589A patent/HU229220B1/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US7928063B2 (en) | 2011-04-19 |
| SI1442059T1 (sl) | 2007-08-31 |
| HU229220B1 (hu) | 2013-09-30 |
| PL350463A1 (en) | 2003-05-05 |
| UA79440C2 (ru) | 2007-06-25 |
| WO2003037928A3 (en) | 2004-03-04 |
| HUP0401589A3 (en) | 2005-11-28 |
| ATE353917T1 (de) | 2007-03-15 |
| US20060172927A1 (en) | 2006-08-03 |
| EP1442059B1 (en) | 2007-02-14 |
| JP2005517633A (ja) | 2005-06-16 |
| WO2003037928A2 (en) | 2003-05-08 |
| HUP0401589A2 (hu) | 2004-11-29 |
| ES2282494T3 (es) | 2007-10-16 |
| CA2465667A1 (en) | 2003-05-08 |
| DE60218199D1 (de) | 2007-03-29 |
| PL195917B1 (pl) | 2007-11-30 |
| AU2002351536A1 (en) | 2003-05-12 |
| EA007841B1 (ru) | 2007-02-27 |
| DE60218199T2 (de) | 2007-11-22 |
| EP1442059A2 (en) | 2004-08-04 |
| JP4401170B2 (ja) | 2010-01-20 |
| CA2465667C (en) | 2011-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NF4A | Restoration of lapsed right to a eurasian patent | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM BY KZ MD TJ RU |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |