GR3031254T3 - Novel derivatives of peptides therapeutically active in the cascade sequence for blood coagulation, process for their preparation and pharmaceutical compositions containing same - Google Patents

Novel derivatives of peptides therapeutically active in the cascade sequence for blood coagulation, process for their preparation and pharmaceutical compositions containing same

Info

Publication number
GR3031254T3
GR3031254T3 GR990402347T GR990402347T GR3031254T3 GR 3031254 T3 GR3031254 T3 GR 3031254T3 GR 990402347 T GR990402347 T GR 990402347T GR 990402347 T GR990402347 T GR 990402347T GR 3031254 T3 GR3031254 T3 GR 3031254T3
Authority
GR
Greece
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
blood coagulation
therapeutically active
Prior art date
Application number
GR990402347T
Other languages
Greek (el)
Inventor
Jean-Luc Fauchere
Christophe Thurieau
Tony Verbeuren
Alain Rupin
Serge Simonet
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of GR3031254T3 publication Critical patent/GR3031254T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PCT No. PCT/FR94/01166 Sec. 371 Date Apr. 2, 1996 Sec. 102(e) Date Apr. 2, 1996 PCT Filed Oct. 6, 1994 PCT Pub. No. WO95/09869 PCT Pub. Date Apr. 13, 1995The invention relates to the compounds of formula (I) (SEQ ID NO: I:H-phe-A1-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Abo-Ile-Pro-Glu-Glu-A2-Leu-glu-OH(I)in which A1 and A2 are as defined in the description. Medicinal products containing the same are useful as anticoagulants.
GR990402347T 1993-10-07 1999-09-20 Novel derivatives of peptides therapeutically active in the cascade sequence for blood coagulation, process for their preparation and pharmaceutical compositions containing same GR3031254T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9311942A FR2710917B1 (en) 1993-10-07 1993-10-07 New derivatives of therapeutically active peptides in the blood coagulation cascade, their preparation process and the pharmaceutical compositions containing them.
PCT/FR1994/001166 WO1995009869A1 (en) 1993-10-07 1994-10-06 Novel derivatives of peptides therapeutically active in the cascade sequence for blood coagulation, process for their preparation and pharmaceutical compositions containing same

Publications (1)

Publication Number Publication Date
GR3031254T3 true GR3031254T3 (en) 1999-12-31

Family

ID=9451616

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990402347T GR3031254T3 (en) 1993-10-07 1999-09-20 Novel derivatives of peptides therapeutically active in the cascade sequence for blood coagulation, process for their preparation and pharmaceutical compositions containing same

Country Status (16)

Country Link
US (1) US5786330A (en)
EP (1) EP0722460B1 (en)
JP (1) JP2899415B2 (en)
CN (1) CN1053451C (en)
AT (1) ATE184287T1 (en)
AU (1) AU680696B2 (en)
CA (1) CA2173598A1 (en)
DE (1) DE69420574T2 (en)
DK (1) DK0722460T3 (en)
ES (1) ES2138668T3 (en)
FI (1) FI961505A (en)
FR (1) FR2710917B1 (en)
GR (1) GR3031254T3 (en)
NO (1) NO961357L (en)
NZ (1) NZ274524A (en)
WO (1) WO1995009869A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2340461A1 (en) * 2000-03-30 2001-09-30 University Of Manitoba Hirulog-like peptide and gene therapy
DE602005023429D1 (en) 2004-10-19 2010-10-21 Lonza Ag PROCESS FOR SOLID PHASE PEPTIDE SYNTHESIS
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686086A1 (en) * 1992-01-15 1993-07-16 Adir NOVEL THERAPEUTICALLY ACTIVE PEPTIDE AND PSEUDOPEPTIDE DERIVATIVES IN BLOOD COAGULATION CASCADE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.

Also Published As

Publication number Publication date
EP0722460A1 (en) 1996-07-24
FI961505A0 (en) 1996-04-03
DK0722460T3 (en) 2000-03-20
AU7858794A (en) 1995-05-01
NO961357D0 (en) 1996-04-02
CA2173598A1 (en) 1995-04-13
JPH09503221A (en) 1997-03-31
AU680696B2 (en) 1997-08-07
EP0722460B1 (en) 1999-09-08
WO1995009869A1 (en) 1995-04-13
FR2710917A1 (en) 1995-04-14
FI961505A (en) 1996-04-03
DE69420574D1 (en) 1999-10-14
FR2710917B1 (en) 1995-11-24
JP2899415B2 (en) 1999-06-02
CN1053451C (en) 2000-06-14
CN1134706A (en) 1996-10-30
DE69420574T2 (en) 2000-05-04
NO961357L (en) 1996-06-06
ES2138668T3 (en) 2000-01-16
ATE184287T1 (en) 1999-09-15
NZ274524A (en) 1996-12-20
US5786330A (en) 1998-07-28

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