HUP0004511A2 - Integrin inhibitor hatású ciklopeptidszármazékok, eljárás ilyen származékok előállítására és alkalmazásuk - Google Patents
Integrin inhibitor hatású ciklopeptidszármazékok, eljárás ilyen származékok előállítására és alkalmazásukInfo
- Publication number
- HUP0004511A2 HUP0004511A2 HU0004511A HUP0004511A HUP0004511A2 HU P0004511 A2 HUP0004511 A2 HU P0004511A2 HU 0004511 A HU0004511 A HU 0004511A HU P0004511 A HUP0004511 A HU P0004511A HU P0004511 A2 HUP0004511 A2 HU P0004511A2
- Authority
- HU
- Hungary
- Prior art keywords
- general formula
- cyclopeptide derivatives
- preparation
- integrin inhibitor
- ch2ch2
- Prior art date
Links
- 102000001189 Cyclic Peptides Human genes 0.000 title abstract 3
- 108010069514 Cyclic Peptides Proteins 0.000 title abstract 3
- 229940125798 integrin inhibitor Drugs 0.000 title 1
- 239000007943 implant Substances 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány ciklopeptidszármazékokra, azok alkalmazására, valamintelőállításukra alkalmas eljárásra vonatkozik. A találmány szerinticiklopeptidszármazékok R-Q-X (I) általános képletében aszubsztituensek főbb jelentései: - R jelentése ciklo[Arg-Gly-Asp-Z)általános képletű csoport, - Q nincs jelen, vagy pedig jelentése -[CO-R1-NH-]m, -[NH-R1-CO-]m, -[CO-R1-CO-]m vagy -(CO-CH2-O-CH2CH2-O- -CH2CH2-NH-)n-[CO-R-NH-]m általános képletű csoport; - X jelentése -CO-CH=CH2, -CO-C(CH3)=CH2, -NH-CH=CH2, -NH-C(CH3)=CH2 vagy -NH-(CH2)p-SR10 általános képletű csoport, - Z jelentése - a többiaminosavmaradéktól függetlenül - aminosav-, dipeptid- vagytripeptidmaradék; - m és n jelentése - egymástól függetlenül - 0, 1, 2vagy 3. A találmány szerinti vegyületek integrin-inhibitorokkénthasználhatók implantátumok által előidézett rendellenességekkezelésére, valamint implantátumok vagy biokompatibilis felületekszövetekbe való beépülését eredményező folyamat gyorsítására éselősegítésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19755800A DE19755800A1 (de) | 1997-12-16 | 1997-12-16 | Cyclopeptidderivate |
| PCT/EP1998/008003 WO1999031126A1 (de) | 1997-12-16 | 1998-12-09 | Cyclopeptidderivate mit integrin-inhibitor-eigenschaften |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0004511A2 true HUP0004511A2 (hu) | 2001-06-28 |
| HUP0004511A3 HUP0004511A3 (en) | 2001-12-28 |
Family
ID=7852041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004511A HUP0004511A3 (en) | 1997-12-16 | 1998-12-09 | Cyclopeptide derivatives with integrin inhibitor properties, process for preparation thereof and their use |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6610826B1 (hu) |
| EP (1) | EP1037906B1 (hu) |
| JP (1) | JP3844655B2 (hu) |
| KR (1) | KR20010033103A (hu) |
| CN (1) | CN1282337A (hu) |
| AT (1) | ATE289320T1 (hu) |
| AU (1) | AU735386B2 (hu) |
| CA (1) | CA2315532C (hu) |
| DE (2) | DE19755800A1 (hu) |
| ES (1) | ES2237857T3 (hu) |
| HU (1) | HUP0004511A3 (hu) |
| PL (1) | PL340502A1 (hu) |
| WO (1) | WO1999031126A1 (hu) |
| ZA (1) | ZA9811462B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7815900B1 (en) | 2000-07-11 | 2010-10-19 | L'ORéAL S.A. | Use of C3-C5 monosaccharides to protect keratinous fibers |
| DE10040103A1 (de) * | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften II |
| DE10040105A1 (de) * | 2000-08-17 | 2002-02-28 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften |
| WO2002040073A1 (en) | 2000-11-20 | 2002-05-23 | Université De Genève | Endosseous implant |
| DE10325049A1 (de) * | 2003-06-02 | 2004-12-23 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III |
| PT2484365E (pt) | 2004-06-04 | 2013-12-12 | Scripps Research Inst | Composições e métodos para o tratamento de doenças neovasculares |
| JP5560393B2 (ja) * | 2005-06-22 | 2014-07-23 | アステリアス バイオセラピューティクス インコーポレイテッド | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
| AU2009209167B8 (en) * | 2008-01-30 | 2015-04-02 | Asterias Biotherapeutics, Inc. | Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells |
| AU2009209157B2 (en) | 2008-01-30 | 2015-06-11 | Asterias Biotherapeutics, Inc. | Synthetic surfaces for culturing stem cell derived cardiomyocytes |
| EP2259768B1 (en) | 2008-04-08 | 2019-05-22 | Merck Patent GmbH | Compositions containing cyclic peptides and methods of use |
| US20110183418A1 (en) * | 2009-07-29 | 2011-07-28 | Arthur Winston Martin | Peptide-Polymer Cell Culture Articles and Methods of Making |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19538741A1 (de) | 1995-10-18 | 1997-04-24 | Merck Patent Gmbh | Cyclopeptidderivate |
| EP0844252A3 (en) | 1996-11-15 | 1998-07-08 | Remacle, José | Cyclic peptides bearing a tail designed for subsequent chemical coupling and process for preparing same |
| DE19725368A1 (de) * | 1997-06-16 | 1998-12-17 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren |
-
1997
- 1997-12-16 DE DE19755800A patent/DE19755800A1/de not_active Withdrawn
-
1998
- 1998-12-09 PL PL98340502A patent/PL340502A1/xx unknown
- 1998-12-09 ES ES98966267T patent/ES2237857T3/es not_active Expired - Lifetime
- 1998-12-09 US US09/581,575 patent/US6610826B1/en not_active Expired - Lifetime
- 1998-12-09 CN CN98812195A patent/CN1282337A/zh active Pending
- 1998-12-09 WO PCT/EP1998/008003 patent/WO1999031126A1/de not_active Application Discontinuation
- 1998-12-09 DE DE59812581T patent/DE59812581D1/de not_active Expired - Lifetime
- 1998-12-09 EP EP98966267A patent/EP1037906B1/de not_active Expired - Lifetime
- 1998-12-09 HU HU0004511A patent/HUP0004511A3/hu unknown
- 1998-12-09 KR KR1020007006466A patent/KR20010033103A/ko not_active Application Discontinuation
- 1998-12-09 AT AT98966267T patent/ATE289320T1/de active
- 1998-12-09 JP JP2000539049A patent/JP3844655B2/ja not_active Expired - Fee Related
- 1998-12-09 AU AU22689/99A patent/AU735386B2/en not_active Ceased
- 1998-12-09 CA CA002315532A patent/CA2315532C/en not_active Expired - Fee Related
- 1998-12-14 ZA ZA9811462A patent/ZA9811462B/xx unknown
-
2002
- 2002-06-28 US US10/183,410 patent/US6995238B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL340502A1 (en) | 2001-02-12 |
| ZA9811462B (en) | 1999-06-15 |
| EP1037906A1 (de) | 2000-09-27 |
| DE19755800A1 (de) | 1999-06-17 |
| US20020198142A1 (en) | 2002-12-26 |
| JP3844655B2 (ja) | 2006-11-15 |
| US6610826B1 (en) | 2003-08-26 |
| KR20010033103A (ko) | 2001-04-25 |
| EP1037906B1 (de) | 2005-02-16 |
| US6995238B2 (en) | 2006-02-07 |
| AU735386B2 (en) | 2001-07-05 |
| JP2002508392A (ja) | 2002-03-19 |
| DE59812581D1 (de) | 2005-03-24 |
| ATE289320T1 (de) | 2005-03-15 |
| AU2268999A (en) | 1999-07-05 |
| ES2237857T3 (es) | 2005-08-01 |
| HUP0004511A3 (en) | 2001-12-28 |
| WO1999031126A1 (de) | 1999-06-24 |
| CN1282337A (zh) | 2001-01-31 |
| CA2315532C (en) | 2008-02-12 |
| CA2315532A1 (en) | 1999-06-24 |
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