HUP0401589A2 - Új peptidek - humán növekedési hormont felszabadító hormonanalógok - Google Patents

Új peptidek - humán növekedési hormont felszabadító hormonanalógok

Info

Publication number
HUP0401589A2
HUP0401589A2 HU0401589A HUP0401589A HUP0401589A2 HU P0401589 A2 HUP0401589 A2 HU P0401589A2 HU 0401589 A HU0401589 A HU 0401589A HU P0401589 A HUP0401589 A HU P0401589A HU P0401589 A2 HUP0401589 A2 HU P0401589A2
Authority
HU
Hungary
Prior art keywords
harg
gab
gap
leu
analogs
Prior art date
Application number
HU0401589A
Other languages
English (en)
Inventor
Jan Izdebski
Danuta Kunce
Alicja Orlowska
Ewa Witkowska
Wieslaw Szelejewski
Andrzej Kutner
Krzysztof Bankowski
Elzbieta Frackiewicz
Original Assignee
Instytut Farmaceutyczny
Zaklady Farmaceutyczne Polpharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Farmaceutyczny, Zaklady Farmaceutyczne Polpharma S.A. filed Critical Instytut Farmaceutyczny
Publication of HUP0401589A2 publication Critical patent/HUP0401589A2/hu
Publication of HUP0401589A3 publication Critical patent/HUP0401589A3/hu
Publication of HU229220B1 publication Critical patent/HU229220B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány új peptidekre - növekedési hormont felszabadító hormonanalógokra, amelyeknek az aminosav-szekvenciája a Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr10-R11-R12-Val-Leu-Ala-Gln-Leu-Ser-AlaR20-R21-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R29-NH2 N> (I) általános képletnek felel meg,a képletben R11 jelentése hArg, Gab vagy Gap; R12 jelentése hArg, Orn,Gab vagy Gap; R20 jelentése hArg, Gab vagy Gap; R21 jelentése hArg,Orn, Gab vagy Gap; R29 jelentése D-Arg, hArg, Gab vagy Gap; ésgyógyászatilag elfogadható sóikra, a vegyületek előállításieljárására, valamint a vegyületeket tartalmazó gyógyászatikészítményekre vonatkozik. Ó
HU0401589A 2001-10-31 2002-10-30 Humán növekedési hormont felszabadító hormon-analógok HU229220B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL350463A PL195917B1 (pl) 2001-10-31 2001-10-31 Nowe peptydy - analogi ludzkiego hormonu uwalniającego hormon wzrostu
PCT/PL2002/000080 WO2003037928A2 (en) 2001-10-31 2002-10-30 Analogs of human growth hormone-releasing hormone, their preparation and use

Publications (3)

Publication Number Publication Date
HUP0401589A2 true HUP0401589A2 (hu) 2004-11-29
HUP0401589A3 HUP0401589A3 (en) 2005-11-28
HU229220B1 HU229220B1 (hu) 2013-09-30

Family

ID=20079564

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401589A HU229220B1 (hu) 2001-10-31 2002-10-30 Humán növekedési hormont felszabadító hormon-analógok

Country Status (14)

Country Link
US (1) US7928063B2 (hu)
EP (1) EP1442059B1 (hu)
JP (1) JP4401170B2 (hu)
AT (1) ATE353917T1 (hu)
AU (1) AU2002351536A1 (hu)
CA (1) CA2465667C (hu)
DE (1) DE60218199T2 (hu)
EA (1) EA007841B1 (hu)
ES (1) ES2282494T3 (hu)
HU (1) HU229220B1 (hu)
PL (1) PL195917B1 (hu)
SI (1) SI1442059T1 (hu)
UA (1) UA79440C2 (hu)
WO (1) WO2003037928A2 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0314619A (pt) * 2002-09-18 2005-08-02 Univ Montreal Ct Hospitalier Chum Análogos de ghrh
WO2011153491A2 (en) 2010-06-03 2011-12-08 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
WO2012037519A2 (en) * 2010-09-16 2012-03-22 University Of Miami Acceleration of wound healing by growth hormone releasing hormone and its agonists
WO2012068187A1 (en) * 2010-11-19 2012-05-24 Merck Sharp & Dohme Corp. Poly(amide) polymers for the delivery of oligonucleotides
RU2639523C2 (ru) * 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
US9079974B2 (en) 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
US9855312B2 (en) 2012-12-21 2018-01-02 University Of Miami GHRH agonists for the treatment of ischemic disorders
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416073A (en) * 1983-08-10 1995-05-16 The Adminstrators Of The Tulane Educational Fund Growth hormone-releasing peptides and method of treating animals, therewith
US5792747A (en) * 1995-01-24 1998-08-11 The Administrators Of The Tulane Educational Fund Highly potent agonists of growth hormone releasing hormone
US6072075A (en) * 1997-05-22 2000-06-06 The Regents Of The University Of California Guanidinylation reagents

Also Published As

Publication number Publication date
CA2465667A1 (en) 2003-05-08
US20060172927A1 (en) 2006-08-03
CA2465667C (en) 2011-03-08
DE60218199D1 (de) 2007-03-29
EA007841B1 (ru) 2007-02-27
HU229220B1 (hu) 2013-09-30
WO2003037928A3 (en) 2004-03-04
HUP0401589A3 (en) 2005-11-28
EP1442059A2 (en) 2004-08-04
PL350463A1 (en) 2003-05-05
AU2002351536A1 (en) 2003-05-12
EA200400603A1 (ru) 2006-06-30
JP4401170B2 (ja) 2010-01-20
SI1442059T1 (sl) 2007-08-31
UA79440C2 (uk) 2007-06-25
DE60218199T2 (de) 2007-11-22
JP2005517633A (ja) 2005-06-16
US7928063B2 (en) 2011-04-19
PL195917B1 (pl) 2007-11-30
ES2282494T3 (es) 2007-10-16
WO2003037928A2 (en) 2003-05-08
EP1442059B1 (en) 2007-02-14
ATE353917T1 (de) 2007-03-15

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MM4A Lapse of definitive patent protection due to non-payment of fees